{"id":"https://openalex.org/W2106763173","doi":"https://doi.org/10.1093/infdis/jit823","title":"Vaccination Against Staphylococcus aureus Pneumonia","display_name":"Vaccination Against Staphylococcus aureus Pneumonia","publication_year":2013,"publication_date":"2013-12-19","ids":{"openalex":"https://openalex.org/W2106763173","doi":"https://doi.org/10.1093/infdis/jit823","mag":"2106763173","pmid":"https://pubmed.ncbi.nlm.nih.gov/24357631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4038136"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/jit823","doi":"https://doi.org/10.1093/infdis/jit823","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jit823","pdf_url":"https://academic.oup.com/jid/article-pdf/209/12/1955/2391264/jit823.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jid/article-pdf/209/12/1955/2391264/jit823.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059719037","display_name":"Adam R. Spaulding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. R. Spaulding","raw_affiliation_strings":["Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030198839","display_name":"Wilmara Salgado\u2010Pab\u00f3n","orcid":"https://orcid.org/0000-0003-0854-1568","observed_orcids":["https://orcid.org/0000-0003-0854-1568"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Salgado-Pabon","raw_affiliation_strings":["Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064795489","display_name":"Joseph A. Merriman","orcid":"https://orcid.org/0000-0002-0725-2265","observed_orcids":["https://orcid.org/0000-0002-0725-2265"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. A. Merriman","raw_affiliation_strings":["Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020178975","display_name":"Christopher S. Stach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. S. Stach","raw_affiliation_strings":["Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069891795","display_name":"Yongping Ji","orcid":"https://orcid.org/0009-0000-8549-8650","observed_orcids":["https://orcid.org/0009-0000-8549-8650"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Ji","raw_affiliation_strings":["Department of Veterinary Biosciences, College of Veterinary Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biosciences, College of Veterinary Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044230704","display_name":"Aaron Nicholas Gillman","orcid":"https://orcid.org/0000-0002-1210-0485","observed_orcids":["https://orcid.org/0000-0002-1210-0485"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. N. Gillman","raw_affiliation_strings":["Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027584053","display_name":"Marnie L. Peterson","orcid":"https://orcid.org/0009-0004-9531-7971","observed_orcids":["https://orcid.org/0009-0004-9531-7971"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. L. Peterson","raw_affiliation_strings":["Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081083158","display_name":"Patrick M. Schlievert","orcid":"https://orcid.org/0000-0001-8314-9369","observed_orcids":["https://orcid.org/0000-0001-8314-9369"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. M. Schlievert","raw_affiliation_strings":["Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059719037"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":8.2177,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.98254483,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"209","issue":"12","first_page":"1955","last_page":"1962"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.578000009059906},{"id":"https://openalex.org/keywords/vaccine-development","display_name":"vaccine development","score":0.6119999885559082},{"id":"https://openalex.org/keywords/superantigens","display_name":"superantigens","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cytolysin","display_name":"cytolysin","score":0.7870000004768372},{"id":"https://openalex.org/keywords/toxic-shock-syndrome-toxin-1","display_name":"toxic shock syndrome toxin-1","score":0.9120000004768372},{"id":"https://openalex.org/keywords/enterotoxin","display_name":"enterotoxin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/toxoid","display_name":"toxoid","score":0.6069999933242798},{"id":"https://openalex.org/keywords/passive-immunization","display_name":"passive immunization","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hyperimmune-serum","display_name":"hyperimmune serum","score":0.8309999704360962},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9700000286102295},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.6819999814033508},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9190000295639038},{"id":"https://openalex.org/keywords/infective-endocarditis","display_name":"infective endocarditis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cell-surface-antigens","display_name":"cell surface antigens","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C36333154","wikidata":"https://www.wikidata.org/wiki/Q772950","display_name":"Superantigen","level":4,"score":0.8598923683166504},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.8387625217437744},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7148716449737549},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.6331945657730103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5596505999565125},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.548276960849762},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5322999954223633},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4947916865348816},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.4197322726249695},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.38715529441833496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2655373811721802},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.22317495942115784},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.16281813383102417},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.14730247855186462},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007116","descriptor_name":"Immunization, Passive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011023","descriptor_name":"Pneumonia, Staphylococcal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011023","descriptor_name":"Pneumonia, Staphylococcal","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013209","descriptor_name":"Staphylococcal Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018089","descriptor_name":"Superantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/infdis/jit823","doi":"https://doi.org/10.1093/infdis/jit823","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jit823","pdf_url":"https://academic.oup.com/jid/article-pdf/209/12/1955/2391264/jit823.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3428420","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4038136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24357631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24357631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4038136","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4038136/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Infect Dis","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.890.4558","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.890.4558","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jid.oxfordjournals.org/content/early/2014/01/16/infdis.jit823.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.897.9469","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.897.9469","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jid.oxfordjournals.org/content/early/2013/12/19/infdis.jit823.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.902.3356","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.902.3356","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jid.oxfordjournals.org/content/209/12/1955.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/infdis/jit823","doi":"https://doi.org/10.1093/infdis/jit823","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jit823","pdf_url":"https://academic.oup.com/jid/article-pdf/209/12/1955/2391264/jit823.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5380290194","display_name":"Staphylococcal Superantigen Interactions With Vaginal Epithelium","funder_award_id":"R01AI073366","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6014488672","display_name":"Molecular Analyses and Interventions for Biodefense and Emerging Pathogens","funder_award_id":"U54AI057153","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6051073308","display_name":"Cardiotoxicity of Streptococcal Pyrogenic Exotoxins","funder_award_id":"R01AI074283","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106763173.pdf","grobid_xml":"https://content.openalex.org/works/W2106763173.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1440745987","https://openalex.org/W1968551240","https://openalex.org/W1974253020","https://openalex.org/W1980496604","https://openalex.org/W1985197678","https://openalex.org/W1995105203","https://openalex.org/W2011419669","https://openalex.org/W2017292954","https://openalex.org/W2023298860","https://openalex.org/W2032733534","https://openalex.org/W2040984625","https://openalex.org/W2044682925","https://openalex.org/W2055329538","https://openalex.org/W2056797050","https://openalex.org/W2084519264","https://openalex.org/W2097143106","https://openalex.org/W2102685111","https://openalex.org/W2113696060","https://openalex.org/W2121410724","https://openalex.org/W2131272563","https://openalex.org/W2138566304","https://openalex.org/W2150090472","https://openalex.org/W2150491739","https://openalex.org/W2155322482","https://openalex.org/W2163449971","https://openalex.org/W2166425259","https://openalex.org/W2168482920","https://openalex.org/W2168516112","https://openalex.org/W2170205901","https://openalex.org/W2170865876","https://openalex.org/W2314649741","https://openalex.org/W2332233558","https://openalex.org/W3145689303","https://openalex.org/W4245663047"],"related_works":["https://openalex.org/W1968551240","https://openalex.org/W2150923940","https://openalex.org/W2104034365","https://openalex.org/W2622222136","https://openalex.org/W2039370850","https://openalex.org/W7098436882","https://openalex.org/W2177655465","https://openalex.org/W2137762541","https://openalex.org/W1558284113","https://openalex.org/W6922496783"],"abstract_inverted_index":{"BACKGROUND:":[0],"Staphylococcus":[1],"aureus":[2,47,140,196],"causes":[3],"serious":[4],"infections":[5],"in":[6,40,126,202],"both":[7,96],"hospital":[8],"and":[9,36,76,78,81,85,87,98,123,198],"community":[10],"settings.":[11],"Attempts":[12],"have":[13,29,199],"been":[14],"made":[15],"to":[16,143],"prevent":[17],"human":[18],"infection":[19],"through":[20],"vaccination":[21,102,119,170,179],"against":[22,65,103,120,171,180,186],"bacterial":[23,107,172],"cell-surface":[24,108,173],"antigens;":[25],"thus":[26],"far":[27],"all":[28],"failed.":[30],"Here":[31],"we":[32],"show":[33],"that":[34,154,169],"superantigens":[35,68,122],"cytolysins,":[37],"when":[38,133],"used":[39],"vaccine":[41],"cocktails,":[42],"provide":[43],"protection":[44,127,185],"from":[45],"S.":[46,94,139,187,195],"USA100-USA400":[48],"intrapulmonary":[49],"challenge.":[50],"METHODS:":[51],"Rabbits":[52],"were":[53],"actively":[54],"vaccinated":[55],"(wild-type":[56],"toxins":[57],"or":[58,60],"toxoids)":[59],"passively":[61],"immunized":[62],"(hyperimmune":[63],"serum)":[64],"combinations":[66],"of":[67,93,128,130,146,156,163,194],"(toxic":[69],"shock":[70],"syndrome":[71],"toxin":[72],"1,":[73],"enterotoxins":[74],"B":[75],"C,":[77],"enterotoxin-like":[79],"X)":[80],"cytolysins":[82,124],"(\u03b1-,":[83],"\u03b2-,":[84],"\u03b3-toxins)":[86],"challenged":[88,134],"intrapulmonarily":[89,135],"with":[90,136],"multiple":[91],"strains":[92],"aureus,":[95],"methicillin-sensitive":[97],"methicillin-resistant.":[99],"RESULTS:":[100],"Active":[101,118],"a":[104],"cocktail":[105],"containing":[106],"antigens":[109,174],"enhanced":[110],"disease":[111,176,203],"severity":[112],"as":[113],"tested":[114],"by":[115],"infective":[116],"endocarditis.":[117],"secreted":[121,181],"resulted":[125],"86":[129],"88":[131,147],"rabbits":[132],"9":[137],"different":[138],"strains,":[141],"compared":[142],"only":[144],"1":[145],"nonvaccinated":[148],"animals.":[149],"Passive":[150],"immunization":[151],"studies":[152],"demonstrated":[153],"production":[155],"neutralizing":[157],"antibodies":[158],"was":[159],"an":[160],"important":[161,200],"mechanism":[162],"protection.":[164],"CONCLUSIONS:":[165],"The":[166],"data":[167],"suggest":[168],"increases":[175],"severity,":[177],"but":[178],"virulence":[182],"factors":[183],"provides":[184],"aureus.":[188],"These":[189],"results":[190],"advance":[191],"our":[192],"understanding":[193],"pathogenesis":[197],"implications":[201],"prevention.":[204]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":13}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}