{"id":"https://openalex.org/W2106317671","doi":"https://doi.org/10.1091/mbc.e04-05-0439","title":"Rapid Effects of Retinoic Acid on CREB and ERK Phosphorylation in Neuronal Cells","display_name":"Rapid Effects of Retinoic Acid on CREB and ERK Phosphorylation in Neuronal Cells","publication_year":2004,"publication_date":"2004-09-16","ids":{"openalex":"https://openalex.org/W2106317671","doi":"https://doi.org/10.1091/mbc.e04-05-0439","mag":"2106317671","pmid":"https://pubmed.ncbi.nlm.nih.gov/15371543","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/532036"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.e04-05-0439","doi":"https://doi.org/10.1091/mbc.e04-05-0439","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e04-05-0439","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/532036","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069295566","display_name":"Estela Ca\u00f1\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210091816","display_name":"Instituto de Investigaciones Biom\u00e9dicas Sols-Morreale","ror":"https://ror.org/00ha1f767","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Estela Ca\u00f1\u00f3n","raw_affiliation_strings":["Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cient\u00edficas and Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cient\u00edficas and Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003892143","display_name":"Jos\u00e9 Miguel Cosgaya","orcid":"https://orcid.org/0000-0002-6005-2916","observed_orcids":["https://orcid.org/0000-0002-6005-2916"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210091816","display_name":"Instituto de Investigaciones Biom\u00e9dicas Sols-Morreale","ror":"https://ror.org/00ha1f767","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Miguel Cosgaya","raw_affiliation_strings":["Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cient\u00edficas and Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cient\u00edficas and Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082704655","display_name":"Sona Scsucova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210091816","display_name":"Instituto de Investigaciones Biom\u00e9dicas Sols-Morreale","ror":"https://ror.org/00ha1f767","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sona Scsucova","raw_affiliation_strings":["Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cient\u00edficas and Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cient\u00edficas and Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046682552","display_name":"Ana Aranda","orcid":"https://orcid.org/0000-0002-8338-9589","observed_orcids":["https://orcid.org/0000-0002-8338-9589"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210091816","display_name":"Instituto de Investigaciones Biom\u00e9dicas Sols-Morreale","ror":"https://ror.org/00ha1f767","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Aranda","raw_affiliation_strings":["Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cient\u00edficas and Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d Consejo Superior de Investigaciones Cient\u00edficas and Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2943,"has_fulltext":false,"cited_by_count":189,"citation_normalized_percentile":{"value":0.96058989,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"12","first_page":"5583","last_page":"5592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":1.0},{"id":"https://openalex.org/keywords/creb-phosphorylation","display_name":"CREB phosphorylation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9110000133514404},{"id":"https://openalex.org/keywords/non-genomic-signaling","display_name":"non-genomic signaling","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.8299999833106995},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.8230000138282776},{"id":"https://openalex.org/keywords/c-fos-expression","display_name":"Fos expression","score":0.7620000243186951},{"id":"https://openalex.org/keywords/camp-response-element","display_name":"cAMP response element","score":0.7789999842643738},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.9129999876022339},{"id":"https://openalex.org/keywords/retinoid-receptors","display_name":"retinoid receptors","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.9466520547866821},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.7832609415054321},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7375997304916382},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7354815006256104},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6090285778045654},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5886212587356567},{"id":"https://openalex.org/C2909511254","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"Cyclic AMP Response Element-Binding Protein","level":5,"score":0.5439678430557251},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5393417477607727},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5227097272872925},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.4674314856529236},{"id":"https://openalex.org/C132376346","wikidata":"https://www.wikidata.org/wiki/Q7315962","display_name":"Response element","level":5,"score":0.4113907516002655},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32937484979629517},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3125882148742676},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.23280611634254456},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20654171705245972},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1730983555316925},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06476154923439026}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1091/mbc.e04-05-0439","doi":"https://doi.org/10.1091/mbc.e04-05-0439","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e04-05-0439","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:532036","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/532036","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmid:15371543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15371543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.8730","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.8730","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.molbiolcell.org/content/15/12/5583.full.pdf","raw_type":"text"},{"id":"pmh:oai:digital.csic.es:10261/5349","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/5349","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:532036","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/532036","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W56197667","https://openalex.org/W139260680","https://openalex.org/W1484397242","https://openalex.org/W1494919617","https://openalex.org/W1545054475","https://openalex.org/W1584818544","https://openalex.org/W1606273823","https://openalex.org/W1656928430","https://openalex.org/W1718768577","https://openalex.org/W1812354839","https://openalex.org/W1927684145","https://openalex.org/W1965907401","https://openalex.org/W1967823521","https://openalex.org/W1976441097","https://openalex.org/W1980745837","https://openalex.org/W1982133004","https://openalex.org/W1982284863","https://openalex.org/W1986082682","https://openalex.org/W1988823654","https://openalex.org/W1994110056","https://openalex.org/W1995819749","https://openalex.org/W1998225973","https://openalex.org/W1998653181","https://openalex.org/W1999782689","https://openalex.org/W2000324336","https://openalex.org/W2006254842","https://openalex.org/W2010975288","https://openalex.org/W2015592781","https://openalex.org/W2017578370","https://openalex.org/W2021494076","https://openalex.org/W2028242823","https://openalex.org/W2032466814","https://openalex.org/W2033529039","https://openalex.org/W2042896578","https://openalex.org/W2045441934","https://openalex.org/W2045798063","https://openalex.org/W2047961525","https://openalex.org/W2052871395","https://openalex.org/W2072231629","https://openalex.org/W2076189206","https://openalex.org/W2081524299","https://openalex.org/W2083029854","https://openalex.org/W2087764271","https://openalex.org/W2088359631","https://openalex.org/W2088452076","https://openalex.org/W2094806135","https://openalex.org/W2094872845","https://openalex.org/W2095435531","https://openalex.org/W2095535075","https://openalex.org/W2112468983","https://openalex.org/W2115736681","https://openalex.org/W2118897660","https://openalex.org/W2120165202","https://openalex.org/W2120666858","https://openalex.org/W2125403403","https://openalex.org/W2125976258","https://openalex.org/W2127133133","https://openalex.org/W2129388998","https://openalex.org/W2137385309","https://openalex.org/W2145828270","https://openalex.org/W2161527794","https://openalex.org/W2162710298","https://openalex.org/W2163803523","https://openalex.org/W2164180561","https://openalex.org/W2168007569","https://openalex.org/W2318562615","https://openalex.org/W2334442124","https://openalex.org/W2413075245","https://openalex.org/W3037891617"],"related_works":["https://openalex.org/W7097334784","https://openalex.org/W2039455906","https://openalex.org/W1968920459","https://openalex.org/W1982133004","https://openalex.org/W2072231629","https://openalex.org/W1606063661","https://openalex.org/W2105123655","https://openalex.org/W2042404209","https://openalex.org/W2025494444","https://openalex.org/W2117198713"],"abstract_inverted_index":{"Retinoic":[0],"acid":[1],"(RA)":[2],"is":[3,131,158],"a":[4,50,65,71,98,132,173],"potent":[5],"regulator":[6],"of":[7,30,55,74,80,84,94,101,108,111,135,155,183,192],"neuronal":[8,143,196],"cell":[9,39],"differentiation.":[10,197],"RA":[11,48,68,150],"normally":[12],"activates":[13],"gene":[14],"expression":[15,110],"by":[16,172],"binding":[17,61],"to":[18,97,106,181],"nuclear":[19],"receptors":[20],"that":[21,36,149,170,179],"interact":[22],"with":[23,64],"response":[24,59,124],"elements":[25,125],"(RAREs)":[26],"in":[27,37,41,77,127,142,187,195],"regulatory":[28],"regions":[29],"target":[31,134],"genes.":[32],"We":[33],"show":[34],"here":[35,148],"PC12":[38],"subclones":[40],"which":[42,116,157,186],"the":[43,109,190],"retinoid":[44],"causes":[45,70],"neurite":[46],"extension,":[47],"induces":[49,151],"rapid":[51,72],"and":[52,83,105,145,164],"sustained":[53],"phosphorylation":[54,76,93,163,182],"CREB":[56,75,95,130,162],"(cyclic":[57],"AMP":[58],"element":[60],"protein),":[62],"compatible":[63],"nongenomic":[66,174],"effect.":[67],"also":[69],"increase":[73],"primary":[78],"cultures":[79],"cerebrocortical":[81],"cells":[82],"dorsal":[85],"root":[86],"ganglia":[87],"neurons":[88],"from":[89],"rat":[90],"embryos.":[91],"RA-mediated":[92],"leads":[96],"direct":[99],"stimulation":[100,154],"CREB-dependent":[102],"transcriptional":[103,165],"activity":[104],"activation":[107],"genes":[112,193],"such":[113],"as":[114],"c-fos,":[115],"do":[117],"not":[118],"contain":[119,122],"RAREs":[120],"but":[121],"cAMP":[123],"(CREs)":[126],"their":[128],"promoters.":[129],"major":[133],"extracellular":[136],"signal":[137],"regulated":[138],"kinase":[139],"ERK1/2":[140],"signaling":[141,177],"cells,":[144],"we":[146],"demonstrate":[147,169],"an":[152],"early":[153],"ERK1/2,":[156],"required":[159],"both":[160],"for":[161],"activity.":[166],"These":[167],"results":[168],"RA,":[171],"mechanism,":[175],"stimulates":[176],"pathways":[178],"lead":[180],"transcription":[184,191],"factors,":[185],"turn":[188],"activate":[189],"involved":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}