{"id":"https://openalex.org/W2105956205","doi":"https://doi.org/10.1086/302366","title":"Modification of BRCA1-Associated Breast Cancer Risk by the Polymorphic Androgen-Receptor CAG Repeat","display_name":"Modification of BRCA1-Associated Breast Cancer Risk by the Polymorphic Androgen-Receptor CAG Repeat","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W2105956205","doi":"https://doi.org/10.1086/302366","mag":"2105956205","pmid":"https://pubmed.ncbi.nlm.nih.gov/10205268","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1377873"},"language":"en","primary_location":{"id":"doi:10.1086/302366","doi":"https://doi.org/10.1086/302366","is_oa":true,"landing_page_url":"https://doi.org/10.1086/302366","pdf_url":null,"source":{"id":"https://openalex.org/S134425043","display_name":"The American Journal of Human Genetics","issn_l":"0002-9297","issn":["0002-9297","1537-6605"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Human Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1086/302366","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074868327","display_name":"Timothy Richard Rebbeck","orcid":"https://orcid.org/0000-0002-4799-1900","observed_orcids":["https://orcid.org/0000-0002-4799-1900"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy R. Rebbeck","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA. rebbeck@cceb.med.upenn.edu rebbeck@cceb.med.upenn.edu","Department of Biostatistics and Epidemiology, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA. rebbeck@cceb.med.upenn.edu rebbeck@cceb.med.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, Philadelphia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056766924","display_name":"Philip W. Kantoff","orcid":"https://orcid.org/0000-0001-7275-0597","observed_orcids":["https://orcid.org/0000-0001-7275-0597"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip W. Kantoff","raw_affiliation_strings":["Department of Adult Oncology, Harvard Medical School, Boston","Lank Center for Genitourinary Cancer, Dana-Farber Cancer Institute, Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Lank Center for Genitourinary Cancer, Dana-Farber Cancer Institute, Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002933047","display_name":"Krishna Krithivas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna Krithivas","raw_affiliation_strings":["Department of Adult Oncology, Harvard Medical School, Boston","Lank Center for Genitourinary Cancer, Dana-Farber Cancer Institute, Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Lank Center for Genitourinary Cancer, Dana-Farber Cancer Institute, Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062123247","display_name":"Susan L. Neuhausen","orcid":"https://orcid.org/0000-0001-5053-0390","observed_orcids":["https://orcid.org/0000-0001-5053-0390"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Neuhausen","raw_affiliation_strings":["University of Utah, Salt Lake City, Creighton University, Omaha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City, Creighton University, Omaha","institution_ids":["https://openalex.org/I114493937","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013408278","display_name":"M. Anne Blackwood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Anne Blackwood","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, Philadelphia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033625395","display_name":"Andrew K. Godwin","orcid":"https://orcid.org/0000-0002-3987-9580","observed_orcids":["https://orcid.org/0000-0002-3987-9580"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew K. Godwin","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107933751","display_name":"Mary B. Daly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary B. Daly","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088516335","display_name":"Steven Alexander Narod","orcid":"https://orcid.org/0000-0001-5798-0626","observed_orcids":["https://orcid.org/0000-0001-5798-0626"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I2801816099","display_name":"Women's College Hospital","ror":"https://ror.org/03cw63y62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801816099"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Steven A. Narod","raw_affiliation_strings":["Women's College Hospital, Toronto, Creighton University, Omaha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's College Hospital, Toronto, Creighton University, Omaha","institution_ids":["https://openalex.org/I114493937","https://openalex.org/I2801816099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005206482","display_name":"Judy Ellen Garber","orcid":"https://orcid.org/0000-0001-9449-3982","observed_orcids":["https://orcid.org/0000-0001-9449-3982"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judy E. Garber","raw_affiliation_strings":["Department of Adult Oncology, Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111409806","display_name":"Henry T. Lynch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry T. Lynch","raw_affiliation_strings":["Department of Preventive Medicine, Creighton University, Omaha"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Creighton University, Omaha","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Barbara L. Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara L. Weber","raw_affiliation_strings":["Medicine and Genetics, University of Pennsylvania School of Medicine, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine and Genetics, University of Pennsylvania School of Medicine, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033532061","display_name":"Myles A Brown","orcid":"https://orcid.org/0000-0002-8213-1658","observed_orcids":["https://orcid.org/0000-0002-8213-1658"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myles Brown","raw_affiliation_strings":["Department of Adult Oncology, Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5074868327"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":5150,"currency":"USD","value_usd":5150},"apc_paid":{"value":5150,"currency":"USD","value_usd":5150},"fwci":18.1353,"has_fulltext":false,"cited_by_count":252,"citation_normalized_percentile":{"value":0.99633713,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"64","issue":"5","first_page":"1371","last_page":"1377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.8399999737739563},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.878000020980835},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.968999981880188},{"id":"https://openalex.org/keywords/cag-repeat-polymorphism","display_name":"CAG repeat polymorphism","score":0.9729999899864197},{"id":"https://openalex.org/keywords/germline-mutation-carriers","display_name":"germline mutation carriers","score":0.8939999938011169},{"id":"https://openalex.org/keywords/age-at-breast-cancer-diagnosis","display_name":"age at breast cancer diagnosis","score":0.746999979019165},{"id":"https://openalex.org/keywords/androgen-signaling","display_name":"androgen signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hormone-signaling","display_name":"hormone signaling","score":0.7039999961853027},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6000000238418579},{"id":"https://openalex.org/keywords/exon-1","display_name":"exon 1","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.8364253044128418},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6282784938812256},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4622464179992676},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43195903301239014},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4102638065814972},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40654420852661133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3919917643070221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3758429288864136},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27494603395462036},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.2382267415523529}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018911","descriptor_name":"Trinucleotide Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019398","descriptor_name":"Genes, BRCA1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1086/302366","doi":"https://doi.org/10.1086/302366","is_oa":true,"landing_page_url":"https://doi.org/10.1086/302366","pdf_url":null,"source":{"id":"https://openalex.org/S134425043","display_name":"The American Journal of Human Genetics","issn_l":"0002-9297","issn":["0002-9297","1537-6605"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Human Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1377873","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1377873","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},{"id":"pmid:10205268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10205268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.574.2728","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.574.2728","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://research4.dfci.harvard.edu/brownlab/pdf_files/1999_Rebbeck.pdf","raw_type":"text"},{"id":"pmh:oai:cdr.creighton.edu:10504/90892","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1086/302366","pdf_url":null,"source":{"id":"https://openalex.org/S7407097583","display_name":"Creighton Digital Repository (CDR)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114493937","host_organization_name":"Creighton University","host_organization_lineage":["https://openalex.org/I114493937"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1086/302366","doi":"https://doi.org/10.1086/302366","is_oa":true,"landing_page_url":"https://doi.org/10.1086/302366","pdf_url":null,"source":{"id":"https://openalex.org/S134425043","display_name":"The American Journal of Human Genetics","issn_l":"0002-9297","issn":["0002-9297","1537-6605"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Human Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1899749387","display_name":null,"funder_award_id":"CA-57601","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2155871650","display_name":null,"funder_award_id":"ES97939","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2262219777","display_name":null,"funder_award_id":"CA737370","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G963233551","display_name":"ISOLATION/ANALYSIS OF BREAST CANCER SUSCEPTIBLITY GENES","funder_award_id":"5r01ca057601-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W121553317","https://openalex.org/W1578641183","https://openalex.org/W1753444892","https://openalex.org/W1974957530","https://openalex.org/W1996261313","https://openalex.org/W1998476721","https://openalex.org/W2000564958","https://openalex.org/W2012658469","https://openalex.org/W2023654765","https://openalex.org/W2026268878","https://openalex.org/W2032432671","https://openalex.org/W2058064521","https://openalex.org/W2070998674","https://openalex.org/W2101065984","https://openalex.org/W2106583119","https://openalex.org/W2113333419","https://openalex.org/W2114957848","https://openalex.org/W2134669147","https://openalex.org/W2145924652","https://openalex.org/W2161103103","https://openalex.org/W2328105863","https://openalex.org/W4237795599","https://openalex.org/W4247097759","https://openalex.org/W6680338339","https://openalex.org/W7027411597"],"related_works":["https://openalex.org/W1897413751","https://openalex.org/W2100816669","https://openalex.org/W2093144760","https://openalex.org/W2089975383","https://openalex.org/W2169491071","https://openalex.org/W2079506269","https://openalex.org/W2007346798","https://openalex.org/W2143661312","https://openalex.org/W2139180751","https://openalex.org/W2017045205"],"abstract_inverted_index":{"Compared":[0],"with":[1,89,115,142,192],"the":[2,13,33,55,63,66,75,201,231],"general":[3],"population,":[4],"women":[5,101,114,118,125,169,181],"who":[6,102,147,170,185,215],"have":[7,16],"inherited":[8,103],"a":[9,17,90,98,160],"germline":[10,104],"mutation":[11,40,213],"in":[12,32,50,71,112,182],"BRCA1":[14,39,105,212],"gene":[15,78],"greatly":[18],"increased":[19,129],"risk":[20,130,232],"of":[21,35,65,74,100,131,152,233],"developing":[22],"breast":[23,36,58,120,132,196,206,235],"cancer.":[24,121,197,236],"However,":[25],"there":[26],"is":[27,209],"also":[28],"substantial":[29],"interindividual":[30],"variability":[31],"occurrence":[34],"cancer":[37,59,133,207],"among":[38,211],"carriers.":[41],"We":[42,61,122],"hypothesize":[43],"that":[44,124,203,224],"other":[45],"genes,":[46],"particularly":[47],"those":[48],"involved":[49],"endocrine":[51],"signaling,":[52],"may":[53,229],"modify":[54],"BRCA1-associated":[56,234],"age-specific":[57],"risk.":[60],"studied":[62],"effect":[64],"CAG":[67,84,144],"repeat-length":[68],"polymorphism":[69],"found":[70,123],"exon":[72],"1":[73],"androgen-receptor":[76],"(AR)":[77],"(AR-CAG).":[79],"AR":[80,140],"alleles":[81],"containing":[82],"longer":[83],"repeat":[85,110],"lengths":[86],"are":[87],"associated":[88],"decreased":[91],"ability":[92],"to":[93],"activate":[94],"androgen-responsive":[95],"genes.":[96],"Using":[97],"sample":[99,184],"mutations,":[106],"we":[107],"compared":[108],"AR-CAG":[109,150,190,219],"length":[111],"165":[113],"and":[116],"139":[117],"without":[119],"were":[126,158],"at":[127,137,174,187,205],"significantly":[128],"if":[134],"they":[135],"carried":[136,148,186],"least":[138,175,188],"one":[139,176,189],"allele":[141,151,191],">/=28":[143],"repeats.":[145,220],"Women":[146],"an":[149],">/=28,":[153],">/=29,":[154],"or":[155,164],">/=30":[156],"repeats":[157,194],"given":[159],"diagnosis":[161,208],"0.8,":[162],"1.8,":[163],"6.3":[165],"years":[166],"earlier":[167,210],"than":[168],"did":[171],"not":[172],"carry":[173,216],"such":[177],"allele.":[178],"All":[179],"11":[180],"our":[183],">/=29":[193],"had":[195],"Our":[198],"results":[199,222],"support":[200],"hypothesis":[202],"age":[204],"carriers":[214],"very":[217],"long":[218],"These":[221],"suggest":[223],"pathways":[225],"involving":[226],"androgen":[227],"signaling":[228],"affect":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}