{"id":"https://openalex.org/W2106545870","doi":"https://doi.org/10.1002/bit.21958","title":"A model predicting delivery of saquinavir in nanoparticles to human monocyte/macrophage (Mo/Mac) cells","display_name":"A model predicting delivery of saquinavir in nanoparticles to human monocyte/macrophage (Mo/Mac) cells","publication_year":2008,"publication_date":"2008-05-03","ids":{"openalex":"https://openalex.org/W2106545870","doi":"https://doi.org/10.1002/bit.21958","mag":"2106545870","pmid":"https://pubmed.ncbi.nlm.nih.gov/18553495"},"language":"en","primary_location":{"id":"doi:10.1002/bit.21958","doi":"https://doi.org/10.1002/bit.21958","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bit.21958","pdf_url":null,"source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110201020","display_name":"D. Ece Gamsiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Ece Gamsiz","raw_affiliation_strings":["Department of Chemical Engineering, 342 Snell Engineering Center, 360 Huntington Avenue, Northeastern University, Boston, Massachusetts 02115, USA","Department of Chemical Engineering, 342 Snell Engineering Center, 360 Huntington Avenue, Northeastern University, Boston, Massachusetts 02115","fax: 617-373-2209","telephone: 617-373-7126"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, 342 Snell Engineering Center, 360 Huntington Avenue, Northeastern University, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Department of Chemical Engineering, 342 Snell Engineering Center, 360 Huntington Avenue, Northeastern University, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"fax: 617-373-2209","institution_ids":[]},{"raw_affiliation_string":"telephone: 617-373-7126","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020742396","display_name":"Lipa K. Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lipa K. Shah","raw_affiliation_strings":["Assistant Professor","Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005964579","display_name":"Harikrishna Devalapally","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harikrishna Devalapally","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064469636","display_name":"Mansoor M. Amiji","orcid":"https://orcid.org/0000-0001-6170-881X","observed_orcids":["https://orcid.org/0000-0001-6170-881X"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mansoor M. Amiji","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045995483","display_name":"Rebecca Lyn Carrier","orcid":"https://orcid.org/0000-0003-3002-7098","observed_orcids":["https://orcid.org/0000-0003-3002-7098"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecca L. Carrier","raw_affiliation_strings":["Department of Chemical Engineering, 342 Snell Engineering Center, 360 Huntington Avenue, Northeastern University, Boston, Massachusetts 02115; telephone: 617-373-7126;fax: 617-373-2209","Department of Chemical Engineering, 342 Snell Engineering Center, 360 Huntington Avenue, Northeastern University, Boston, Massachusetts 02115","fax: 617-373-2209","telephone: 617-373-7126"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, 342 Snell Engineering Center, 360 Huntington Avenue, Northeastern University, Boston, Massachusetts 02115; telephone: 617-373-7126;fax: 617-373-2209","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Department of Chemical Engineering, 342 Snell Engineering Center, 360 Huntington Avenue, Northeastern University, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"fax: 617-373-2209","institution_ids":[]},{"raw_affiliation_string":"telephone: 617-373-7126","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045995483"],"corresponding_institution_ids":["https://openalex.org/I12912129"],"apc_list":{"value":5060,"currency":"USD","value_usd":5060},"apc_paid":null,"fwci":1.1477,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.7564495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"101","issue":"5","first_page":"1072","last_page":"1082"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saquinavir","display_name":"saquinavir","score":0.9869999885559082},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.9049999713897705},{"id":"https://openalex.org/keywords/intracellular-drug-concentration","display_name":"intracellular drug concentration","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.5},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.722000002861023},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.9129999876022339},{"id":"https://openalex.org/keywords/low-solubility-drugs","display_name":"low solubility drugs","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pharmaceutical-formulation-design","display_name":"drug formulation design","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7743493318557739},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.7006994485855103},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6044440865516663},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5075932741165161},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4798371493816376},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4263022541999817},{"id":"https://openalex.org/C2776937687","wikidata":"https://www.wikidata.org/wiki/Q422654","display_name":"Saquinavir","level":5,"score":0.4131469130516052},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37078437209129333},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3285260796546936},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.29494941234588623},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19016194343566895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08589902520179749},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019258","descriptor_name":"Saquinavir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019258","descriptor_name":"Saquinavir","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bit.21958","doi":"https://doi.org/10.1002/bit.21958","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bit.21958","pdf_url":null,"source":{"id":"https://openalex.org/S151564723","display_name":"Biotechnology and Bioengineering","issn_l":"0006-3592","issn":["0006-3592","1097-0290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and Bioengineering","raw_type":"journal-article"},{"id":"pmid:18553495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18553495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology and bioengineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W154100634","https://openalex.org/W189220689","https://openalex.org/W1557083683","https://openalex.org/W1954597686","https://openalex.org/W1973701873","https://openalex.org/W1983473009","https://openalex.org/W1983934583","https://openalex.org/W2006784090","https://openalex.org/W2009841111","https://openalex.org/W2018107016","https://openalex.org/W2028220931","https://openalex.org/W2039279797","https://openalex.org/W2059435135","https://openalex.org/W2060320802","https://openalex.org/W2067178343","https://openalex.org/W2112417177","https://openalex.org/W2115439624","https://openalex.org/W2127310510","https://openalex.org/W2160271899","https://openalex.org/W2161262271","https://openalex.org/W2163472100"],"related_works":["https://openalex.org/W2006784090","https://openalex.org/W2767377747","https://openalex.org/W2902859521","https://openalex.org/W2001028059","https://openalex.org/W4234338172","https://openalex.org/W2059435135","https://openalex.org/W2555894087","https://openalex.org/W2912722564","https://openalex.org/W1877297947","https://openalex.org/W2071636590"],"abstract_inverted_index":{"Modeling":[0],"the":[1,30,75,78,133,152],"influence":[2],"of":[3,42,104,114,154,157,167],"a":[4,43,106,112],"technology":[5],"such":[6],"as":[7,67,69,77,111],"nanoparticle":[8,72,158],"systems":[9],"on":[10],"drug":[11,25,52,63,70,109,139,161,169],"delivery":[12,26,41,103],"is":[13],"beneficial":[14],"in":[15,54,92,97,123,135,142,163],"rational":[16],"formulation":[17,113],"design.":[18],"While":[19],"there":[20],"are":[21,38],"many":[22],"studies":[23],"showing":[24],"enhancement":[27,134,166],"by":[28,74],"nanoparticles,":[29,120],"literature":[31],"provides":[32],"little":[33],"guidance":[34],"regarding":[35],"when":[36,138,171],"nanoparticles":[37,66,143],"useful":[39],"for":[40,84],"given":[44],"drug.":[45],"A":[46],"model":[47,61,130,150],"was":[48,121,140],"developed":[49],"predicting":[50],"intracellular":[51,102,136,168],"concentration":[53,137,170],"cultured":[55],"cells":[56,76],"dosed":[57,110],"with":[58,173],"nanoparticles.":[59,174],"The":[60,129],"considered":[62],"release":[64,162],"from":[65],"well":[68],"and":[71,160],"uptake":[73,159],"key":[79,86],"system":[80],"processes.":[81],"Mathematical":[82],"expressions":[83],"these":[85,100],"processes":[87],"were":[88],"determined":[89],"using":[90],"experiments":[91],"which":[93],"each":[94],"process":[95],"occurred":[96],"isolation.":[98],"In":[99],"experiments,":[101],"saquinavir,":[105],"low":[107],"solubility":[108],"poly(ethylene":[115],"oxide)-modified":[116],"poly(epsilon-":[117],"caprolactone)":[118],"(PEO-PCL)":[119],"studied":[122],"THP-1":[124],"human":[125],"monocyte/macrophage":[126],"(Mo/Mac)":[127],"cells.":[128],"accurately":[131],"predicted":[132],"administered":[141],"compared":[144],"to":[145],"aqueous":[146],"solution.":[147],"This":[148],"simple":[149],"highlights":[151],"importance":[153],"relative":[155],"kinetics":[156],"determining":[164],"overall":[165],"dosing":[172]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
