{"id":"https://openalex.org/W2106802201","doi":"https://doi.org/10.1128/ec.00379-09","title":"The Conjugation-Specific Die5 Protein Is Required for Development of the Somatic Nucleus in both Paramecium and Tetrahymena","display_name":"The Conjugation-Specific Die5 Protein Is Required for Development of the Somatic Nucleus in both Paramecium and Tetrahymena","publication_year":2010,"publication_date":"2010-05-22","ids":{"openalex":"https://openalex.org/W2106802201","doi":"https://doi.org/10.1128/ec.00379-09","mag":"2106802201","pmid":"https://pubmed.ncbi.nlm.nih.gov/20495055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2901671"},"language":"en","primary_location":{"id":"doi:10.1128/ec.00379-09","doi":"https://doi.org/10.1128/ec.00379-09","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00379-09","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/ec.00379-09","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051819621","display_name":"Atsushi Matsuda","orcid":"https://orcid.org/0000-0003-0510-213X","observed_orcids":["https://orcid.org/0000-0003-0510-213X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atsushi Matsuda","raw_affiliation_strings":["Department of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907-2063","Department of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, IN 47907-2063, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907-2063","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, IN 47907-2063, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013687475","display_name":"Annie Wan-Yi Shieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annie Wan-Yi Shieh","raw_affiliation_strings":["Biology Department, Washington University in St. Louis, Campus Box 1137, One Brookings Drive, St. Louis, Missouri 63130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Washington University in St. Louis, Campus Box 1137, One Brookings Drive, St. Louis, Missouri 63130","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075351356","display_name":"Douglas L. Chalker","orcid":"https://orcid.org/0000-0002-0285-3344","observed_orcids":["https://orcid.org/0000-0002-0285-3344"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas L. Chalker","raw_affiliation_strings":["Biology Department, Washington University in St. Louis, Campus Box 1137, One Brookings Drive, St. Louis, Missouri 63130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Washington University in St. Louis, Campus Box 1137, One Brookings Drive, St. Louis, Missouri 63130","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082657792","display_name":"JAMES D. FORNEY","orcid":"https://orcid.org/0000-0002-6144-732X","observed_orcids":["https://orcid.org/0000-0002-6144-732X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D. Forney","raw_affiliation_strings":["Department of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907-2063"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Purdue University, 175 S. University Street, West Lafayette, Indiana 47907-2063","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5621,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.81800209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"7","first_page":"1087","last_page":"1099"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11879","display_name":"Protist diversity and phylogeny","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11879","display_name":"Protist diversity and phylogeny","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.31839999556541443,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macronuclear-development","display_name":"macronuclear development","score":0.843999981880188},{"id":"https://openalex.org/keywords/genome-amplification","display_name":"genome amplification","score":0.6880000233650208},{"id":"https://openalex.org/keywords/chromosome-fragmentation","display_name":"chromosome fragmentation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/paramecium-tetraurelia","display_name":"Paramecium tetraurelia","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tetrahymena-thermophila","display_name":"Tetrahymena thermophila","score":1.0},{"id":"https://openalex.org/keywords/rnai-knockdown","display_name":"RNAi knockdown","score":0.6240000128746033},{"id":"https://openalex.org/keywords/zygotic-gene-expression","display_name":"zygotic gene expression","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9134461879730225},{"id":"https://openalex.org/C2777166614","wikidata":"https://www.wikidata.org/wiki/Q1198419","display_name":"Tetrahymena","level":2,"score":0.8894094228744507},{"id":"https://openalex.org/C2780536333","wikidata":"https://www.wikidata.org/wiki/Q199456","display_name":"Paramecium","level":2,"score":0.7950351238250732},{"id":"https://openalex.org/C56683836","wikidata":"https://www.wikidata.org/wiki/Q1886511","display_name":"Macronucleus","level":3,"score":0.6945910453796387},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6873720288276672},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6104453206062317},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49989962577819824},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4509352147579193},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.4185195863246918},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.22986239194869995}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003227","descriptor_name":"Conjugation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010247","descriptor_name":"Paramecium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010247","descriptor_name":"Paramecium","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013768","descriptor_name":"Tetrahymena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013768","descriptor_name":"Tetrahymena","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D015053","descriptor_name":"Zygote","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048648","descriptor_name":"Macronucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/ec.00379-09","doi":"https://doi.org/10.1128/ec.00379-09","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00379-09","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2901671","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2901671","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryot Cell","raw_type":"Text"},{"id":"pmid:20495055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20495055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/ec.00379-09","doi":"https://doi.org/10.1128/ec.00379-09","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00379-09","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4676289586","display_name":null,"funder_award_id":"GM06593","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6932373299","display_name":"Analysis on the higher-order chromatin structure in the interphase nucleus using super-resolution fluorescence microscopy","funder_award_id":"22870042","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7777966283","display_name":"Regulation of variable surface protein gene expression      in paramecium","funder_award_id":"9506009","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W203551320","https://openalex.org/W233486025","https://openalex.org/W994306213","https://openalex.org/W1463780262","https://openalex.org/W1481542900","https://openalex.org/W1486450190","https://openalex.org/W1504048311","https://openalex.org/W1592230168","https://openalex.org/W1912524364","https://openalex.org/W1965124661","https://openalex.org/W1973435901","https://openalex.org/W1973840212","https://openalex.org/W1979153554","https://openalex.org/W1983804962","https://openalex.org/W1983811433","https://openalex.org/W1991255060","https://openalex.org/W1993527455","https://openalex.org/W1993997766","https://openalex.org/W2002799010","https://openalex.org/W2024334429","https://openalex.org/W2027738731","https://openalex.org/W2033155012","https://openalex.org/W2035782066","https://openalex.org/W2039596689","https://openalex.org/W2044046206","https://openalex.org/W2061302142","https://openalex.org/W2064440116","https://openalex.org/W2073007371","https://openalex.org/W2073403450","https://openalex.org/W2077476382","https://openalex.org/W2083367733","https://openalex.org/W2084366928","https://openalex.org/W2084734893","https://openalex.org/W2085085592","https://openalex.org/W2095724228","https://openalex.org/W2097952880","https://openalex.org/W2099663912","https://openalex.org/W2109116286","https://openalex.org/W2109298048","https://openalex.org/W2109444179","https://openalex.org/W2110491192","https://openalex.org/W2111791871","https://openalex.org/W2117788069","https://openalex.org/W2124939132","https://openalex.org/W2125980154","https://openalex.org/W2128125656","https://openalex.org/W2129161084","https://openalex.org/W2132629319","https://openalex.org/W2133749577","https://openalex.org/W2137153000","https://openalex.org/W2140172560","https://openalex.org/W2142529984","https://openalex.org/W2145932272","https://openalex.org/W2156135552","https://openalex.org/W2161079626","https://openalex.org/W2166186329","https://openalex.org/W2167527994","https://openalex.org/W2167852846","https://openalex.org/W2168015856","https://openalex.org/W2279544091"],"related_works":["https://openalex.org/W4402063741","https://openalex.org/W2144993001","https://openalex.org/W2052693103","https://openalex.org/W4391171787","https://openalex.org/W2035782066","https://openalex.org/W1980474015","https://openalex.org/W6992758499","https://openalex.org/W1996378657","https://openalex.org/W200802985","https://openalex.org/W2021594002"],"abstract_inverted_index":{"Development":[0],"in":[1,65,106,123,143,150,167,179,206,218,225],"ciliated":[2],"protozoa":[3],"involves":[4],"extensive":[5],"genome":[6,15,36,129,210,246],"reorganization":[7,247],"within":[8,244],"differentiating":[9],"macronuclei,":[10],"which":[11,170],"shapes":[12],"the":[13,17,62,107,141,151,200,238,245],"somatic":[14,116],"of":[16,23,28,71,90,109,153,185,204,235,240],"next":[18],"vegetative":[19],"generation.":[20],"Major":[21],"events":[22,42],"macronuclear":[24,138,219],"differentiation":[25],"include":[26,43],"excision":[27,160],"internal":[29],"eliminated":[30],"sequences":[31],"(IESs),":[32],"chromosome":[33,162],"fragmentation,":[34],"and":[35,75,125,161],"amplification.":[37],"Proteins":[38],"required":[39],"for":[40],"these":[41,154,180,226],"those":[44],"with":[45,199],"homology":[46],"throughout":[47],"eukaryotes":[48],"as":[49,51,79],"well":[50],"proteins":[52,84],"apparently":[53],"unique":[54],"to":[55,112,127,165,192,230],"ciliates.":[56],"In":[57,182],"this":[58,214],"study,":[59],"we":[60],"identified":[61],"ciliate-specific":[63],"Defective":[64],"IES":[66,159],"Excision":[67],"5":[68],"(DIE5)":[69],"genes":[70],"Paramecium":[72,133,207],"tetraurelia":[73],"(PtDIE5)":[74],"Tetrahymena":[76,118],"thermophila":[77],"(TtDIE5)":[78],"orthologs":[80],"that":[81,146,173,202,213],"encode":[82],"nuclear":[83,194],"expressed":[85],"exclusively":[86],"during":[87,188],"development.":[88,220],"Abrogation":[89],"PtDie5":[91],"protein":[92,215],"(PtDie5p)":[93],"function":[94],"by":[95,102],"RNA":[96],"interference":[97],"(RNAi)-mediated":[98],"silencing":[99],"or":[100],"TtDie5p":[101],"gene":[103],"disruption":[104],"resulted":[105],"failure":[108,142],"developing":[110],"macronuclei":[111],"differentiate":[113],"into":[114],"new":[115,137],"nuclei.":[117],"DeltaDIE5":[119],"cells":[120,134],"arrested":[121],"late":[122,217],"development":[124,189],"failed":[126,164],"complete":[128],"amplification,":[130,211],"whereas":[131],"RNAi-treated":[132],"highly":[135],"amplified":[136],"DNA":[139,223],"before":[140],"differentiation,":[144],"findings":[145],"highlight":[147],"clear":[148],"differences":[149],"biology":[152],"distantly":[155],"related":[156],"species.":[157],"Nevertheless,":[158],"fragmentation":[163],"occur":[166],"either":[168],"ciliate,":[169],"strongly":[171],"supports":[172],"Die5p":[174,205],"is":[175],"a":[176,241],"critical":[177],"player":[178],"processes.":[181],"Tetrahymena,":[183],"loss":[184],"zygotic":[186],"expression":[187],"was":[190],"sufficient":[191],"block":[193],"differentiation.":[195],"This":[196],"observation,":[197],"together":[198],"finding":[201],"knockdown":[203],"still":[208],"allows":[209],"indicates":[212],"acts":[216],"Even":[221],"though":[222],"rearrangements":[224],"two":[227],"ciliates":[228],"look":[229],"be":[231],"quite":[232],"distinct,":[233],"analysis":[234],"DIE5":[236],"establishes":[237],"action":[239],"conserved":[242],"mechanism":[243],"pathway.":[248]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
