{"id":"https://openalex.org/W2106645674","doi":"https://doi.org/10.1371/journal.pgen.1002823","title":"Let-7b/c Enhance the Stability of a Tissue-Specific mRNA during Mammalian Organogenesis as Part of a Feedback Loop Involving KSRP","display_name":"Let-7b/c Enhance the Stability of a Tissue-Specific mRNA during Mammalian Organogenesis as Part of a Feedback Loop Involving KSRP","publication_year":2012,"publication_date":"2012-07-26","ids":{"openalex":"https://openalex.org/W2106645674","doi":"https://doi.org/10.1371/journal.pgen.1002823","mag":"2106645674","pmid":"https://pubmed.ncbi.nlm.nih.gov/22844247","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3405994"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1002823","doi":"https://doi.org/10.1371/journal.pgen.1002823","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1002823","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002823&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002823&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040052169","display_name":"Emanuela Repetto","orcid":"https://orcid.org/0000-0002-6270-3540","observed_orcids":["https://orcid.org/0000-0002-6270-3540"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118704","display_name":"Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire","ror":"https://ror.org/029rfe283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emanuela Repetto","raw_affiliation_strings":["INSERM U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Team 10-Control of Gene Expression, Nice, France","University of Nice Sophia-Antipolis, Faculty of Medicine, IFR50, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Team 10-Control of Gene Expression, Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118704"]},{"raw_affiliation_string":"University of Nice Sophia-Antipolis, Faculty of Medicine, IFR50, Nice, France","institution_ids":["https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060878254","display_name":"Paola Briata","orcid":"https://orcid.org/0000-0003-3470-0454","observed_orcids":["https://orcid.org/0000-0003-3470-0454"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Briata","raw_affiliation_strings":["Gene Expression Regulation Laboratory, IRCCS San Martino-IST, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Regulation Laboratory, IRCCS San Martino-IST, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090944527","display_name":"Nathalie Kuziner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118704","display_name":"Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire","ror":"https://ror.org/029rfe283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Kuziner","raw_affiliation_strings":["INSERM U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Team 10 \u201cControl of Gene Expression,\u201d Nice, France","University of Nice Sophia-Antipolis, Faculty of Medicine, IFR50, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Team 10 \u201cControl of Gene Expression,\u201d Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118704"]},{"raw_affiliation_string":"University of Nice Sophia-Antipolis, Faculty of Medicine, IFR50, Nice, France","institution_ids":["https://openalex.org/I4387154757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047977465","display_name":"Brian D. Harfe","orcid":"https://orcid.org/0000-0002-4410-3525","observed_orcids":["https://orcid.org/0000-0002-4410-3525"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian D. Harfe","raw_affiliation_strings":["Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039780162","display_name":"Michael T. McManus","orcid":"https://orcid.org/0000-0003-3013-6569","observed_orcids":["https://orcid.org/0000-0003-3013-6569"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T. McManus","raw_affiliation_strings":["UCSF Diabetes Center, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF Diabetes Center, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074852816","display_name":"Roberto Gherzi","orcid":"https://orcid.org/0000-0001-8654-0611","observed_orcids":["https://orcid.org/0000-0001-8654-0611"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Gherzi","raw_affiliation_strings":["Gene Expression Regulation Laboratory, IRCCS San Martino-IST, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Regulation Laboratory, IRCCS San Martino-IST, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000068004","display_name":"Michael G. Rosenfeld","orcid":"https://orcid.org/0000-0002-1572-156X","observed_orcids":["https://orcid.org/0000-0002-1572-156X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael G. Rosenfeld","raw_affiliation_strings":["Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027762642","display_name":"Mich\u00e8le Trabucchi","orcid":"https://orcid.org/0000-0001-6885-5628","observed_orcids":["https://orcid.org/0000-0001-6885-5628"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210118704","display_name":"Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire","ror":"https://ror.org/029rfe283","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210118704"]},{"id":"https://openalex.org/I4387154757","display_name":"Universit\u00e9 Nice Sophia Antipolis","ror":"https://ror.org/02k9vew78","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394","https://openalex.org/I4387154757"]}],"countries":["FR","US"],"is_corresponding":true,"raw_author_name":"Michele Trabucchi","raw_affiliation_strings":["Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, California, United States of America","INSERM U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Team 10 \u201cControl of Gene Expression,\u201d Nice, France","University of Nice Sophia-Antipolis, Faculty of Medicine, IFR50, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I36258959"]},{"raw_affiliation_string":"INSERM U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Team 10 \u201cControl of Gene Expression,\u201d Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118704"]},{"raw_affiliation_string":"University of Nice Sophia-Antipolis, Faculty of Medicine, IFR50, Nice, France","institution_ids":["https://openalex.org/I4387154757"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5000068004","https://openalex.org/A5027762642"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I154526488","https://openalex.org/I36258959","https://openalex.org/I4210118704","https://openalex.org/I4387154757"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":0.7217,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.70424084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"7","first_page":"e1002823","last_page":"e1002823"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0697999969124794,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ksrp","display_name":"KSRP","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.574999988079071},{"id":"https://openalex.org/keywords/mirna-silencing","display_name":"microRNA silencing","score":0.734000027179718},{"id":"https://openalex.org/keywords/negative-feedback-loop","display_name":"negative feedback loop","score":0.7170000076293945},{"id":"https://openalex.org/keywords/pituitary-development","display_name":"pituitary development","score":0.7960000038146973},{"id":"https://openalex.org/keywords/3-utr-binding","display_name":"3' UTR binding","score":0.7960000038146973},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/organogenesis","display_name":"organogenesis","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8184491395950317},{"id":"https://openalex.org/C2779867133","wikidata":"https://www.wikidata.org/wiki/Q21111297","display_name":"Dicer","level":5,"score":0.7497339248657227},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6026965975761414},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.5955775380134583},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5209392309188843},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4980294704437256},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47268038988113403},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4682190418243408},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4650619626045227},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.33906251192092896},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.29197412729263306},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2794022262096405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2706746757030487}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010907","descriptor_name":"Pituitary Hormones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010907","descriptor_name":"Pituitary Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015292","descriptor_name":"Glycoprotein Hormones, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015292","descriptor_name":"Glycoprotein Hormones, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043244","descriptor_name":"Ribonuclease III","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pgen.1002823","doi":"https://doi.org/10.1371/journal.pgen.1002823","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1002823","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002823&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2408974","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3405994","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3405994","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3405994","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:22844247","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22844247","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.772.2456","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.772.2456","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7e/c0/pgen.1002823.PMC3405994.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:bc7e7b54fbd649c39bf677e76a9c9d75","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bc7e7b54fbd649c39bf677e76a9c9d75","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 8, Iss 7, p e1002823 (2012)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt8b27d8bn","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8b27d8bn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/122324","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Let_7b_c_Enhance_the_Stability_of_a_Tissue_Specific_mRNA_during_Mammalian_Organogenesis_as_Part_of_a_Feedback_Loop_Involving_KSRP/122324","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:qt8b27d8bn","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/8b27d8bn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"McManus, Thomas; Repetto, E; Briata, P; Kuziner, N; Harfe, BD; McManus, MT; \u00c2\u00a0et al.(2012). Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8b27d8bn","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1002823","doi":"https://doi.org/10.1371/journal.pgen.1002823","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1002823","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002823&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4286035780","display_name":"Ligand Regulated Epigenetic/Nuclear Architectural Strategies and Human Disease","funder_award_id":"R01NS034934","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000895692","display_name":"Enhancer Connectomes in Regulation of Gene Expression","funder_award_id":"R01DK018477","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106645674.pdf","grobid_xml":"https://content.openalex.org/works/W2106645674.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1964631913","https://openalex.org/W1964668704","https://openalex.org/W1970760326","https://openalex.org/W1985140771","https://openalex.org/W1992935306","https://openalex.org/W2001453032","https://openalex.org/W2006768369","https://openalex.org/W2008932845","https://openalex.org/W2015205234","https://openalex.org/W2026541961","https://openalex.org/W2027097889","https://openalex.org/W2030180346","https://openalex.org/W2030311046","https://openalex.org/W2034806022","https://openalex.org/W2040335200","https://openalex.org/W2045342567","https://openalex.org/W2059357290","https://openalex.org/W2062502773","https://openalex.org/W2074915514","https://openalex.org/W2075559286","https://openalex.org/W2079377989","https://openalex.org/W2089001345","https://openalex.org/W2094786733","https://openalex.org/W2102107106","https://openalex.org/W2102876017","https://openalex.org/W2104119190","https://openalex.org/W2122991629","https://openalex.org/W2125279845","https://openalex.org/W2126712329","https://openalex.org/W2139602536","https://openalex.org/W2147095295","https://openalex.org/W2151821298","https://openalex.org/W2163106706","https://openalex.org/W2165178850","https://openalex.org/W2166403834","https://openalex.org/W2168723894","https://openalex.org/W2169689875","https://openalex.org/W4242743062"],"related_works":["https://openalex.org/W7096531176","https://openalex.org/W2045342567","https://openalex.org/W7101214499","https://openalex.org/W2026387680","https://openalex.org/W2016673390","https://openalex.org/W2019752388","https://openalex.org/W1940829406","https://openalex.org/W1550591422","https://openalex.org/W1975060079","https://openalex.org/W7100765480"],"abstract_inverted_index":{"Gene":[0],"silencing":[1,61],"mediated":[2],"by":[3,198,276],"either":[4],"microRNAs":[5],"(miRNAs)":[6],"or":[7],"Adenylate/uridylate-rich":[8],"elements":[9],"Mediated":[10],"mRNA":[11,133,197],"Degradation":[12],"(AMD)":[13],"is":[14,78,107,134,274],"a":[15,151,207,216,257,285],"powerful":[16],"way":[17],"to":[18,123,167,185,201,242],"post-transcriptionally":[19,232],"modulate":[20],"gene":[21,60,292],"expression.":[22],"We":[23,81,161,254],"and":[24,42,58,100,112,136,212,290],"others":[25],"have":[26,62,255],"reported":[27],"that":[28,105,163],"the":[29,34,46,69,72,193,202,225,234,250,268,271],"RNA-binding":[30],"protein":[31],"KSRP":[32,155,164,190,213,223,237],"favors":[33],"biogenesis":[35],"of":[36,48,54,115,146,154,195,227,236,244,270,280],"select":[37],"miRNAs":[38],"(including":[39],"let-7":[40],"family)":[41],"activates":[43],"AMD":[44],"promoting":[45,170,192],"decay":[47],"inherently":[49],"labile":[50],"mRNAs.":[51],"Different":[52],"layers":[53],"interplay":[55],"between":[56,71,288],"miRNA-":[57,289],"AMD-mediated":[59],"been":[63],"proposed":[64],"in":[65,75,85,129,157,209,230,266],"cultured":[66],"cells,":[67],"but":[68],"relationship":[70,184],"two":[73],"pathways":[74],"living":[76],"organisms":[77],"still":[79],"elusive.":[80],"conditionally":[82],"deleted":[83],"Dicer":[84,106],"mouse":[86,263],"pituitary":[87,110,125,141,176,264],"from":[88,221],"embryonic":[89],"day":[90],"(E)":[91],"9.5":[92],"through":[93,278],"Cre-mediated":[94],"recombination.":[95],"In":[96],"situ":[97],"hybridization,":[98],"immunohistochemistry,":[99],"quantitative":[101],"reverse":[102],"transcriptase-PCR":[103],"revealed":[104,150],"essential":[108],"for":[109],"morphogenesis":[111],"correct":[113],"expression":[114,156,179,235,252,269],"hormones.":[116],"Strikingly,":[117],"\u03b1GSU":[118,132,168,178,245,273],"(alpha":[119],"glycoprotein":[120],"subunit,":[121],"common":[122],"three":[124],"hormones)":[126],"was":[127],"absent":[128],"Dicer-deleted":[130,159],"pituitaries.":[131],"unstable":[135],"its":[137,171,196],"half-life":[138],"increases":[139],"during":[140,175,262,294],"development.":[142],"A":[143],"transcriptome-wide":[144],"analysis":[145],"microdissected":[147],"E12.5":[148],"pituitaries":[149],"significant":[152],"increment":[153],"conditional":[158],"mice.":[160],"found":[162],"directly":[165,199],"binds":[166],"mRNA,":[169,246],"rapid":[172],"decay;":[173],"and,":[174],"development,":[177],"displays":[180],"an":[181],"inverse":[182],"temporal":[183],"KSRP.":[186,281],"Further,":[187],"let-7b/c":[188,211,228],"downregulated":[189],"expression,":[191],"degradation":[194],"binding":[200],"3'UTR.":[203],"Therefore,":[204],"we":[205],"propose":[206],"model":[208],"which":[210,247,267],"operate":[214],"within":[215],"negative":[217],"feedback":[218],"loop.":[219],"Starting":[220],"E12.5,":[222],"induces":[224],"maturation":[226],"that,":[229],"turn,":[231],"downregulates":[233],"itself.":[238],"This":[239],"event":[240],"leads":[241],"stabilization":[243],"ultimately":[248],"enhances":[249],"steady-state":[251],"levels.":[253],"identified":[256],"post-transcriptional":[258],"regulatory":[259],"network":[260],"active":[261],"development":[265],"hormone":[272],"increased":[275],"let7b/c":[277],"downregulation":[279],"Our":[282],"study":[283],"unveils":[284],"functional":[286],"crosstalk":[287],"AMD-dependent":[291],"regulation":[293],"mammalian":[295],"organogenesis":[296],"events.":[297]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}