{"id":"https://openalex.org/W2105947281","doi":"https://doi.org/10.1128/iai.19.3.867-874.1978","title":"Lymphocyte blastogenic responses to influenza virus antigens after influenza infection and vaccination in humans","display_name":"Lymphocyte blastogenic responses to influenza virus antigens after influenza infection and vaccination in humans","publication_year":1978,"publication_date":"1978-03-01","ids":{"openalex":"https://openalex.org/W2105947281","doi":"https://doi.org/10.1128/iai.19.3.867-874.1978","mag":"2105947281","pmid":"https://pubmed.ncbi.nlm.nih.gov/640733","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/422269"},"language":"en","primary_location":{"id":"doi:10.1128/iai.19.3.867-874.1978","doi":"https://doi.org/10.1128/iai.19.3.867-874.1978","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.19.3.867-874.1978","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC422269","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110272121","display_name":"Raphael Dolin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Dolin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062733502","display_name":"Brian R. Murphy","orcid":"https://orcid.org/0000-0002-3771-5283","observed_orcids":["https://orcid.org/0000-0002-3771-5283"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B R Murphy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088271841","display_name":"Ellis A. Caplan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E A Caplan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6042,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.94177732,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"19","issue":"3","first_page":"867","last_page":"874"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.871999979019165},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/inactivated-influenza-vaccine","display_name":"inactivated influenza vaccine","score":0.8659999966621399},{"id":"https://openalex.org/keywords/hemagglutinin-subtypes","display_name":"hemagglutinin subtypes","score":0.7730000019073486},{"id":"https://openalex.org/keywords/neuraminidase-subtypes","display_name":"neuraminidase subtypes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/h3n2","display_name":"H3N2","score":0.628000020980835},{"id":"https://openalex.org/keywords/virus-specific-immune-response","display_name":"virus-specific immune response","score":0.5320000052452087},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.6589999794960022},{"id":"https://openalex.org/keywords/vaccine-induced-antibody-response","display_name":"vaccine-induced antibody response","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7675365209579468},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7425513863563538},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7159363031387329},{"id":"https://openalex.org/C134164806","wikidata":"https://www.wikidata.org/wiki/Q409485","display_name":"Neuraminidase","level":3,"score":0.662647008895874},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.6552762985229492},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6359158158302307},{"id":"https://openalex.org/C2781416681","wikidata":"https://www.wikidata.org/wiki/Q287246","display_name":"Orthomyxoviridae","level":4,"score":0.6042178273200989},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5533381700515747},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5167704820632935},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5108177661895752},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4900990426540375},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4648657441139221},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4372369945049286},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.32203274965286255}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006385","descriptor_name":"Hemagglutination Inhibition Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006389","descriptor_name":"Hemagglutinins, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009439","descriptor_name":"Neuraminidase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.19.3.867-874.1978","doi":"https://doi.org/10.1128/iai.19.3.867-874.1978","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.19.3.867-874.1978","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:27786","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC422269","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:422269","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/422269","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:640733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/640733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:27786","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC422269","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W141710187","https://openalex.org/W1410972655","https://openalex.org/W1845926440","https://openalex.org/W1935466217","https://openalex.org/W1953832000","https://openalex.org/W1954718724","https://openalex.org/W1978708112","https://openalex.org/W1998170980","https://openalex.org/W2005463778","https://openalex.org/W2006946258","https://openalex.org/W2020850769","https://openalex.org/W2046669246","https://openalex.org/W2059544899","https://openalex.org/W2073471802","https://openalex.org/W2074421553","https://openalex.org/W2075822499","https://openalex.org/W2077235770","https://openalex.org/W2083784303","https://openalex.org/W2099829129","https://openalex.org/W2133980753","https://openalex.org/W2149995314","https://openalex.org/W2152169043","https://openalex.org/W2161099850","https://openalex.org/W2163885304","https://openalex.org/W2179678549","https://openalex.org/W2322875587","https://openalex.org/W2397881023","https://openalex.org/W2411938839","https://openalex.org/W2414802006"],"related_works":["https://openalex.org/W2411947233","https://openalex.org/W2133980753","https://openalex.org/W2074368202","https://openalex.org/W2110944190","https://openalex.org/W2043173519","https://openalex.org/W7098581327","https://openalex.org/W1849408080","https://openalex.org/W2113032412","https://openalex.org/W2073915438","https://openalex.org/W2073471802"],"abstract_inverted_index":{"Virus-specific":[0],"in":[1,8,22,84,138,163],"vitro":[2,85],"cell-mediated":[3,157],"immune":[4],"responses":[5,135,154],"were":[6,13,26,39,81,96,136],"investigated":[7],"20":[9],"normal":[10],"volunteers":[11,24],"who":[12,25,143],"challenged":[14],"with":[15,28,66,87,118,170],"liver":[16],"influenza":[17,70,171],"A/VIC/3/75":[18],"(H3N2)":[19,100],"virus":[20,119],"and":[21,33,48,92,168],"13":[23],"vaccinated":[27],"inactivated":[29],"vaccine":[30],"containing":[31],"A/VIC":[32],"A/NJ/8/76":[34],"(HswN1)":[35],"antigens.":[36],"Lymphocyte":[37],"cultures":[38,65,140],"established":[40],"from":[41,104,141],"peripheral":[42],"blood":[43],"samples":[44],"obtained":[45],"prior":[46],"to":[47],"at":[49],"various":[50],"times":[51],"after":[52,62,74,83,148,166],"infection":[53,167],"or":[54,101,106],"vaccination.":[55,149],"Blastogenesis":[56],"was":[57,116],"determined":[58],"by":[59],"[3H]thymidine":[60],"incorporation":[61],"stimulation":[63,86,115],"of":[64,79,90,109,120,152],"purified,":[67],"inactivated,":[68],"whole":[69],"viruses.":[71],"Six":[72],"days":[73],"infection,":[75],"significantly":[76],"elevated":[77],"levels":[78],"blastogenesis":[80],"observed":[82],"A":[88],"viruses":[89],"hemagglutinin":[91,123],"neuraminidase":[93],"subtypes":[94],"that":[95,156],"the":[97,110,121,127],"same":[98,122],"as":[99,126],"antigenically":[102],"distinct":[103],"(Heq1Neq1":[105],"HswN1)":[107],"those":[108],"challenge":[111,128],"virus,":[112],"although":[113,131],"maximum":[114],"noted":[117,137],"subtype":[124],"(H3)":[125],"virus.":[129,172],"Similar":[130],"more":[132],"prolonged":[133],"blastogenic":[134],"lymphocyte":[139],"vaccinees":[142],"had":[144],"serum":[145],"antibody":[146],"rises":[147],"The":[150],"kinetics":[151],"these":[153],"suggest":[155],"immunity":[158],"may":[159],"play":[160],"a":[161],"role":[162],"early":[164],"events":[165],"vaccination":[169]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}