{"id":"https://openalex.org/W2106205643","doi":"https://doi.org/10.1155/2013/632121","title":"Resveratrol Inhibits Alpha-Melanocyte-Stimulating Hormone Signaling, Viability, and Invasiveness in Melanoma Cells","display_name":"Resveratrol Inhibits Alpha-Melanocyte-Stimulating Hormone Signaling, Viability, and Invasiveness in Melanoma Cells","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2106205643","doi":"https://doi.org/10.1155/2013/632121","mag":"2106205643","pmid":"https://pubmed.ncbi.nlm.nih.gov/23762150","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3676971"},"language":"en","primary_location":{"id":"doi:10.1155/2013/632121","doi":"https://doi.org/10.1155/2013/632121","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/632121","pdf_url":"https://downloads.hindawi.com/journals/ecam/2013/632121.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/ecam/2013/632121.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100731673","display_name":"Yu-Jen Chen","orcid":"https://orcid.org/0000-0001-5755-6200","observed_orcids":["https://orcid.org/0000-0001-5755-6200","https://orcid.org/0000-0002-9646-2247"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]},{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Jen Chen","raw_affiliation_strings":["Department & Graduate Institute of Pharmacology, College of Medicine, Taipei Medical University, Taipei 110, Taiwan","Department of Biochemical Science and Technology, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","Department of Radiation Oncology, Mackay Memorial Hospital, Taipei 104, Taiwan","Institute of Traditional Medicine, National Yang Ming University, Taipei 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department & Graduate Institute of Pharmacology, College of Medicine, Taipei Medical University, Taipei 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]},{"raw_affiliation_string":"Department of Radiation Oncology, Mackay Memorial Hospital, Taipei 104, Taiwan","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Institute of Traditional Medicine, National Yang Ming University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089422219","display_name":"Ying-Yin Chen","orcid":"https://orcid.org/0000-0002-9151-5346","observed_orcids":["https://orcid.org/0000-0002-9151-5346"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]},{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying-Yin Chen","raw_affiliation_strings":["Department & Graduate Institute of Pharmacology, College of Medicine, Taipei Medical University, Taipei 110, Taiwan","Department of Biochemical Science and Technology, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","Department of Radiation Oncology, Mackay Memorial Hospital, Taipei 104, Taiwan","Institute of Traditional Medicine, National Yang Ming University, Taipei 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department & Graduate Institute of Pharmacology, College of Medicine, Taipei Medical University, Taipei 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]},{"raw_affiliation_string":"Department of Radiation Oncology, Mackay Memorial Hospital, Taipei 104, Taiwan","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Institute of Traditional Medicine, National Yang Ming University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002422447","display_name":"Yifeng Lin","orcid":"https://orcid.org/0000-0003-4411-8388","observed_orcids":["https://orcid.org/0000-0003-4411-8388"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Feng Lin","raw_affiliation_strings":["Department of Biochemical Science and Technology, National Chiayi University, 300 University Road, Chiayi 600, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004102176","display_name":"Hsuan-Yun Hu","orcid":"https://orcid.org/0000-0002-2825-6740","observed_orcids":["https://orcid.org/0000-0002-2825-6740"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsuan-Yun Hu","raw_affiliation_strings":["Department of Biochemical Science and Technology, National Chiayi University, 300 University Road, Chiayi 600, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011493063","display_name":"Hui\u2010Fen Liao","orcid":"https://orcid.org/0000-0001-9060-2176","observed_orcids":["https://orcid.org/0000-0001-9060-2176"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Hui-Fen Liao","raw_affiliation_strings":["Department of Biochemical Science and Technology, National Chiayi University, 300 University Road, Chiayi 600, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011493063"],"corresponding_institution_ids":["https://openalex.org/I183570559"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":1.6131,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.8282639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"2013","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.12479999661445618,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/alpha-msh","display_name":"alpha-melanocyte-stimulating hormone","score":0.9509999752044678},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.5870000123977661},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.949999988079071},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mitf","display_name":"MITF","score":0.7649999856948853},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.6259999871253967},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.9632676839828491},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.8542981147766113},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.7519229650497437},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6749457716941833},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5965290665626526},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5862149596214294},{"id":"https://openalex.org/C2780989459","wikidata":"https://www.wikidata.org/wiki/Q423981","display_name":"Melanocyte-stimulating hormone","level":3,"score":0.535378098487854},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5140941739082336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42298033833503723},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4136617183685303},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.4100053906440735},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3873123526573181},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3503594994544983},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2699446380138397},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23061725497245789},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20764794945716858},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.18254616856575012},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08767238259315491},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2013/632121","doi":"https://doi.org/10.1155/2013/632121","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/632121","pdf_url":"https://downloads.hindawi.com/journals/ecam/2013/632121.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2676409","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3676971","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23762150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23762150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-based complementary and alternative medicine : eCAM","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3676971","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3676971/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evid Based Complement Alternat Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2013/632121","doi":"https://doi.org/10.1155/2013/632121","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/632121","pdf_url":"https://downloads.hindawi.com/journals/ecam/2013/632121.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2834885449","display_name":null,"funder_award_id":"NSC 98-2314-B-195-005-MY3","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G3006427632","display_name":null,"funder_award_id":"NSC99","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G377077593","display_name":null,"funder_award_id":"NSC 101-2321-B-415-001","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G6433005851","display_name":null,"funder_award_id":"NSC99-2313-B-415-002-MY3","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G8254228167","display_name":null,"funder_award_id":"NSC 100-2314-B-195-007-MY3","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106205643.pdf","grobid_xml":"https://content.openalex.org/works/W2106205643.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1667206495","https://openalex.org/W1670693985","https://openalex.org/W1963716103","https://openalex.org/W1967656020","https://openalex.org/W1976877097","https://openalex.org/W1980507809","https://openalex.org/W1982705938","https://openalex.org/W1984144048","https://openalex.org/W1985970349","https://openalex.org/W1986155894","https://openalex.org/W1987859800","https://openalex.org/W2002682475","https://openalex.org/W2004211520","https://openalex.org/W2010684135","https://openalex.org/W2014329049","https://openalex.org/W2035490264","https://openalex.org/W2038843436","https://openalex.org/W2052921676","https://openalex.org/W2053312776","https://openalex.org/W2063827609","https://openalex.org/W2072569544","https://openalex.org/W2073924618","https://openalex.org/W2085110097","https://openalex.org/W2087913451","https://openalex.org/W2089166857","https://openalex.org/W2092244004","https://openalex.org/W2093791734","https://openalex.org/W2096169126","https://openalex.org/W2113766255","https://openalex.org/W2125474740","https://openalex.org/W2128096701","https://openalex.org/W2129448796","https://openalex.org/W2142353380","https://openalex.org/W2158117735","https://openalex.org/W2166441970"],"related_works":["https://openalex.org/W7097306493","https://openalex.org/W3166047265","https://openalex.org/W1975018537","https://openalex.org/W2041713141","https://openalex.org/W4404977889","https://openalex.org/W2405394493","https://openalex.org/W2101314829","https://openalex.org/W2365048150","https://openalex.org/W1553915897","https://openalex.org/W2091117319"],"abstract_inverted_index":{"Melanoma":[0],"is":[1],"a":[2,31,89,121],"malignancy":[3],"with":[4],"high":[5],"potential":[6,184],"to":[7,34,51,185],"invasion":[8,154],"and":[9,26,62,70,108,135,146,153,173],"treatment":[10,132],"resistance.":[11],"The":[12,97],"\u03b1":[13,17,66,76,94,101,124,147,169],"-melanocyte-stimulating":[14],"hormone":[15],"(":[16],"-MSH)":[18],"signal":[19],"transduction":[20],"involving":[21],"Wnt/":[22],"\u03b2":[23,105],"-catenin,":[24,106],"c-Kit,":[25,107],"microphthalmia-associated":[27],"transcription":[28],"factor":[29],"(MITF),":[30],"known":[32],"pathway":[33],"produce":[35],"melanin,":[36],"has":[37],"been":[38],"demonstrated":[39],"as":[40,88],"one":[41],"of":[42,55,60,93,100,119,123,133,156,192],"cancer":[43,188],"stem":[44,189],"cell":[45,144,190],"characteristics.":[46],"This":[47],"study":[48],"was":[49,86,110,128],"aimed":[50],"examine":[52],"the":[53,79,168,187],"effect":[54,165],"resveratrol,":[56],"an":[57],"abundant":[58],"ingredient":[59],"grape":[61],"medicinal":[63],"plants,":[64],"on":[65,166],"-MSH":[67,77,95,102,125,170],"signaling,":[68,171],"viability,":[69,172],"invasiveness":[71,174],"in":[72,82,175],"melanoma":[73,84,158,176],"cells.":[74,159,177],"By":[75],"treatment,":[78],"melanin":[80],"production":[81],"B16":[83,157],"cells":[85],"augmented":[87],"validation":[90],"for":[91],"activation":[92],"signaling.":[96],"upregulated":[98],"expression":[99,152],"signaling-related":[103],"molecules":[104],"MITF":[109],"suppressed":[111],"by":[112,130],"resveratrol":[113,134,140,162,181],"and/or":[114,141],"STI571":[115,142,164],"treatment.":[116],"Nuclear":[117],"translocation":[118],"MITF,":[120],"hallmark":[122],"signaling":[126],"activation,":[127],"inhibited":[129,143],"combined":[131],"STI571.":[136],"At":[137],"effective":[138],"concentration,":[139],"viability":[145],"-MSH-activated":[148],"matrix":[149],"metalloproteinase-":[150],"(MMP-)9":[151],"capacity":[155],"In":[160],"conclusion,":[161],"enhances":[163],"suppressing":[167],"It":[178],"implicates":[179],"that":[180],"may":[182],"have":[183],"modulate":[186],"characteristics":[191],"melanoma.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}