{"id":"https://openalex.org/W2106582399","doi":"https://doi.org/10.3390/molecules15064423","title":"Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides","display_name":"Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides","publication_year":2010,"publication_date":"2010-06-21","ids":{"openalex":"https://openalex.org/W2106582399","doi":"https://doi.org/10.3390/molecules15064423","mag":"2106582399","pmid":"https://pubmed.ncbi.nlm.nih.gov/20657451","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6264576"},"language":"en","primary_location":{"id":"doi:10.3390/molecules15064423","doi":"https://doi.org/10.3390/molecules15064423","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules15064423","pdf_url":"https://www.mdpi.com/1420-3049/15/6/4423/pdf?version=1403112801","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/15/6/4423/pdf?version=1403112801","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084246316","display_name":"Markus K. Dahlgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Markus K. Dahlgren","raw_affiliation_strings":["Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037576236","display_name":"Christopher T. \u00d6berg","orcid":"https://orcid.org/0000-0002-8804-829X","observed_orcids":["https://orcid.org/0000-0002-8804-829X"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christopher T. \u00d6berg","raw_affiliation_strings":["Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050961871","display_name":"Erika A. Wallin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Erika A. Wallin","raw_affiliation_strings":["Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043241066","display_name":"P\u00e4r G. Janson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"P\u00e4r G. Janson","raw_affiliation_strings":["Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072343210","display_name":"Mikael Elofsson","orcid":"https://orcid.org/0000-0002-3219-4669","observed_orcids":["https://orcid.org/0000-0002-3219-4669"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Mikael Elofsson","raw_affiliation_strings":["Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ume\u00e5 University, SE-90187 Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072343210"],"corresponding_institution_ids":["https://openalex.org/I90267481"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.5909,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.61069732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"6","first_page":"4423","last_page":"4438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.19040000438690186,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.15539999306201935,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioisosteres","display_name":"bioisosteres","score":0.8930000066757202},{"id":"https://openalex.org/keywords/scaffold-hopping","display_name":"scaffold hopping","score":0.9409999847412109},{"id":"https://openalex.org/keywords/gram-negative-pathogens","display_name":"Gram-negative pathogens","score":0.8859999775886536},{"id":"https://openalex.org/keywords/compound-library-synthesis","display_name":"compound library synthesis","score":0.47200000286102295},{"id":"https://openalex.org/keywords/pyrimidine-derivatives","display_name":"pyrimidine derivatives","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.7532333135604858},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.7347515821456909},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6819669604301453},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5876625776290894},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5627231001853943},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.4213813841342926},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1379091441631317},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/molecules15064423","doi":"https://doi.org/10.3390/molecules15064423","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules15064423","pdf_url":"https://www.mdpi.com/1420-3049/15/6/4423/pdf?version=1403112801","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5244518","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6264576","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:20657451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20657451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6264576","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6264576/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.388.7680","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.388.7680","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mdpi.com/1420-3049/15/6/4423/pdf/","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b653e168f7f64dc3883acad0b36d989b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b653e168f7f64dc3883acad0b36d989b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 15, Iss 6, Pp 4423-4438 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules15064423","doi":"https://doi.org/10.3390/molecules15064423","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules15064423","pdf_url":"https://www.mdpi.com/1420-3049/15/6/4423/pdf?version=1403112801","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321030","display_name":"VINNOVA","ror":"https://ror.org/01kd5m353"},{"id":"https://openalex.org/F4320321501","display_name":"Carl Tryggers Stiftelse f\u00f6r Vetenskaplig Forskning","ror":"https://ror.org/048p4fn82"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106582399.pdf","grobid_xml":"https://content.openalex.org/works/W2106582399.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1560562144","https://openalex.org/W1966055091","https://openalex.org/W1973843350","https://openalex.org/W1984341140","https://openalex.org/W1993394468","https://openalex.org/W1999003262","https://openalex.org/W2007262878","https://openalex.org/W2013285329","https://openalex.org/W2016351706","https://openalex.org/W2020696885","https://openalex.org/W2030561445","https://openalex.org/W2030893951","https://openalex.org/W2047172408","https://openalex.org/W2050922231","https://openalex.org/W2062768126","https://openalex.org/W2071224695","https://openalex.org/W2072322668","https://openalex.org/W2086254747","https://openalex.org/W2094709857","https://openalex.org/W2095393243","https://openalex.org/W2104945888","https://openalex.org/W2112174816","https://openalex.org/W2127318266","https://openalex.org/W2127541870","https://openalex.org/W2132267745","https://openalex.org/W2139993960","https://openalex.org/W2144878722","https://openalex.org/W2162051865","https://openalex.org/W2165524414","https://openalex.org/W2174906180"],"related_works":["https://openalex.org/W1994931487","https://openalex.org/W1968366699","https://openalex.org/W2885316546","https://openalex.org/W2609517313","https://openalex.org/W2994368395","https://openalex.org/W2951477082","https://openalex.org/W2581760654","https://openalex.org/W2009009622","https://openalex.org/W2158039697","https://openalex.org/W2148216384"],"abstract_inverted_index":{"Salicylidene":[0],"acylhydrazides":[1],"are":[2],"inhibitors":[3],"of":[4,27,48,51],"type":[5],"III":[6],"secretion":[7],"in":[8,55],"several":[9],"gram-negative":[10],"pathogens.":[11],"To":[12],"further":[13],"develop":[14],"the":[15,24,28,41],"salicylidene":[16,42],"acylhydrazides,":[17],"scaffold":[18,33],"hopping":[19],"was":[20,34],"applied":[21],"to":[22,40],"replace":[23],"core":[25,44],"fragment":[26],"compounds.":[29],"The":[30,46],"novel":[31],"2-(2-amino-pyrimidine)-2,2-difluoroethanol":[32],"identified":[35],"as":[36],"a":[37,49],"possible":[38],"analog":[39],"acylhydrazide":[43],"structure.":[45],"synthesis":[47],"library":[50],"2-(2-amino-pyrimidine)-2,2-difluoro-ethanols":[52],"is":[53],"described":[54],"this":[56],"paper.":[57]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
