{"id":"https://openalex.org/W2106592750","doi":"https://doi.org/10.1152/ajpregu.00880.2006","title":"Development of contractile dysfunction in rat heart failure: hierarchy of cellular events","display_name":"Development of contractile dysfunction in rat heart failure: hierarchy of cellular events","publication_year":2007,"publication_date":"2007-03-15","ids":{"openalex":"https://openalex.org/W2106592750","doi":"https://doi.org/10.1152/ajpregu.00880.2006","mag":"2106592750","pmid":"https://pubmed.ncbi.nlm.nih.gov/17363676"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.00880.2006","doi":"https://doi.org/10.1152/ajpregu.00880.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00880.2006","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111893135","display_name":"Marcel C. G. Daniels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcel C. G. Daniels","raw_affiliation_strings":["Department of Physiology and Biophysics MC901, Center for Cardiovascular Research, University of Illinois at Chicago, 835 S. Wolcott Ave., Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics MC901, Center for Cardiovascular Research, University of Illinois at Chicago, 835 S. Wolcott Ave., Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091408552","display_name":"Taihei Naya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taihei Naya","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065265953","display_name":"Veronica L. M. Rundell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veronica L. M. Rundell","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056694490","display_name":"Pieter P. de Tombe","orcid":"https://orcid.org/0000-0003-3178-0233","observed_orcids":["https://orcid.org/0000-0003-3178-0233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pieter P. de Tombe","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5708,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.93387111,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"293","issue":"1","first_page":"R284","last_page":"R292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.31690001487731934,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.31690001487731934,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.23270000517368317,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.19599999487400055,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9169999957084656},{"id":"https://openalex.org/keywords/myocardial-contractile-dysfunction","display_name":"myocardial contractile dysfunction","score":0.8730000257492065},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-ca2-atpase","display_name":"sarcoplasmic reticulum Ca2+-ATPase","score":0.9359999895095825},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.8560000061988831},{"id":"https://openalex.org/keywords/na-ca2-exchanger","display_name":"Na+/Ca2+ exchanger","score":0.8289999961853027},{"id":"https://openalex.org/keywords/phospholamban","display_name":"phospholamban","score":0.9929999709129333},{"id":"https://openalex.org/keywords/right-ventricular-trabeculae","display_name":"right ventricular trabeculae","score":0.847000002861023},{"id":"https://openalex.org/keywords/skinned-muscle-fibers","display_name":"skinned muscle fibers","score":0.5249999761581421},{"id":"https://openalex.org/keywords/twitch-force","display_name":"twitch force","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C174054327","wikidata":"https://www.wikidata.org/wiki/Q6947920","display_name":"Myofilament","level":3,"score":0.8571354150772095},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6830438375473022},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.667326807975769},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5576693415641785},{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.5568620562553406},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.5522841215133667},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.528417706489563},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5136051177978516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4826265275478363},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.48244887590408325},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4747781455516815},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.44712692499160767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3284955620765686},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.2937290668487549},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11930185556411743}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002303","descriptor_name":"Cardiac Output, Low","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002303","descriptor_name":"Cardiac Output, Low","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpregu.00880.2006","doi":"https://doi.org/10.1152/ajpregu.00880.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00880.2006","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:17363676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17363676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.963.3076","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.963.3076","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajpregu.physiology.org/content/ajpregu/early/2007/03/15/ajpregu.00880.2006.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1007206038","display_name":null,"funder_award_id":"T32 07692","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G891108873","display_name":"Integrated Mechanisms of Cardiac Maladaptation","funder_award_id":"P01HL062426","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1826549280","https://openalex.org/W1964485054","https://openalex.org/W1977051351","https://openalex.org/W1979852829","https://openalex.org/W1988792839","https://openalex.org/W2001594849","https://openalex.org/W2016255823","https://openalex.org/W2023591835","https://openalex.org/W2027162244","https://openalex.org/W2031233485","https://openalex.org/W2036424054","https://openalex.org/W2039826528","https://openalex.org/W2044110796","https://openalex.org/W2050853946","https://openalex.org/W2054693521","https://openalex.org/W2058581105","https://openalex.org/W2067639050","https://openalex.org/W2068613600","https://openalex.org/W2069292608","https://openalex.org/W2071913945","https://openalex.org/W2090993901","https://openalex.org/W2096448410","https://openalex.org/W2099302775","https://openalex.org/W2103906100","https://openalex.org/W2110787501","https://openalex.org/W2112735350","https://openalex.org/W2115916099","https://openalex.org/W2119706727","https://openalex.org/W2121622232","https://openalex.org/W2122991452","https://openalex.org/W2127179347","https://openalex.org/W2131022985","https://openalex.org/W2133356598","https://openalex.org/W2133430515","https://openalex.org/W2135927881","https://openalex.org/W2147343486","https://openalex.org/W2147602331","https://openalex.org/W2151912878","https://openalex.org/W2160416495","https://openalex.org/W2167489666","https://openalex.org/W2169669126","https://openalex.org/W2179863336","https://openalex.org/W2185764459","https://openalex.org/W2237191041","https://openalex.org/W2401085244","https://openalex.org/W2418267971","https://openalex.org/W2977097895","https://openalex.org/W4293179290"],"related_works":["https://openalex.org/W7095723437","https://openalex.org/W2237191041","https://openalex.org/W2016255823","https://openalex.org/W2029246040","https://openalex.org/W2058517027","https://openalex.org/W2093779496","https://openalex.org/W1974588788","https://openalex.org/W2149465858","https://openalex.org/W2096667649","https://openalex.org/W2049131800"],"abstract_inverted_index":{"The":[0],"cellular":[1,147],"mechanisms":[2],"underlying":[3],"the":[4,150,160],"development":[5,114,151],"of":[6,101,146,152],"congestive":[7],"heart":[8],"failure":[9],"(HF)":[10],"are":[11],"not":[12,138],"well":[13],"understood.":[14],"Accordingly,":[15],"we":[16],"studied":[17],"myocardial":[18,35],"function":[19],"in":[20,27,88,99,115,120,125,134,139],"isolated":[21],"right":[22],"ventricular":[23,34],"trabeculae":[24,117],"from":[25],"rats":[26],"which":[28],"HF":[29,47,54,69,89],"was":[30,55,86,118,132],"induced":[31],"by":[32,164],"left":[33],"infarction":[36],"(MI).":[37],"Both":[38],"early-stage":[39],"(12":[40],"wk":[41,49],"post-MI;":[42],"E-pMI)":[43],"and":[44],"late,":[45],"end-stage":[46,168],"(28":[48],"post-Mi;":[50],"L-pMI)":[51],"were":[52],"studied.":[53],"associated":[56],"with":[57,95,155],"decreased":[58],"sarcoplasmic":[59],"reticulum":[60],"Ca(2+)":[61],"ATPase":[62],"protein":[63,78],"levels":[64],"(28%":[65],"E-pMI;":[66,91,108],"52%":[67],"L-pMI).":[68,110],"affected":[70],"neither":[71],"sodium/calcium":[72],"exchange,":[73],"ryanodine":[74],"receptor,":[75],"nor":[76],"phospholamban":[77],"levels.":[79],"Twitch":[80],"force":[81,103,113],"at":[82,167],"saturating":[83],"extracellular":[84,105],"[Ca(2+)]":[85,106],"depressed":[87,124,133],"(30%":[90],"38%":[92],"L-pMI),":[93],"concomitant":[94],"a":[96,144],"marked":[97],"increase":[98],"sensitivity":[100],"twitch":[102],"toward":[104],"(26%":[107],"68%":[109],"Ca(2+)-saturated":[111],"myofilament":[112,165],"skinned":[116],"unchanged":[119],"E-pMI":[121],"but":[122,137],"significantly":[123],"L-pMI":[126,135],"(45%).":[127],"Tension-dependent":[128],"ATP":[129],"hydrolysis":[130],"rate":[131],"(49%),":[136],"E-pMI.":[140],"Our":[141],"results":[142],"suggest":[143],"hierarchy":[145],"events":[148],"during":[149,159],"HF,":[153],"starting":[154],"altered":[156],"calcium":[157],"homeostasis":[158],"early":[161],"phase":[162],"followed":[163],"dysfunction":[166],"HF.":[169]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}