{"id":"https://openalex.org/W2106413201","doi":null,"title":"Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu.","display_name":"Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu.","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2106413201","mag":"2106413201","pmid":"https://pubmed.ncbi.nlm.nih.gov/10430096"},"language":"en","primary_location":{"id":"pmid:10430096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10430096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108593387","display_name":"Ruey Long Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"R L Hong","raw_affiliation_strings":["Department of Oncology, National Taiwan University Hospital, Taipei"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, National Taiwan University Hospital, Taipei","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111592432","display_name":"William H. Spohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W H Spohn","raw_affiliation_strings":["University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076834432","display_name":"Mien\u2010Chie Hung","orcid":"https://orcid.org/0000-0003-4317-4740","observed_orcids":["https://orcid.org/0000-0003-4317-4740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Hung","raw_affiliation_strings":["Molecular & Cellular Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular & Cellular Oncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8598,"has_fulltext":false,"cited_by_count":160,"citation_normalized_percentile":{"value":0.83333333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"5","issue":"7","first_page":"1884","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/p185neu","display_name":"p185neu","score":0.9179999828338623},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibition","display_name":"tyrosine kinase inhibition","score":0.9779999852180481},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/grp94","display_name":"GRP94","score":0.8289999961853027},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.906000018119812},{"id":"https://openalex.org/keywords/autophosphorylation","display_name":"autophosphorylation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/transphosphorylation","display_name":"transphosphorylation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.6660000085830688},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.7850804924964905},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.6853338479995728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5835390090942383},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.49832916259765625},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4854791462421417},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.44252216815948486},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4408561885356903},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43772655725479126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35760873556137085},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3447800874710083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3408133387565613},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3272784948348999},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.21597811579704285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19854405522346497},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17258763313293457},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10430096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10430096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.587.9623","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.587.9623","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.curcumin.co.nz/pdf/Curcumin_And_Her2.pdf","raw_type":"text"},{"id":"mag:2106413201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10430096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3287273538","display_name":"PEA 3 IN HER 2/NEU OVEREXPRESSING OVARIAN CANCER","funder_award_id":"R01CA077858","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3339836640","display_name":"E1A GENE THERAPY IN BREAST CANCER","funder_award_id":"R01CA058880","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6551190536","display_name":"HER-2/NEU AND HEREGULIN IN HUMAN OVARIAN CANCER","funder_award_id":"R01CA060856","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W48654288","https://openalex.org/W1479809193","https://openalex.org/W1489973637","https://openalex.org/W1569077405","https://openalex.org/W1631701494","https://openalex.org/W1656644300","https://openalex.org/W1965144265","https://openalex.org/W1983651655","https://openalex.org/W1993570389","https://openalex.org/W2000311561","https://openalex.org/W2002079983","https://openalex.org/W2004152200","https://openalex.org/W2040429946","https://openalex.org/W2048639599","https://openalex.org/W2053189267","https://openalex.org/W2058839845","https://openalex.org/W2060857477","https://openalex.org/W2082670466","https://openalex.org/W2082721745","https://openalex.org/W2083855590","https://openalex.org/W2089815933","https://openalex.org/W2092229345","https://openalex.org/W2098562843","https://openalex.org/W2107386750","https://openalex.org/W2114918609","https://openalex.org/W2122048408","https://openalex.org/W2137155864","https://openalex.org/W2141393790","https://openalex.org/W2145045978","https://openalex.org/W2147772438","https://openalex.org/W2171584014","https://openalex.org/W2209846658","https://openalex.org/W2222638000","https://openalex.org/W2239089021","https://openalex.org/W2262517746","https://openalex.org/W2418327139","https://openalex.org/W2419111200","https://openalex.org/W2429335205"],"related_works":["https://openalex.org/W7099036443","https://openalex.org/W1538056938","https://openalex.org/W2057065997","https://openalex.org/W2029309876","https://openalex.org/W2124955356","https://openalex.org/W2163762983","https://openalex.org/W7096886326","https://openalex.org/W3029882321","https://openalex.org/W2359925635","https://openalex.org/W2161015285"],"abstract_inverted_index":{"Curcumin,":[0],"a":[1,18,31,44,92,119,165],"natural":[2],"compound":[3],"present":[4],"in":[5,20,37,74,80,160,174,224],"turmeric,":[6],"possessing":[7],"both":[8],"anti-inflammatory":[9],"and":[10,58,72,76,95,210],"antioxidant":[11],"effects,":[12],"has":[13],"been":[14],"studied":[15],"vigorously":[16],"as":[17],"chemopreventative":[19],"several":[21,132],"cancer":[22,39,64,134,218,227],"models.":[23],"The":[24,101,129],"erbB2/neu":[25],"gene-encoded":[26],"p185neu":[27,36,55,70,78,87,104,203,209],"tyrosine":[28,56,204],"kinase":[29,57,125,205],"is":[30,40,228],"potent":[32],"oncoprotein.":[33],"Overexpression":[34],"of":[35,52,62,86,99,103,122,127,131,156,167,183,215,230],"breast":[38,63,133,217,226],"known":[41],"to":[42,144],"be":[43],"poor":[45],"prognostic":[46],"factor.":[47],"We":[48],"investigated":[49],"the":[50,60,84,97,107,123,139,153,161,168,213],"effect":[51],"curcumin":[53,114,181,200],"on":[54,59,106],"growth":[61,130,214],"cell":[65,108,135,176,219],"lines.":[66],"Curcumin":[67],"dose-dependently":[68],"inhibited":[69,202],"autophosphorylation":[71],"transphosphorylation":[73],"vitro":[75],"depleted":[77],"protein":[79,105],"vivo.":[81],"It":[82],"dissociated":[83],"binding":[85],"with":[88,152],"GRP94":[89],"(glucose-regulated":[90],"protein),":[91],"molecular":[93],"chaperone,":[94],"enhanced":[96],"depletion":[98],"p185neu.":[100,157],"amount":[102],"membrane":[109],"was":[110,137,171],"drastically":[111],"decreased":[112],"after":[113],"treatment.":[115],"These":[116],"data":[117],"demonstrated":[118],"new":[120],"mechanism":[121],"anti-tyrosine":[124],"activity":[126,206],"curcumin.":[128],"lines":[136,177],"inhibited;":[138],"IC50":[140],"ranged":[141],"from":[142],"7":[143],"18":[145],"microM,":[146],"which,":[147],"however,":[148],"did":[149],"not":[150],"correlate":[151],"expression":[154],"level":[155,186],"Colony":[158],"formation":[159],"soft":[162],"agar":[163],"assay,":[164],"hallmark":[166],"transformation":[169],"phenotype,":[170],"preferentially":[172],"suppressed":[173,212],"p185neu-overexpressing":[175],"by":[178,195,207],"5":[179],"microM":[180],"(%":[182],"control,":[184],"basal":[185],"versus":[187,190],"overexpression:":[188],"59.3":[189],"16.7%;":[191],"P":[192],"<":[193],"0.001":[194],"Student's":[196],"t":[197],"test).":[198],"Because":[199],"effectively":[201],"depleting":[208],"potently":[211],"multiple":[216],"lines,":[220],"its":[221],"therapeutic":[222],"potential":[223],"advanced":[225],"worthy":[229],"further":[231],"investigation.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}