{"id":"https://openalex.org/W2106443798","doi":"https://doi.org/10.1091/mbc.e10-01-0023","title":"Phosphorylation of eIF2\u03b1 at Serine 51 Is an Important Determinant of Cell Survival and Adaptation to Glucose Deficiency","display_name":"Phosphorylation of eIF2\u03b1 at Serine 51 Is an Important Determinant of Cell Survival and Adaptation to Glucose Deficiency","publication_year":2010,"publication_date":"2010-07-22","ids":{"openalex":"https://openalex.org/W2106443798","doi":"https://doi.org/10.1091/mbc.e10-01-0023","mag":"2106443798","pmid":"https://pubmed.ncbi.nlm.nih.gov/20660158","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2938387"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.e10-01-0023","doi":"https://doi.org/10.1091/mbc.e10-01-0023","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e10-01-0023","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2938387","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008455068","display_name":"Hala Muaddi","orcid":"https://orcid.org/0000-0001-9721-2808","observed_orcids":["https://orcid.org/0000-0001-9721-2808"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hala Muaddi","raw_affiliation_strings":["*Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, H3T 1E2, Canada;","Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC H3A 1A3, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, H3T 1E2, Canada;","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]},{"raw_affiliation_string":"Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC H3A 1A3, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034301619","display_name":"Mithu Majumder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mithu Majumder","raw_affiliation_strings":["Departments of Nutrition, School of Medicine, Case Western University, Cleveland, OH 44106-4954;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, School of Medicine, Case Western University, Cleveland, OH 44106-4954;","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072538995","display_name":"Philippos Peidis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Philippos Peidis","raw_affiliation_strings":["*Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, H3T 1E2, Canada;","Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC H3A 1A3, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, H3T 1E2, Canada;","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]},{"raw_affiliation_string":"Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC H3A 1A3, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054648214","display_name":"Andreas Ioannis Papadakis","orcid":"https://orcid.org/0000-0003-0026-6581","observed_orcids":["https://orcid.org/0000-0003-0026-6581"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andreas I. Papadakis","raw_affiliation_strings":["*Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, H3T 1E2, Canada;","Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC H3A 1A3, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, H3T 1E2, Canada;","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]},{"raw_affiliation_string":"Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC H3A 1A3, Canada;","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083053290","display_name":"Martin Hol\u010d\u0131\u0301k","orcid":"https://orcid.org/0000-0002-1922-5299","observed_orcids":["https://orcid.org/0000-0002-1922-5299"]},"institutions":[{"id":"https://openalex.org/I2799330578","display_name":"Children's Hospital of Eastern Ontario","ror":"https://ror.org/05nsbhw27","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799330578"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Martin Holcik","raw_affiliation_strings":["Apoptosis Research Centre, Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Apoptosis Research Centre, Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada;","institution_ids":["https://openalex.org/I2799330578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081084192","display_name":"Donalyn L. Scheuner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donalyn Scheuner","raw_affiliation_strings":["Internal Medicine and the Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine and the Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015378855","display_name":"Randal J. Kaufman","orcid":"https://orcid.org/0000-0003-4277-316X","observed_orcids":["https://orcid.org/0000-0003-4277-316X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randal J. Kaufman","raw_affiliation_strings":["Internal Medicine and the Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine and the Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035546319","display_name":"Maria Hatzoglou","orcid":"https://orcid.org/0000-0003-2037-1231","observed_orcids":["https://orcid.org/0000-0003-2037-1231"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Hatzoglou","raw_affiliation_strings":["Departments of Nutrition, School of Medicine, Case Western University, Cleveland, OH 44106-4954;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, School of Medicine, Case Western University, Cleveland, OH 44106-4954;","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002284937","display_name":"Antonis E. Koromilas","orcid":"https://orcid.org/0000-0003-1972-0799","observed_orcids":["https://orcid.org/0000-0003-1972-0799"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Antonis E. Koromilas","raw_affiliation_strings":["*Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, H3T 1E2, Canada;","Department of Oncology, Faculty of Medicine, McGill University, Montreal, QC H2W 1S6, Canada","Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC H3A 1A3, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, H3T 1E2, Canada;","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]},{"raw_affiliation_string":"Department of Oncology, Faculty of Medicine, McGill University, Montreal, QC H2W 1S6, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC H3A 1A3, Canada;","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5002284937"],"corresponding_institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":4.1825,"has_fulltext":false,"cited_by_count":115,"citation_normalized_percentile":{"value":0.94734279,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"21","issue":"18","first_page":"3220","last_page":"3231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eif2alpha-phosphorylation","display_name":"eIF2\u03b1 phosphorylation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/glucose-deficiency","display_name":"glucose deficiency","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5320000052452087},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.9629999995231628},{"id":"https://openalex.org/keywords/gcn2","display_name":"GCN2","score":0.640999972820282},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pkr","display_name":"PKR","score":0.9980000257492065},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.9769999980926514},{"id":"https://openalex.org/keywords/translation-initiation-inhibition","display_name":"translation initiation inhibition","score":0.4830000102519989},{"id":"https://openalex.org/keywords/stress-adaptation","display_name":"stress adaptation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8187447190284729},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.8115719556808472},{"id":"https://openalex.org/C93734116","wikidata":"https://www.wikidata.org/wiki/Q1017133","display_name":"eIF2","level":5,"score":0.682040810585022},{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.6251713037490845},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6095400452613831},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5971369743347168},{"id":"https://openalex.org/C2779638656","wikidata":"https://www.wikidata.org/wiki/Q6043166","display_name":"Integrated stress response","level":5,"score":0.5956751704216003},{"id":"https://openalex.org/C104551158","wikidata":"https://www.wikidata.org/wiki/Q7187581","display_name":"Phosphorylation cascade","level":5,"score":0.5467048287391663},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4725239872932434},{"id":"https://openalex.org/C156902634","wikidata":"https://www.wikidata.org/wiki/Q5058346","display_name":"Cellular adaptation","level":3,"score":0.4660811126232147},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4421751797199249},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.41912198066711426},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3964195251464844},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.35975727438926697},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3058244585990906},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2560831308364868},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.1482676863670349},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.07436534762382507},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06306448578834534}],"mesh":[{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1091/mbc.e10-01-0023","doi":"https://doi.org/10.1091/mbc.e10-01-0023","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e10-01-0023","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2001062","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2938387","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2938387","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2938387","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmid:20660158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20660158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2001062","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2938387","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1296135302","display_name":"Regulation of ER stress-induced cell death","funder_award_id":"R01DK088227","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G166941743","display_name":null,"funder_award_id":"HL 52173","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G225434608","display_name":"Mechanism of ER Protein Misfolding-Induced Mitochondrial Dysfunction","funder_award_id":"R01DK113171","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2716412589","display_name":"Unfolded Protein Response in Glucose Homeostasis","funder_award_id":"R01DK042394","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3300121300","display_name":"Regulation of Factor FVIII Secretion","funder_award_id":"R01HL052173","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3337023614","display_name":null,"funder_award_id":"HCT116","funder_id":"https://openalex.org/F4320310145","funder_display_name":"Johns Hopkins University"},{"id":"https://openalex.org/G533944174","display_name":null,"funder_award_id":"DK42394","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5480140640","display_name":"Molecular Genetics of Coagulation Disorders","funder_award_id":"P01HL057346","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6054488679","display_name":null,"funder_award_id":"DK53307","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G642802645","display_name":"Regulation of Gene Expression During Stress","funder_award_id":"R01DK053307","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6919961434","display_name":"Regulation of internal initiation of translation in cell death and survival","funder_award_id":"89737_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G6954546729","display_name":null,"funder_award_id":"DK60596","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7554731503","display_name":"Translational Control by Osmotically Active Solutes","funder_award_id":"R37DK060596","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8499346130","display_name":"Role of the Unfolded Protein Response in Beta Cell","funder_award_id":"R37DK042394","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000901175","display_name":"Translational control by nutrients","funder_award_id":"R01DK060596","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320310638","display_name":"McGill University","ror":"https://ror.org/01pxwe438"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334576","display_name":"Canadian Cancer Society Research Institute","ror":"https://ror.org/017343w90"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W136179538","https://openalex.org/W186782872","https://openalex.org/W1902126081","https://openalex.org/W1964015820","https://openalex.org/W1972931075","https://openalex.org/W1974070035","https://openalex.org/W1976161806","https://openalex.org/W1978949887","https://openalex.org/W1980438612","https://openalex.org/W1980959289","https://openalex.org/W1984426737","https://openalex.org/W1991429659","https://openalex.org/W1991999080","https://openalex.org/W1993431643","https://openalex.org/W1994731715","https://openalex.org/W1997017449","https://openalex.org/W2009536847","https://openalex.org/W2012695878","https://openalex.org/W2020437934","https://openalex.org/W2027821655","https://openalex.org/W2031170847","https://openalex.org/W2034567067","https://openalex.org/W2036981704","https://openalex.org/W2037313242","https://openalex.org/W2041122594","https://openalex.org/W2042134430","https://openalex.org/W2053442171","https://openalex.org/W2058792931","https://openalex.org/W2060878129","https://openalex.org/W2061184351","https://openalex.org/W2062203284","https://openalex.org/W2067189757","https://openalex.org/W2072754204","https://openalex.org/W2074501845","https://openalex.org/W2079768195","https://openalex.org/W2082483448","https://openalex.org/W2084459589","https://openalex.org/W2087249772","https://openalex.org/W2093158584","https://openalex.org/W2098143217","https://openalex.org/W2099616702","https://openalex.org/W2102322990","https://openalex.org/W2103127692","https://openalex.org/W2114360920","https://openalex.org/W2119902047","https://openalex.org/W2120736516","https://openalex.org/W2123836804","https://openalex.org/W2125351585","https://openalex.org/W2126034825","https://openalex.org/W2127848114","https://openalex.org/W2129532016","https://openalex.org/W2140487984","https://openalex.org/W2148923106","https://openalex.org/W2151559423","https://openalex.org/W2157224263","https://openalex.org/W2164032619","https://openalex.org/W2168120533","https://openalex.org/W2168919362","https://openalex.org/W2169205569"],"related_works":["https://openalex.org/W7033066243","https://openalex.org/W1974316110","https://openalex.org/W2012695878","https://openalex.org/W2093158584","https://openalex.org/W247737228","https://openalex.org/W2068069992","https://openalex.org/W2039026321","https://openalex.org/W2899317165","https://openalex.org/W2042134430","https://openalex.org/W2032186020"],"abstract_inverted_index":{"Various":[0],"forms":[1],"of":[2,11,16,34,59,66,87,125,129,143,183,187],"stress":[3],"induce":[4],"pathways":[5,130],"that":[6,28,46,71,100,150,176,197],"converge":[7],"on":[8],"the":[9,12,83,122,140,152],"phosphorylation":[10,41,73,94,178],"alpha":[13],"(\u03b1)":[14],"subunit":[15],"eukaryotic":[17],"translation":[18],"initiation":[19],"factor":[20],"eIF2":[21],"at":[22],"serine":[23],"51":[24],"(S51),":[25],"a":[26,31,43,75,80,88,97,104,107,157,165,180],"modification":[27],"results":[29],"in":[30,78,110,168,194],"global":[32],"inhibition":[33],"protein":[35,145],"synthesis.":[36],"In":[37],"many":[38],"cases":[39],"eIF2\u03b1":[40,72,93,153,177],"is":[42,61,74,119,179],"biological":[44,195],"response":[45,111,169],"facilitates":[47],"cells":[48,102,189],"to":[49,106,112,134,170],"cope":[50],"with":[51,63,121,131,190,199],"stressful":[52],"environments.":[53],"Glucose":[54],"deficiency,":[55],"an":[56,64],"important":[57,192],"form":[58],"stress,":[60],"associated":[62,120],"induction":[65],"apoptosis.":[67],"Herein,":[68],"we":[69],"demonstrate":[70,175],"key":[76],"step":[77],"maintaining":[79],"balance":[81],"between":[82],"life":[84],"and":[85,127,137,162,185],"death":[86],"glucose-deficient":[89,188],"cell.":[90],"That":[91],"is,":[92],"acts":[95],"as":[96],"molecular":[98],"switch":[99],"shifts":[101],"from":[103],"proapoptotic":[105,158],"cytoprotective":[108,166],"state":[109],"prolonged":[113],"glucose":[114,171,200],"deficiency.":[115,172],"This":[116],"adaptation":[117,138,186],"process":[118],"timely":[123],"expression":[124],"proteins":[126],"activation":[128],"significant":[132,181],"contributions":[133],"cell":[135],"survival":[136,184],"including":[139],"X-linked":[141],"inhibitor":[142],"apoptosis":[144],"(XIAP).":[146],"We":[147],"also":[148],"show":[149],"among":[151],"kinases":[154],"GCN2":[155],"plays":[156],"role":[159],"whereas":[160],"PERK":[161],"PKR":[163],"play":[164],"one":[167],"Our":[173],"data":[174],"determinant":[182],"possible":[191],"implications":[193],"processes":[196],"interfere":[198],"metabolism.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}