{"id":"https://openalex.org/W2106817237","doi":"https://doi.org/10.1210/me.2005-0531","title":"Acetylation of Estrogen Receptor \u03b1 by p300 at Lysines 266 and 268 Enhances the Deoxyribonucleic Acid Binding and Transactivation Activities of the Receptor","display_name":"Acetylation of Estrogen Receptor \u03b1 by p300 at Lysines 266 and 268 Enhances the Deoxyribonucleic Acid Binding and Transactivation Activities of the Receptor","publication_year":2006,"publication_date":"2006-02-24","ids":{"openalex":"https://openalex.org/W2106817237","doi":"https://doi.org/10.1210/me.2005-0531","mag":"2106817237","pmid":"https://pubmed.ncbi.nlm.nih.gov/16497729","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1483068"},"language":"en","primary_location":{"id":"doi:10.1210/me.2005-0531","doi":"https://doi.org/10.1210/me.2005-0531","is_oa":false,"landing_page_url":"https://doi.org/10.1210/me.2005-0531","pdf_url":null,"source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1483068","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mi Young Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mi Young Kim","raw_affiliation_strings":["Department of Molecular Biology and Genetics (M.Y.K., Y.T.E.C., D.R.H., W.L.K.), Cornell University, Ithaca, New York 14853;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics (M.Y.K., Y.T.E.C., D.R.H., W.L.K.), Cornell University, Ithaca, New York 14853;","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006798582","display_name":"Eileen M. Woo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eileen M. Woo","raw_affiliation_strings":["Laboratory of Chromatin Biology and Epigenetics (E.M.W.), The Rockefeller University, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chromatin Biology and Epigenetics (E.M.W.), The Rockefeller University, New York, New York 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029224249","display_name":"Yeeting Esther Chong","orcid":"https://orcid.org/0000-0002-8396-8898","observed_orcids":["https://orcid.org/0000-0002-8396-8898"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yee Ting Esther Chong","raw_affiliation_strings":["Department of Molecular Biology and Genetics (M.Y.K., Y.T.E.C., D.R.H., W.L.K.), Cornell University, Ithaca, New York 14853;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics (M.Y.K., Y.T.E.C., D.R.H., W.L.K.), Cornell University, Ithaca, New York 14853;","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022102083","display_name":"Daria R. Homenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daria R. Homenko","raw_affiliation_strings":["Department of Molecular Biology and Genetics (M.Y.K., Y.T.E.C., D.R.H., W.L.K.), Cornell University, Ithaca, New York 14853;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics (M.Y.K., Y.T.E.C., D.R.H., W.L.K.), Cornell University, Ithaca, New York 14853;","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049927586","display_name":"W. Lee Kraus","orcid":"https://orcid.org/0000-0002-8786-2986","observed_orcids":["https://orcid.org/0000-0002-8786-2986"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Lee Kraus","raw_affiliation_strings":["Department of Molecular Biology and Genetics (M.Y.K., Y.T.E.C., D.R.H., W.L.K.), Cornell University, Ithaca, New York 14853;","Department of Pharmacology (W.L.K.), Weill Medical College of Cornell University, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics (M.Y.K., Y.T.E.C., D.R.H., W.L.K.), Cornell University, Ithaca, New York 14853;","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Pharmacology (W.L.K.), Weill Medical College of Cornell University, New York, New York 10021","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.1222,"has_fulltext":false,"cited_by_count":236,"citation_normalized_percentile":{"value":0.98725535,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"20","issue":"7","first_page":"1479","last_page":"1493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":1.0},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.9549999833106995},{"id":"https://openalex.org/keywords/lysine-acetylation","display_name":"lysine acetylation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.7979999780654907},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.656000018119812},{"id":"https://openalex.org/keywords/deacetylase","display_name":"deacetylase","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.8830000162124634},{"id":"https://openalex.org/keywords/glutamine-substitution","display_name":"glutamine substitution","score":0.7870000004768372},{"id":"https://openalex.org/keywords/estrogen-signaling","display_name":"estrogen signaling","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.8074880838394165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7505955696105957},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.6286298036575317},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5926569104194641},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5392478704452515},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.48280560970306396},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.4496708810329437},{"id":"https://openalex.org/C2776901170","wikidata":"https://www.wikidata.org/wiki/Q12499775","display_name":"Nicotinamide adenine dinucleotide","level":4,"score":0.4441049098968506},{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.4399505853652954},{"id":"https://openalex.org/C2911110750","wikidata":"https://www.wikidata.org/wiki/Q7117884","display_name":"P300-CBP Transcription Factors","level":5,"score":0.422332227230072},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.414775013923645},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.35822194814682007},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.2943926453590393},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2510114312171936},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.21862098574638367},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18609967827796936},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.17755737900733948},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1695280373096466},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14570456743240356},{"id":"https://openalex.org/C2910921701","wikidata":"https://www.wikidata.org/wiki/Q1036906","display_name":"Histone Acetyltransferases","level":4,"score":0.10480013489723206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08742514252662659},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037761","descriptor_name":"Sirtuins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050880","descriptor_name":"p300-CBP Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051958","descriptor_name":"Nuclear Receptor Coactivator 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1210/me.2005-0531","doi":"https://doi.org/10.1210/me.2005-0531","is_oa":false,"landing_page_url":"https://doi.org/10.1210/me.2005-0531","pdf_url":null,"source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmid:16497729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16497729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular endocrinology (Baltimore, Md.)","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:1483068","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1483068","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Endocrinol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.537.4712","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.537.4712","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://lab.rockefeller.edu/chait/pdf/06/06_kim_mol-endocrin.pdf","raw_type":"text"},{"id":"mag:2141887956","doi":null,"is_oa":false,"landing_page_url":"http://lab.rockefeller.edu/chait/pdf/06/06_kim_mol-endocrin.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1483068","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1483068","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Endocrinol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000890397","display_name":"Dose-Dependent Effects of Hormone on the Activity of Estrogen Receptor Enhancers and Target Genes","funder_award_id":"R01DK058110","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W1497395693","https://openalex.org/W1537193412","https://openalex.org/W1592701628","https://openalex.org/W1603613943","https://openalex.org/W1884928119","https://openalex.org/W1967364632","https://openalex.org/W1977306646","https://openalex.org/W1981718275","https://openalex.org/W1995902306","https://openalex.org/W1999730611","https://openalex.org/W2000177129","https://openalex.org/W2003686815","https://openalex.org/W2004335766","https://openalex.org/W2005783395","https://openalex.org/W2008547479","https://openalex.org/W2010710786","https://openalex.org/W2011957030","https://openalex.org/W2012537034","https://openalex.org/W2015626650","https://openalex.org/W2018274913","https://openalex.org/W2020725121","https://openalex.org/W2024653188","https://openalex.org/W2026350621","https://openalex.org/W2029583949","https://openalex.org/W2031352187","https://openalex.org/W2037640972","https://openalex.org/W2043852388","https://openalex.org/W2049970571","https://openalex.org/W2050339689","https://openalex.org/W2051152566","https://openalex.org/W2054267961","https://openalex.org/W2059792018","https://openalex.org/W2060760516","https://openalex.org/W2066204526","https://openalex.org/W2070840393","https://openalex.org/W2072255567","https://openalex.org/W2073148985","https://openalex.org/W2073286776","https://openalex.org/W2073944950","https://openalex.org/W2074362522","https://openalex.org/W2079003739","https://openalex.org/W2082221765","https://openalex.org/W2088993196","https://openalex.org/W2091041925","https://openalex.org/W2091446670","https://openalex.org/W2092411075","https://openalex.org/W2092722802","https://openalex.org/W2094838095","https://openalex.org/W2096501714","https://openalex.org/W2100049410","https://openalex.org/W2103279939","https://openalex.org/W2103309832","https://openalex.org/W2105439521","https://openalex.org/W2107558077","https://openalex.org/W2107733280","https://openalex.org/W2117717795","https://openalex.org/W2123927456","https://openalex.org/W2125751034","https://openalex.org/W2128787958","https://openalex.org/W2137135419","https://openalex.org/W2143027433","https://openalex.org/W2143471382","https://openalex.org/W2146027649","https://openalex.org/W2149149696","https://openalex.org/W2156381084","https://openalex.org/W2156575042","https://openalex.org/W2165265831","https://openalex.org/W2167203556","https://openalex.org/W2167550154","https://openalex.org/W2172256092","https://openalex.org/W2187452737","https://openalex.org/W2216094174","https://openalex.org/W4212936275","https://openalex.org/W4251934001","https://openalex.org/W4388278375"],"related_works":["https://openalex.org/W2141887956","https://openalex.org/W2103309832","https://openalex.org/W2268096124","https://openalex.org/W2944411720","https://openalex.org/W2944236696","https://openalex.org/W2148204746","https://openalex.org/W2166153112","https://openalex.org/W2133850696","https://openalex.org/W2773947652","https://openalex.org/W2148378944"],"abstract_inverted_index":{"Using":[0,29],"a":[1,22,127,157,168,184,191],"variety":[2,192],"of":[3,50,79,119,138,144,154,170,176,193],"biochemical":[4],"and":[5,24,31,43,75,96,99,115,146,200],"cell-based":[6,158],"approaches,":[7],"we":[8,34],"show":[9],"that":[10,45,68,129],"estrogen":[11,194],"receptor":[12,26],"alpha":[13],"(ERalpha)":[14],"is":[15,83,180],"acetylated":[16,56,72,131],"by":[17,61,81,85],"the":[18,47,120,134,151,171],"p300":[19,82],"acetylase":[20],"in":[21,40,57,140,156,186,190,197],"ligand-":[23],"steroid":[25],"coactivator-dependent":[27],"manner.":[28],"mutagenesis":[30],"mass":[32],"spectrometry,":[33],"identified":[35],"two":[36],"conserved":[37],"lysine":[38],"residues":[39,54,122],"ERalpha":[41,71,80,139,155],"(Lys266":[42],"Lys268)":[44],"are":[46,55],"primary":[48],"targets":[49],"p300-mediated":[51],"acetylation.":[52],"These":[53],"cells,":[58],"as":[59,109,167],"determined":[60],"immunoprecipitation-Western":[62],"blotting":[63],"experiments":[64],"using":[65],"an":[66],"antibody":[67],"specifically":[69],"recognizes":[70],"at":[73,113],"Lys266":[74,114,145],"Lys268.":[76],"The":[77],"acetylation":[78,166],"reversed":[84],"native":[86],"cellular":[87],"deacetylases,":[88,107],"including":[89],"trichostatin":[90],"A-sensitive":[91],"enzymes":[92,103],"(i.e.":[93,104,125],"class":[94,105],"I":[95],"II":[97],"deacetylases)":[98],"nicotinamide":[100],"adenine":[101],"dinucleotide-dependent/nicotinamide-sensitive":[102],"III":[106],"such":[108],"sirtuin":[110],"1).":[111],"Acetylation":[112],"Lys268,":[116],"or":[117],"substitution":[118,143],"same":[121],"with":[123,148],"glutamine":[124,149],"K266/268Q),":[126],"residue":[128],"mimics":[130],"lysine,":[132],"enhances":[133,150],"DNA":[135],"binding":[136],"activity":[137,153,175],"EMSAs.":[141],"Likewise,":[142],"Lys268":[147],"ligand-dependent":[152,172],"reporter":[159],"gene":[160,173],"assay.":[161],"Collectively,":[162],"our":[163],"results":[164],"implicate":[165],"modulator":[169],"regulatory":[174],"ERalpha.":[177],"Such":[178],"regulation":[179],"likely":[181],"to":[182],"play":[183],"role":[185],"estrogen-dependent":[187],"signaling":[188],"outcomes":[189],"target":[195],"tissues":[196],"both":[198],"normal":[199],"pathological":[201],"states.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
