{"id":"https://openalex.org/W2105841559","doi":"https://doi.org/10.1128/jvi.76.9.4634-4642.2002","title":"Highly Stable Trimers Formed by Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Fused with the Trimeric Motif of T4 Bacteriophage Fibritin","display_name":"Highly Stable Trimers Formed by Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Fused with the Trimeric Motif of T4 Bacteriophage Fibritin","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2105841559","doi":"https://doi.org/10.1128/jvi.76.9.4634-4642.2002","mag":"2105841559","pmid":"https://pubmed.ncbi.nlm.nih.gov/11932429","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/155086"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.76.9.4634-4642.2002","doi":"https://doi.org/10.1128/jvi.76.9.4634-4642.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.76.9.4634-4642.2002","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/155086","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111810820","display_name":"Xinzhen Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinzhen Yang","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute","Department of Pathology, Division of AIDS, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Pathology, Division of AIDS, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078995179","display_name":"Juliette Lee","orcid":"https://orcid.org/0009-0000-4088-9607","observed_orcids":["https://orcid.org/0009-0000-4088-9607"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliette Lee","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016370772","display_name":"Erin M. Mahony","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin M. Mahony","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043677118","display_name":"Peter D. Kwong","orcid":"https://orcid.org/0000-0003-3560-232X","observed_orcids":["https://orcid.org/0000-0003-3560-232X"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter D. Kwong","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032","Structural Biology Section"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Structural Biology Section","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037123473","display_name":"Richard T. Wyatt","orcid":"https://orcid.org/0000-0001-7085-1351","observed_orcids":["https://orcid.org/0000-0001-7085-1351"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405268911","display_name":"Vaccine Research Center","ror":"https://ror.org/02fve6a73","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268911"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Wyatt","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute","Laboratory of Structural Virology, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Laboratory of Structural Virology, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405268911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071476197","display_name":"Joseph Sodroski","orcid":"https://orcid.org/0000-0002-9750-1615","observed_orcids":["https://orcid.org/0000-0002-9750-1615"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph Sodroski","raw_affiliation_strings":["Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute","Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115","Department of Pathology, Division of AIDS, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Division of AIDS, Harvard Medical School","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5071476197"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":5.4063,"has_fulltext":false,"cited_by_count":277,"citation_normalized_percentile":{"value":0.97366185,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"76","issue":"9","first_page":"4634","last_page":"4642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-envelope-glycoprotein","display_name":"HIV-1 envelope glycoprotein","score":0.953000009059906},{"id":"https://openalex.org/keywords/gp120","display_name":"gp120","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gp41","display_name":"gp41","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.7599999904632568},{"id":"https://openalex.org/keywords/antibody-binding","display_name":"antibody binding","score":0.6539999842643738},{"id":"https://openalex.org/keywords/six-helix-bundle","display_name":"six-helix bundle","score":0.781000018119812},{"id":"https://openalex.org/keywords/epitopes","display_name":"antigenic determinants","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.8580195903778076},{"id":"https://openalex.org/C2776258796","wikidata":"https://www.wikidata.org/wiki/Q5590520","display_name":"Gp41","level":4,"score":0.804496705532074},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.685104489326477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.619045615196228},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.4885026216506958},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46621400117874146},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.46094852685928345},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.44856569170951843},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.43524760007858276},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.384552538394928},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3623313009738922},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.27730268239974976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20093059539794922},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.1890793740749359},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1343112587928772},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.07622453570365906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07224306464195251},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015700","descriptor_name":"HIV Envelope Protein gp41","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015700","descriptor_name":"HIV Envelope Protein gp41","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015700","descriptor_name":"HIV Envelope Protein gp41","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.76.9.4634-4642.2002","doi":"https://doi.org/10.1128/jvi.76.9.4634-4642.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.76.9.4634-4642.2002","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1265102","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/155086","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:155086","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/155086","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:11932429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11932429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1265102","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/155086","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1049814011","display_name":"HIV-1 Envelope Glycoproteins","funder_award_id":"R37AI024755","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1794871384","display_name":"Molecular Studies of HIV1 Neutralizing Antibodies","funder_award_id":"R01AI031783","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3193714930","display_name":null,"funder_award_id":"AI 24755","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3881889837","display_name":"DFCI-BIDMC-CH CENTER FOR AIDS RESEARCH","funder_award_id":"P30AI028691","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3949682742","display_name":"TOPOLOGICAL ANALYSIS OF HIV-1 ENVELOPE GLYCOPROTEINS","funder_award_id":"R01AI039420","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W82820957","https://openalex.org/W1512910131","https://openalex.org/W1517203114","https://openalex.org/W1607434342","https://openalex.org/W1708167719","https://openalex.org/W1762774688","https://openalex.org/W1794879226","https://openalex.org/W1830489709","https://openalex.org/W1837383530","https://openalex.org/W1965019797","https://openalex.org/W1965378596","https://openalex.org/W1968301751","https://openalex.org/W1971777539","https://openalex.org/W1973581581","https://openalex.org/W1974053173","https://openalex.org/W1974092202","https://openalex.org/W1974980673","https://openalex.org/W1977074400","https://openalex.org/W1981164507","https://openalex.org/W1981440980","https://openalex.org/W1981644527","https://openalex.org/W1989894477","https://openalex.org/W1990798903","https://openalex.org/W1996183144","https://openalex.org/W1998859554","https://openalex.org/W2005780220","https://openalex.org/W2008493977","https://openalex.org/W2036656105","https://openalex.org/W2037490596","https://openalex.org/W2038063067","https://openalex.org/W2039905832","https://openalex.org/W2047472099","https://openalex.org/W2051005349","https://openalex.org/W2060620553","https://openalex.org/W2063701397","https://openalex.org/W2068340726","https://openalex.org/W2069851285","https://openalex.org/W2073173214","https://openalex.org/W2075009216","https://openalex.org/W2085662163","https://openalex.org/W2090763940","https://openalex.org/W2113216940","https://openalex.org/W2113282092","https://openalex.org/W2116875438","https://openalex.org/W2119745827","https://openalex.org/W2125400731","https://openalex.org/W2125488268","https://openalex.org/W2131376910","https://openalex.org/W2131906141","https://openalex.org/W2140457265","https://openalex.org/W2156557297","https://openalex.org/W2157585612","https://openalex.org/W2160959707","https://openalex.org/W2318162832","https://openalex.org/W4237410627","https://openalex.org/W4248416695"],"related_works":["https://openalex.org/W2140457265","https://openalex.org/W2157585612","https://openalex.org/W2110679986","https://openalex.org/W1976584377","https://openalex.org/W2092620639","https://openalex.org/W2005752122","https://openalex.org/W1837383530","https://openalex.org/W1973581581","https://openalex.org/W2065672846","https://openalex.org/W6920693957"],"abstract_inverted_index":{"The":[0,99,162,190],"envelope":[1,79,133,175],"glycoproteins":[2,19,27,85,120,204],"of":[3,15,29,33,68,76,123,150,158,180,186,197,214],"human":[4],"immunodeficiency":[5],"virus":[6],"type":[7],"1":[8],"(HIV-1)":[9],"function":[10],"as":[11],"a":[12,51],"trimer":[13],"composed":[14,28],"three":[16,21],"gp120":[17,34,160],"exterior":[18],"and":[20,35,107,116,125,144,168,183,193,200],"gp41":[22,36],"transmembrane":[23],"proteins.":[24,189],"Soluble":[25],"gp140":[26,43,84,119,203],"the":[30,66,69,74,111,131,147,151,159,166,173,181,198,215],"uncleaved":[31],"ectodomains":[32,177],"form":[37],"unstable,":[38],"heterogeneous":[39],"oligomers,":[40],"but":[41],"soluble":[42,77,83,118,153,202],"trimers":[44],"can":[45],"be":[46],"stabilized":[47,87],"by":[48,88],"fusion":[49,89,188],"with":[50,90],"C-terminal,":[52],"trimeric":[53,92],"GCN4":[54,112,167],"motif":[55,93],"(X.":[56],"Yang":[57],"et":[58],"al.,":[59],"J.":[60],"Virol.":[61],"74:5716-5725,":[62],"2000).":[63],"To":[64],"understand":[65],"influence":[67],"C-terminal":[70],"trimerization":[71],"domain":[72],"on":[73],"properties":[75,196],"HIV-1":[78,174],"glycoprotein":[80,134,176],"trimers,":[81,154],"uncleaved,":[82],"were":[86],"another":[91],"derived":[94],"from":[95,212],"T4":[96],"bacteriophage":[97],"fibritin.":[98],"fibritin":[100,169],"construct":[101],"was":[102],"more":[103],"stable":[104],"to":[105,156],"heat":[106],"reducing":[108],"conditions":[109],"than":[110],"construct.":[113],"Both":[114],"GCN4-":[115,199],"fibritin-stabilized":[117,201],"exhibited":[121,146],"patterns":[122],"neutralizing":[124,140],"nonneutralizing":[126],"antibody":[127],"binding":[128],"expected":[129],"for":[130],"functional":[132],"spike.":[135],"Of":[136],"note,":[137],"two":[138],"potently":[139],"antibodies,":[141],"immunoglobulin":[142],"G1b12":[143],"2G12,":[145],"greatest":[148],"recognition":[149,157,195],"stabilized,":[152],"relative":[155],"monomer.":[161],"observed":[163],"similarities":[164],"between":[165],"constructs":[170],"indicate":[171],"that":[172,206,213],"dictate":[178],"many":[179],"antigenic":[182],"structural":[184],"features":[185],"these":[187,207],"melting":[191],"temperatures":[192],"ligand":[194],"suggest":[205],"molecules":[208],"assume":[209],"conformations":[210],"distinct":[211],"fusion-active,":[216],"six-helix":[217],"bundle.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}