{"id":"https://openalex.org/W2106611664","doi":"https://doi.org/10.1001/jama.298.11.1300","title":"Association of Apolipoprotein E Genotypes With Lipid Levels and Coronary Risk","display_name":"Association of Apolipoprotein E Genotypes With Lipid Levels and Coronary Risk","publication_year":2007,"publication_date":"2007-09-18","ids":{"openalex":"https://openalex.org/W2106611664","doi":"https://doi.org/10.1001/jama.298.11.1300","mag":"2106611664","pmid":"https://pubmed.ncbi.nlm.nih.gov/17878422"},"language":"en","primary_location":{"id":"doi:10.1001/jama.298.11.1300","doi":"https://doi.org/10.1001/jama.298.11.1300","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.298.11.1300","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34632858","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082785548","display_name":"Anna M. Bennet","orcid":"https://orcid.org/0000-0003-2704-2625","observed_orcids":["https://orcid.org/0000-0003-2704-2625"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna M. Bennet","raw_affiliation_strings":["Department of Public Health and Primary Care, University of Cambridge, Cambridge, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and Primary Care, University of Cambridge, Cambridge, England","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012263812","display_name":"Emanuele Di Angelantonio","orcid":"https://orcid.org/0000-0001-8776-6719","observed_orcids":["https://orcid.org/0000-0001-8776-6719"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emanuele Di Angelantonio","raw_affiliation_strings":["University of Cambridge,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge,","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101538412","display_name":"Zheng Ye","orcid":"https://orcid.org/0000-0001-5532-6428","observed_orcids":["https://orcid.org/0000-0001-5532-6428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zheng Ye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085345849","display_name":"Frances Wensley","orcid":"https://orcid.org/0000-0003-4371-5340","observed_orcids":["https://orcid.org/0000-0003-4371-5340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frances Wensley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054177893","display_name":"Anette Dahlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anette Dahlin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082442083","display_name":"Anders Ahlbom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anders Ahlbom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035095307","display_name":"Bernard D. Keavney","orcid":"https://orcid.org/0000-0001-9573-0812","observed_orcids":["https://orcid.org/0000-0001-9573-0812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard Keavney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090621185","display_name":"Rory Collins","orcid":"https://orcid.org/0000-0001-8288-8602","observed_orcids":["https://orcid.org/0000-0001-8288-8602","https://orcid.org/0000-0002-3387-6629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rory Collins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109115551","display_name":"Bj\u00f6rn Wiman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Wiman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045299069","display_name":"Ulf d\u00e9 Fair\u00e9","orcid":"https://orcid.org/0000-0002-6000-3698","observed_orcids":["https://orcid.org/0000-0002-6000-3698"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulf de Faire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033502820","display_name":"John Danesh","orcid":"https://orcid.org/0000-0003-1158-6791","observed_orcids":["https://orcid.org/0000-0003-1158-6791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Danesh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":30.6038,"has_fulltext":false,"cited_by_count":785,"citation_normalized_percentile":{"value":0.9975711,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"298","issue":"11","first_page":"1300","last_page":"1300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9520000219345093},{"id":"https://openalex.org/keywords/apoe-genotype","display_name":"APOE genotype","score":0.7450000047683716},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.6589999794960022},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7269999980926514},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9679999947547913},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":1.0},{"id":"https://openalex.org/keywords/circulating-lipids","display_name":"circulating lipids","score":0.7229999899864197},{"id":"https://openalex.org/keywords/coronary-heart-disease-risk","display_name":"coronary heart disease risk","score":0.7680000066757202},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.4699999988079071},{"id":"https://openalex.org/keywords/epsilon4-allele","display_name":"\u03b54 allele","score":0.8119999766349792},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.43799999356269836},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.453000009059906},{"id":"https://openalex.org/keywords/meta-regression","display_name":"meta-regression","score":0.38999998569488525},{"id":"https://openalex.org/keywords/effect-heterogeneity","display_name":"heterogeneous effects","score":0.40400001406669617},{"id":"https://openalex.org/keywords/publication-bias","display_name":"publication bias","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.798858642578125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.647056519985199},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.59442138671875},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5575020909309387},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5518081784248352},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.4718846082687378},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.44167277216911316},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4212955832481384},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.41345053911209106},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3838246464729309},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3610716462135315},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33971038460731506},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2202397584915161},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10546091198921204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07637643814086914},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1001/jama.298.11.1300","doi":"https://doi.org/10.1001/jama.298.11.1300","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.298.11.1300","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"pmid:17878422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17878422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/57c62d2c-bde3-4e54-ae14-32ce543fcd2e","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/57c62d2c-bde3-4e54-ae14-32ce543fcd2e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bennet, A M, Di Angelantonio, E, Ye, Z, Wensley, F, Dahlin, A, Ahlbom, A, Keavney, B, Collins, R, Wiman, B, de Faire, U & Danesh, J 2007, 'Association of apolipoprotein E genotypes with lipid levels and coronary risk', JAMA, vol. 298, no. 11, pp. 1300-11. https://doi.org/10.1001/jama.298.11.1300","raw_type":"info:eu-repo/semantics/review"},{"id":"doi:10.25405/ncl.34632858","doi":"https://doi.org/10.25405/ncl.34632858","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34632858","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34632858.v1","doi":"https://doi.org/10.25405/ncl.34632858.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34632858.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.25405/ncl.34632858","doi":"https://doi.org/10.25405/ncl.34632858","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34632858","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":148,"referenced_works":["https://openalex.org/W115288193","https://openalex.org/W147823787","https://openalex.org/W199774941","https://openalex.org/W256414136","https://openalex.org/W828435897","https://openalex.org/W839676919","https://openalex.org/W1500145074","https://openalex.org/W1538827582","https://openalex.org/W1575441863","https://openalex.org/W1577502861","https://openalex.org/W1837896746","https://openalex.org/W1939948612","https://openalex.org/W1964655913","https://openalex.org/W1965548901","https://openalex.org/W1969420738","https://openalex.org/W1971045141","https://openalex.org/W1972598797","https://openalex.org/W1974323476","https://openalex.org/W1974363862","https://openalex.org/W1976114496","https://openalex.org/W1979485513","https://openalex.org/W1979671319","https://openalex.org/W1982579882","https://openalex.org/W1982972035","https://openalex.org/W1983271161","https://openalex.org/W1983538052","https://openalex.org/W1986654454","https://openalex.org/W1987716493","https://openalex.org/W1988781290","https://openalex.org/W1996359690","https://openalex.org/W1998290897","https://openalex.org/W1998345704","https://openalex.org/W1998524389","https://openalex.org/W2001052319","https://openalex.org/W2006144775","https://openalex.org/W2007518825","https://openalex.org/W2007903896","https://openalex.org/W2009075724","https://openalex.org/W2013713979","https://openalex.org/W2017676429","https://openalex.org/W2018480908","https://openalex.org/W2018670815","https://openalex.org/W2022687056","https://openalex.org/W2026860413","https://openalex.org/W2028858864","https://openalex.org/W2029454905","https://openalex.org/W2031498851","https://openalex.org/W2031599647","https://openalex.org/W2033585778","https://openalex.org/W2034968148","https://openalex.org/W2035411029","https://openalex.org/W2038144491","https://openalex.org/W2041341233","https://openalex.org/W2050555193","https://openalex.org/W2051394059","https://openalex.org/W2052439321","https://openalex.org/W2058412302","https://openalex.org/W2059923100","https://openalex.org/W2061259138","https://openalex.org/W2061571369","https://openalex.org/W2064118608","https://openalex.org/W2066507905","https://openalex.org/W2069096459","https://openalex.org/W2069461486","https://openalex.org/W2070901692","https://openalex.org/W2072459924","https://openalex.org/W2075311308","https://openalex.org/W2075638202","https://openalex.org/W2077568591","https://openalex.org/W2079156005","https://openalex.org/W2079413267","https://openalex.org/W2081863934","https://openalex.org/W2082212224","https://openalex.org/W2082655419","https://openalex.org/W2084667081","https://openalex.org/W2085218211","https://openalex.org/W2086588832","https://openalex.org/W2089240778","https://openalex.org/W2090568412","https://openalex.org/W2095499249","https://openalex.org/W2096499083","https://openalex.org/W2096855826","https://openalex.org/W2099917119","https://openalex.org/W2100989562","https://openalex.org/W2100997592","https://openalex.org/W2101126324","https://openalex.org/W2105776190","https://openalex.org/W2106158806","https://openalex.org/W2107328434","https://openalex.org/W2113765208","https://openalex.org/W2114063969","https://openalex.org/W2116443347","https://openalex.org/W2117655698","https://openalex.org/W2119535733","https://openalex.org/W2121101037","https://openalex.org/W2124767266","https://openalex.org/W2124905540","https://openalex.org/W2125435699","https://openalex.org/W2127331838","https://openalex.org/W2128417045","https://openalex.org/W2128519424","https://openalex.org/W2130947021","https://openalex.org/W2135981552","https://openalex.org/W2137033054","https://openalex.org/W2139137121","https://openalex.org/W2140334576","https://openalex.org/W2141738130","https://openalex.org/W2142054160","https://openalex.org/W2142752948","https://openalex.org/W2144024528","https://openalex.org/W2146892666","https://openalex.org/W2148550388","https://openalex.org/W2155559959","https://openalex.org/W2156073870","https://openalex.org/W2157823046","https://openalex.org/W2160149030","https://openalex.org/W2162235775","https://openalex.org/W2169064270","https://openalex.org/W2182459071","https://openalex.org/W2188938709","https://openalex.org/W2214366941","https://openalex.org/W2247997571","https://openalex.org/W2272070467","https://openalex.org/W2319424860","https://openalex.org/W2332014676","https://openalex.org/W2335918640","https://openalex.org/W2356872863","https://openalex.org/W2357143329","https://openalex.org/W2360989260","https://openalex.org/W2362764139","https://openalex.org/W2362888606","https://openalex.org/W2365006289","https://openalex.org/W2366285912","https://openalex.org/W2370396363","https://openalex.org/W2370985540","https://openalex.org/W2371137699","https://openalex.org/W2379622290","https://openalex.org/W2383339449","https://openalex.org/W2384304655","https://openalex.org/W2385445129","https://openalex.org/W2391136134","https://openalex.org/W2394596818","https://openalex.org/W2399880281","https://openalex.org/W2401187718","https://openalex.org/W2406680428","https://openalex.org/W2415352540","https://openalex.org/W2435123233","https://openalex.org/W3150904256"],"related_works":["https://openalex.org/W2133959779","https://openalex.org/W142575532","https://openalex.org/W4213391652","https://openalex.org/W6998658611","https://openalex.org/W2128519424","https://openalex.org/W2750216034","https://openalex.org/W7100118468","https://openalex.org/W2008583133","https://openalex.org/W2362764139","https://openalex.org/W4200143517"],"abstract_inverted_index":{"CONTEXT:":[0],"Previous":[1],"reviews":[2],"of":[3,5,28,76,82,89,98,206,278,302],"associations":[4,27],"apolipoprotein":[6],"E":[7],"(apoE)":[8],"genotype":[9,134,166],"and":[10,35,49,60,71,79,95,103,122,140,142,219,231,233,239,263,285,306],"coronary":[11,37,99,128,138,221,253,286,303],"disease":[12,254,305],"have":[13,297,309],"been":[14],"dominated":[15],"by":[16,148,153],"smaller":[17],"studies":[18,88,97,113],"that":[19,234],"are":[20,274],"liable":[21],"to":[22,242],"biases.":[23],"OBJECTIVE:":[24],"To":[25],"reassess":[26],"apoE":[29,207,279],"genotypes":[30,208,280],"with":[31,36,108,114,124,163,197,217,220,225,235,247,281,289,291],"circulating":[32],"lipid":[33,90,136],"levels":[34,91,284],"risk.":[38,222,287,313],"DATA":[39,130],"SOURCES:":[40],"We":[41],"conducted":[42],"an":[43],"updated":[44],"meta-analysis":[45],"including":[46],"both":[47,282],"published":[48,67],"previously":[50],"unreported":[51],"studies,":[52],"using":[53],"MEDLINE,":[54],"EMBASE,":[55],"BIOSIS,":[56],"Science":[57],"Citation":[58],"Index,":[59],"the":[61,158,164,198,243,249,292],"Chinese":[62],"National":[63],"Knowledge":[64],"Infrastructure":[65],"Database":[66],"between":[68],"January":[69,72],"1970":[70],"2007,":[73],"reference":[74],"lists":[75],"articles":[77],"retrieved,":[78],"a":[80,298,310],"registry":[81],"relevant":[83],"studies.":[84],"STUDY":[85],"SELECTION:":[86],"Eighty-two":[87],"(86,067":[92],"healthy":[93,118],"participants)":[94],"121":[96],"outcomes":[100],"(37,850":[101],"cases":[102],"82,727":[104],"controls)":[105],"were":[106,145,202],"identified,":[107],"prespecified":[109],"principal":[110],"focus":[111],"on":[112,133],"at":[115,125],"least":[116,126],"1000":[117],"participants":[119],"for":[120,252],"lipids":[121],"those":[123,196],"500":[127],"outcomes.":[129],"EXTRACTION:":[131],"Information":[132],"frequencies,":[135],"levels,":[137],"outcomes,":[139],"laboratory":[141],"population":[143],"characteristics":[144],"recorded":[146],"independently":[147],"2":[149],"investigators":[150],"and/or":[151],"supplied":[152],"study":[154],"investigators.":[155],"RESULTS:":[156],"In":[157],"most":[159],"extreme":[160],"comparison,":[161],"people":[162],"epsilon2/epsilon2":[165,244],"had":[167],"1.14":[168],"mmol/L":[169,175],"(95%":[170,185,257,266],"confidence":[171],"interval":[172],"[CI],":[173],"0.87-1.40":[174],"[44.0":[176],"mg/dL;":[177],"95%":[178],"CI;":[179],"33.6-51.1":[180],"mg/dL])":[181],"or":[182],"about":[183],"31%":[184],"CI,":[186,258,267],"23%-38%)":[187],"lower":[188,300],"mean":[189],"low-density":[190],"lipoprotein":[191,227],"cholesterol":[192,228],"(LDL-C)":[193],"values":[194],"than":[195],"epsilon4/epsilon4":[199],"genotype.":[200,245],"There":[201,273],"approximately":[203,275],"linear":[204,276],"relationships":[205,277],"(when":[209],"ordered":[210],"epsilon2/epsilon2,":[211],"epsilon2/epsilon3,":[212],"epsilon2/epsilon4,":[213],"epsilon3/epsilon3,":[214,248],"epsilon3/epsilon4,":[215],"epsilon4/epsilon4)":[216],"LDL-C":[218,283],"The":[223],"relationship":[224],"high-density":[226],"was":[229,237,255,264],"inverse":[230],"shallow":[232],"triglycerides":[236],"nonlinear":[238],"largely":[240],"confined":[241],"Compared":[246,288],"odds":[250],"ratio":[251],"0.80":[256],"0.70-0.90)":[259],"in":[260,269],"epsilon2":[261,295],"carriers":[262,296,308],"1.06":[265],"0.99-1.13)":[268],"epsilon4":[270,307],"carriers.":[271],"CONCLUSIONS:":[272],"individuals":[290],"epsilon3/epsilon3":[293],"genotype,":[294],"20%":[299],"risk":[301],"heart":[304],"slightly":[311],"higher":[312]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":40},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":47},{"year":2021,"cited_by_count":44},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":33},{"year":2018,"cited_by_count":45},{"year":2017,"cited_by_count":41},{"year":2016,"cited_by_count":52},{"year":2015,"cited_by_count":45},{"year":2014,"cited_by_count":47},{"year":2013,"cited_by_count":45},{"year":2012,"cited_by_count":48}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
