{"id":"https://openalex.org/W2106092523","doi":null,"title":"Degeneration of the mouse retina upon dysregulated activity of serum response factor.","display_name":"Degeneration of the mouse retina upon dysregulated activity of serum response factor.","publication_year":2011,"publication_date":"2011-04-29","ids":{"openalex":"https://openalex.org/W2106092523","mag":"2106092523","pmid":"https://pubmed.ncbi.nlm.nih.gov/21552476","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3087454"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3087454","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3087454/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3087454/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3087454/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052761638","display_name":"Jenny Sandstr\u00f6m","orcid":"https://orcid.org/0000-0003-0117-6975","observed_orcids":["https://orcid.org/0000-0003-0117-6975"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jenny Sandstr\u00f6m","raw_affiliation_strings":["Department of Molecular Biology, Interfaculty Institute for Cell Biology, University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Interfaculty Institute for Cell Biology, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052060292","display_name":"Peter Heiduschka","orcid":"https://orcid.org/0000-0003-0246-1380","observed_orcids":["https://orcid.org/0000-0003-0246-1380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Heiduschka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070032669","display_name":"Susanne C Beck","orcid":"https://orcid.org/0000-0002-7856-8072","observed_orcids":["https://orcid.org/0000-0002-7856-8072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susanne C Beck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015576679","display_name":"Ulrike Philippar","orcid":"https://orcid.org/0000-0002-9028-3782","observed_orcids":["https://orcid.org/0000-0002-9028-3782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrike Philippar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110200482","display_name":"Matthias W. Seeliger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias W Seeliger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064834609","display_name":"Ulrich Schraermeyer","orcid":"https://orcid.org/0000-0002-7969-8426","observed_orcids":["https://orcid.org/0000-0002-7969-8426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrich Schraermeyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068872608","display_name":"Alfred Nordheim","orcid":"https://orcid.org/0000-0003-4680-0778","observed_orcids":["https://orcid.org/0000-0003-4680-0778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alfred Nordheim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.449,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.79721862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"17","issue":null,"first_page":"1110","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-response-factor","display_name":"serum response factor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.6990000009536743},{"id":"https://openalex.org/keywords/retinal-neurons","display_name":"retinal neurons","score":0.5759999752044678},{"id":"https://openalex.org/keywords/retinal-vascularization","display_name":"retinal vascularization","score":0.621999979019165},{"id":"https://openalex.org/keywords/retinal-function","display_name":"retinal function","score":0.5059999823570251},{"id":"https://openalex.org/keywords/transcriptional-dysregulation","display_name":"transcriptional dysregulation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/retinal-development","display_name":"retinal development","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6686926484107971},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5869275331497192},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5854907035827637},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.5529384016990662},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5432767271995544},{"id":"https://openalex.org/C69053785","wikidata":"https://www.wikidata.org/wiki/Q907394","display_name":"Serum response factor","level":4,"score":0.5232923626899719},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5147666931152344},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.4244338870048523},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32739102840423584},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2429882287979126},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2100973129272461},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006416","descriptor_name":"Hematoxylin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017405","descriptor_name":"Herpes Simplex Virus Protein Vmw65","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017405","descriptor_name":"Herpes Simplex Virus Protein Vmw65","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026362","descriptor_name":"Serum Response Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D026362","descriptor_name":"Serum Response Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3087454","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3087454/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3087454/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:21552476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21552476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:2106092523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21552476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3087454","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3087454/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3087454/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106092523.pdf","grobid_xml":"https://content.openalex.org/works/W2106092523.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W198477152","https://openalex.org/W1525882285","https://openalex.org/W1584978389","https://openalex.org/W1652393711","https://openalex.org/W1678986767","https://openalex.org/W1768274470","https://openalex.org/W1816187765","https://openalex.org/W1975544799","https://openalex.org/W1979315750","https://openalex.org/W1984343548","https://openalex.org/W1995318569","https://openalex.org/W2003494557","https://openalex.org/W2008162435","https://openalex.org/W2009708495","https://openalex.org/W2012372812","https://openalex.org/W2015150335","https://openalex.org/W2027196409","https://openalex.org/W2027847781","https://openalex.org/W2028439456","https://openalex.org/W2031929368","https://openalex.org/W2035857873","https://openalex.org/W2044806898","https://openalex.org/W2048938442","https://openalex.org/W2050389860","https://openalex.org/W2051628416","https://openalex.org/W2053428527","https://openalex.org/W2053897822","https://openalex.org/W2064261105","https://openalex.org/W2064884011","https://openalex.org/W2073676612","https://openalex.org/W2073941950","https://openalex.org/W2084237826","https://openalex.org/W2090392605","https://openalex.org/W2115224200","https://openalex.org/W2116583607","https://openalex.org/W2120605643","https://openalex.org/W2127524138","https://openalex.org/W2129344787","https://openalex.org/W2131968097","https://openalex.org/W2132823963","https://openalex.org/W2149404122","https://openalex.org/W2161405552","https://openalex.org/W2162507144","https://openalex.org/W2162754660","https://openalex.org/W2164687648","https://openalex.org/W2170647144"],"related_works":["https://openalex.org/W7100660959","https://openalex.org/W2054043360","https://openalex.org/W2995416791","https://openalex.org/W2995008401","https://openalex.org/W3028680828","https://openalex.org/W2068886010","https://openalex.org/W1140201214","https://openalex.org/W2783404334","https://openalex.org/W2003583829","https://openalex.org/W6924703672"],"abstract_inverted_index":{"PURPOSE:":[0],"Our":[1],"aim":[2],"was":[3,95,137,165],"to":[4,86,97,167,185,422,442],"generate":[5],"and":[6,112,114,130,144,154,171,196,246,254,262,273,302,355,377,437],"phenotypically":[7],"characterize":[8],"a":[9,14,186,406],"transgenic":[10,220,394],"mouse":[11,33,54,90,202,403,410,454],"line":[12],"expressing":[13],"constitutively":[15,232],"active":[16,233],"variant":[17],"of":[18,49,74,100,127,157,194,199,208,211,218,231,240,249,258,270,276,312,328,335,347,357,368,385,432,450,459,462,470],"the":[19,28,39,53,71,88,101,105,124,180,192,200,206,212,216,238,283,290,305,313,329,336,341,348,353,358,366,415,427,452,460,467],"transcription":[20,349],"regulatory":[21],"protein":[22],"serum":[23],"response":[24],"factor":[25,350],"(SRF),":[26],"namely":[27],"SRF-VP16":[29,63,102,181,234,362,393],"protein.":[30],"This":[31,339],"new":[32,424],"strain":[34,404,455],"has":[35],"been":[36],"registered":[37],"under":[38],"designation":[40],"Gt(ROSA)26Sor(tm1(SRF-VP16)Antu).":[41],"We":[42,121,177],"found":[43,267],"phenotypic":[44],"changes":[45],"upon":[46],"ectopic":[47],"expression":[48,68,99,230,364],"SRF-VP16,":[50,451],"especially":[51],"in":[52,109,141,173,191,205,243,268,365,392,434],"retina.":[55,360],"METHODS:":[56],"Using":[57],"homologous":[58],"recombination,":[59],"we":[60],"integrated":[61],"an":[62,345,382],"conditional":[64,447],"(i.e.,":[65],"\"flox-STOP\"":[66,213],"repressed)":[67],"transgene":[69,103,307],"into":[70,426],"Rosa26":[72],"locus":[73],"murine":[75,359],"embryonic":[76],"stem":[77],"(ES)":[78],"cells.":[79],"These":[80],"engineered":[81],"ES":[82],"cells":[83],"were":[84],"used":[85,96,166],"derive":[87],"Gt(ROSA)26Sor(tm1(SRF-VP16)Antu)":[89,119,201,402],"strain.":[91],"Semiquantitative":[92],"real-time":[93],"PCR":[94],"determine":[98],"at":[104],"mRNA":[106,182,363],"level,":[107],"both":[108,142,244,250,271,296],"young":[110,143,195,277,369],"(P20":[111,253],"P30)":[113],"adult":[115,145,174,197,293],"(six":[116],"months":[117],"old)":[118],"mice.":[120,146,175],"also":[122],"investigated":[123],"transcript":[125,226],"levels":[126],"endogenous":[128,222],"Srf":[129,223],"several":[131],"SRF":[132,351,408,417,433,464],"target":[133],"genes.":[134],"Retinal":[135],"function":[136,356],"tested":[138],"by":[139,152,397],"electroretinography":[140],"Morphological":[147],"abnormalities":[148],"could":[149],"be":[150],"visualized":[151],"hematoxylin":[153],"eosin":[155],"staining":[156],"sectioned,":[158],"paraffin-embedded":[159],"eye":[160],"tissue":[161],"samples.":[162],"Scanning-laser":[163],"ophthalmoscopy":[164],"investigate":[168],"retinal":[169,229,241,259,379,399,435],"vascularization":[170],"degeneration":[172],"RESULTS:":[176],"show":[178,323],"that":[179,299,412],"is":[183,235,340,371],"expressed":[184],"low":[187],"but":[188],"significant":[189],"degree":[190],"retinas":[193,217,269,295,367,395],"animals":[198,248,275,298,370],"strain,":[203],"even":[204],"absence":[207],"Cre-mediated":[209,448],"deletion":[210],"cassette.":[214],"In":[215,279],"these":[219],"mice,":[221],"displays":[224],"elevated":[225],"levels.":[227],"Ectopic":[228,361],"correlated":[236,372],"with":[237,333,373],"malfunction":[239],"neurons":[242],"heterozygous":[245,272,301],"homozygous":[247,274,280,303],"age":[251,384],"groups":[252],"adult).":[255],"Additionally,":[256],"mislamination":[257,376],"cell":[260,315],"layers":[261],"cellular":[263,284],"rosette":[264],"formations":[265],"are":[266,286,300,390],"age.":[278],"individuals,":[281],"however,":[282,320],"rosettes":[285],"more":[287],"widespread":[288],"over":[289],"fundus.":[291],"At":[292,381],"age,":[294],"from":[297],"for":[304],"floxSTOP/SRF-VP16":[306],"display":[308],"severe":[309],"degeneration,":[310],"mainly":[311],"photoreceptor":[314,374],"layer.":[316],"Wild-type":[317],"age-matched":[318],"littermates,":[319],"do":[321],"not":[322],"any":[324],"degeneration.":[325],"The":[326,401],"severity":[327],"observed":[330],"effects":[331],"correlates":[332],"dosage":[334],"transgene.":[337],"CONCLUSIONS:":[338],"first":[342],"report":[343],"suggesting":[344],"influence":[346],"on":[352,466],"development":[354,436],"layer":[375],"impaired":[378,398],"function.":[380,400],"advanced":[383],"six":[386],"months,":[387],"degenerative":[388],"processes":[389],"detected":[391],"accompanied":[396],"represents":[405],"genetic":[407],"gain-of-function":[409],"model":[411],"will":[413,456],"complement":[414],"current":[416],"loss-of-function":[418],"models.":[419],"It":[420],"promises":[421],"provide":[423],"insight":[425],"hitherto":[428],"poorly":[429],"defined":[430],"role":[431],"function,":[438],"including":[439],"potential":[440],"contributions":[441],"ophthalmologic":[443],"disorders.":[444],"Furthermore,":[445],"using":[446],"activation":[449],"described":[453],"enable":[457],"assessment":[458],"impact":[461],"dysregulated":[463],"activity":[465],"physiologic":[468],"functions":[469],"various":[471],"other":[472],"organs.":[473]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
