{"id":"https://openalex.org/W2105961374","doi":"https://doi.org/10.1586/ern.11.162","title":"Charting the path for early diagnosis and prevention of Alzheimer\u2019s disease","display_name":"Charting the path for early diagnosis and prevention of Alzheimer\u2019s disease","publication_year":2011,"publication_date":"2011-11-17","ids":{"openalex":"https://openalex.org/W2105961374","doi":"https://doi.org/10.1586/ern.11.162","mag":"2105961374","pmid":"https://pubmed.ncbi.nlm.nih.gov/22091590"},"language":"en","primary_location":{"id":"doi:10.1586/ern.11.162","doi":"https://doi.org/10.1586/ern.11.162","is_oa":false,"landing_page_url":"https://doi.org/10.1586/ern.11.162","pdf_url":null,"source":{"id":"https://openalex.org/S1502225","display_name":"Expert Review of Neurotherapeutics","issn_l":"1473-7175","issn":["1473-7175","1744-8360"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Neurotherapeutics","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055843167","display_name":"Yakeel T. Quiroz","orcid":"https://orcid.org/0000-0001-9714-8244","observed_orcids":["https://orcid.org/0000-0001-9714-8244"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO","US"],"is_corresponding":false,"raw_author_name":"Yakeel T Quiroz","raw_affiliation_strings":["Center for Memory and Brain, Psychology Department, Boston University, Boston, MA, USA and Grupo de Neurociencias, Universidad de Antioquia, Medell\u00edn, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Memory and Brain, Psychology Department, Boston University, Boston, MA, USA and Grupo de Neurociencias, Universidad de Antioquia, Medell\u00edn, Colombia","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I35961687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024744959","display_name":"Francisco Javier Lopera","orcid":"https://orcid.org/0000-0003-3986-1484","observed_orcids":["https://orcid.org/0000-0003-3986-1484","https://orcid.org/0000-0002-5238-0231"]},"institutions":[{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Francisco Lopera","raw_affiliation_strings":["Grupo de Neurociencias, Universidad de Antioquia, Medell\u00edn, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Neurociencias, Universidad de Antioquia, Medell\u00edn, Colombia","institution_ids":["https://openalex.org/I35961687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037914760","display_name":"Andrew E. Budson","orcid":"https://orcid.org/0000-0002-2913-0015","observed_orcids":["https://orcid.org/0000-0002-2913-0015"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew E Budson","raw_affiliation_strings":["VA Boston Healthcare System, MA, USA and Boston University Alzheimer\u2019s Disease Center, Department of Neurology, Boston University School of Medicine, Boston, MA, USA. abudson@bu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VA Boston Healthcare System, MA, USA and Boston University Alzheimer\u2019s Disease Center, Department of Neurology, Boston University School of Medicine, Boston, MA, USA. abudson@bu.edu","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I2801671727"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"12","first_page":"1665","last_page":"1667"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/disease-prevention","display_name":"disease prevention","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.9929999709129333},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/medial-temporal-lobe","display_name":"medial temporal lobe","score":0.8759999871253967},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5951612591743469},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5798458456993103},{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.5649070739746094},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5478222370147705},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.531322181224823},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.5138419270515442},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.5099073648452759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44280803203582764},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.37488165497779846},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36769434809684753},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013020","descriptor_name":"South America","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013020","descriptor_name":"South America","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013020","descriptor_name":"South America","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1586/ern.11.162","doi":"https://doi.org/10.1586/ern.11.162","is_oa":false,"landing_page_url":"https://doi.org/10.1586/ern.11.162","pdf_url":null,"source":{"id":"https://openalex.org/S1502225","display_name":"Expert Review of Neurotherapeutics","issn_l":"1473-7175","issn":["1473-7175","1744-8360"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Neurotherapeutics","raw_type":"journal-article"},{"id":"pmid:22091590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22091590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of neurotherapeutics","raw_type":"Editorial"},{"id":"pmh:oai:repositorio.accefyn.org.co:001/3765","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.accefyn.org.co/handle/001/3765","pdf_url":null,"source":{"id":"https://openalex.org/S7407055250","display_name":"Repositorio Digital - Academia Colombiana de Ciencias Exactas, Fisicas y Naturales","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5400000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1657404554","https://openalex.org/W1986144956","https://openalex.org/W2020621266","https://openalex.org/W2034250070","https://openalex.org/W2060164680","https://openalex.org/W2102496376","https://openalex.org/W2111425471","https://openalex.org/W2128197886","https://openalex.org/W2129497119","https://openalex.org/W2131328232","https://openalex.org/W2135803915","https://openalex.org/W2150177485","https://openalex.org/W2154125779","https://openalex.org/W2162670762","https://openalex.org/W2171892383","https://openalex.org/W2319754722","https://openalex.org/W4247759744"],"related_works":["https://openalex.org/W2029883685","https://openalex.org/W2015888096","https://openalex.org/W7097649290","https://openalex.org/W2901791696","https://openalex.org/W3217557562","https://openalex.org/W2941198005","https://openalex.org/W4253035007","https://openalex.org/W2033178503","https://openalex.org/W2593846365","https://openalex.org/W3022707652"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1],"(AD)":[2],"is":[3],"a":[4],"complex":[5],"disorder":[6],"defined":[7],"at":[8],"the":[9,25],"molecular":[10],"level":[11],"by":[12],"tau":[13],"pathology":[14,20],"and":[15,29],"amyloid":[16],"aggregations":[17],"[1].":[18],"Tau":[19],"starts":[21],"in":[22],"regions":[23],"of":[24],"medial":[26],"temporal":[27],"lobe,":[28],"amyloid...":[30]},"counts_by_year":[{"year":2018,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}