{"id":"https://openalex.org/W2106065367","doi":"https://doi.org/10.3346/jkms.2008.23.2.288","title":"Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Augments Acute Lung Injury via Its Neutrophil Priming Effects","display_name":"Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Augments Acute Lung Injury via Its Neutrophil Priming Effects","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2106065367","doi":"https://doi.org/10.3346/jkms.2008.23.2.288","mag":"2106065367","pmid":"https://pubmed.ncbi.nlm.nih.gov/18437014","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2526424"},"language":"en","primary_location":{"id":"doi:10.3346/jkms.2008.23.2.288","doi":"https://doi.org/10.3346/jkms.2008.23.2.288","is_oa":true,"landing_page_url":"https://doi.org/10.3346/jkms.2008.23.2.288","pdf_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-23-288.pdf","source":{"id":"https://openalex.org/S11290066","display_name":"Journal of Korean Medical Science","issn_l":"1011-8934","issn":["1011-8934","1598-6357"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320101","host_organization_name":"Korean Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310320101"],"host_organization_lineage_names":["Korean Academy of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean Medical Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-23-288.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058179457","display_name":"Jae Chol Choi","orcid":"https://orcid.org/0000-0002-8761-6494","observed_orcids":["https://orcid.org/0000-0002-8761-6494"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Chol Choi","raw_affiliation_strings":["Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101624294","display_name":"Jae\u2010Woo Jung","orcid":"https://orcid.org/0000-0002-3411-735X","observed_orcids":["https://orcid.org/0000-0002-3411-735X"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Woo Jung","raw_affiliation_strings":["Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110025829","display_name":"Hee Won Kwak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee Won Kwak","raw_affiliation_strings":["Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102749643","display_name":"Ju Han Song","orcid":"https://orcid.org/0000-0001-6049-3212","observed_orcids":["https://orcid.org/0000-0001-6049-3212"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju Han Song","raw_affiliation_strings":["Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103846510","display_name":"Eun Ju Jeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun Ju Jeon","raw_affiliation_strings":["Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057962627","display_name":"Jong Wook Shin","orcid":"https://orcid.org/0000-0002-3988-1680","observed_orcids":["https://orcid.org/0000-0002-3988-1680"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Wook Shin","raw_affiliation_strings":["Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032126177","display_name":"In Won Park","orcid":"https://orcid.org/0000-0001-9686-7386","observed_orcids":["https://orcid.org/0000-0001-9686-7386"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"In Won Park","raw_affiliation_strings":["Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110214198","display_name":"Byoung Whui Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byoung Whui Choi","raw_affiliation_strings":["Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029009261","display_name":"Jae Yeol Kim","orcid":"https://orcid.org/0000-0003-3631-4610","observed_orcids":["https://orcid.org/0000-0003-3631-4610"]},"institutions":[{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jae Yeol Kim","raw_affiliation_strings":["Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029009261"],"corresponding_institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"],"apc_list":{"value":900000,"currency":"KRW","value_usd":690},"apc_paid":{"value":900000,"currency":"KRW","value_usd":690},"fwci":1.8384,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.86423525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"23","issue":"2","first_page":"288","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.6743000149726868,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.6743000149726868,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.1647000014781952,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.11410000175237656,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9129999876022339},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neutrophil-priming","display_name":"neutrophil priming","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.828000009059906},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.925000011920929},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nf-kappab-nuclear-translocation","display_name":"NF-\u03baB nuclear translocation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pulmonary-edema","display_name":"pulmonary edema","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5823159217834473},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5756112933158875},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5723369717597961},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.5576785206794739},{"id":"https://openalex.org/C170217031","wikidata":"https://www.wikidata.org/wiki/Q6725509","display_name":"Macrophage inflammatory protein","level":4,"score":0.5568236708641052},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.48543959856033325},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4785352647304535},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4638279676437378},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45143112540245056},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4360818564891815}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3346/jkms.2008.23.2.288","doi":"https://doi.org/10.3346/jkms.2008.23.2.288","is_oa":true,"landing_page_url":"https://doi.org/10.3346/jkms.2008.23.2.288","pdf_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-23-288.pdf","source":{"id":"https://openalex.org/S11290066","display_name":"Journal of Korean Medical Science","issn_l":"1011-8934","issn":["1011-8934","1598-6357"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320101","host_organization_name":"Korean Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310320101"],"host_organization_lineage_names":["Korean Academy of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean Medical Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2526424","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2526424","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Korean Med Sci","raw_type":"Text"},{"id":"pmid:18437014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18437014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean medical science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3346/jkms.2008.23.2.288","doi":"https://doi.org/10.3346/jkms.2008.23.2.288","is_oa":true,"landing_page_url":"https://doi.org/10.3346/jkms.2008.23.2.288","pdf_url":"http://jkms.org/Synapse/Data/PDFData/0063JKMS/jkms-23-288.pdf","source":{"id":"https://openalex.org/S11290066","display_name":"Journal of Korean Medical Science","issn_l":"1011-8934","issn":["1011-8934","1598-6357"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320101","host_organization_name":"Korean Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310320101"],"host_organization_lineage_names":["Korean Academy of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Korean Medical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321202","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106065367.pdf","grobid_xml":"https://content.openalex.org/works/W2106065367.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W169476826","https://openalex.org/W1555939683","https://openalex.org/W1642680313","https://openalex.org/W1967643308","https://openalex.org/W1982713513","https://openalex.org/W2041835292","https://openalex.org/W2043230064","https://openalex.org/W2050842983","https://openalex.org/W2072036820","https://openalex.org/W2082681974","https://openalex.org/W2110764412","https://openalex.org/W2119035160","https://openalex.org/W2140547471","https://openalex.org/W2144585115","https://openalex.org/W2158528246","https://openalex.org/W2165706792","https://openalex.org/W2404155076"],"related_works":["https://openalex.org/W7095647790","https://openalex.org/W2121013799","https://openalex.org/W2410755645","https://openalex.org/W2072860716","https://openalex.org/W2384891595","https://openalex.org/W1978695761","https://openalex.org/W2110764412","https://openalex.org/W2023143687","https://openalex.org/W2038407645","https://openalex.org/W2925961191"],"abstract_inverted_index":{"Granulocyte":[0],"macrophage-colony":[1],"stimulating":[2],"factor":[3,139],"(GM-CSF)":[4],"has":[5],"immuno-stimulatory":[6],"effects.":[7],"We":[8,26],"hypothesized":[9],"that":[10,29],"GM-CSF":[11,30,100,157,178,199],"plays":[12,200],"an":[13,201],"important":[14,202],"role":[15,203],"both":[16],"in":[17,40,171,204],"lipopolysaccharide":[18],"(LPS)-":[19],"and":[20,72,75,80,96,99,104,118,133,151,166,182,188,207],"hemorrhage-induced":[21,208],"acute":[22],"lung":[23,56,76,173],"injury":[24,77],"(ALI).":[25],"also":[27],"postulated":[28],"augments":[31],"LPS-induced":[32,180],"inflammation":[33,54],"by":[34,47,51,146,193,215],"priming":[35,217],"neutrophils.":[36,112,220],"ALI":[37],"was":[38,120,191],"induced":[39],"GM-CSF-/-":[41],"or":[42,50,176],"control":[43],"C57BL":[44],"mice":[45,159],"either":[46],"LPS":[48,92,175,206],"injection":[49],"hemorrhage.":[52,177],"Lung":[53],"(by":[55,78],"expression":[57,114,129,168,184],"for":[58],"tumor":[59],"necrosis":[60],"factor-alpha":[61],"(TNF-alpha),":[62],"macrophage":[63],"inflammatory":[64],"protein-2":[65],"(MIP-2),":[66],"interleukin-1beta":[67],"(IL-1beta),":[68],"interleukin-":[69],"6":[70],"(IL-6),":[71],"keratinocyte-derived":[73],"chemokine)":[74],"myeloperoxidase":[79],"Evans":[81],"blue":[82],"dye":[83],"assay)":[84],"were":[85,107,144],"evaluated":[86,121,145],"after":[87,174],"ALI.":[88],"Incremental":[89],"doses":[90],"of":[91,115,130,137,169,185,197],"(0,":[93,101],"1,":[94,102],"10,":[95,103],"100":[97,105],"ng/mL)":[98,106],"added":[108],"to":[109,212],"bone":[110],"marrow":[111],"The":[113,127],"TNF-alpha,":[116,186],"MIP-2,":[117],"IL-1beta":[119],"with":[122],"enzyme":[123],"linked":[124],"immunosorbent":[125],"assay.":[126],"mRNA":[128,183],"three":[131],"cytokines,":[132],"the":[134,172],"nuclear":[135,138],"translocation":[136,196],"kappa":[140],"B":[141],"(NF":[142],"kappa-B)":[143],"reverse":[147],"transcriptase-polymerase":[148],"chain":[149],"reaction":[150],"electrophoretic":[152],"mobility":[153],"shift":[154],"assay,":[155],"respectively.":[156],"-/-":[158],"showed":[160],"decreased":[161],"neutrophil":[162],"infiltration,":[163],"less":[164],"leakage,":[165],"lower":[167],"cytokines":[170],"augmented":[179],"protein":[181],"MIP-2":[187],"IL-1beta,":[189],"which":[190,210],"mediated":[192,214],"increased":[194],"intra-nuclear":[195],"NF-kappaB.":[198],"high-dose":[205],"ALI,":[209],"appears":[211],"be":[213],"its":[216],"effect":[218],"on":[219]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}