{"id":"https://openalex.org/W2106435751","doi":"https://doi.org/10.1158/1078-0432.ccr-05-0283","title":"Reduction of Raf-1 Kinase Inhibitor Protein Expression Correlates with Breast Cancer Metastasis","display_name":"Reduction of Raf-1 Kinase Inhibitor Protein Expression Correlates with Breast Cancer Metastasis","publication_year":2005,"publication_date":"2005-10-15","ids":{"openalex":"https://openalex.org/W2106435751","doi":"https://doi.org/10.1158/1078-0432.ccr-05-0283","mag":"2106435751","pmid":"https://pubmed.ncbi.nlm.nih.gov/16243812"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-05-0283","doi":"https://doi.org/10.1158/1078-0432.ccr-05-0283","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-05-0283","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034426801","display_name":"Suzanne Hagan","orcid":"https://orcid.org/0000-0001-9836-159X","observed_orcids":["https://orcid.org/0000-0001-9836-159X"]},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Suzanne Hagan","raw_affiliation_strings":["1Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory;","institution_ids":["https://openalex.org/I4210143228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045720408","display_name":"Fahd Al\u2010Mulla","orcid":"https://orcid.org/0000-0001-5409-3829","observed_orcids":["https://orcid.org/0000-0001-5409-3829"]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Fahd Al-Mulla","raw_affiliation_strings":["5Molecular Pathology Laboratory, Department of Pathology, Kuwait University, Faculty of Medicine, Safat, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Molecular Pathology Laboratory, Department of Pathology, Kuwait University, Faculty of Medicine, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109636768","display_name":"Elizabeth Mallon","orcid":"https://orcid.org/0009-0009-3423-4220","observed_orcids":["https://orcid.org/0009-0009-3423-4220"]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth Mallon","raw_affiliation_strings":["3Department of Pathology, Western Infirmary;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pathology, Western Infirmary;","institution_ids":["https://openalex.org/I2801120601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111421910","display_name":"Karin A. Oien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karin Oien","raw_affiliation_strings":["1Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory;","3Department of Pathology, Western Infirmary;","1Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory;; 3Department of Pathology, Western Infirmary;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory;","institution_ids":["https://openalex.org/I4210143228"]},{"raw_affiliation_string":"3Department of Pathology, Western Infirmary;","institution_ids":["https://openalex.org/I2801120601"]},{"raw_affiliation_string":"1Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory;; 3Department of Pathology, Western Infirmary;","institution_ids":["https://openalex.org/I2801120601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110200891","display_name":"Rhona Ferrier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rhona Ferrier","raw_affiliation_strings":["3Department of Pathology, Western Infirmary;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pathology, Western Infirmary;","institution_ids":["https://openalex.org/I2801120601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111788976","display_name":"Barry A. Gusterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barry Gusterson","raw_affiliation_strings":["3Department of Pathology, Western Infirmary;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pathology, Western Infirmary;","institution_ids":["https://openalex.org/I2801120601"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jorge J. Curto Garci\u0301a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jorge J. Curto Garci\u0301a","raw_affiliation_strings":["2Centre for Oncology and Applied Pharmacology, Cancer Research UK, Beatson Laboratories;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Centre for Oncology and Applied Pharmacology, Cancer Research UK, Beatson Laboratories;","institution_ids":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036674933","display_name":"Walter K\u00f6lch","orcid":"https://orcid.org/0000-0001-5777-5016","observed_orcids":["https://orcid.org/0000-0001-5777-5016"]},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Walter Kolch","raw_affiliation_strings":["1Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory;","4Institute of Biomedical and Life Sciences, Sir Henry Wellcome Functional Genomics Facility, University of Glasgow, Glasgow, United Kingdom;","1Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory;; 4Institute of Biomedical and Life Sciences, Sir Henry Wellcome Functional Genomics Facility, University of Glasgow, Glasgow, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory;","institution_ids":["https://openalex.org/I4210143228"]},{"raw_affiliation_string":"4Institute of Biomedical and Life Sciences, Sir Henry Wellcome Functional Genomics Facility, University of Glasgow, Glasgow, United Kingdom;","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"1Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory;; 4Institute of Biomedical and Life Sciences, Sir Henry Wellcome Functional Genomics Facility, University of Glasgow, Glasgow, United Kingdom;","institution_ids":["https://openalex.org/I4210143228","https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.407,"has_fulltext":false,"cited_by_count":256,"citation_normalized_percentile":{"value":0.93693975,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"11","issue":"20","first_page":"7392","last_page":"7397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rkip","display_name":"RKIP","score":0.9750000238418579},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.824999988079071},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/metastasis-suppressor-gene","display_name":"metastasis suppressor gene","score":0.996999979019165},{"id":"https://openalex.org/keywords/raf-mek-erk-pathway","display_name":"Raf/MEK/ERK pathway","score":0.8700000047683716},{"id":"https://openalex.org/keywords/erk-activation","display_name":"ERK activation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/protein-expression","display_name":"protein expression","score":0.5540000200271606},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7539888620376587},{"id":"https://openalex.org/C2778025950","wikidata":"https://www.wikidata.org/wiki/Q6823243","display_name":"Metastasis suppressor","level":4,"score":0.68329918384552},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6581752896308899},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6406499147415161},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5517640709877014},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5435996651649475},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5429127216339111},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5274329781532288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4711303412914276},{"id":"https://openalex.org/C2909960190","wikidata":"https://www.wikidata.org/wiki/Q6823243","display_name":"Metastasis Suppressor Gene","level":4,"score":0.4479024410247803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3935265839099884},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34178996086120605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2125033736228943},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09099054336547852}],"mesh":[{"descriptor_ui":"D000727","descriptor_name":"Androgen-Binding Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049488","descriptor_name":"Phosphatidylethanolamine Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-05-0283","doi":"https://doi.org/10.1158/1078-0432.ccr-05-0283","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-05-0283","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:16243812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16243812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.452.1226","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.452.1226","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://med.miami.edu/mnbws/documents/HaganSR05.pdf","raw_type":"text"},{"id":"pmh:oai:eprints.gla.ac.uk:19147","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/19147/","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Articles"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320336662","display_name":"Beatson Institute for Cancer Research","ror":"https://ror.org/03pv69j64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1578523240","https://openalex.org/W1836453327","https://openalex.org/W1967818195","https://openalex.org/W1977983659","https://openalex.org/W1980790180","https://openalex.org/W1981813507","https://openalex.org/W1985008806","https://openalex.org/W2043106387","https://openalex.org/W2074089133","https://openalex.org/W2090282678","https://openalex.org/W2107321102","https://openalex.org/W2131605616","https://openalex.org/W2135803007","https://openalex.org/W2136627244","https://openalex.org/W2141290206","https://openalex.org/W2142242441","https://openalex.org/W2149847890","https://openalex.org/W2164363164"],"related_works":["https://openalex.org/W2132974858","https://openalex.org/W1579294736","https://openalex.org/W1976649319","https://openalex.org/W2061040732","https://openalex.org/W2375140762","https://openalex.org/W2126934083","https://openalex.org/W1898564425","https://openalex.org/W1484889110","https://openalex.org/W3005265713","https://openalex.org/W4383067023"],"abstract_inverted_index":{"PURPOSE:":[0],"Raf-1":[1],"kinase":[2,18,21],"inhibitor":[3,13],"protein":[4,17],"(RKIP)":[5],"was":[6,114,127,149],"originally":[7],"identified":[8],"as":[9,39,50],"the":[10,15,100,111,180,193],"first":[11,181],"physiologic":[12],"of":[14,76,102,110,183,195,226],"Raf/mitogen-activated":[16],"kinase/extracellular":[19],"signal-regulated":[20],"(ERK)":[22],"pathway.":[23],"This":[24,178],"pathway":[25],"regulates":[26],"fundamental":[27],"cellular":[28],"functions,":[29],"including":[30],"those":[31],"that":[32,202],"are":[33],"subverted":[34],"in":[35,59,73,129,138,143,186,203],"cancer":[36,94,231],"cells,":[37],"such":[38],"proliferation,":[40],"transformation,":[41],"survival,":[42],"and":[43,61,81,106,133,166,198,233],"metastasis.":[44],"Recently,":[45],"RKIP":[46,69,122,125,147,164,184,207,222],"has":[47],"been":[48],"recognized":[49],"a":[51,55,187,209],"strong":[52],"candidate":[53],"for":[54,99,218,229],"metastasis":[56,210],"suppressor":[57,211],"gene":[58,212],"cell":[60,196],"animal":[62,199],"model":[63],"systems.":[64],"Therefore,":[65],"we":[66],"investigated":[67],"whether":[68],"expression":[70,101,126,148,165,185,214,223],"is":[71,179,208,224],"altered":[72],"clinical":[74,189],"specimens":[75],"human":[77,204],"primary":[78,139],"breast":[79,93,130,140,205,230],"cancers":[80],"their":[82],"lymph":[83,144],"node":[84,145],"metastases.":[85],"EXPERIMENTAL":[86],"DESIGN:":[87],"Paraffin-embedded":[88],"tumor":[89,169],"samples":[90],"from":[91],"103":[92],"patients":[95],"were":[96,161],"examined":[97],"immunohistochemically":[98],"RKIP,":[103],"activated":[104],"ERK,":[105],"apoptosis.":[107],"The":[108],"specificity":[109],"antibodies":[112],"used":[113],"validated":[115],"by":[116],"competition":[117],"experiments":[118],"with":[119],"purified":[120],"recombinant":[121],"protein.":[123],"RESULTS:":[124],"high":[128],"duct":[131],"epithelia":[132],"retained":[134],"to":[135,220],"varying":[136],"degrees":[137],"tumors.":[141],"However,":[142],"metastases,":[146],"highly":[150],"significantly":[151],"reduced":[152],"or":[153,173],"lost":[154],"(P":[155],"=":[156],"0.000003).":[157],"No":[158],"significant":[159],"correlations":[160],"observed":[162],"between":[163],"histologic":[167],"type,":[168],"differentiation":[170],"grade,":[171],"size,":[172],"estrogen":[174],"receptor":[175],"status.":[176],"CONCLUSION:":[177],"study":[182],"large":[188],"cohort.":[190],"It":[191],"confirms":[192],"results":[194],"culture":[197],"studies,":[200],"suggesting":[201],"cancer,":[206],"whose":[213],"must":[215],"be":[216],"down-regulated":[217],"metastases":[219],"develop.":[221],"independent":[225],"other":[227],"markers":[228],"progression":[232],"prognosis.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":30}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
