{"id":"https://openalex.org/W2105874877","doi":null,"title":"Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.","display_name":"Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2105874877","mag":"2105874877","pmid":"https://pubmed.ncbi.nlm.nih.gov/10197639"},"language":"en","primary_location":{"id":"pmid:10197639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10197639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110103860","display_name":"Gillian M. Tozer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G M Tozer","raw_affiliation_strings":["Tumor Microcirculation Group, Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Microcirculation Group, Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom","institution_ids":["https://openalex.org/I2801038905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113931941","display_name":"Vivien E. Prise","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V E Prise","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Wilson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021972219","display_name":"Rosalind J. Locke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Locke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044642169","display_name":"Borivoj Vojnovic","orcid":"https://orcid.org/0000-0001-9013-3816","observed_orcids":["https://orcid.org/0000-0001-9013-3816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Vojnovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108397428","display_name":"M.R.L. Stratford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Stratford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111620270","display_name":"M.F. Dennis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M F Dennis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111866561","display_name":"David J. Chaplin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D J Chaplin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0334,"has_fulltext":false,"cited_by_count":323,"citation_normalized_percentile":{"value":0.97654932,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"59","issue":"7","first_page":"1626","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/combretastatin-a4-phosphate","display_name":"combretastatin A4 phosphate","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ca4","display_name":"CA4","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tumor-vascular-targeting","display_name":"tumor vascular targeting","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-perfusion","display_name":"tumor perfusion","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6299999952316284},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.8790000081062317},{"id":"https://openalex.org/keywords/normal-tissue-toxicity","display_name":"normal tissue toxicity","score":0.5189999938011169},{"id":"https://openalex.org/keywords/spleen-blood-flow","display_name":"spleen blood flow","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2778275628","wikidata":"https://www.wikidata.org/wiki/Q5150954","display_name":"Combretastatin","level":4,"score":0.864073634147644},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5901322960853577},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5628848075866699},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5217326879501343},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.47328752279281616},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.44663071632385254},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4416981637477875},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4304865598678589},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4272359311580658},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4254772663116455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3286079168319702},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3257771134376526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2629488706588745},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.10288602113723755},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10197639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10197639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2105874877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10197639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W29628264","https://openalex.org/W65585328","https://openalex.org/W76462616","https://openalex.org/W175938947","https://openalex.org/W1488333493","https://openalex.org/W1537080306","https://openalex.org/W1593154204","https://openalex.org/W1986774826","https://openalex.org/W1988721729","https://openalex.org/W1989115595","https://openalex.org/W1994297035","https://openalex.org/W1994303699","https://openalex.org/W2000719340","https://openalex.org/W2006273356","https://openalex.org/W2009953484","https://openalex.org/W2011233979","https://openalex.org/W2011953196","https://openalex.org/W2024130943","https://openalex.org/W2028187749","https://openalex.org/W2033535859","https://openalex.org/W2035532191","https://openalex.org/W2043297474","https://openalex.org/W2047280987","https://openalex.org/W2059620424","https://openalex.org/W2063326751","https://openalex.org/W2067593747","https://openalex.org/W2077851812","https://openalex.org/W2080861194","https://openalex.org/W2084179338","https://openalex.org/W2093672204","https://openalex.org/W2096025152","https://openalex.org/W2130906103","https://openalex.org/W2131798870","https://openalex.org/W2163308073","https://openalex.org/W2170446694","https://openalex.org/W2172230065","https://openalex.org/W2294376824","https://openalex.org/W2329509752","https://openalex.org/W2344697950","https://openalex.org/W2407397308","https://openalex.org/W2565067454","https://openalex.org/W2916412814","https://openalex.org/W2992175571","https://openalex.org/W4238316255"],"related_works":["https://openalex.org/W2026445504","https://openalex.org/W2147490767","https://openalex.org/W1639784955","https://openalex.org/W7099648738","https://openalex.org/W2374740109","https://openalex.org/W2294376824","https://openalex.org/W2065388753","https://openalex.org/W2004112610","https://openalex.org/W1725865716","https://openalex.org/W2109341852"],"abstract_inverted_index":{"The":[0,41,122,176,211,295],"potential":[1],"for":[2,153,223,328],"tumor":[3,30,38,85,113,173,180,209,214,248,257,307,335],"vascular-targeting":[4,336],"by":[5,66],"using":[6,259],"the":[7,28,34,50,67,125,149,169,192,195,204,226,239,264,277,322,329],"tubulin":[8],"destabilizing":[9],"agent":[10],"disodium":[11],"combretastatin":[12,300],"A-4":[13,301],"3-0-phosphate":[14],"(CA-4-P)":[15],"was":[16,64,75,124,303,319],"assessed":[17,48],"in":[18,49,56,84,95,112,134,148,160,172,191,208,247,255,272,306,309,321],"a":[19,57,92,108,131,260,334],"rat":[20],"system.":[21],"This":[22,229,274],"approach":[23],"aims":[24],"to":[25,33,77,317],"shut":[26],"down":[27],"established":[29],"vasculature,":[31],"leading":[32],"development":[35],"of":[36,45,59,69,81,141,187,194,206,225,234,243,279,297,315,331],"extensive":[37],"cell":[39,288],"necrosis.":[40],"early":[42],"vascular":[43,142,146,215,241,249],"effects":[44,242],"CA-4-P":[46,87,167,188,207,280,298,316,332],"were":[47,156,266],"s.c.":[51],"implanted":[52],"P22":[53],"carcinosarcoma":[54],"and":[55,72,102,107,151,292,299,313],"range":[58],"normal":[60,128,227],"tissues.":[61,228],"Blood":[62],"flow":[63,83,136],"measured":[65],"uptake":[68,296],"radiolabeled":[70],"iodoantipyrine,":[71],"quantitative":[73],"autoradiography":[74,164],"used":[76],"measure":[78],"spatial":[79,170],"heterogeneity":[80,171],"blood":[82,98,114,135,161,174],"sections.":[86],"(100":[88],"mg/kg":[89],"i.p.)":[90],"caused":[91],"significant":[93,158],"increase":[94],"mean":[96],"arterial":[97],"pressure":[99],"at":[100,137],"1":[101],"6":[103,117,138],"h":[104],"after":[105],"treatment":[106],"very":[109],"large":[110],"decrease":[111],"flow,":[115],"which-by":[116],"h-was":[118],"reduced":[119],"approximately":[120],"100-fold.":[121],"spleen":[123],"most":[126],"affected":[127,178],"tissue":[129,232,312],"with":[130,219],"7-fold":[132,222],"reduction":[133],"h.":[139],"Calculations":[140],"resistance":[143,216,250],"revealed":[144],"some":[145],"changes":[147,159,246,265],"heart":[150],"kidney":[152],"which":[154],"there":[155],"no":[157],"flow.":[162,175],"Quantitative":[163],"showed":[165],"that":[166,231,276],"increased":[168,213],"drug":[177],"peripheral":[179],"regions":[181],"less":[182,220,268],"than":[183,221,269,284,308],"central":[184],"regions.":[185],"Administration":[186],"(30":[189],"mg/kg)":[190],"presence":[193],"nitric":[196,235],"oxide":[197,236],"synthase":[198],"inhibitor,":[199],"N(omega)-nitro-L-arginine":[200],"methyl":[201],"ester,":[202],"potentiated":[203],"effect":[205],"tissue.":[210],"combination":[212],"300-fold":[217],"compared":[218],"any":[224],"shows":[230,275],"production":[233],"protects":[237],"against":[238],"damaging":[240],"CA-4-P.":[244],"Significant":[245],"could":[251],"also":[252],"be":[253],"obtained":[254],"isolated":[256],"perfusions":[258],"cell-free":[261],"perfusate,":[262],"although":[263],"much":[267],"those":[270,285],"observed":[271],"vivo.":[273],"action":[278],"includes":[281],"mechanisms":[282],"other":[283],"involving":[286],"red":[287],"viscosity,":[289],"intravascular":[290],"coagulation,":[291],"neutrophil":[293],"adhesion.":[294],"(CA-4)":[302],"more":[304],"efficient":[305],"skeletal":[310],"muscle":[311],"dephosphorylation":[314],"CA-4":[318],"faster":[320],"former.":[323],"These":[324],"results":[325],"are":[326],"promising":[327],"use":[330],"as":[333],"agent.":[337]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
