{"id":"https://openalex.org/W2106836962","doi":"https://doi.org/10.1002/biot.201400020","title":"Efficient myogenic commitment of human mesenchymal stem cells on biomimetic materials replicating myoblast topography","display_name":"Efficient myogenic commitment of human mesenchymal stem cells on biomimetic materials replicating myoblast topography","publication_year":2014,"publication_date":"2014-09-15","ids":{"openalex":"https://openalex.org/W2106836962","doi":"https://doi.org/10.1002/biot.201400020","mag":"2106836962","pmid":"https://pubmed.ncbi.nlm.nih.gov/25224309"},"language":"en","primary_location":{"id":"doi:10.1002/biot.201400020","doi":"https://doi.org/10.1002/biot.201400020","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biot.201400020","pdf_url":null,"source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024897924","display_name":"Eunjee A. Lee","orcid":"https://orcid.org/0000-0002-7132-3822","observed_orcids":["https://orcid.org/0000-0002-7132-3822"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunjee A. Lee","raw_affiliation_strings":["School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014240047","display_name":"Sung Gap Im","orcid":"https://orcid.org/0000-0002-2802-6398","observed_orcids":["https://orcid.org/0000-0002-2802-6398","https://orcid.org/0000-0001-7562-2929","https://orcid.org/0000-0002-4722-1893"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung\u2010Gap Im","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering & KI for the NanoCentury, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering & KI for the NanoCentury, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075710060","display_name":"Nathaniel Suk-Yeon Hwang","orcid":"https://orcid.org/0000-0003-3735-7727","observed_orcids":["https://orcid.org/0000-0003-3735-7727"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Nathaniel S. Hwang","raw_affiliation_strings":["School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea","The BioMAX Institute of Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"The BioMAX Institute of Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075710060"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.5604,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.57284423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"12","first_page":"1604","last_page":"1612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7221999764442444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7221999764442444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.09740000218153,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.08699999749660492,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-mesenchymal-stem-cells","display_name":"human mesenchymal stem cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/biomimetic-substrates","display_name":"biomimetic substrates","score":0.9160000085830688},{"id":"https://openalex.org/keywords/surface-topography","display_name":"surface topography","score":0.515999972820282},{"id":"https://openalex.org/keywords/musculoskeletal-tissue-regeneration","display_name":"musculoskeletal regeneration","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.821894645690918},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6659636497497559},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6620954871177673},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.6460180282592773},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6192160844802856},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5642173290252686},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.49556100368499756},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.49360597133636475},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4844188988208771},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4524078667163849},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4387039542198181},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.415691077709198},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3766842782497406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3665620684623718},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2858080267906189},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27149346470832825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1016065776348114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07644331455230713},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D024510","descriptor_name":"Muscle Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D040761","descriptor_name":"Biomimetic Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044968","descriptor_name":"Regenerative Medicine","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D044968","descriptor_name":"Regenerative Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/biot.201400020","doi":"https://doi.org/10.1002/biot.201400020","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biot.201400020","pdf_url":null,"source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},{"id":"pmid:25224309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25224309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G548037508","display_name":null,"funder_award_id":"2013071521","funder_id":"https://openalex.org/F4320322349","funder_display_name":"Ministry of Education, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1612175405","https://openalex.org/W1973126965","https://openalex.org/W1973403961","https://openalex.org/W1973615948","https://openalex.org/W1976988389","https://openalex.org/W1981169249","https://openalex.org/W1982367958","https://openalex.org/W1983890981","https://openalex.org/W1988265183","https://openalex.org/W1997974665","https://openalex.org/W2011305371","https://openalex.org/W2015054568","https://openalex.org/W2016395056","https://openalex.org/W2018884883","https://openalex.org/W2023748814","https://openalex.org/W2025587555","https://openalex.org/W2029378543","https://openalex.org/W2032574661","https://openalex.org/W2037023035","https://openalex.org/W2054635074","https://openalex.org/W2061218357","https://openalex.org/W2071680558","https://openalex.org/W2073719511","https://openalex.org/W2084672767","https://openalex.org/W2091928488","https://openalex.org/W2093569973","https://openalex.org/W2093801161","https://openalex.org/W2096347843","https://openalex.org/W2096398122","https://openalex.org/W2106606171","https://openalex.org/W2121312142","https://openalex.org/W2123207426","https://openalex.org/W2125691717","https://openalex.org/W2134208433","https://openalex.org/W2139107295","https://openalex.org/W2141233228","https://openalex.org/W2143287675","https://openalex.org/W2144023435","https://openalex.org/W2149211067","https://openalex.org/W2149605222","https://openalex.org/W2160651248","https://openalex.org/W2169755701","https://openalex.org/W2172119289","https://openalex.org/W2314463096","https://openalex.org/W2317519097","https://openalex.org/W2327425609"],"related_works":["https://openalex.org/W83365050","https://openalex.org/W2770300040","https://openalex.org/W1783001233","https://openalex.org/W2765592627","https://openalex.org/W2758662019","https://openalex.org/W4414984413","https://openalex.org/W2096398122","https://openalex.org/W1983776635","https://openalex.org/W2767685396","https://openalex.org/W2979484018"],"abstract_inverted_index":{"Recent":[0],"developments":[1],"in":[2,37,184],"stem":[3,10],"cell":[4,16],"technologies":[5],"have":[6,31,79],"demonstrated":[7],"human":[8],"mesenchymal":[9],"cells":[11,144],"(hMSCs)":[12],"as":[13,124],"a":[14,81,113,125],"possible":[15],"source":[17],"for":[18,128],"cell-based":[19],"therapies":[20],"and":[21,26,122,138,150,171,191],"regenerative":[22],"medicine":[23],"applications.":[24],"Self-renewal":[25],"differentiation":[27],"abilities":[28],"of":[29,39,66,91,106,132,163,197],"hMSCs":[30,33,42,67,135,164],"enabled":[32],"to":[34,45,68,154,194],"be":[35,182],"applied":[36,193],"regeneration":[38],"musculoskeletal":[40],"tissue.":[41],"are":[43,165],"able":[44],"myogenically":[46],"differentiate":[47],"via":[48],"various":[49],"approaches;":[50],"however,":[51],"the":[52,63,69,87,129,146,169,176],"most":[53],"efficient":[54,64],"method":[55],"has":[56],"not":[57],"been":[58],"developed.":[59],"Here,":[60],"we":[61],"describe":[62],"commitment":[65],"myogenic":[70,130,155,161],"lineage":[71,196],"on":[72,140,168],"biomimetic":[73,142],"substrates":[74],"replicating":[75],"myoblast":[76,148],"topography.":[77],"We":[78],"created":[80],"tissue":[82,178],"culture":[83,179,186],"platform":[84,180],"that":[85,160],"replicates":[86],"micro-and":[88],"nanoscale":[89,172],"topography":[90],"fully":[92,107],"differentiated":[93,108,139],"skeletal":[94],"myoblasts.":[95],"Using":[96],"UV-assisted":[97],"capillary":[98],"force":[99],"lithography,":[100],"an":[101],"optically":[102],"transparent":[103],"cellular":[104],"model":[105],"myoblasts":[109],"was":[110,120],"developed":[111],"using":[112],"UV":[114],"curable":[115],"poly(urethane":[116],"acrylate)":[117],"resin,":[118],"which":[119],"fabricated":[121],"employed":[123],"cell-culture":[126],"substrate":[127],"pattern":[131,149],"hMSCs.":[133,198],"When":[134],"were":[136],"cultured":[137],"these":[141],"patterns,":[143],"followed":[145],"underlying":[147],"more":[151],"efficiently":[152],"committed":[153],"fate.":[156],"These":[157],"results":[158,190],"demonstrate":[159],"potentials":[162],"highly":[166],"depended":[167],"micro-":[170],"topographical":[173],"cues.":[174],"Furthermore,":[175],"described":[177],"can":[181],"used":[183],"larger":[185],"settings":[187],"with":[188],"consistent":[189],"easily":[192],"other":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}