{"id":"https://openalex.org/W2106484151","doi":"https://doi.org/10.1016/j.gene.2013.05.027","title":"Comparison of dynamics of wildtype and V94M human UDP-galactose 4-epimerase\u2014A computational perspective on severe epimerase-deficiency galactosemia","display_name":"Comparison of dynamics of wildtype and V94M human UDP-galactose 4-epimerase\u2014A computational perspective on severe epimerase-deficiency galactosemia","publication_year":2013,"publication_date":"2013-05-31","ids":{"openalex":"https://openalex.org/W2106484151","doi":"https://doi.org/10.1016/j.gene.2013.05.027","mag":"2106484151","pmid":"https://pubmed.ncbi.nlm.nih.gov/23732289","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3763920"},"language":"en","primary_location":{"id":"doi:10.1016/j.gene.2013.05.027","doi":"https://doi.org/10.1016/j.gene.2013.05.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gene.2013.05.027","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3763920","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007546946","display_name":"David J. Timson","orcid":"https://orcid.org/0000-0002-0985-8818","observed_orcids":["https://orcid.org/0000-0002-0985-8818"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Timson","raw_affiliation_strings":["School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044975181","display_name":"Steffen Lindert","orcid":"https://orcid.org/0000-0002-3976-3473","observed_orcids":["https://orcid.org/0000-0002-3976-3473"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steffen Lindert","raw_affiliation_strings":["Center for Theoretical Biological Physics, La Jolla, CA, USA","Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics, La Jolla, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044975181"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.8954,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.7379255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"526","issue":"2","first_page":"318","last_page":"324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8012999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8012999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.15330000221729279,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/udp-galactose-4-epimerase","display_name":"UDP-galactose 4-epimerase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gale","display_name":"gales","score":0.9470000267028809},{"id":"https://openalex.org/keywords/enzyme-dynamics","display_name":"enzyme dynamics","score":0.7300000190734863},{"id":"https://openalex.org/keywords/substrate-binding","display_name":"substrate binding","score":0.8050000071525574},{"id":"https://openalex.org/keywords/nad-cofactor","display_name":"NAD+ cofactor","score":0.8650000095367432},{"id":"https://openalex.org/keywords/udp-n-acetylgalactosamine","display_name":"UDP-N-acetylgalactosamine","score":0.8299999833106995},{"id":"https://openalex.org/keywords/udp-n-acetylglucosamine","display_name":"UDP-N-acetylglucosamine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.4099999964237213},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8754074573516846},{"id":"https://openalex.org/C2779274956","wikidata":"https://www.wikidata.org/wiki/Q774483","display_name":"Galactosemia","level":3,"score":0.8683393001556396},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.5828230977058411},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.5628141760826111},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4485739469528198},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3568020462989807},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29167115688323975},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1640835404396057},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.10182240605354309},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005693","descriptor_name":"Galactosemias","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014534","descriptor_name":"UDPglucose 4-Epimerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014534","descriptor_name":"UDPglucose 4-Epimerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.gene.2013.05.027","doi":"https://doi.org/10.1016/j.gene.2013.05.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gene.2013.05.027","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},{"id":"pmid:23732289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23732289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3763920","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3763920","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Gene","raw_type":"Text"},{"id":"pmh:oai:pure.qub.ac.uk/portal:publications/62c965d3-00eb-4aaa-a018-62ccb1737128","doi":null,"is_oa":false,"landing_page_url":"https://pure.qub.ac.uk/en/publications/62c965d3-00eb-4aaa-a018-62ccb1737128","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Timson, D J & Lindert, S 2013, 'Comparison of dynamics of wildtype and V94M human UDP-galactose 4-epimerase-A computational perspective on severe epimerase-deficiency galactosemia', Gene, vol. 525, no. 2, pp. 318-324. https://doi.org/10.1016/j.gene.2013.05.027","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3763920","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3763920","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Gene","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7174882636","display_name":"Theory of Biomolecular Diffusion","funder_award_id":"R01GM031749","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320317089","display_name":"National Biomedical Computation Resource","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332774","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/008zs3103"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W193377992","https://openalex.org/W310044633","https://openalex.org/W1512694863","https://openalex.org/W1569706781","https://openalex.org/W1607590325","https://openalex.org/W1681697851","https://openalex.org/W1689047764","https://openalex.org/W1714751522","https://openalex.org/W1874341760","https://openalex.org/W1891017166","https://openalex.org/W1907130758","https://openalex.org/W1965501888","https://openalex.org/W1967081827","https://openalex.org/W1978159078","https://openalex.org/W1986883777","https://openalex.org/W1992098812","https://openalex.org/W1996205406","https://openalex.org/W1997719105","https://openalex.org/W2002977794","https://openalex.org/W2007735611","https://openalex.org/W2016840767","https://openalex.org/W2026350419","https://openalex.org/W2027920182","https://openalex.org/W2029216532","https://openalex.org/W2036190266","https://openalex.org/W2041985227","https://openalex.org/W2049515194","https://openalex.org/W2051955172","https://openalex.org/W2052579446","https://openalex.org/W2056753467","https://openalex.org/W2057333730","https://openalex.org/W2061280343","https://openalex.org/W2068023771","https://openalex.org/W2070981649","https://openalex.org/W2074614070","https://openalex.org/W2086840043","https://openalex.org/W2092232457","https://openalex.org/W2106140689","https://openalex.org/W2106383417","https://openalex.org/W2118233996","https://openalex.org/W2118380639","https://openalex.org/W2129153475","https://openalex.org/W2141920771","https://openalex.org/W2144288821","https://openalex.org/W2158907165","https://openalex.org/W2161605421","https://openalex.org/W2173721404","https://openalex.org/W6607804476","https://openalex.org/W6685478102"],"related_works":["https://openalex.org/W1681697851","https://openalex.org/W2044423214","https://openalex.org/W2061280343","https://openalex.org/W310044633","https://openalex.org/W2036190266","https://openalex.org/W2267498412","https://openalex.org/W2070981649","https://openalex.org/W2068023771","https://openalex.org/W2051955172","https://openalex.org/W2092232457"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}