{"id":"https://openalex.org/W2106711620","doi":"https://doi.org/10.1007/s12975-014-0324-3","title":"Dysregulation of Diverse Ion Transport Pathways Controlling Cell Volume Homoestasis Contribute to Neuroglial Cell Injury Following Ischemic Stroke","display_name":"Dysregulation of Diverse Ion Transport Pathways Controlling Cell Volume Homoestasis Contribute to Neuroglial Cell Injury Following Ischemic Stroke","publication_year":2014,"publication_date":"2014-01-26","ids":{"openalex":"https://openalex.org/W2106711620","doi":"https://doi.org/10.1007/s12975-014-0324-3","mag":"2106711620","pmid":"https://pubmed.ncbi.nlm.nih.gov/24464825","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3913849"},"language":"en","primary_location":{"id":"doi:10.1007/s12975-014-0324-3","doi":"https://doi.org/10.1007/s12975-014-0324-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12975-014-0324-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12975-014-0324-3.pdf","source":{"id":"https://openalex.org/S59392935","display_name":"Translational Stroke Research","issn_l":"1868-4483","issn":["1868-4483","1868-601X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Stroke Research","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12975-014-0324-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049938481","display_name":"Dandan Sun","orcid":"https://orcid.org/0000-0001-8548-1525","observed_orcids":["https://orcid.org/0000-0001-8548-1525"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dandan Sun","raw_affiliation_strings":["Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15217, USA, sund@upmc.edu","University of Pittsburgh School Of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15217, USA, sund@upmc.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh School Of Medicine","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058936141","display_name":"Kristopher Thomas Kahle","orcid":"https://orcid.org/0000-0002-5922-7547","observed_orcids":["https://orcid.org/0000-0002-5922-7547"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405269205","display_name":"Manton Center for Orphan Disease Research","ror":"https://ror.org/03drre408","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405269205"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristopher T. Kahle","raw_affiliation_strings":["Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical, Boston, MA, 02115, USA","Manton Center for Orphan Disease Research, Children\u2019s Hospital Boston, Boston, MA, 02115, USA","Children\u2019s Hospital Boston","Massachusetts General Hospital and Harvard Medical"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Manton Center for Orphan Disease Research, Children\u2019s Hospital Boston, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I4405269205"]},{"raw_affiliation_string":"Children\u2019s Hospital Boston","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5049938481"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":5490,"currency":"USD","value_usd":5490},"apc_paid":{"value":5490,"currency":"USD","value_usd":5490},"fwci":null,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"1","first_page":"1","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.03610000014305115,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ion-transport","display_name":"ion transport","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cell-volume-homeostasis","display_name":"cell volume homeostasis","score":0.968999981880188},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.7129999995231628},{"id":"https://openalex.org/keywords/vasogenic-edema","display_name":"vasogenic edema","score":0.8550000190734863},{"id":"https://openalex.org/keywords/astrocyte-swelling","display_name":"astrocyte swelling","score":0.7480000257492065},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.8669999837875366},{"id":"https://openalex.org/keywords/asic1a","display_name":"ASIC1a","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hv1-proton-channel","display_name":"Hv1 proton channel","score":0.7730000019073486},{"id":"https://openalex.org/keywords/na-h-exchanger","display_name":"Na+/H+ exchanger","score":0.8180000185966492},{"id":"https://openalex.org/keywords/na-ca2-exchanger","display_name":"Na+/Ca2+ exchanger","score":0.9179999828338623},{"id":"https://openalex.org/keywords/calcium-efflux","display_name":"calcium efflux","score":0.7260000109672546},{"id":"https://openalex.org/keywords/perinatal-brain-injury","display_name":"perinatal brain injury","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6404067873954773},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.47799840569496155},{"id":"https://openalex.org/C2779493303","wikidata":"https://www.wikidata.org/wiki/Q979168","display_name":"Cerebral edema","level":2,"score":0.461118221282959},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41660889983177185},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3205256760120392},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30876803398132324},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2758604884147644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19480258226394653}],"mesh":[{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1007/s12975-014-0324-3","doi":"https://doi.org/10.1007/s12975-014-0324-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12975-014-0324-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12975-014-0324-3.pdf","source":{"id":"https://openalex.org/S59392935","display_name":"Translational Stroke Research","issn_l":"1868-4483","issn":["1868-4483","1868-601X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Stroke Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2902944","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3913849","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3913849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3913849","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Stroke Res","raw_type":"Text"},{"id":"pmid:24464825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24464825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational stroke research","raw_type":"Editorial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.664.8632","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.664.8632","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913849/pdf/12975_2014_Article_324.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.874.1134","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.874.1134","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Dandan_Sun2/publication/259919432_Dysregulation_of_Diverse_Ion_Transport_Pathways_Controlling_Cell_Volume_Homoestasis_Contribute_to_Neuroglial_Cell_Injury_Following_Ischemic_Stroke/links/542476e60cf238c6ea6ecb7f.pdf","raw_type":"text"},{"id":"pmh:oai:dash.harvard.edu:1/11879932","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879932","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1007/s12975-014-0324-3","doi":"https://doi.org/10.1007/s12975-014-0324-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12975-014-0324-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12975-014-0324-3.pdf","source":{"id":"https://openalex.org/S59392935","display_name":"Translational Stroke Research","issn_l":"1868-4483","issn":["1868-4483","1868-601X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Stroke Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106711620.pdf","grobid_xml":"https://content.openalex.org/works/W2106711620.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1982678041","https://openalex.org/W1983705394","https://openalex.org/W1990603467","https://openalex.org/W1997074250","https://openalex.org/W2006626341","https://openalex.org/W2015534344","https://openalex.org/W2022915497","https://openalex.org/W2029051466","https://openalex.org/W2030310426","https://openalex.org/W2035858812","https://openalex.org/W2039618919","https://openalex.org/W2059050443","https://openalex.org/W2070537661","https://openalex.org/W2091663444","https://openalex.org/W2106585100","https://openalex.org/W2118322074","https://openalex.org/W2246829293"],"related_works":["https://openalex.org/W7096108668","https://openalex.org/W1966183236","https://openalex.org/W2766006599","https://openalex.org/W2039618919","https://openalex.org/W2074841206","https://openalex.org/W2091663444","https://openalex.org/W4401031225","https://openalex.org/W2165984519","https://openalex.org/W4379513952","https://openalex.org/W4256298944"],"abstract_inverted_index":{"gives":[0],"readers":[1],"a":[2],"timely":[3],"update":[4],"on":[5,32,48,67,116],"the":[6,26,33,49,56,60,68,71,86,99,117],"emerging":[7],"roles":[8],"of":[9,51,62,70,88,120],"gluta-mate":[10],"receptor-independent":[11],"ion":[12,36,53],"channels":[13],"and":[14,90,94,106,127],"transporters":[15],"in":[16,55,59,85,98,124],"ischemic":[17,63],"brain":[18],"injury.":[19],"This":[20],"issue":[21],"has":[22],"collected":[23],"contributions":[24],"from":[25],"leading":[27],"research":[28],"laboratories":[29],"with":[30],"expertise":[31],"most":[34],"important":[35],"transport":[37],"targets.":[38],"For":[39],"example,":[40],"Khanna":[41],"et":[42,110],"al.":[43,111],"[1]":[44],"provide":[45],"an":[46,113],"overview":[47],"significance":[50],"dysreg-ulated":[52],"homeostasis":[54,123],"neurogliovascular":[57],"unit":[58],"pathogenesis":[61],"cerebral":[64],"edema,":[65],"focusing":[66],"role":[69],"sulfonylurea":[72],"receptor":[73,75],"1-transient":[74],"potential":[76],"melastatin":[77],"4":[78],"(SUR1-TRPM4)":[79],"channel":[80],"complex":[81],"which":[82],"is":[83],"up-regulated":[84],"context":[87],"hypoxia":[89],"promotes":[91],"capillary":[92],"fragmentation":[93],"oncotic":[95],"cell":[96,121],"death":[97],"vascular":[100,104],"endothe-lium,":[101],"thereby":[102],"increasing":[103],"permeability":[105],"vasogenic":[107],"edema.":[108],"Song":[109],"write":[112],"elegant":[114],"review":[115],"distinct":[118],"changes":[119],"volume":[122],"necrotic,":[125],"apoptotic,":[126]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
