{"id":"https://openalex.org/W2106442871","doi":"https://doi.org/10.1074/jbc.274.8.4481","title":"Regulation of Transition Metal Transport across the Yeast Plasma Membrane","display_name":"Regulation of Transition Metal Transport across the Yeast Plasma Membrane","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W2106442871","doi":"https://doi.org/10.1074/jbc.274.8.4481","mag":"2106442871","pmid":"https://pubmed.ncbi.nlm.nih.gov/9988676"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.274.8.4481","doi":"https://doi.org/10.1074/jbc.274.8.4481","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.8.4481","pdf_url":"http://www.jbc.org/article/S0021925819877554/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819877554/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048587108","display_name":"Derek C. Radisky","orcid":"https://orcid.org/0000-0002-1962-8784","observed_orcids":["https://orcid.org/0000-0002-1962-8784"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Radisky","raw_affiliation_strings":["Division of Immunology and Cell Biology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Cell Biology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069634632","display_name":"Jerry Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerry Kaplan","raw_affiliation_strings":["From the Division of Immunology and Cell Biology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Immunology and Cell Biology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069634632"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.6546,"has_fulltext":true,"cited_by_count":144,"citation_normalized_percentile":{"value":0.9695358,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"274","issue":"8","first_page":"4481","last_page":"4484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.6157000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.6157000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.1136000007390976,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.09650000184774399,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.8240000009536743},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.7549999952316284},{"id":"https://openalex.org/keywords/metal-homeostasis","display_name":"metal homeostasis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/metal-uptake","display_name":"metal uptake","score":0.9269999861717224},{"id":"https://openalex.org/keywords/metal-solubilization","display_name":"metal solubilization","score":0.7519999742507935},{"id":"https://openalex.org/keywords/metal-toxicity","display_name":"metal toxicity","score":0.5910000205039978},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.7160000205039978},{"id":"https://openalex.org/keywords/redox-reactions","display_name":"redox reactions","score":0.7440000176429749},{"id":"https://openalex.org/keywords/metal-binding-proteins","display_name":"metal-binding proteins","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.822759747505188},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.6728287935256958},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5808912515640259},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5529490113258362},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.5509372353553772},{"id":"https://openalex.org/C106773901","wikidata":"https://www.wikidata.org/wiki/Q19588","display_name":"Transition metal","level":3,"score":0.5378496050834656},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.498593807220459},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.4925163686275482},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4700770676136017},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.4643780291080475},{"id":"https://openalex.org/C2776053758","wikidata":"https://www.wikidata.org/wiki/Q105789","display_name":"Heavy metals","level":2,"score":0.4307779371738434},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4297114610671997},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23497360944747925},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.2155398428440094},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20617464184761047},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.19392722845077515},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.13981986045837402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12662273645401},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08327102661132812},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06016862392425537}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.274.8.4481","doi":"https://doi.org/10.1074/jbc.274.8.4481","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.8.4481","pdf_url":"http://www.jbc.org/article/S0021925819877554/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9988676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9988676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.274.8.4481","doi":"https://doi.org/10.1074/jbc.274.8.4481","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.8.4481","pdf_url":"http://www.jbc.org/article/S0021925819877554/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106442871.pdf","grobid_xml":"https://content.openalex.org/works/W2106442871.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W165130051","https://openalex.org/W278992421","https://openalex.org/W1486881477","https://openalex.org/W1494276851","https://openalex.org/W1534809362","https://openalex.org/W1563689661","https://openalex.org/W1568628619","https://openalex.org/W1696228719","https://openalex.org/W1944610530","https://openalex.org/W1969060808","https://openalex.org/W1972120846","https://openalex.org/W1974015253","https://openalex.org/W1975190250","https://openalex.org/W1996735555","https://openalex.org/W2005806732","https://openalex.org/W2007632640","https://openalex.org/W2009730483","https://openalex.org/W2010355719","https://openalex.org/W2015326313","https://openalex.org/W2017861724","https://openalex.org/W2025144653","https://openalex.org/W2029143720","https://openalex.org/W2031462677","https://openalex.org/W2039192785","https://openalex.org/W2046440396","https://openalex.org/W2047334595","https://openalex.org/W2066456671","https://openalex.org/W2068713458","https://openalex.org/W2080390432","https://openalex.org/W2082806735","https://openalex.org/W2084163699","https://openalex.org/W2087276505","https://openalex.org/W2087385198","https://openalex.org/W2090401018","https://openalex.org/W2097888227","https://openalex.org/W2111479061","https://openalex.org/W2122749282","https://openalex.org/W2123550712","https://openalex.org/W2130346547","https://openalex.org/W2136728068","https://openalex.org/W2140561339","https://openalex.org/W2168684404","https://openalex.org/W4248060357"],"related_works":["https://openalex.org/W1496977441","https://openalex.org/W2031718554","https://openalex.org/W2025743000","https://openalex.org/W2015420494","https://openalex.org/W4391090783","https://openalex.org/W1990869997","https://openalex.org/W2934724584","https://openalex.org/W594555144","https://openalex.org/W4249497231","https://openalex.org/W2155107340"],"abstract_inverted_index":{"Transition":[0],"metals":[1,36],"are":[2,71],"essential":[3],"for":[4,23,30],"the":[5,31,38,48,52,58],"function":[6],"of":[7,35,54],"many":[8],"proteins,":[9],"either":[10],"by":[11,16],"facilitating":[12],"redox":[13,60],"reactions":[14,61],"or":[15],"stabilizing":[17],"protein":[18],"structure.":[19],"To":[20],"satisfy":[21],"requirements":[22],"these":[24,55],"metals,":[25,56],"cells":[26],"have":[27],"numerous":[28],"mechanisms":[29],"solubilization":[32],"and":[33],"uptake":[34],"from":[37,47],"extracellular":[39],"environment.":[40],"Cells":[41],"must,":[42],"however,":[43],"simultaneously":[44],"protect":[45],"themselves":[46],"hazards":[49],"inherent":[50],"in":[51],"versatility":[53],"as":[57],"facile":[59],"can":[62],"produce":[63],"toxic":[64],"free":[65],"radicals":[66],"if":[67],"cytosolic":[68],"metal":[69],"concentrations":[70],"not":[72],"carefully":[73],"regulated.":[74]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
