{"id":"https://openalex.org/W2106461518","doi":"https://doi.org/10.1016/j.jalz.2009.04.376","title":"P2\u2010066: Web\u2010based application to estimate and project the burden of Alzheimer's disease and evaluate the impact of potential interventions","display_name":"P2\u2010066: Web\u2010based application to estimate and project the burden of Alzheimer's disease and evaluate the impact of potential interventions","publication_year":2009,"publication_date":"2009-06-25","ids":{"openalex":"https://openalex.org/W2106461518","doi":"https://doi.org/10.1016/j.jalz.2009.04.376","mag":"2106461518"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2009.04.376","doi":"https://doi.org/10.1016/j.jalz.2009.04.376","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.376","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002491643","display_name":"Elizabeth Colantuoni","orcid":"https://orcid.org/0000-0002-0091-9434","observed_orcids":["https://orcid.org/0000-0002-0091-9434"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth Colantuoni","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081970058","display_name":"Andre Hackman","orcid":"https://orcid.org/0000-0002-6401-2831","observed_orcids":["https://orcid.org/0000-0002-6401-2831"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andre Hackman","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073783403","display_name":"Ron Brookmeyer","orcid":"https://orcid.org/0000-0002-8639-3399","observed_orcids":["https://orcid.org/0000-0002-8639-3399"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron Brookmeyer","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058984019","display_name":"Henry Michael Arrighi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097160","display_name":"Denali Therapeutics (United States)","ror":"https://ror.org/00pprn321","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Michael Arrighi","raw_affiliation_strings":["Elan Pharmaceuticals, Inc, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elan Pharmaceuticals, Inc, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210097160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002491643"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24936576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"4S_Part_9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/disease-burden-projections","display_name":"disease burden projections","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.7054405212402344},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6278696656227112},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5414133667945862},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5375158190727234},{"id":"https://openalex.org/C64332521","wikidata":"https://www.wikidata.org/wiki/Q614165","display_name":"Quality-adjusted life year","level":3,"score":0.5275623202323914},{"id":"https://openalex.org/C2780664029","wikidata":"https://www.wikidata.org/wiki/Q5282120","display_name":"Disease burden","level":3,"score":0.5239560604095459},{"id":"https://openalex.org/C3020448403","wikidata":"https://www.wikidata.org/wiki/Q5282120","display_name":"Burden of disease","level":3,"score":0.5029699206352234},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.4981818199157715},{"id":"https://openalex.org/C13774568","wikidata":"https://www.wikidata.org/wiki/Q439112","display_name":"Population ageing","level":3,"score":0.4807876944541931},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.47825825214385986},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.47457078099250793},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.42469391226768494},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.4157005846500397},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.41507551074028015},{"id":"https://openalex.org/C3019080777","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost effectiveness","level":2,"score":0.3161224126815796},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.24856552481651306},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.10293042659759521},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2009.04.376","doi":"https://doi.org/10.1016/j.jalz.2009.04.376","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.376","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2074745011","https://openalex.org/W2003514808","https://openalex.org/W2002126568","https://openalex.org/W2122320288","https://openalex.org/W2126639923","https://openalex.org/W2050438584","https://openalex.org/W4312768005","https://openalex.org/W3181994995","https://openalex.org/W4291146664","https://openalex.org/W4322496605"],"abstract_inverted_index":{"Projecting":[0],"the":[1,23,55,64,78,84,93,109,116,126,143,155,163,166,204,223,226,249,253],"future":[2],"burden":[3,85],"of":[4,25,58,66,80,86,128,146,225,241,255],"Alzheimer's":[5],"disease":[6,31,35,49,87,124,208],"is":[7,137],"useful":[8],"for":[9,63,176],"health":[10,98,210],"care":[11,99,211],"planning":[12],"purposes.":[13],"Additionally,":[14],"researchers":[15],"and":[16,42,53,101,133,171,184,201,245],"policy":[17],"makers":[18],"are":[19],"interested":[20],"in":[21],"evaluating":[22],"impact":[24,79,127,254],"potential":[26,67],"interventions":[27,68,256],"that":[28,69,257],"may":[29,118,188,228],"reduce":[30,71,258],"risk":[32,72,197,259],"or":[33,73,158,198,213,260],"slow":[34,74,261],"progression.":[36,262],"Brookmeyer,":[37],"et":[38],"al":[39],"(2007)":[40],"developed":[41],"implemented":[43],"a":[44,112,140,177,235],"multi-stage,":[45],"incidence":[46],"to":[47,51,95,122,192,237,251],"prevalence":[48,57,174],"model":[50,61,94,110,167],"estimate":[52],"project":[54],"global":[56],"AD.":[59],"The":[60,135,152,186],"allows":[62,234],"introduction":[65],"either":[70],"progression":[75,200],"which":[76],"assesses":[77],"an":[81],"intervention":[82],"on":[83,130,139,207],"by":[88],"stage.":[89],"We":[90,107],"have":[91],"expanded":[92],"incorporate":[96],"associated":[97,182],"costs":[100,183],"DALYs":[102],"(disability":[103],"adjusted":[104],"life":[105],"years).":[106],"adapted":[108],"into":[111],"web-based":[113,232],"application":[114,136,233],"where":[115],"user":[117,153,187,236],"specify":[119],"inputs":[120],"related":[121,191],"incidence,":[123],"progression,":[125],"AD":[129,173,242],"mortality,":[131],"costs,":[132,244],"DALYs.":[134,185],"located":[138],"server":[141],"at":[142],"Bloomberg":[144],"School":[145],"Public":[147],"Health,":[148],"Johns":[149],"Hopkins":[150],"University.":[151],"specifies":[154],"input":[156,189,221],"parameters":[157],"selects":[159],"predefined":[160],"inputs.":[161],"For":[162],"specified":[164],"population,":[165],"generates":[168],"annual,":[169],"gender-":[170],"stage-specific":[172],"projections":[175,240],"50-year":[178],"interval,":[179],"along":[180,247],"with":[181,219,248],"aspects":[190],"treatments":[193],"such":[194],"as":[195],"reducing":[196],"slowing":[199],"then":[202],"evaluate":[203],"subsequent":[205],"effect":[206],"burden,":[209,243],"cost":[212],"DALYS.":[214],"By":[215],"running":[216],"several":[217],"simulations":[218],"varying":[220],"parameters,":[222],"sensitivity":[224],"results":[227],"be":[229],"assessed.":[230],"A":[231],"generate":[238],"population-specific":[239],"DALYs,":[246],"ability":[250],"explore":[252]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
