{"id":"https://openalex.org/W2105889936","doi":null,"title":"Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8.","display_name":"Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8.","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2105889936","mag":"2105889936","pmid":"https://pubmed.ncbi.nlm.nih.gov/12855659"},"language":"en","primary_location":{"id":"pmid:12855659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12855659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029797576","display_name":"Takashi Karashima","orcid":"https://orcid.org/0000-0001-7338-8059","observed_orcids":["https://orcid.org/0000-0001-7338-8059","https://orcid.org/0009-0009-7227-8531"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takashi Karashima","raw_affiliation_strings":["Departments of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112468575","display_name":"Paul Sweeney","orcid":"https://orcid.org/0009-0002-7504-0253","observed_orcids":["https://orcid.org/0009-0002-7504-0253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Sweeney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034005227","display_name":"Ashish M. Kamat","orcid":"https://orcid.org/0000-0003-3546-9928","observed_orcids":["https://orcid.org/0000-0003-3546-9928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashish Kamat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004378997","display_name":"Suyun Huang","orcid":"https://orcid.org/0000-0001-7682-2631","observed_orcids":["https://orcid.org/0000-0001-7682-2631","https://orcid.org/0000-0002-1602-2832"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suyun Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100785065","display_name":"Sun Jung Kim","orcid":"https://orcid.org/0000-0001-6818-3956","observed_orcids":["https://orcid.org/0000-0001-6818-3956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sun J Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108608169","display_name":"Menashe Bar\u2010Eli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Menashe Bar-Eli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059536506","display_name":"David James McConkey","orcid":"https://orcid.org/0000-0003-1971-0638","observed_orcids":["https://orcid.org/0000-0003-1971-0638"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J McConkey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002737792","display_name":"Colin P. Dinney","orcid":"https://orcid.org/0000-0002-8969-711X","observed_orcids":["https://orcid.org/0000-0002-8969-711X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colin P N Dinney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2767,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.88119203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"7","first_page":"2786","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.08730000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8830000162124634},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.968999981880188},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.8309999704360962},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8230000138282776},{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ikappabalpha","display_name":"I\u03baB\u03b1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/activator-protein-1","display_name":"activator protein-1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.5690000057220459},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7061944007873535},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6335304975509644},{"id":"https://openalex.org/C68324877","wikidata":"https://www.wikidata.org/wiki/Q421859","display_name":"Interleukin 8","level":3,"score":0.5940614938735962},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5574352741241455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.555512011051178},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47894150018692017},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4652363359928131},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.46054571866989136},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.43781623244285583},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4351285398006439},{"id":"https://openalex.org/C11957725","wikidata":"https://www.wikidata.org/wiki/Q5533590","display_name":"Gentamicin protection assay","level":4,"score":0.42045852541923523},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2985023856163025},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25958123803138733},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.227149099111557},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13349655270576477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05865797400474548},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12855659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12855659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2105889936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12855659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2310867924","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000386701?l=ja","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5380964245","display_name":"SPORE in Genitourinary Cancer","funder_award_id":"P50CA091846","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W95988660","https://openalex.org/W103495436","https://openalex.org/W149707854","https://openalex.org/W158236942","https://openalex.org/W1042403926","https://openalex.org/W1481925502","https://openalex.org/W1492381941","https://openalex.org/W1495743471","https://openalex.org/W1532257606","https://openalex.org/W1534395710","https://openalex.org/W1570230480","https://openalex.org/W1594458791","https://openalex.org/W1607406251","https://openalex.org/W1661592221","https://openalex.org/W1829804413","https://openalex.org/W1866793215","https://openalex.org/W1915074145","https://openalex.org/W1926342466","https://openalex.org/W1934086060","https://openalex.org/W1956944003","https://openalex.org/W1964167504","https://openalex.org/W1964228939","https://openalex.org/W1970159513","https://openalex.org/W1973562827","https://openalex.org/W1976441097","https://openalex.org/W1983668987","https://openalex.org/W1994835768","https://openalex.org/W1999334756","https://openalex.org/W2007200118","https://openalex.org/W2010601153","https://openalex.org/W2026158949","https://openalex.org/W2027193300","https://openalex.org/W2029790299","https://openalex.org/W2033080437","https://openalex.org/W2035280748","https://openalex.org/W2035907364","https://openalex.org/W2037785089","https://openalex.org/W2045793427","https://openalex.org/W2051819610","https://openalex.org/W2056088187","https://openalex.org/W2061903251","https://openalex.org/W2068197542","https://openalex.org/W2070853191","https://openalex.org/W2072036820","https://openalex.org/W2079906459","https://openalex.org/W2083308557","https://openalex.org/W2083430194","https://openalex.org/W2088377055","https://openalex.org/W2091695331","https://openalex.org/W2093098202","https://openalex.org/W2096801163","https://openalex.org/W2097983921","https://openalex.org/W2101064494","https://openalex.org/W2102714295","https://openalex.org/W2108527315","https://openalex.org/W2116161064","https://openalex.org/W2116482468","https://openalex.org/W2118684251","https://openalex.org/W2121239154","https://openalex.org/W2122794487","https://openalex.org/W2126055089","https://openalex.org/W2141748646","https://openalex.org/W2145740856","https://openalex.org/W2145921423","https://openalex.org/W2147114673","https://openalex.org/W2150033965","https://openalex.org/W2150078035","https://openalex.org/W2151892297","https://openalex.org/W2152065691","https://openalex.org/W2157255230","https://openalex.org/W2166781237","https://openalex.org/W2166994863","https://openalex.org/W2171865516","https://openalex.org/W2181986476","https://openalex.org/W2314325548","https://openalex.org/W2319962899","https://openalex.org/W2331176038","https://openalex.org/W2336321455","https://openalex.org/W2397228914","https://openalex.org/W2399259556","https://openalex.org/W2427880780","https://openalex.org/W4300503127"],"related_works":["https://openalex.org/W2310867924","https://openalex.org/W2582020865","https://openalex.org/W2565273921","https://openalex.org/W1534395710","https://openalex.org/W1921956470","https://openalex.org/W16292151","https://openalex.org/W2021389034","https://openalex.org/W2026783331","https://openalex.org/W2373992446","https://openalex.org/W2404763684"],"abstract_inverted_index":{"PURPOSE:":[0],"Interleukin":[1],"(IL)-8":[2],"is":[3],"an":[4],"important":[5],"mediator":[6],"of":[7,17,32,47,56,64,106,115,131,213,226],"angiogenesis,":[8],"tumorigenicity,":[9],"and":[10,53,72,84,93,99,108,128,146,153,179,191,218,238],"metastasis":[11,194],"in":[12,27,49,112,174,184,197,235],"transitional":[13],"cell":[14,78,162],"carcinoma":[15],"(TCC)":[16],"the":[18,39,45,113,126,211,227,236],"bladder.":[19],"Nuclear":[20],"factor":[21],"kappaB":[22],"(NF-kappaB)/relA":[23],"regulates":[24,44],"IL-8":[25,48,65,69,116,150,214],"expression":[26,46,71,152],"several":[28],"neoplasms.":[29],"The":[30,104],"purpose":[31],"this":[33],"study":[34],"was":[35,118,171,208],"to":[36,232],"determine":[37],"whether":[38,54],"organ":[40],"microenvironment":[41,237],"(hypoxia,":[42],"acidosis)":[43],"TCC":[50,77,161],"via":[51],"NF-kappaB,":[52,165],"inhibition":[55,212],"NF-kappaB":[57,107,240],"function":[58],"by":[59,75,89,120,156],"mutant":[60,139,186,199],"IkappaB-alpha":[61,187,200],"prevents":[62],"induction":[63],"expression.":[66],"EXPERIMENTAL":[67],"DESIGN:":[68],"mRNA":[70,151],"protein":[73,110,154,169],"production":[74,117,155],"human":[76],"lines":[79,163],"(UM-UC-14,":[80],"HTB-9,":[81],"RT-4,":[82],"KU-7":[83],"253J":[85],"B-V)":[86],"were":[87,134,195],"measured":[88],"Northern":[90],"blot":[91],"analysis":[92],"ELISA":[94],"under":[95,176],"acidic":[96,145,178],"(pH":[97],"7.35-6.0)":[98],"hypoxic":[100,147,180],"(1.0%":[101],"O(2))":[102],"conditions.":[103],"involvement":[105],"activator":[109,168],"1":[111],"regulation":[114],"evaluated":[119],"electrophoretic":[121],"mobility":[122],"shift":[123],"assay.":[124],"Furthermore,":[125],"tumorigenicity":[127],"metastatic":[129],"potential":[130,243],"UM-UC-14":[132,175,185,198,204],"cells":[133],"determined":[135],"after":[136],"transfection":[137],"with":[138,203,210],"IkappaB-alpha.":[140],"RESULTS:":[141],"We":[142],"found":[143],"that":[144,224],"conditions":[148],"increased":[149],"several,":[157],"but":[158,166,182],"not":[159,167,183],"all,":[160],"evaluated.":[164],"1,":[170],"inducibly":[172],"activated":[173],"both":[177],"conditions,":[181],"transfectants.":[188],"Tumor":[189],"growth":[190],"lymph":[192],"node":[193],"inhibited":[196],"transfectants":[201],"compared":[202],"controls.":[205],"This":[206],"effect":[207],"associated":[209],"production,":[215],"cellular":[216],"proliferation,":[217],"angiogenesis.":[219],"CONCLUSIONS:":[220],"These":[221],"results":[222],"suggest":[223],"TCCs":[225],"bladder":[228],"have":[229],"heterogenic":[230],"responses":[231],"physicochemical":[233],"changes":[234],"identify":[239],"as":[241],"a":[242],"molecular":[244],"target":[245],"for":[246],"therapy.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}