{"id":"https://openalex.org/W2105976216","doi":"https://doi.org/10.1021/ac901525g","title":"In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry","display_name":"In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry","publication_year":2009,"publication_date":"2009-09-17","ids":{"openalex":"https://openalex.org/W2105976216","doi":"https://doi.org/10.1021/ac901525g","mag":"2105976216","pmid":"https://pubmed.ncbi.nlm.nih.gov/19824712"},"language":"en","primary_location":{"id":"doi:10.1021/ac901525g","doi":"https://doi.org/10.1021/ac901525g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac901525g","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2105976216"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066290980","display_name":"Bindesh Shrestha","orcid":"https://orcid.org/0000-0002-7595-3506","observed_orcids":["https://orcid.org/0000-0002-7595-3506"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bindesh Shrestha","raw_affiliation_strings":["Department of Chemistry, W. M. Keck Institute for Proteomics Technology and Applications, The George Washington University, Washington, District of Columbia 20052","Department of Chemistry, W. M. Keck Institute for Proteomics Technology and Applications, The George Washington University, Washington, District of Columbia 20052, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, W. M. Keck Institute for Proteomics Technology and Applications, The George Washington University, Washington, District of Columbia 20052","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Department of Chemistry, W. M. Keck Institute for Proteomics Technology and Applications, The George Washington University, Washington, District of Columbia 20052, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009353480","display_name":"\u00c1kos V\u00e9rtes","orcid":"https://orcid.org/0000-0001-5186-5352","observed_orcids":["https://orcid.org/0000-0001-5186-5352"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Akos Vertes","raw_affiliation_strings":["Department of Chemistry, W. M. Keck Institute for Proteomics Technology and Applications, The George Washington University, Washington, District of Columbia 20052"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, W. M. Keck Institute for Proteomics Technology and Applications, The George Washington University, Washington, District of Columbia 20052","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009353480"],"corresponding_institution_ids":["https://openalex.org/I193531525"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":8.3102,"has_fulltext":false,"cited_by_count":272,"citation_normalized_percentile":{"value":0.99050423,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"81","issue":"20","first_page":"8265","last_page":"8271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11854","display_name":"Laser-induced spectroscopy and plasma","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-cell-metabolic-profiling","display_name":"single-cell metabolic profiling","score":0.7839999794960022},{"id":"https://openalex.org/keywords/laser-ablation-electrospray-ionization","display_name":"laser ablation electrospray ionization","score":0.9449999928474426},{"id":"https://openalex.org/keywords/allium-cepa","display_name":"onion","score":0.8859999775886536},{"id":"https://openalex.org/keywords/narcissus-pseudonarcissus","display_name":"Narcissus pseudonarcissus","score":0.9390000104904175},{"id":"https://openalex.org/keywords/oligosaccharides","display_name":"oligosaccharides","score":0.7940000295639038},{"id":"https://openalex.org/keywords/fructans","display_name":"fructans","score":0.9739999771118164},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.8090000152587891},{"id":"https://openalex.org/keywords/lycorine","display_name":"lycorine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anthocyanidins","display_name":"anthocyanidins","score":0.9679999947547913},{"id":"https://openalex.org/keywords/flavonoid-glucosides","display_name":"flavonoid glucosides","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cell-age","display_name":"cell age","score":0.527999997138977},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.6100000143051147},{"id":"https://openalex.org/keywords/plant-metabolites","display_name":"plant metabolites","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8664476871490479},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5443785190582275},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.5382978320121765},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.44321441650390625},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3657502233982086},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33191758394241333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0847613513469696},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07352927327156067}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010860","descriptor_name":"Pigments, Biological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012617","descriptor_name":"Sea Urchins","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012617","descriptor_name":"Sea Urchins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019441","descriptor_name":"Plant Epidermis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019441","descriptor_name":"Plant Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019697","descriptor_name":"Onions","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019697","descriptor_name":"Onions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031427","descriptor_name":"Narcissus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D031427","descriptor_name":"Narcissus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ac901525g","doi":"https://doi.org/10.1021/ac901525g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac901525g","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:19824712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19824712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W614757388","https://openalex.org/W1965949837","https://openalex.org/W1975871554","https://openalex.org/W1978131006","https://openalex.org/W1983865877","https://openalex.org/W1986472367","https://openalex.org/W2009077510","https://openalex.org/W2010004076","https://openalex.org/W2025708452","https://openalex.org/W2026916042","https://openalex.org/W2028205367","https://openalex.org/W2028811987","https://openalex.org/W2033031329","https://openalex.org/W2033201793","https://openalex.org/W2035956992","https://openalex.org/W2043021553","https://openalex.org/W2044450978","https://openalex.org/W2053670834","https://openalex.org/W2055534015","https://openalex.org/W2061044319","https://openalex.org/W2065007156","https://openalex.org/W2077496528","https://openalex.org/W2080833272","https://openalex.org/W2084851498","https://openalex.org/W2094371794","https://openalex.org/W2104096412","https://openalex.org/W2105089251","https://openalex.org/W2109847775","https://openalex.org/W2111678083","https://openalex.org/W2127068865","https://openalex.org/W2128372016","https://openalex.org/W2142296723","https://openalex.org/W2644804608","https://openalex.org/W4211193454","https://openalex.org/W4249005591"],"related_works":["https://openalex.org/W2901477360","https://openalex.org/W3149405437","https://openalex.org/W3016796999","https://openalex.org/W2187679506","https://openalex.org/W3191777733","https://openalex.org/W2150904871","https://openalex.org/W2803287966","https://openalex.org/W2288192121","https://openalex.org/W2043021553","https://openalex.org/W2106339283"],"abstract_inverted_index":{"Depending":[0],"on":[1],"age,":[2],"phase":[3],"in":[4,22,37,135,142,153,157,163,185,207,212,218],"the":[5,36,57,93,106,122,166,200,206],"cell":[6,23,47,74,220],"cycle,":[7],"nutrition,":[8],"and":[9,72,79,112,138,173,227],"environmental":[10],"factors,":[11],"individual":[12,41,148],"cells":[13,42,71,120,149,168,180,214],"exhibit":[14],"large":[15,128],"metabolic":[16,20,116,191],"diversity.":[17],"To":[18],"explore":[19],"variations":[21],"populations,":[24],"laser":[25,54],"ablation":[26,48],"electrospray":[27],"ionization":[28],"(LAESI)":[29],"mass":[30],"spectrometry":[31],"(MS)":[32],"was":[33,49,67],"used":[34],"for":[35,97,205],"situ":[38,208],"analysis":[39,66,209],"of":[40,60,76,89,108,121,130,146,177,202,210],"at":[43],"atmospheric":[44],"pressure.":[45],"Single":[46],"achieved":[50],"by":[51],"delivering":[52],"mid-IR":[53],"pulses":[55],"through":[56],"etched":[58],"tip":[59],"a":[61,127,151],"GeO(2)-based":[62],"glass":[63],"fiber.":[64],"Metabolic":[65],"performed":[68],"from":[69,118,181],"single":[70,87,119,178,213],"small":[73],"populations":[75],"Allium":[77],"cepa":[78,188],"Narcissus":[80],"pseudonarcissus":[81],"bulb":[82,189],"epidermis,":[83],"as":[84,86],"well":[85],"eggs":[88],"Lytechinus":[90],"pictus.":[91],"Of":[92],"332":[94],"peaks":[95],"detected":[96],"A.":[98,136,187],"cepa,":[99,137],"35":[100],"were":[101],"assigned":[102],"to":[103,159,194,224,229],"metabolites":[104,161,211],"with":[105,150,215],"help":[107],"accurate":[109],"ion":[110],"masses":[111],"tandem":[113],"MS.":[114],"The":[115],"profiles":[117],"two":[123],"plant":[124],"species":[125],"included":[126],"variety":[129],"oligosaccharides":[131],"including":[132],"possibly":[133],"fructans":[134],"alkaloids,":[139],"e.g.,":[140],"lycorine":[141],"N.":[143],"pseudonarcissus.":[144],"Analysis":[145,176],"adjacent":[147],"difference":[152],"pigmentation":[154],"showed":[155,190],"that,":[156],"addition":[158],"essential":[160],"found":[162],"both":[164],"variants,":[165],"pigmented":[167],"contained":[169],"anthocyanidins,":[170],"other":[171],"flavonoids,":[172],"their":[174,195],"glucosides.":[175],"epidermal":[179],"different":[182],"scale":[183],"leaves":[184],"an":[186],"differences":[192],"corresponding":[193],"age.":[196],"Our":[197],"results":[198],"indicate":[199],"feasibility":[201],"using":[203],"LAESI-MS":[204],"potential":[216],"applications":[217],"studying":[219],"differentiation,":[221],"changes":[222],"due":[223],"disease":[225],"states,":[226],"response":[228],"xenobiotics.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
