{"id":"https://openalex.org/W2106039722","doi":"https://doi.org/10.1128/iai.60.6.2397-2401.1992","title":"Protection of Aotus monkeys from malaria infection by immunization with recombinant hybrid proteins","display_name":"Protection of Aotus monkeys from malaria infection by immunization with recombinant hybrid proteins","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W2106039722","doi":"https://doi.org/10.1128/iai.60.6.2397-2401.1992","mag":"2106039722","pmid":"https://pubmed.ncbi.nlm.nih.gov/1587607","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/257172"},"language":"en","primary_location":{"id":"doi:10.1128/iai.60.6.2397-2401.1992","doi":"https://doi.org/10.1128/iai.60.6.2397-2401.1992","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.60.6.2397-2401.1992","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC257172","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034280556","display_name":"Bernhard Knapp","orcid":"https://orcid.org/0000-0002-5714-7105","observed_orcids":["https://orcid.org/0000-0002-5714-7105"]},"institutions":[{"id":"https://openalex.org/I4210105121","display_name":"Behringwerke (Germany)","ror":"https://ror.org/01647vc39","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210105121"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Knapp","raw_affiliation_strings":["Research Laboratories, Behringwerke AG, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Behringwerke AG, Marburg, Germany","institution_ids":["https://openalex.org/I4210105121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033276004","display_name":"Erika Hundt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105121","display_name":"Behringwerke (Germany)","ror":"https://ror.org/01647vc39","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210105121"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E Hundt","raw_affiliation_strings":["Research Laboratories, Behringwerke AG, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Behringwerke AG, Marburg, Germany","institution_ids":["https://openalex.org/I4210105121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076405449","display_name":"Burkhard Enders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105121","display_name":"Behringwerke (Germany)","ror":"https://ror.org/01647vc39","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210105121"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Enders","raw_affiliation_strings":["Research Laboratories, Behringwerke AG, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Behringwerke AG, Marburg, Germany","institution_ids":["https://openalex.org/I4210105121"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067075124","display_name":"H K\u00fcpper","orcid":"https://orcid.org/0009-0001-1813-941X","observed_orcids":["https://orcid.org/0009-0001-1813-941X"]},"institutions":[{"id":"https://openalex.org/I4210105121","display_name":"Behringwerke (Germany)","ror":"https://ror.org/01647vc39","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210105121"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H A K\u00fcpper","raw_affiliation_strings":["Research Laboratories, Behringwerke AG, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Behringwerke AG, Marburg, Germany","institution_ids":["https://openalex.org/I4210105121"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210105121"],"apc_list":null,"apc_paid":null,"fwci":9.0076,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.97796043,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"60","issue":"6","first_page":"2397","last_page":"2401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aotus-monkeys","display_name":"Aotus monkeys","score":0.8429999947547913},{"id":"https://openalex.org/keywords/malaria-vaccine","display_name":"malaria vaccine","score":0.5860000252723694},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9739999771118164},{"id":"https://openalex.org/keywords/blood-stage-antigens","display_name":"blood-stage antigens","score":0.7900000214576721},{"id":"https://openalex.org/keywords/antibody-mediated-protection","display_name":"antibody-mediated protection","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8714410066604614},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.7951451539993286},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6746749877929688},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6597291231155396},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.6527400612831116},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.6418017148971558},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6113643050193787},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5919172167778015},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3701540231704712},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12359818816184998},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12155327200889587}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000913","descriptor_name":"Antibodies, Protozoan","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001029","descriptor_name":"Aotus trivirgatus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016052","descriptor_name":"Protozoan Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/iai.60.6.2397-2401.1992","doi":"https://doi.org/10.1128/iai.60.6.2397-2401.1992","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.60.6.2397-2401.1992","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:18420","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC257172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:257172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/257172","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:1587607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1587607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.989.9410","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.989.9410","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://iai.asm.org/content/60/6/2397.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:18420","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC257172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1836449346","https://openalex.org/W1956342499","https://openalex.org/W1963531005","https://openalex.org/W1970883558","https://openalex.org/W1971955888","https://openalex.org/W1994079004","https://openalex.org/W1998591058","https://openalex.org/W2010316691","https://openalex.org/W2033605057","https://openalex.org/W2042960754","https://openalex.org/W2048357158","https://openalex.org/W2048463045","https://openalex.org/W2053124485","https://openalex.org/W2057738766","https://openalex.org/W2065335949","https://openalex.org/W2069027832","https://openalex.org/W2076854208","https://openalex.org/W2082762936","https://openalex.org/W2102127741","https://openalex.org/W2133791917","https://openalex.org/W2144865403","https://openalex.org/W2161423855","https://openalex.org/W2413253636"],"related_works":["https://openalex.org/W7100910265","https://openalex.org/W2010841737","https://openalex.org/W2135450229","https://openalex.org/W2053892558","https://openalex.org/W2461010319","https://openalex.org/W1956342499","https://openalex.org/W1992873693","https://openalex.org/W1984208024","https://openalex.org/W1939795561","https://openalex.org/W2089008531"],"abstract_inverted_index":{"On":[0],"the":[1,6,43,62,73],"basis":[2],"of":[3,5,28,56,61],"investigations":[4],"malarial":[7],"blood-stage":[8],"antigens":[9],"SERP,":[10],"HRPII,":[11],"and":[12,39],"MSAI":[13],"from":[14,75],"Plasmodium":[15],"falciparum,":[16],"we":[17],"chose":[18],"two":[19,49,63],"Escherichia":[20],"coli-expressed":[21],"hybrid":[22,35,64],"proteins":[23,36,65],"containing":[24],"selected":[25],"partial":[26],"sequences":[27],"these":[29],"antigens.":[30],"Antibodies":[31],"raised":[32],"against":[33],"both":[34],"in":[37,67],"rabbits":[38],"Aotus":[40,57],"monkeys":[41,58],"recognize":[42],"corresponding":[44],"P.":[45,78],"falciparum":[46,79],"polypeptides.":[47],"In":[48],"independent":[50],"trials":[51],"with":[52,59],"13":[53],"animals,":[54],"immunization":[55],"either":[60],"administered":[66],"a":[68],"well-tolerated":[69],"oil-based":[70],"formulation":[71],"protected":[72],"animals":[74],"an":[76],"experimental":[77],"infection.":[80]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}