{"id":"https://openalex.org/W2106812445","doi":"https://doi.org/10.1073/pnas.1217812110","title":"Conditionals by inversion provide a universal method for the generation of conditional alleles","display_name":"Conditionals by inversion provide a universal method for the generation of conditional alleles","publication_year":2013,"publication_date":"2013-08-05","ids":{"openalex":"https://openalex.org/W2106812445","doi":"https://doi.org/10.1073/pnas.1217812110","mag":"2106812445","pmid":"https://pubmed.ncbi.nlm.nih.gov/23918385","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3752204"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1217812110","doi":"https://doi.org/10.1073/pnas.1217812110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1217812110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3752204","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002782925","display_name":"Aris N. Economides","orcid":"https://orcid.org/0000-0002-6508-8942","observed_orcids":["https://orcid.org/0000-0002-6508-8942"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aris N. Economides","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","Regeneron Pharmaceuticals, Inc. Tarrytown NY 10591 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]},{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc. Tarrytown NY 10591 USA","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045570041","display_name":"David A. Frendewey","orcid":"https://orcid.org/0000-0003-2305-3490","observed_orcids":["https://orcid.org/0000-0003-2305-3490"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Frendewey","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101942940","display_name":"Peter C. Yang","orcid":"https://orcid.org/0000-0002-1870-7464","observed_orcids":["https://orcid.org/0000-0002-1870-7464"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Yang","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058539484","display_name":"Melissa G. Dominguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa G. Dominguez","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008546075","display_name":"Anthony T. Dore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony T. Dore","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036444816","display_name":"Ivan B. Lobov","orcid":"https://orcid.org/0000-0002-2845-8895","observed_orcids":["https://orcid.org/0000-0002-2845-8895"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan B. Lobov","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054915112","display_name":"Trikaldarshi Persaud","orcid":"https://orcid.org/0000-0002-3236-9932","observed_orcids":["https://orcid.org/0000-0002-3236-9932"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trikaldarshi Persaud","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101991023","display_name":"Jos\u00e9 Rojas","orcid":"https://orcid.org/0000-0001-5327-5508","observed_orcids":["https://orcid.org/0000-0001-5327-5508"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Rojas","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112461936","display_name":"Joyce McClain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce McClain","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056435911","display_name":"P\u00e9ter Lengyel","orcid":"https://orcid.org/0000-0003-0737-8586","observed_orcids":["https://orcid.org/0000-0003-0737-8586"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Lengyel","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066757897","display_name":"Gustavo Droguett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustavo Droguett","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004816868","display_name":"Rostislav Chernomorsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rostislav Chernomorsky","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102719676","display_name":"Sean Gregory Stevens","orcid":"https://orcid.org/0000-0003-3522-1412","observed_orcids":["https://orcid.org/0000-0003-3522-1412"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Stevens","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006600943","display_name":"Wojtek Auerbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wojtek Auerbach","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111899916","display_name":"Thomas M. DeChiara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. DeChiara","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046324630","display_name":"William Pouyemirou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Pouyemirou","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052415460","display_name":"Joseph M. Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Cruz","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035280367","display_name":"Kieran Feeley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kieran Feeley","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050540428","display_name":"Ian A. Mellis","orcid":"https://orcid.org/0000-0002-6239-4821","observed_orcids":["https://orcid.org/0000-0002-6239-4821"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian A. Mellis","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071231999","display_name":"Jason Yasenchak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Yasenchack","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089607333","display_name":"Sarah J. Hatsell","orcid":"https://orcid.org/0000-0003-1103-6087","observed_orcids":["https://orcid.org/0000-0003-1103-6087"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah J. Hatsell","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110057432","display_name":"Liqin Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LiQin Xie","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067579135","display_name":"Esther Latres","orcid":"https://orcid.org/0009-0003-8330-1393","observed_orcids":["https://orcid.org/0009-0003-8330-1393","https://orcid.org/0000-0002-8853-0019"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther Latres","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lily Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lily Huang","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110827204","display_name":"Yuhong Zhang","orcid":"https://orcid.org/0000-0003-4230-5868","observed_orcids":["https://orcid.org/0000-0003-4230-5868"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhong Zhang","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006097900","display_name":"Evangelos Pefanis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evangelos Pefanis","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089320668","display_name":"Dimitris Skokos","orcid":"https://orcid.org/0000-0003-1196-3139","observed_orcids":["https://orcid.org/0000-0003-1196-3139"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dimitris Skokos","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020868256","display_name":"Ron A. Deckelbaum","orcid":"https://orcid.org/0000-0003-1028-3019","observed_orcids":["https://orcid.org/0000-0003-1028-3019"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron A. Deckelbaum","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070887960","display_name":"Susan D. Croll","orcid":"https://orcid.org/0000-0002-3949-1877","observed_orcids":["https://orcid.org/0000-0002-3949-1877"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan D. Croll","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001365928","display_name":"Samuel H. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Davis","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111979617","display_name":"David M. Valenzuela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Valenzuela","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036682345","display_name":"Nicholas W. Gale","orcid":"https://orcid.org/0000-0001-9324-268X","observed_orcids":["https://orcid.org/0000-0001-9324-268X"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas W. Gale","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101917021","display_name":"Andrew J. Murphy","orcid":"https://orcid.org/0000-0003-4152-4081","observed_orcids":["https://orcid.org/0000-0003-4152-4081"]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Murphy","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085672493","display_name":"George D. Yancopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186523950","display_name":"Regeneron (United States)","ror":"https://ror.org/02f51rf24","country_code":"US","type":"company","lineage":["https://openalex.org/I186523950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George D. Yancopoulos","raw_affiliation_strings":["Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591","institution_ids":["https://openalex.org/I186523950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I186523950"],"apc_list":null,"apc_paid":null,"fwci":1.9795,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.87187138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"110","issue":"34","first_page":"E3179","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conditional-alleles","display_name":"conditional alleles","score":0.8659999966621399},{"id":"https://openalex.org/keywords/conditional-mutagenesis","display_name":"conditional mutagenesis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/site-specific-recombinases","display_name":"site-specific recombinases","score":0.7929999828338623},{"id":"https://openalex.org/keywords/transcription-termination","display_name":"transcription termination","score":0.578000009059906},{"id":"https://openalex.org/keywords/conditional-knockout","display_name":"conditional knockout","score":0.7450000047683716},{"id":"https://openalex.org/keywords/gene-function-analysis","display_name":"gene function analysis","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5995966196060181},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.576353132724762},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5415878295898438},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5097269415855408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5095610618591309},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46447718143463135},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4295356869697571},{"id":"https://openalex.org/C44492722","wikidata":"https://www.wikidata.org/wiki/Q327069","display_name":"Conditional probability","level":2,"score":0.4128761887550354},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4120885729789734},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17452728748321533},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004254","descriptor_name":"DNA Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057345","descriptor_name":"Sequence Inversion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1217812110","doi":"https://doi.org/10.1073/pnas.1217812110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1217812110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2754717","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3752204","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3752204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3752204","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:23918385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23918385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2754717","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3752204","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W197177817","https://openalex.org/W1512136761","https://openalex.org/W1523950660","https://openalex.org/W1580639168","https://openalex.org/W1783181079","https://openalex.org/W1963522337","https://openalex.org/W1966725512","https://openalex.org/W1972044265","https://openalex.org/W1973304749","https://openalex.org/W1976886867","https://openalex.org/W1977397104","https://openalex.org/W1978737031","https://openalex.org/W1983133780","https://openalex.org/W1983188063","https://openalex.org/W1985366513","https://openalex.org/W1988488966","https://openalex.org/W1988904557","https://openalex.org/W1989482194","https://openalex.org/W1996670527","https://openalex.org/W2018045673","https://openalex.org/W2020693389","https://openalex.org/W2031724207","https://openalex.org/W2032002636","https://openalex.org/W2035046591","https://openalex.org/W2050367709","https://openalex.org/W2052344595","https://openalex.org/W2052513354","https://openalex.org/W2053058135","https://openalex.org/W2056916102","https://openalex.org/W2062240872","https://openalex.org/W2067194336","https://openalex.org/W2082311924","https://openalex.org/W2085544097","https://openalex.org/W2100979164","https://openalex.org/W2128295200","https://openalex.org/W2136002991","https://openalex.org/W2136401958","https://openalex.org/W2136942244","https://openalex.org/W2138161663","https://openalex.org/W2142084348","https://openalex.org/W2159015766","https://openalex.org/W2160331473","https://openalex.org/W2160769285","https://openalex.org/W2293072912"],"related_works":["https://openalex.org/W7099909153","https://openalex.org/W2940783316","https://openalex.org/W7117141738","https://openalex.org/W4311281453","https://openalex.org/W2582559254","https://openalex.org/W4313399423","https://openalex.org/W3048619260","https://openalex.org/W2414378945","https://openalex.org/W3043163052","https://openalex.org/W4319778190"],"abstract_inverted_index":{"Conditional":[0],"mutagenesis":[1],"is":[2,16],"becoming":[3],"a":[4,38,62,72,88],"method":[5,141],"of":[6,61,80,111,131,139,150,162,197],"choice":[7],"for":[8,90,194],"studying":[9],"gene":[10,22],"function,":[11],"but":[12],"constructing":[13],"conditional":[14,30,126,172],"alleles":[15,135],"often":[17,174],"laborious,":[18],"limited":[19],"by":[20,42,71],"target":[21,82],"structure,":[23],"and":[24,85,121,142,165],"at":[25],"times,":[26],"prone":[27],"to":[28,146,176,182],"incomplete":[29],"ablation.":[31],"To":[32],"address":[33],"these":[34],"issues,":[35],"we":[36],"developed":[37],"technology":[39],"termed":[40],"conditionals":[41],"inversion":[43],"(COIN).":[44],"Before":[45],"activation,":[46],"COINs":[47],"contain":[48],"an":[49,112],"inverted":[50,66],"module":[51,77],"(COIN":[52],"module)":[53],"that":[54,158],"lies":[55],"inertly":[56],"within":[57],"the":[58,68,75,81,137,140,180,186,195],"antisense":[59],"strand":[60,70],"resident":[63],"gene.":[64],"When":[65],"into":[67,99,106],"sense":[69],"site-specific":[73],"recombinase,":[74],"COIN":[76,94,134],"causes":[78],"termination":[79],"gene's":[83],"transcription":[84],"simultaneously":[86],"provides":[87,156],"reporter":[89],"tracking":[91],"this":[92,163],"event.":[93],"modules":[95],"can":[96],"be":[97],"inserted":[98],"natural":[100],"introns":[101],"(intronic":[102],"COINs)":[103],"or":[104],"directly":[105],"coding":[107],"exons":[108,184],"as":[109],"part":[110],"artificial":[113,188],"intron":[114,189],"(exonic":[115],"COINs),":[116],"greatly":[117],"simplifying":[118],"allele":[119],"design":[120],"increasing":[122],"flexibility":[123],"over":[124,132],"previous":[125],"KO":[127],"approaches.":[128],"Detailed":[129],"analysis":[130],"20":[133],"establishes":[136],"reliability":[138],"its":[143],"broad":[144],"applicability":[145],"any":[147],"gene,":[148],"regardless":[149],"exon-intron":[151],"structure.":[152],"Our":[153],"extensive":[154],"testing":[155],"rules":[157],"help":[159],"ensure":[160],"success":[161],"approach":[164],"also":[166],"explains":[167],"why":[168],"other":[169],"currently":[170],"available":[171],"approaches":[173],"fail":[175],"function":[177],"optimally.":[178],"Finally,":[179],"ability":[181],"split":[183],"using":[185],"COIN's":[187],"opens":[190],"up":[191],"engineering":[192],"modalities":[193],"generation":[196],"multifunctional":[198],"alleles.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
