{"id":"https://openalex.org/W2106586604","doi":"https://doi.org/10.1530/eje-14-0556","title":"MANAGEMENT OF ENDOCRINE DISEASE: Mortality remains increased in Cushing's disease despite biochemical remission: a systematic review and meta-analysis","display_name":"MANAGEMENT OF ENDOCRINE DISEASE: Mortality remains increased in Cushing's disease despite biochemical remission: a systematic review and meta-analysis","publication_year":2015,"publication_date":"2015-02-27","ids":{"openalex":"https://openalex.org/W2106586604","doi":"https://doi.org/10.1530/eje-14-0556","mag":"2106586604","pmid":"https://pubmed.ncbi.nlm.nih.gov/25722097"},"language":"en","primary_location":{"id":"doi:10.1530/eje-14-0556","doi":"https://doi.org/10.1530/eje-14-0556","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje-14-0556","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019709846","display_name":"Femke M. van Haalen","orcid":"https://orcid.org/0000-0001-9551-9064","observed_orcids":["https://orcid.org/0000-0001-9551-9064"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["DK","NL"],"is_corresponding":false,"raw_author_name":"Femke M van Haalen","raw_affiliation_strings":["Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark","Departments of Endocrinology, Leiden University Medical Centre, Leiden 2300RC, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Departments of Endocrinology, Leiden University Medical Centre, Leiden 2300RC, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085593111","display_name":"Leonie H. A. Broersen","orcid":"https://orcid.org/0000-0001-5210-407X","observed_orcids":["https://orcid.org/0000-0001-5210-407X"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["DK","NL"],"is_corresponding":false,"raw_author_name":"Leonie H A Broersen","raw_affiliation_strings":["Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark","Clinical Epidemiology, Leiden University Medical Centre, Leiden 2300RC, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Clinical Epidemiology, Leiden University Medical Centre, Leiden 2300RC, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090850055","display_name":"Jens Otto Lunde J\u00f8rgensen","orcid":"https://orcid.org/0000-0001-7408-1526","observed_orcids":["https://orcid.org/0000-0001-7408-1526"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["DK","NL"],"is_corresponding":false,"raw_author_name":"Jens O Jorgensen","raw_affiliation_strings":["Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark","Department of Endocrinology, Aarhus University, 8000 Aarhus C, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Endocrinology, Aarhus University, 8000 Aarhus C, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032760472","display_name":"Alberto M. Pereira","orcid":"https://orcid.org/0000-0002-1194-9866","observed_orcids":["https://orcid.org/0000-0002-1194-9866"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["DK","NL"],"is_corresponding":false,"raw_author_name":"Alberto M Pereira","raw_affiliation_strings":["Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark","Departments of Endocrinology, Leiden University Medical Centre, Leiden 2300RC, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Departments of Endocrinology, Leiden University Medical Centre, Leiden 2300RC, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069014026","display_name":"Olaf M. Dekkers","orcid":"https://orcid.org/0000-0002-1333-7580","observed_orcids":["https://orcid.org/0000-0002-1333-7580"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["DK","NL"],"is_corresponding":true,"raw_author_name":"Olaf M Dekkers","raw_affiliation_strings":["Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark o.m.dekkers@lumc.nl","Clinical Epidemiology, Leiden University Medical Centre, Leiden 2300RC, The Netherlands","Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark","Departments of Endocrinology, Leiden University Medical Centre, Leiden 2300RC, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark Departments of EndocrinologyClinical EpidemiologyLeiden University Medical Centre, Leiden 2300RC, The NetherlandsDepartment of EndocrinologyAarhus University, 8000 Aarhus C, DenmarkDepartment of Clinical EpidemiologyAarhus University, Aarhus, Denmark o.m.dekkers@lumc.nl","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Clinical Epidemiology, Leiden University Medical Centre, Leiden 2300RC, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Departments of Endocrinology, Leiden University Medical Centre, Leiden 2300RC, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069014026"],"corresponding_institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800006345"],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":null,"fwci":1.3613,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.79396092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"172","issue":"4","first_page":"R143","last_page":"R149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cushing-disease","display_name":"Cushing's disease","score":1.0},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7609999775886536},{"id":"https://openalex.org/keywords/biochemical-remission","display_name":"biochemical remission","score":0.9860000014305115},{"id":"https://openalex.org/keywords/standardized-mortality-ratio","display_name":"standardized mortality ratio","score":0.753000020980835},{"id":"https://openalex.org/keywords/hypopituitarism","display_name":"hypopituitarism","score":0.9169999957084656},{"id":"https://openalex.org/keywords/adrenal-insufficiency","display_name":"adrenal insufficiency","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pituitary-surgery","display_name":"pituitary surgery","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8361474275588989},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.8011185526847839},{"id":"https://openalex.org/C2776810848","wikidata":"https://www.wikidata.org/wiki/Q1947304","display_name":"Cushing's disease","level":3,"score":0.6056990623474121},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6023396253585815},{"id":"https://openalex.org/C2778491484","wikidata":"https://www.wikidata.org/wiki/Q922411","display_name":"Hypopituitarism","level":2,"score":0.5661234855651855},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5306695103645325},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4401625692844391},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.431589812040329},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.37427979707717896}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047748","descriptor_name":"Pituitary ACTH Hypersecretion","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D047748","descriptor_name":"Pituitary ACTH Hypersecretion","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D047748","descriptor_name":"Pituitary ACTH Hypersecretion","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D047748","descriptor_name":"Pituitary ACTH Hypersecretion","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1530/eje-14-0556","doi":"https://doi.org/10.1530/eje-14-0556","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje-14-0556","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:25722097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25722097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of endocrinology","raw_type":"Journal Article"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_2995351","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/101935","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Endocrinology, 172(4), R143 - R149","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.31UKB_LEU:9940754538702711","doi":null,"is_oa":false,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/101935","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Endocrinology, Vol. 172, no. 4, p. R143-R149","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/101935","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/101935","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"172","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:pure.atira.dk:publications/f7b32ea5-9180-44c1-be28-12a9c57c1aca","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/f7b32ea5-9180-44c1-be28-12a9c57c1aca","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"van Haalen, F M, Broersen, L H A, Jorgensen, J O, Pereira, A M & Dekkers, O M 2015, 'MANAGEMENT OF ENDOCRINE DISEASE: Mortality remains increased in Cushing's disease despite biochemical remission: a systematic review and meta-analysis', European journal of endocrinology / European Federation of Endocrine Societies, vol. 172, no. 4, pp. R143-R149. https://doi.org/10.1530/EJE-14-0556","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2995351","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/101935","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Endocrinology","raw_type":"Article / Letter to editor"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G150490421","display_name":null,"funder_award_id":"NNF-13OC0007869","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1526232299","https://openalex.org/W1853250143","https://openalex.org/W1981722144","https://openalex.org/W1995365748","https://openalex.org/W2000020742","https://openalex.org/W2000378947","https://openalex.org/W2001003028","https://openalex.org/W2001077013","https://openalex.org/W2030042518","https://openalex.org/W2064227011","https://openalex.org/W2071773521","https://openalex.org/W2086924944","https://openalex.org/W2093010614","https://openalex.org/W2093593211","https://openalex.org/W2097490026","https://openalex.org/W2108430953","https://openalex.org/W2116795137","https://openalex.org/W2117589135","https://openalex.org/W2118784254","https://openalex.org/W2122999501","https://openalex.org/W2129909048","https://openalex.org/W2140913018","https://openalex.org/W2159632410"],"related_works":["https://openalex.org/W4281706236","https://openalex.org/W4221114456","https://openalex.org/W2064227011","https://openalex.org/W2409671948","https://openalex.org/W1526232299","https://openalex.org/W2028311382","https://openalex.org/W4409148116","https://openalex.org/W2914799087","https://openalex.org/W2409533058","https://openalex.org/W2086924944"],"abstract_inverted_index":{"The":[0,119,127],"aim":[1],"of":[2,32,72,93,101,107,173],"this":[3],"systematic":[4,28],"review":[5,29],"and":[6,30],"meta-analysis":[7,31,146],"was":[8,44,89,122,139],"to":[9,53,56,176,192],"investigate":[10],"whether":[11],"mortality":[12,66,149,195],"is":[13,26],"increased":[14,151,194],"in":[15,35,82,152],"patients":[16,36,70,103,153],"biochemically":[17],"cured":[18,37,71,117],"after":[19,41,158,187],"initial":[20,42,159],"treatment":[21,43],"for":[22,69,77,91,116,132],"Cushing's":[23,39,73,155],"disease.":[24],"This":[25,145],"a":[27,83,99],"follow-up":[33],"studies":[34,97],"from":[38,51],"disease":[40,74,156],"performed.":[45],"Eight":[46,95],"electronic":[47],"databases":[48],"were":[49,75,80,104],"searched":[50],"1975":[52],"March":[54],"2014":[55],"identify":[57],"potentially":[58],"relevant":[59],"articles.":[60],"Original":[61],"articles":[62],"reporting":[63],"the":[64,170,193],"standardized":[65],"ratio":[67],"(SMR)":[68],"eligible":[76],"inclusion.":[78],"SMRs":[79],"pooled":[81,120],"random":[84],"effects":[85],"model.":[86],"I(2)":[87,128],"statistics":[88,129],"used":[90],"quantification":[92],"heterogeneity.":[94],"cohort":[96],"with":[98,154],"total":[100],"766":[102],"included.":[105],"Out":[106],"eight":[108],"studies,":[109],"seven":[110],"showed":[111,130],"an":[112],"SMR":[113,121],"above":[114],"1.0":[115],"patients.":[118],"2.5":[123],"(95%":[124],"CI":[125],"1.4-4.2).":[126],"evidence":[131],"statistical":[133],"heterogeneity":[134],"(78%,":[135],"Q-statistics":[136],"P<0.001),":[137],"which":[138],"largely":[140],"explained":[141],"by":[142],"two":[143],"outliers.":[144],"reveals":[147],"that":[148,164],"remains":[150],"even":[157],"biochemical":[160],"cure":[161,165],"remission,":[162],"suggesting":[163],"does":[166],"not":[167],"directly":[168],"reverse":[169],"metabolic":[171],"consequences":[172],"long-term":[174],"overexposure":[175],"cortisol.":[177],"Other":[178],"conditions":[179],"such":[180],"as":[181],"hypopituitarism,":[182],"including":[183],"persistent":[184],"adrenocortical":[185],"insufficiency":[186],"surgery,":[188],"may":[189],"also":[190],"contribute":[191],"risk.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
