{"id":"https://openalex.org/W2105934277","doi":null,"title":"Drg1, a novel target for modulating sensitivity to CPT-11 in colon cancer cells.","display_name":"Drg1, a novel target for modulating sensitivity to CPT-11 in colon cancer cells.","publication_year":2002,"publication_date":"2002-07-15","ids":{"openalex":"https://openalex.org/W2105934277","mag":"2105934277","pmid":"https://pubmed.ncbi.nlm.nih.gov/12124325"},"language":"en","primary_location":{"id":"pmid:12124325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12124325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103552874","display_name":"Monica Motwani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Motwani","raw_affiliation_strings":["Gastrointestinal Oncology Research Laboratory, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Oncology Research Laboratory, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066518191","display_name":"Francis M. Sirotnak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francis M Sirotnak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085810259","display_name":"Yuhong She","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuhong She","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033671208","display_name":"Th\u00e9r\u00e8se Commes","orcid":"https://orcid.org/0000-0002-7918-0176","observed_orcids":["https://orcid.org/0000-0002-7918-0176"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Therese Commes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006913373","display_name":"Gary K. Schwartz","orcid":"https://orcid.org/0000-0003-1813-5061","observed_orcids":["https://orcid.org/0000-0003-1813-5061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary K Schwartz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9524,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.85835669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"62","issue":"14","first_page":"3950","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drg1","display_name":"DRG1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.7149999737739563},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.8610000014305115},{"id":"https://openalex.org/keywords/sn-38","display_name":"SN-38","score":0.9610000252723694},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7839999794960022},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/g2-cell-cycle-arrest","display_name":"G2 cell cycle arrest","score":0.9340000152587891},{"id":"https://openalex.org/keywords/flavopiridol","display_name":"flavopiridol","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/sw620-cells","display_name":"SW620 cells","score":0.9559999704360962},{"id":"https://openalex.org/keywords/antisense-gene-expression","display_name":"antisense gene expression","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8572374582290649},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7531849145889282},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.7304044365882874},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5371293425559998},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5085502862930298},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5028614401817322},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4937661588191986},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45539823174476624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4492812752723694},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33852696418762207},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25882020592689514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1219930648803711},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06568464636802673}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016373","descriptor_name":"DNA, Antisense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016373","descriptor_name":"DNA, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12124325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12124325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.980.5573","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.980.5573","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hwmaint.cancerres.aacrjournals.org/cgi/reprint/62/14/3950.pdf","raw_type":"text"},{"id":"mag:2105934277","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12124325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7205842776","display_name":"Clinical Trials of Flavopiridol with Chemotherapy","funder_award_id":"R01CA067819","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W77262767","https://openalex.org/W1605281376","https://openalex.org/W1751787421","https://openalex.org/W1831102019","https://openalex.org/W1835830368","https://openalex.org/W1893406814","https://openalex.org/W1908304664","https://openalex.org/W1959988533","https://openalex.org/W1982097971","https://openalex.org/W1990206463","https://openalex.org/W2005354295","https://openalex.org/W2038809726","https://openalex.org/W2046887163","https://openalex.org/W2053718134","https://openalex.org/W2054268096","https://openalex.org/W2059956556","https://openalex.org/W2070214589","https://openalex.org/W2078751203","https://openalex.org/W2084147994","https://openalex.org/W2097555718","https://openalex.org/W2140224514","https://openalex.org/W2142101377","https://openalex.org/W2171465492","https://openalex.org/W2314927739"],"related_works":["https://openalex.org/W7097795222","https://openalex.org/W1959988533","https://openalex.org/W2059224614","https://openalex.org/W2329218979","https://openalex.org/W2377453202","https://openalex.org/W2325099755","https://openalex.org/W2792787940","https://openalex.org/W2412431550","https://openalex.org/W7097671050","https://openalex.org/W3043809546"],"abstract_inverted_index":{"Treatment":[0],"of":[1,13,23,28,37,73,83,92,120,128,136,211,222],"the":[2,38,90,112,125,134,220],"human":[3],"colon":[4,223],"cancer":[5,224],"cells":[6,31,59,79,93,106,132,138,152,173,187,225],"Hct116":[7,30,58,78,151,164],"with":[8,32,103,122,161,181],"SN-38":[9,47,53,70],"(an":[10],"active":[11],"metabolite":[12],"CPT-11)":[14],"resulted":[15],"in":[16,57,77,111,118,130,147,188,206],"G2":[17],"cell":[18,43],"cycle":[19,44],"arrest":[20,45],"without":[21],"induction":[22,119],"apoptosis.":[24,35],"However,":[25],"subsequent":[26],"treatment":[27],"SN-38-treated":[29],"flavopiridol":[33,56],"induced":[34],"One":[36],"genes":[39],"markedly":[40],"up-regulated":[41],"during":[42,50],"by":[46,52,55,80,97,142],"and":[48,100,114],"suppressed":[49],"apoptosis":[51,96,101,121,141],"followed":[54],"is":[60,197],"Drg1.":[61],"We":[62],"found":[63],"that":[64,195,201],"Drg1":[65,75,87,129,170,196,212],"had":[66],"profound":[67],"effects":[68],"on":[69],"sensitivity.":[71],"Inhibition":[72,210],"endogenous":[74],"expression":[76,82,127],"stable":[81],"an":[84],"antisense":[85],"(AS)":[86],"cDNA":[88],"increased":[89,133],"sensitivity":[91,221],"to":[94,139,157,177,208,218,226],"undergo":[95],"SN-38.":[98,123],"Clonogenic":[99],"assays":[102],"AS":[104,149],"Drg1-expressing":[105,150],"showed":[107],"a":[108,115,198,203,215],"2-fold":[109],"decrease":[110],"IC50":[113],"4-5-fold":[116],"increase":[117,219],"Conversely,":[124],"forced":[126],"SW620":[131,172,186],"resistance":[135,207],"these":[137],"SN-38-induced":[140],"2-5-fold.":[143],"Moreover,":[144],"when":[145],"xenografted":[146],"mice,":[148],"were":[153,174],"3-fold":[154],"more":[155,175],"sensitive":[156],"CPT-11":[158,178],"as":[159,179],"compared":[160,180],"vector":[162],"transfected":[163],"cells.":[165],"Similarly,":[166],"tumors":[167,182],"established":[168,183],"from":[169,184],"overexpressing":[171],"resistant":[176],"vector-transfected":[185],"mice.":[189],"Taken":[190],"together,":[191],"our":[192],"data":[193],"suggest":[194],"novel":[199],"gene":[200],"plays":[202],"direct":[204],"role":[205],"CPT-11.":[209,227],"may":[213],"provide":[214],"new":[216],"means":[217]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
