{"id":"https://openalex.org/W2106330360","doi":"https://doi.org/10.1101/gad.1606308","title":"Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells","display_name":"Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells","publication_year":2008,"publication_date":"2008-02-18","ids":{"openalex":"https://openalex.org/W2106330360","doi":"https://doi.org/10.1101/gad.1606308","mag":"2106330360","pmid":"https://pubmed.ncbi.nlm.nih.gov/18283123","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2259027"},"language":"en","primary_location":{"id":"doi:10.1101/gad.1606308","doi":"https://doi.org/10.1101/gad.1606308","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1606308","pdf_url":"http://genesdev.cshlp.org/content/22/5/575.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genesdev.cshlp.org/content/22/5/575.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059640216","display_name":"Dana N. Levasseur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana N. Levasseur","raw_affiliation_strings":["Division of Hematology-Oncology, Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100666570","display_name":"Jianlong Wang","orcid":"https://orcid.org/0000-0002-1317-6457","observed_orcids":["https://orcid.org/0000-0002-1317-6457","https://orcid.org/0000-0003-4667-9365"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianlong Wang","raw_affiliation_strings":["Division of Hematology-Oncology, Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Harvard Stem\n                           Cell Institute, Boston, Massachusetts 02115, USA;","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Harvard Stem\n                           Cell Institute, Boston, Massachusetts 02115, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108419547","display_name":"Michael O. Dorschner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael O. Dorschner","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA;","University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA;","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006847496","display_name":"John\u00a0A. Stamatoyannopoulos","orcid":"https://orcid.org/0000-0002-2664-5769","observed_orcids":["https://orcid.org/0000-0002-2664-5769"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Stamatoyannopoulos","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA;","University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA;","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079784932","display_name":"Stuart H. Orkin","orcid":"https://orcid.org/0000-0002-0313-152X","observed_orcids":["https://orcid.org/0000-0002-0313-152X","https://orcid.org/0000-0002-3523-7687"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart H. Orkin","raw_affiliation_strings":["Division of Hematology-Oncology, Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Harvard Stem\n                           Cell Institute, Boston, Massachusetts 02115, USA;","Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA","Howard Hughes Medical Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Children\u2019s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Harvard Stem\n                           Cell Institute, Boston, Massachusetts 02115, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Howard Hughes Medical Institute","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":110,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"5","first_page":"575","last_page":"580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.056699998676776886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nanog","display_name":"Nanog","score":0.9129999876022339},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.9359999895095825},{"id":"https://openalex.org/keywords/dnase-i-hypersensitive-sites","display_name":"DNase I hypersensitive sites","score":0.9070000052452087},{"id":"https://openalex.org/keywords/gdf3","display_name":"GDF3","score":0.7850000262260437},{"id":"https://openalex.org/keywords/dppa3","display_name":"DPPA3","score":0.996999979019165},{"id":"https://openalex.org/keywords/homeodomain-transcription-factor","display_name":"homeodomain transcription factor","score":0.7630000114440918},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8429999947547913},{"id":"https://openalex.org/keywords/chromatin-occupancy","display_name":"chromatin occupancy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/gene-regulatory-elements","display_name":"gene regulatory elements","score":0.5609999895095825},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.9482921957969666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9145735502243042},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8514267206192017},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.8366230130195618},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.6559354662895203},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5852150321006775},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5002000331878662},{"id":"https://openalex.org/C39981086","wikidata":"https://www.wikidata.org/wiki/Q3455568","display_name":"Locus control region","level":5,"score":0.49662667512893677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48941507935523987},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.47861188650131226},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.47537484765052795},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.46427056193351746},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.44842344522476196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42994141578674316},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.41603022813796997},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.2548596262931824},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.22592204809188843}],"mesh":[{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076246","descriptor_name":"CCCTC-Binding Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003850","descriptor_name":"Deoxyribonuclease I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038101","descriptor_name":"Insulator Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055451","descriptor_name":"Growth Differentiation Factor 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1101/gad.1606308","doi":"https://doi.org/10.1101/gad.1606308","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1606308","pdf_url":"http://genesdev.cshlp.org/content/22/5/575.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2259027","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2259027","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes Dev","raw_type":"Text"},{"id":"pmid:18283123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18283123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & development","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/gad.1606308","doi":"https://doi.org/10.1101/gad.1606308","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1606308","pdf_url":"http://genesdev.cshlp.org/content/22/5/575.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4815953798","display_name":"Computational discovery of cis-regulatory sequences","funder_award_id":"R01GM071923","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8041485139","display_name":"Identification of Functional DNA Elements by HSqPCR","funder_award_id":"U01HG003161","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106330360.pdf","grobid_xml":"https://content.openalex.org/works/W2106330360.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1608762409","https://openalex.org/W1643500256","https://openalex.org/W1669374546","https://openalex.org/W1975200987","https://openalex.org/W1979431956","https://openalex.org/W1997360516","https://openalex.org/W2010031978","https://openalex.org/W2011457803","https://openalex.org/W2011633097","https://openalex.org/W2015396326","https://openalex.org/W2017535650","https://openalex.org/W2019666363","https://openalex.org/W2029722028","https://openalex.org/W2038249969","https://openalex.org/W2053911973","https://openalex.org/W2056105211","https://openalex.org/W2062565707","https://openalex.org/W2063599822","https://openalex.org/W2073026107","https://openalex.org/W2079301404","https://openalex.org/W2083103029","https://openalex.org/W2090260381","https://openalex.org/W2107575419","https://openalex.org/W2109264912","https://openalex.org/W2110015307","https://openalex.org/W2112350806","https://openalex.org/W2126851387","https://openalex.org/W2128016314","https://openalex.org/W2150163104","https://openalex.org/W2164683872"],"related_works":["https://openalex.org/W2110015307","https://openalex.org/W2351990965","https://openalex.org/W2055759147","https://openalex.org/W2150163104","https://openalex.org/W1965931598","https://openalex.org/W134825780","https://openalex.org/W843231200","https://openalex.org/W2011388270","https://openalex.org/W2078167812","https://openalex.org/W2005437050"],"abstract_inverted_index":{"Embryonic":[0],"stem":[1],"(ES)":[2],"cells":[3],"offer":[4],"insight":[5],"into":[6],"early":[7],"developmental":[8],"fate":[9],"decisions,":[10],"and":[11,34,52,67,75,83],"their":[12],"controlled":[13],"differentiation":[14],"may":[15],"yield":[16],"vast":[17],"regenerative":[18],"potential.":[19],"The":[20,30],"molecular":[21],"determinants":[22],"supporting":[23],"ES":[24,40],"cell":[25,41],"self-renewal":[26],"are":[27,36],"incompletely":[28],"understood.":[29],"homeodomain":[31],"proteins":[32],"Nanog":[33],"Oct4":[35,91],"essential":[37],"for":[38],"mouse":[39],"self-renewal.":[42],"Using":[43],"a":[44,57],"high-throughput":[45],"approach,":[46],"we":[47],"discovered":[48],"DNaseI":[49],"hypersensitive":[50],"sites":[51],"potential":[53],"regulatory":[54],"elements":[55],"along":[56],"160-kb":[58],"region":[59],"of":[60,87],"the":[61,88],"genome":[62],"that":[63,85],"includes":[64],"GDF3,":[65],"Dppa3,":[66],"Nanog.":[68],"We":[69],"analyzed":[70],"gene":[71,81],"expression,":[72],"chromatin":[73,77],"occupancy,":[74],"higher-order":[76],"structure":[78],"throughout":[79],"this":[80],"locus":[82],"found":[84],"expression":[86],"reprogramming":[89],"factor":[90],"is":[92],"required":[93],"to":[94],"maintain":[95],"its":[96],"integrity.":[97]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
