{"id":"https://openalex.org/W2106059650","doi":"https://doi.org/10.1186/s12943-015-0388-z","title":"Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms","display_name":"Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms","publication_year":2015,"publication_date":"2015-06-11","ids":{"openalex":"https://openalex.org/W2106059650","doi":"https://doi.org/10.1186/s12943-015-0388-z","mag":"2106059650","pmid":"https://pubmed.ncbi.nlm.nih.gov/26062813","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4464249"},"language":"en","primary_location":{"id":"doi:10.1186/s12943-015-0388-z","doi":"https://doi.org/10.1186/s12943-015-0388-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-015-0388-z","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/s12943-015-0388-z","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/s12943-015-0388-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068395011","display_name":"Ruchi Pandey","orcid":"https://orcid.org/0000-0002-7846-7415","observed_orcids":["https://orcid.org/0000-0002-7846-7415"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruchi Pandey","raw_affiliation_strings":["Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. pandeyru@iupui.edu","Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. pandeyru@iupui.edu","Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. pandeyru@iupui.edu","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. pandeyru@iupui.edu","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035841414","display_name":"Reuben Kapur","orcid":"https://orcid.org/0000-0003-2225-1700","observed_orcids":["https://orcid.org/0000-0003-2225-1700","https://orcid.org/0009-0008-1025-5126"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Reuben Kapur","raw_affiliation_strings":["Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. rkapur@iupui.edu","Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. rkapur@iupui.edu","Department of Molecular Biology and Biochemistry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. rkapur@iupui.edu","Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. rkapur@iupui.edu","Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. rkapur@iupui.edu","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. rkapur@iupui.edu","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. rkapur@iupui.edu","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. rkapur@iupui.edu","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035841414"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":{"value":5090,"currency":"USD","value_usd":5090},"fwci":0.4216,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.37644788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"118","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/philadelphia-chromosome-negative-myeloproliferative-neoplasms","display_name":"Philadelphia-negative myeloproliferative neoplasms","score":0.9549999833106995},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.9610000252723694},{"id":"https://openalex.org/keywords/jak2-mutation","display_name":"JAK2 mutation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-mutations","display_name":"receptor tyrosine kinase mutations","score":0.8360000252723694},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.7200000286102295},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2910274570","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative Disorders","level":2,"score":0.6682126522064209},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.6664746999740601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6411222219467163},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6390202641487122},{"id":"https://openalex.org/C41650920","wikidata":"https://www.wikidata.org/wiki/Q14912399","display_name":"CD135","level":4,"score":0.581390380859375},{"id":"https://openalex.org/C2775855021","wikidata":"https://www.wikidata.org/wiki/Q968436","display_name":"Cytokine receptor","level":3,"score":0.5292196869850159},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5106475949287415},{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.4834795594215393},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.47646164894104004},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4588734209537506},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.4473534822463989},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4411256015300751},{"id":"https://openalex.org/C130523297","wikidata":"https://www.wikidata.org/wiki/Q14914487","display_name":"Tyrosine kinase 2","level":5,"score":0.4157485365867615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33890485763549805},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2587863504886627},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.24295803904533386},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24028939008712769},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1285666823387146},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.09092989563941956}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010677","descriptor_name":"Philadelphia Chromosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058539","descriptor_name":"Phosphatidylinositol 3-Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1186/s12943-015-0388-z","doi":"https://doi.org/10.1186/s12943-015-0388-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-015-0388-z","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/s12943-015-0388-z","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3428047","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4464249","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4464249","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4464249","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cancer","raw_type":"Text"},{"id":"pmid:26062813","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26062813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.696.1040","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.696.1040","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.molecular-cancer.com/content/pdf/s12943-015-0388-z.pdf","raw_type":"text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/9654","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/9654","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/9654","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1805/9654","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"mag:2394495932","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.iupui.edu/bitstream/1805/9654/1/12943_2015_Article_388.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306522653","display_name":"PMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":null}],"best_oa_location":{"id":"doi:10.1186/s12943-015-0388-z","doi":"https://doi.org/10.1186/s12943-015-0388-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12943-015-0388-z","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/s12943-015-0388-z","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G110600694","display_name":"Novel Mechanisms of C-Kit Regulation in Mast Cells","funder_award_id":"R01HL077177","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4157328775","display_name":"Regulation of Hematopoietic Cell Production","funder_award_id":"T32DK007519","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4758498903","display_name":"Role of Vav and Rac in KIT oncogenesis","funder_award_id":"R01HL081111","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5370055700","display_name":"Role of Shp2 in FLT3-ITD induced leukemogenesis","funder_award_id":"R01CA134777","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000870434","display_name":"Role of p21 activated kinase in Leukemogenesis","funder_award_id":"R01CA173852","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320316717","display_name":"Riley Children's Foundation","ror":"https://ror.org/03sabpy05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2106059650.pdf","grobid_xml":"https://content.openalex.org/works/W2106059650.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W1514208610","https://openalex.org/W1542516598","https://openalex.org/W1573108393","https://openalex.org/W1605230984","https://openalex.org/W1773341657","https://openalex.org/W1963866495","https://openalex.org/W1965626427","https://openalex.org/W1972960063","https://openalex.org/W1976128103","https://openalex.org/W1977590248","https://openalex.org/W1978853026","https://openalex.org/W1979456024","https://openalex.org/W1979937839","https://openalex.org/W1980402007","https://openalex.org/W1985809519","https://openalex.org/W1986595955","https://openalex.org/W1987362309","https://openalex.org/W1987463051","https://openalex.org/W1991885817","https://openalex.org/W1993878351","https://openalex.org/W1995149934","https://openalex.org/W1995370367","https://openalex.org/W1996560058","https://openalex.org/W1998912715","https://openalex.org/W1999999605","https://openalex.org/W2003560510","https://openalex.org/W2005880838","https://openalex.org/W2007765910","https://openalex.org/W2009803958","https://openalex.org/W2010539557","https://openalex.org/W2010625878","https://openalex.org/W2014644181","https://openalex.org/W2015408520","https://openalex.org/W2015969861","https://openalex.org/W2023823393","https://openalex.org/W2024510824","https://openalex.org/W2026602389","https://openalex.org/W2026644362","https://openalex.org/W2030868349","https://openalex.org/W2033008376","https://openalex.org/W2034700616","https://openalex.org/W2040928176","https://openalex.org/W2044710086","https://openalex.org/W2047079894","https://openalex.org/W2048993739","https://openalex.org/W2049145190","https://openalex.org/W2054917860","https://openalex.org/W2056777053","https://openalex.org/W2056871730","https://openalex.org/W2057360098","https://openalex.org/W2057895084","https://openalex.org/W2061637822","https://openalex.org/W2062961282","https://openalex.org/W2064453268","https://openalex.org/W2065109166","https://openalex.org/W2066564017","https://openalex.org/W2066680787","https://openalex.org/W2067019627","https://openalex.org/W2071622027","https://openalex.org/W2074849382","https://openalex.org/W2075741861","https://openalex.org/W2076738134","https://openalex.org/W2078743099","https://openalex.org/W2079044387","https://openalex.org/W2082732339","https://openalex.org/W2084050646","https://openalex.org/W2085404468","https://openalex.org/W2086221920","https://openalex.org/W2090642317","https://openalex.org/W2093301943","https://openalex.org/W2094640639","https://openalex.org/W2095226581","https://openalex.org/W2095447519","https://openalex.org/W2104167441","https://openalex.org/W2107398329","https://openalex.org/W2107661677","https://openalex.org/W2109619078","https://openalex.org/W2109714765","https://openalex.org/W2114414564","https://openalex.org/W2114553148","https://openalex.org/W2115351357","https://openalex.org/W2117869971","https://openalex.org/W2118323591","https://openalex.org/W2123633897","https://openalex.org/W2124465965","https://openalex.org/W2132052921","https://openalex.org/W2134919790","https://openalex.org/W2135429827","https://openalex.org/W2136977400","https://openalex.org/W2140146704","https://openalex.org/W2144664431","https://openalex.org/W2146505525","https://openalex.org/W2153272770","https://openalex.org/W2155046477","https://openalex.org/W2157694607","https://openalex.org/W2160315579","https://openalex.org/W2161282346","https://openalex.org/W2166191023","https://openalex.org/W2166342674","https://openalex.org/W2171630203","https://openalex.org/W2281555888","https://openalex.org/W4239839403","https://openalex.org/W4243559800"],"related_works":["https://openalex.org/W7099371233","https://openalex.org/W2505858050","https://openalex.org/W2075075980","https://openalex.org/W2010298068","https://openalex.org/W15071589","https://openalex.org/W4388997807","https://openalex.org/W1993550858","https://openalex.org/W2333971169","https://openalex.org/W2051373733","https://openalex.org/W4229032500"],"abstract_inverted_index":{"Myeloproliferative":[0],"neoplasms":[1],"(MPN)":[2],"are":[3,23],"a":[4,67,112,184],"diverse":[5],"group":[6],"of":[7,16,21,40,62,69,77,81,106,114,125,172,217,231],"chronic":[8,70],"hematological":[9],"disorders":[10],"that":[11,221],"involve":[12],"unregulated":[13],"clonal":[14],"proliferation":[15],"white":[17],"blood":[18],"cells.":[19],"Sevearl":[20],"them":[22,38],"associated":[24,34,110],"with":[25,111,122,134,151],"mutations":[26,107,138,148],"in":[27,85,96,108,139,170],"receptor":[28,33,191],"tyrosine":[29,35,64,83],"kinases":[30,36,84],"or":[31,57,225],"cytokine":[32,157],"rendering":[37],"independent":[39,158],"cytokine-mediated":[41],"regulation.":[42],"Classically":[43],"they":[44],"have":[45,88,144,222],"been":[46,145,223],"broadly":[47],"divided":[48],"into":[49],"BCR-ABL1":[50,63],"fusion":[51],"+":[52,55],"ve":[53],"(Ph":[54],"ve)":[56],"-ve":[58],"(Ph-ve)":[59],"MPNs.":[60,99,173,233],"Identification":[61],"kinase":[65,93,130,179],"as":[66,183,187],"driver":[68],"myeloid":[71],"leukemia":[72],"(CML)":[73],"and":[74,154,164,207],"successful":[75,169],"application":[76],"small":[78],"molecule":[79],"inhibitors":[80,216],"the":[82,86,90,101,117,197,213,218,229],"clinic":[87],"triggered":[89],"search":[91],"for":[92,119,228],"dependent":[94],"pathways":[95,165,194],"other":[97,141,175],"Ph-ve":[98,232],"In":[100],"past":[102],"few":[103],"years,":[104],"identification":[105],"JAK2":[109,129,143],"majority":[113],"MPNs":[115,153],"raised":[116],"hopes":[118],"similar":[120],"success":[121],"specific":[123],"targeting":[124,128,161],"JAK2.":[126],"However,":[127],"activity":[131],"has":[132,181],"met":[133],"limited":[135],"success.":[136],"Subsequently,":[137],"genes":[140],"than":[142],"identified.":[146],"These":[147],"specifically":[149],"associate":[150],"certain":[152],"can":[155],"drive":[156],"growth.":[159],"Therefore,":[160],"alternate":[162],"molecules":[163],"may":[166],"be":[167],"more":[168],"management":[171],"Among":[174],"pathways,":[176],"phosphatidylinositol":[177],"-3":[178],"(PI3K)":[180],"emerged":[182],"promising":[185],"target":[186],"different":[188],"cell":[189,203],"surface":[190],"induced":[192],"signaling":[193,199],"converge":[195],"on":[196],"PI3K":[198,219],"axis":[200],"to":[201],"regulate":[202],"metabolism,":[204],"growth,":[205],"proliferation,":[206],"survival.":[208],"Herein,":[209],"we":[210],"will":[211],"review":[212],"clinically":[214],"relevant":[215],"pathway":[220],"evaluated":[224],"hold":[226],"promise":[227],"treatment":[230]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}