{"id":"https://openalex.org/W2106003336","doi":"https://doi.org/10.1002/(sici)1097-0282(2000)57:1<2::aid-bip2>3.0.co;2-g","title":"Raman spectroscopic study of polycrystalline mono- and polyunsaturated 1-eicosanoyl-d39-2-eicosenoyl-sn-glycero-3-phosphocholines: Bilayer lipid clustering and acyl chain order and disorder characteristics","display_name":"Raman spectroscopic study of polycrystalline mono- and polyunsaturated 1-eicosanoyl-d39-2-eicosenoyl-sn-glycero-3-phosphocholines: Bilayer lipid clustering and acyl chain order and disorder characteristics","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2106003336","doi":"https://doi.org/10.1002/(sici)1097-0282(2000)57:1<2::aid-bip2>3.0.co;2-g","mag":"2106003336","pmid":"https://pubmed.ncbi.nlm.nih.gov/10679634"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0282(2000)57:1<2::aid-bip2>3.0.co;2-g","doi":"https://doi.org/10.1002/(sici)1097-0282(2000)57:1<2::aid-bip2>3.0.co;2-g","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0282(2000)57:1<2::aid-bip2>3.0.co;2-g","pdf_url":null,"source":{"id":"https://openalex.org/S56808608","display_name":"Biopolymers","issn_l":"0006-3525","issn":["0006-3525","1097-0282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopolymers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005567472","display_name":"Patty K. McCarthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patty K. McCarthy","raw_affiliation_strings":["Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0510, USA","Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892\u20100510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0510, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"raw_affiliation_string":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892\u20100510","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109987699","display_name":"Ching-hsien Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ching-Hsien Huang","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, Health Sciences Center, University of Virginia, Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, Health Sciences Center, University of Virginia, Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111569185","display_name":"Ira W. Levin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ira W. Levin","raw_affiliation_strings":["Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0510","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111569185"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.2407,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.52791802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"57","issue":"1","first_page":"2","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.8399999737739563},{"id":"https://openalex.org/keywords/polyunsaturated-lipids","display_name":"polyunsaturated lipids","score":0.7350000143051147},{"id":"https://openalex.org/keywords/perdeuteration","display_name":"perdeuteration","score":0.7049999833106995},{"id":"https://openalex.org/keywords/lipid-microdomains","display_name":"lipid microdomains","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7894761562347412},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.6465874910354614},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.6429039835929871},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5922831892967224},{"id":"https://openalex.org/C68381374","wikidata":"https://www.wikidata.org/wiki/Q258652","display_name":"Double bond","level":2,"score":0.575905978679657},{"id":"https://openalex.org/C137637335","wikidata":"https://www.wikidata.org/wiki/Q899604","display_name":"Crystallite","level":2,"score":0.5119877457618713},{"id":"https://openalex.org/C2777454769","wikidata":"https://www.wikidata.org/wiki/Q11172462","display_name":"Methylene","level":2,"score":0.5004425048828125},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.4595367908477783},{"id":"https://openalex.org/C201268389","wikidata":"https://www.wikidata.org/wiki/Q905639","display_name":"Degree of unsaturation","level":2,"score":0.4478793144226074},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4015129506587982},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15326756238937378},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.12109041213989258},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004537","descriptor_name":"Eicosanoic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-0282(2000)57:1<2::aid-bip2>3.0.co;2-g","doi":"https://doi.org/10.1002/(sici)1097-0282(2000)57:1<2::aid-bip2>3.0.co;2-g","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0282(2000)57:1<2::aid-bip2>3.0.co;2-g","pdf_url":null,"source":{"id":"https://openalex.org/S56808608","display_name":"Biopolymers","issn_l":"0006-3525","issn":["0006-3525","1097-0282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopolymers","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1097-0282(2000)57:1<2::aid-bip2>3.3.co;2-7","doi":"https://doi.org/10.1002/(sici)1097-0282(2000)57:1<2::aid-bip2>3.3.co;2-7","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0282(2000)57:1<2::aid-bip2>3.3.co;2-7","pdf_url":null,"source":{"id":"https://openalex.org/S56808608","display_name":"Biopolymers","issn_l":"0006-3525","issn":["0006-3525","1097-0282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopolymers","raw_type":"journal-article"},{"id":"pmid:10679634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10679634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopolymers","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W114431963","https://openalex.org/W1522941546","https://openalex.org/W1551250836","https://openalex.org/W1584730117","https://openalex.org/W1970917597","https://openalex.org/W1973566285","https://openalex.org/W1977878447","https://openalex.org/W1989784582","https://openalex.org/W1990404865","https://openalex.org/W1991296357","https://openalex.org/W1991655565","https://openalex.org/W1997063557","https://openalex.org/W2015670561","https://openalex.org/W2017071790","https://openalex.org/W2019608751","https://openalex.org/W2020061656","https://openalex.org/W2052852328","https://openalex.org/W2060548005","https://openalex.org/W2092712871","https://openalex.org/W2140900740","https://openalex.org/W4255987109"],"related_works":["https://openalex.org/W2082960898","https://openalex.org/W1996677077","https://openalex.org/W1978991073","https://openalex.org/W2067334547","https://openalex.org/W2129230282","https://openalex.org/W2061184186","https://openalex.org/W341402516","https://openalex.org/W2026583808","https://openalex.org/W2176678663","https://openalex.org/W2090534305"],"abstract_inverted_index":{"Polycrystalline":[0],"lipid":[1,170],"samples":[2,104],"of":[3,6,14,51,58,109,124,161,182,185,196,204],"a":[4,106],"series":[5,184],"mono-":[7],"and":[8,28,46,73,76,88,97,179,187],"polyunsaturated,":[9],"double":[10,119,149,162],"bond":[11,120,150],"positional":[12],"isomers":[13],"1-eicosanoyl-d(39)-2-eicosenoyl-sn-glycero-3-phosphocholines":[15],"[C(20-d(39)):C(20:1":[16],"Delta(j))PC,":[17],"with":[18],"j":[19],"=":[20],"5,":[21],"8,":[22],"11,":[23],"or":[24,122,158],"13;":[25],"C(20-d(39)):C(20:2":[26],"Delta(11,14))PC;":[27],"C(20-d(39)):C(20:3":[29],"Delta(11,":[30],"14,17))PC]":[31],"were":[32],"investigated":[33],"using":[34],"vibrational":[35],"Raman":[36],"spectroscopy":[37],"to":[38,79,167],"assess":[39],"the":[40,52,60,102,118,128,133,147,155,159,177,194,202],"acyl":[41,55,63,141],"chain":[42,85,111,136,142,156,172,191,209],"packing":[43,173],"order-disorder":[44],"characteristics":[45],"putative":[47],"bilayer":[48,67,171],"cluster":[49],"formation":[50,203],"isotopically":[53],"differentiated":[54],"chains.":[56],"Perdeuteration":[57],"specifically":[59],"saturated":[61,84,207],"sn-1":[62,110,178,208],"chains":[64,181],"for":[65,101],"these":[66],"systems":[68],"enables":[69],"each":[70],"chain's":[71],"intra-":[72],"intermolecular":[74],"conformational":[75,143],"organizational":[77],"properties":[78],"be":[80],"evaluated":[81],"separately.":[82],"Various":[83],"methylene":[86],"CD(2)":[87],"carbon-carbon":[89],"(C&bond;C)":[90],"stretching":[91],"mode":[92],"peak":[93],"height":[94],"intensity":[95],"ratios":[96],"line":[98],"width":[99],"parameters":[100],"polycrystalline":[103],"demonstrate":[105],"high":[107],"degree":[108],"order":[112],"that":[113],"is":[114,151],"unaffected":[115],"by":[116],"either":[117,146],"placement":[121],"number":[123,160],"unsaturated":[125,134],"bonds":[126,163],"within":[127],"sn-2":[129,135,180],"chain.":[130],"In":[131],"contrast,":[132],"spectral":[137],"signatures":[138],"reflect":[139],"increasing":[140],"disorder":[144],"as":[145],"cis":[148],"generally":[152],"repositioned":[153],"toward":[154],"terminus":[157],"increases":[164],"from":[165],"one":[166],"three.":[168],"The":[169],"differences":[174],"observed":[175],"between":[176],"this":[183],"monounsaturated":[186],"polyunsaturated":[188],"20":[189],"carbon":[190],"lipids":[192],"suggest":[193],"existence":[195],"laterally":[197],"distributed":[198],"microdomains":[199],"predicated":[200],"on":[201],"highly":[205],"ordered,":[206],"clusters.":[210]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}