{"id":"https://openalex.org/W2106749899","doi":"https://doi.org/10.1210/jcem.83.6.4908","title":"A Healthy Body in a Healthy Mind--and Vice Versa--The Damaging Power of \"Uncontrollable\" Stress","display_name":"A Healthy Body in a Healthy Mind--and Vice Versa--The Damaging Power of \"Uncontrollable\" Stress","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2106749899","doi":"https://doi.org/10.1210/jcem.83.6.4908","mag":"2106749899","pmid":"https://pubmed.ncbi.nlm.nih.gov/9626106"},"language":"en","primary_location":{"id":"doi:10.1210/jcem.83.6.4908","doi":"https://doi.org/10.1210/jcem.83.6.4908","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.83.6.4908","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046164327","display_name":"George Panagiotis Chrousos","orcid":"https://orcid.org/0000-0002-3098-5264","observed_orcids":["https://orcid.org/0000-0002-3098-5264"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George P. Chrousos","raw_affiliation_strings":["National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110425058","display_name":"Philip W. Gold","orcid":"https://orcid.org/0000-0002-2199-6076","observed_orcids":["https://orcid.org/0000-0002-2199-6076"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip W. Gold","raw_affiliation_strings":["National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046164327"],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.5609,"has_fulltext":true,"cited_by_count":305,"citation_normalized_percentile":{"value":0.96597938,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"83","issue":"6","first_page":"1842","last_page":"1845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12947","display_name":"Health, psychology, and well-being","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.7009999752044678},{"id":"https://openalex.org/keywords/stress-response-system","display_name":"stress system","score":0.6299999952316284},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.4269999861717224},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9200000166893005},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":0.9269999861717224},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.800000011920929},{"id":"https://openalex.org/keywords/negative-feedback-regulation","display_name":"negative feedback regulation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mind-body-relationship","display_name":"mind-body problem","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2777655698","wikidata":"https://www.wikidata.org/wiki/Q1209358","display_name":"Versa","level":2,"score":0.8237313032150269},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.650231122970581},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6450700759887695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48090219497680664},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3723500967025757},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10863107442855835},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1210/jcem.83.6.4908","doi":"https://doi.org/10.1210/jcem.83.6.4908","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.83.6.4908","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"doi:10.1210/jc.83.6.1842","doi":"https://doi.org/10.1210/jc.83.6.1842","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.83.6.1842","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:9626106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9626106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1968680063","https://openalex.org/W1977046004","https://openalex.org/W1985953874","https://openalex.org/W1987278019","https://openalex.org/W2005668937","https://openalex.org/W2009842219","https://openalex.org/W2016961635","https://openalex.org/W2024083496","https://openalex.org/W2026899038","https://openalex.org/W2060151000","https://openalex.org/W2065332267","https://openalex.org/W2068527329","https://openalex.org/W2072709114","https://openalex.org/W2077626212","https://openalex.org/W2118442033","https://openalex.org/W2128979836","https://openalex.org/W2135491929","https://openalex.org/W2142893637","https://openalex.org/W2163762845","https://openalex.org/W2317060418","https://openalex.org/W2334787351","https://openalex.org/W2340023437","https://openalex.org/W4250686555","https://openalex.org/W4255304519"],"related_works":["https://openalex.org/W7213924663","https://openalex.org/W1971639265","https://openalex.org/W2040032672","https://openalex.org/W2056702525","https://openalex.org/W2150734066","https://openalex.org/W4235839392","https://openalex.org/W4238494678","https://openalex.org/W110288464","https://openalex.org/W1988157043","https://openalex.org/W262822309"],"abstract_inverted_index":{"The":[0,21,84,100],"hypothalamic-pituitary-adrenal":[1],"(HPA)":[2],"axis":[3,30],"together":[4],"with":[5,12],"the":[6,10,13,16,28,32,37,47,51,54,58,64,97,103,106,133,152],"sympathetic":[7,33],"system":[8,24,34,117,142],"connect":[9],"brain":[11,65],"periphery":[14],"of":[15,27,46,50,57,63,102,105],"body":[17,134],"(1)":[18],"(Fig.":[19],"1).":[20],"central":[22],"nervous":[23],"(CNS)":[25],"centers":[26,69],"HPA":[29,107],"and":[31,42,53,71,75,81,86,89],"are,":[35],"respectively,":[36],"parvicellular":[38],"corticotropin-releasing":[39],"hormone":[40],"(CRH)":[41],"arginine-vasopressin":[43],"(AVP)":[44],"neurons":[45,56,88],"paraventricular":[48],"nuclei":[49,62],"hypothalamus":[52],"noradrenergic":[55],"locus":[59],"ceruleus/norepinephrine":[60],"(LC/NE)":[61],"stem.":[66],"These":[67],"neuronal":[68],"innervate":[70],"stimulate":[72],"each":[73],"other":[74],"have":[76,136],"both":[77],"a":[78,138],"baseline":[79],"circadian":[80],"stress-related":[82],"activity.":[83],"CRH/AVP":[85],"LC/NE":[87],"their":[90],"peripheral":[91],"axes":[92],"are":[93],"heuristically":[94],"known":[95],"as":[96],"stress":[98],"system.":[99],"secretion":[101],"end-product":[104],"axis,":[108],"cortisol,":[109],"is":[110,125],"kept":[111],"by":[112],"an":[113,119,129],"elaborate":[114],"negative":[115],"feedback":[116],"within":[118],"optimal":[120],"time-integrated":[121],"narrow":[122],"range,":[123],"which":[124],"quite":[126],"stable":[127],"in":[128],"individual":[130],"subject.":[131],"That":[132],"would":[135],"such":[137],"tightly":[139],"regulated":[140],"servo-control":[141],"suggests":[143],"that":[144],"excessive,":[145],"unchecked":[146],"activity":[147],"could":[148],"be":[149],"detrimental":[150],"to":[151],"organism.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}