{"id":"https://openalex.org/W2106862730","doi":"https://doi.org/10.1242/jcs.110.9.1073","title":"A nematode gene required for sperm vesicle fusion","display_name":"A nematode gene required for sperm vesicle fusion","publication_year":1997,"publication_date":"1997-05-01","ids":{"openalex":"https://openalex.org/W2106862730","doi":"https://doi.org/10.1242/jcs.110.9.1073","mag":"2106862730","pmid":"https://pubmed.ncbi.nlm.nih.gov/9175703"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.110.9.1073","doi":"https://doi.org/10.1242/jcs.110.9.1073","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.110.9.1073","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071294871","display_name":"William E. Achanzar","orcid":"https://orcid.org/0000-0002-5333-7374","observed_orcids":["https://orcid.org/0000-0002-5333-7374"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Achanzar","raw_affiliation_strings":["The University of Arizona Department of Molecular and Cellular Biology , , Tucson, Arizona 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Arizona Department of Molecular and Cellular Biology , , Tucson, Arizona 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050465263","display_name":"Samuel F Ward","orcid":"https://orcid.org/0000-0002-3206-4880","observed_orcids":["https://orcid.org/0000-0002-3206-4880"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Ward","raw_affiliation_strings":["The University of Arizona Department of Molecular and Cellular Biology , , Tucson, Arizona 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Arizona Department of Molecular and Cellular Biology , , Tucson, Arizona 85721, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":null,"apc_paid":null,"fwci":7.0596,"has_fulltext":false,"cited_by_count":186,"citation_normalized_percentile":{"value":0.9728486,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"110","issue":"9","first_page":"1073","last_page":"1081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membranous-organelles","display_name":"membranous organelles","score":0.9800000190734863},{"id":"https://openalex.org/keywords/spermatid-maturation","display_name":"spermatid maturation","score":0.765999972820282},{"id":"https://openalex.org/keywords/spermatozoa","display_name":"spermatozoa","score":0.7559999823570251},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9259999990463257},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.8040000200271606},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.8859999775886536},{"id":"https://openalex.org/keywords/viral-fusion-protein","display_name":"viral fusion protein","score":0.9259999990463257},{"id":"https://openalex.org/keywords/protein-sequence-similarity","display_name":"protein sequence similarity","score":0.5809999704360962},{"id":"https://openalex.org/keywords/spermatocytes","display_name":"spermatocytes","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8959267139434814},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.6311898827552795},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5766355395317078},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.5465107560157776},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5354058742523193},{"id":"https://openalex.org/C2777394357","wikidata":"https://www.wikidata.org/wiki/Q1494188","display_name":"Spermatid","level":3,"score":0.5200755000114441},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4986851215362549},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.46555644273757935},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46475353837013245},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.4331223964691162},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.42824673652648926},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4182107150554657},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.17858177423477173},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0992668867111206},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06733477115631104},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005306","descriptor_name":"Fertilization","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015801","descriptor_name":"Helminth Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015801","descriptor_name":"Helminth Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017238","descriptor_name":"Genes, Helminth","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1242/jcs.110.9.1073","doi":"https://doi.org/10.1242/jcs.110.9.1073","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.110.9.1073","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:9175703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9175703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:joces:110/9/1073","doi":null,"is_oa":false,"landing_page_url":"http://jcs.biologists.org/cgi/content/short/110/9/1073","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1764626999","display_name":null,"funder_award_id":"HL-07249","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7825434168","display_name":null,"funder_award_id":"25243","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W100904254","https://openalex.org/W118370999","https://openalex.org/W1506325257","https://openalex.org/W1575480196","https://openalex.org/W1792515822","https://openalex.org/W1821435713","https://openalex.org/W1823517735","https://openalex.org/W1841398683","https://openalex.org/W1847602617","https://openalex.org/W1847616262","https://openalex.org/W1941233963","https://openalex.org/W1944127002","https://openalex.org/W1948560580","https://openalex.org/W1968574939","https://openalex.org/W1972189437","https://openalex.org/W1972714306","https://openalex.org/W1975116894","https://openalex.org/W1975304761","https://openalex.org/W1980896223","https://openalex.org/W1986542876","https://openalex.org/W1986997657","https://openalex.org/W1990668385","https://openalex.org/W1996840861","https://openalex.org/W1997168691","https://openalex.org/W2009310436","https://openalex.org/W2030937967","https://openalex.org/W2038191833","https://openalex.org/W2044162798","https://openalex.org/W2053737073","https://openalex.org/W2055043387","https://openalex.org/W2068048199","https://openalex.org/W2085871244","https://openalex.org/W2093733249","https://openalex.org/W2095450147","https://openalex.org/W2102313902","https://openalex.org/W2106820084","https://openalex.org/W2109596301","https://openalex.org/W2117468188","https://openalex.org/W2122163057","https://openalex.org/W2127790730","https://openalex.org/W2147997150","https://openalex.org/W2167012621","https://openalex.org/W2167162915","https://openalex.org/W2168799539","https://openalex.org/W2412522645","https://openalex.org/W2508755412","https://openalex.org/W3135190686","https://openalex.org/W4211239492","https://openalex.org/W4244881657","https://openalex.org/W4285719527","https://openalex.org/W6604037654","https://openalex.org/W6757799867","https://openalex.org/W6844269570"],"related_works":["https://openalex.org/W755696977","https://openalex.org/W837651088","https://openalex.org/W2118881578","https://openalex.org/W1990668385","https://openalex.org/W2594952490","https://openalex.org/W7161601875","https://openalex.org/W2971294280","https://openalex.org/W2801147611","https://openalex.org/W2193499855","https://openalex.org/W2409542222"],"abstract_inverted_index":{"During":[0],"maturation":[1],"of":[2,115,182,186,195,201,210,217,223],"spermatids":[3],"to":[4,53,61,71,85,129,177],"motile":[5],"spermatozoa":[6,29],"in":[7,23,30,58,77,133,167,193],"Caenorhabditis":[8],"elegans,":[9],"large":[10],"vesicles":[11],"called":[12],"membranous":[13],"organelles":[14],"(MOs)":[15],"fuse":[16],"with":[17,110],"the":[18,24,32,40,47,72,75,79,102,107,145,187,207,226],"spermatid":[19],"plasma":[20,41],"membrane.":[21],"Mutations":[22],"gene":[25],"fer-1":[26,48,82,112,189],"cause":[27],"abnormal":[28],"which":[31,50,78,91,116],"MOs":[33,80],"do":[34],"not":[35,127],"fuse,":[36],"although":[37],"they":[38],"abut":[39],"membrane":[42,169],"normally.":[43],"Here":[44],"we":[45,51],"describe":[46],"gene,":[49],"found":[52],"be":[54],"approximately":[55],"8.6":[56],"kb":[57,65],"length":[59],"and":[60,199,213,225],"encode":[62,86],"a":[63,87,97,164],"6.2":[64],"transcript":[66],"whose":[67],"expression":[68],"is":[69,83,92,126],"limited":[70],"primary":[73],"spermatocytes,":[74],"cells":[76],"form.":[81],"predicted":[84,146,179,203],"235":[88],"kDa":[89],"protein":[90],"highly":[93],"charged":[94],"except":[95],"for":[96],"putative":[98],"transmembrane":[99,147,151],"domain":[100,152],"near":[101],"C":[103],"terminus.":[104],"We":[105],"identified":[106,188],"mutations":[108,119,190],"associated":[109],"five":[111],"alleles,":[113],"all":[114],"are":[117,191],"missense":[118],"causing":[120],"single":[121],"amino":[122],"acid":[123],"changes.":[124],"FER-1":[125,154,171,198,224],"similar":[128],"any":[130],"characterized":[131],"proteins":[132,181],"sequence":[134,175],"databases,":[135],"nor":[136],"does":[137,172],"it":[138,161],"contain":[139],"known":[140],"functional":[141],"motifs":[142],"other":[143],"than":[144],"domain.":[148],"The":[149],"C-terminal":[150],"makes":[153],"resemble":[155],"some":[156],"viral":[157],"fusion":[158],"proteins,":[159],"suggesting":[160],"may":[162],"play":[163],"direct":[165],"role":[166],"MO-plasma":[168],"fusion.":[170],"show":[173],"significant":[174],"similarity":[176,196,218],"several":[178],"human":[180,227],"unknown":[183],"function.":[184],"Two":[185],"located":[192],"regions":[194,216],"between":[197],"two":[200],"these":[202,211,215],"proteins.":[204,228],"This":[205],"strengthens":[206],"biological":[208],"significance":[209],"similarities":[212],"suggests":[214],"represent":[219],"functionally":[220],"important":[221],"domains":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}