{"id":"https://openalex.org/W2105834225","doi":"https://doi.org/10.1200/jco.2007.14.0111","title":"Increased EGFR Gene Copy Number Detected by Fluorescent In Situ Hybridization Predicts Outcome in Non\u2013Small-Cell Lung Cancer Patients Treated With Cetuximab and Chemotherapy","display_name":"Increased EGFR Gene Copy Number Detected by Fluorescent In Situ Hybridization Predicts Outcome in Non\u2013Small-Cell Lung Cancer Patients Treated With Cetuximab and Chemotherapy","publication_year":2008,"publication_date":"2008-07-09","ids":{"openalex":"https://openalex.org/W2105834225","doi":"https://doi.org/10.1200/jco.2007.14.0111","mag":"2105834225","pmid":"https://pubmed.ncbi.nlm.nih.gov/18612151","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3368372"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.14.0111","doi":"https://doi.org/10.1200/jco.2007.14.0111","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2007.14.0111","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.14.0111?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.14.0111?role=tab","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071851332","display_name":"Fred R. Hirsch","orcid":"https://orcid.org/0000-0002-6885-1894","observed_orcids":["https://orcid.org/0000-0002-6885-1894"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred R. Hirsch","raw_affiliation_strings":["From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601","https://openalex.org/I4210134151","https://openalex.org/I4210165553","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008593691","display_name":"Roy S. Herbst","orcid":"https://orcid.org/0000-0003-2535-5847","observed_orcids":["https://orcid.org/0000-0003-2535-5847"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy S. Herbst","raw_affiliation_strings":["From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601","https://openalex.org/I4210134151","https://openalex.org/I4210165553","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007582269","display_name":"Christine Cecilia Olsen","orcid":"https://orcid.org/0000-0002-9630-1099","observed_orcids":["https://orcid.org/0000-0002-9630-1099"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Olsen","raw_affiliation_strings":["From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601","https://openalex.org/I4210134151","https://openalex.org/I4210165553","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050671910","display_name":"Kari Chansky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kari Chansky","raw_affiliation_strings":["From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601","https://openalex.org/I4210134151","https://openalex.org/I4210165553","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103408877","display_name":"John J. Crowley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Crowley","raw_affiliation_strings":["From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601","https://openalex.org/I4210134151","https://openalex.org/I4210165553","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077352149","display_name":"Karen L. Kelly","orcid":"https://orcid.org/0000-0002-2235-6636","observed_orcids":["https://orcid.org/0000-0002-2235-6636"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Kelly","raw_affiliation_strings":["From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601","https://openalex.org/I4210134151","https://openalex.org/I4210165553","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109210308","display_name":"Wilbur A. Franklin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilbur A. Franklin","raw_affiliation_strings":["From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601","https://openalex.org/I4210134151","https://openalex.org/I4210165553","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071670695","display_name":"Paul A. Bunn","orcid":"https://orcid.org/0000-0003-0518-5959","observed_orcids":["https://orcid.org/0000-0003-0518-5959"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Bunn","raw_affiliation_strings":["From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601","https://openalex.org/I4210134151","https://openalex.org/I4210165553","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024045160","display_name":"Marileila Varella\u2010Garcia","orcid":"https://orcid.org/0000-0002-2310-5863","observed_orcids":["https://orcid.org/0000-0002-2310-5863"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marileila Varella-Garcia","raw_affiliation_strings":["From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601","https://openalex.org/I4210134151","https://openalex.org/I4210165553","https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036091074","display_name":"David R. Gandara","orcid":"https://orcid.org/0000-0003-1784-048X","observed_orcids":["https://orcid.org/0000-0003-1784-048X"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I4210165553","display_name":"SWOG Cancer Research Network","ror":"https://ror.org/05n6zrm60","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210165553"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Gandara","raw_affiliation_strings":["From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Southwest Oncology Group, San Antonio; M.D. Anderson Cancer Center, Houston, TX; University of Colorado Cancer Center, Aurora, CO; University of Kansas Cancer Center, Kansas City, KS; and the University of California Davis Cancer Center, Davis, CA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601","https://openalex.org/I4210134151","https://openalex.org/I4210165553","https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":42.2918,"has_fulltext":true,"cited_by_count":270,"citation_normalized_percentile":{"value":0.9988635,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"26","issue":"20","first_page":"3351","last_page":"3357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-gene-copy-number","display_name":"EGFR gene copy number","score":0.9440000057220459},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9350000023841858},{"id":"https://openalex.org/keywords/egfr-amplification","display_name":"EGFR amplification","score":0.8180000185966492},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8500000238418579},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemotherapy-naive-patients","display_name":"chemotherapy-naive patients","score":0.6570000052452087},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8320000171661377},{"id":"https://openalex.org/keywords/concurrent-chemotherapy","display_name":"concurrent chemotherapy","score":0.5109999775886536},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7882653474807739},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.7652559876441956},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.6864285469055176},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6335763335227966},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5585929751396179},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.5067518353462219},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4813143014907837},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4783696234226227},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.43361395597457886},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41204580664634705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3927634656429291},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3886631429195404},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36982858180999756},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21194371581077576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17507275938987732},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1369900405406952},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.11082929372787476},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.08646842837333679},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.08213582634925842}],"mesh":[{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018773","descriptor_name":"Genes, erbB-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1200/jco.2007.14.0111","doi":"https://doi.org/10.1200/jco.2007.14.0111","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2007.14.0111","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.14.0111?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:18612151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18612151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:europepmc.org:2375878","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3368372","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3368372","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3368372","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Clin Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1200/jco.2007.14.0111","doi":"https://doi.org/10.1200/jco.2007.14.0111","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2007.14.0111","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.14.0111?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2435896781","display_name":null,"funder_award_id":"N01 CA038926","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3065506811","display_name":"SOUTHWEST ONCOLOGY GROUP STATISTICAL CENTER","funder_award_id":"2u10ca038926-25","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3211879625","display_name":"UCDCCC NCTN U10 Program","funder_award_id":"U10CA180846","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G36541222","display_name":null,"funder_award_id":"N01 CA032102","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G379387698","display_name":null,"funder_award_id":"U10-CA038926","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6134390630","display_name":"Southwest Oncology Group Treatment Grant","funder_award_id":"U10CA032102","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G763325562","display_name":null,"funder_award_id":"CA 38926","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8447659275","display_name":"SPORE in Lung Cancer","funder_award_id":"P50CA058187","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891461","display_name":"University of Colorado Cancer Center Support Grant","funder_award_id":"P30CA046934","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308982","display_name":"American Society of Clinical Oncology","ror":"https://ror.org/04fy6j421"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105834225.pdf","grobid_xml":"https://content.openalex.org/works/W2105834225.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1965734230","https://openalex.org/W1970476748","https://openalex.org/W1988442083","https://openalex.org/W2015378165","https://openalex.org/W2020830322","https://openalex.org/W2030882637","https://openalex.org/W2083491499","https://openalex.org/W2101778620","https://openalex.org/W2102639464","https://openalex.org/W2104110140","https://openalex.org/W2106372363","https://openalex.org/W2106787323","https://openalex.org/W2107304950","https://openalex.org/W2110835998","https://openalex.org/W2118004874","https://openalex.org/W2120612535","https://openalex.org/W2120953374","https://openalex.org/W2127101185","https://openalex.org/W2127645603","https://openalex.org/W2136871952","https://openalex.org/W2138297714","https://openalex.org/W2138604360","https://openalex.org/W2142564546","https://openalex.org/W2142850084","https://openalex.org/W2145835533","https://openalex.org/W2148686475","https://openalex.org/W2148783573","https://openalex.org/W2149412903","https://openalex.org/W2152755651","https://openalex.org/W2155384808","https://openalex.org/W2156188896","https://openalex.org/W2160866033","https://openalex.org/W2162724777","https://openalex.org/W2230977600","https://openalex.org/W2244058194","https://openalex.org/W2261332349","https://openalex.org/W2267518034","https://openalex.org/W2318605753","https://openalex.org/W2324889632"],"related_works":["https://openalex.org/W1937846560","https://openalex.org/W3205352786","https://openalex.org/W2244353329","https://openalex.org/W2045199981","https://openalex.org/W2769988386","https://openalex.org/W2148783573","https://openalex.org/W2262841898","https://openalex.org/W2036260695","https://openalex.org/W2018922262","https://openalex.org/W2036773776"],"abstract_inverted_index":{"PURPOSE:":[0],"Epidermal":[1],"growth":[2],"factor":[3,225],"receptor":[4],"(EGFR)":[5],"gene":[6,105,116],"copy":[7],"number":[8],"detected":[9],"by":[10],"fluorescent":[11],"in":[12,45,91,109,118,127],"situ":[13],"hybridization":[14],"(FISH)":[15],"has":[16],"proven":[17],"to":[18,217],"be":[19],"useful":[20],"for":[21,29,174,186,194,226,231],"selection":[22,74,227],"of":[23,112,167,228,237],"non-small-cell":[24],"lung":[25],"cancer":[26],"(NSCLC)":[27],"patients":[28,47,64,93,133,176,195,207,230],"treatment":[30],"with":[31,65,84,94,158,171,191],"EGFR":[32,39,50,87,220],"tyrosine":[33],"kinase":[34],"inhibitors.":[35],"Here,":[36],"we":[37],"evaluate":[38],"FISH":[40,88,198,221],"as":[41,100],"a":[42,71,162,223],"predictive":[43,224],"marker":[44],"NSCLC":[46,67,229],"receiving":[48,208],"the":[49,113,187,215],"monoclonal":[51],"antibody":[52],"inhibitor":[53],"cetuximab":[54,232],"plus":[55,82,144,233],"chemotherapy.":[56,234],"PATIENTS":[57],"AND":[58],"METHODS:":[59],"Two":[60],"hundred":[61],"twenty-nine":[62],"chemotherapy-naive":[63],"advanced-stage":[66],"were":[68,197],"enrolled":[69],"onto":[70],"phase":[72],"II":[73],"trial":[75],"evaluating":[76],"sequential":[77],"or":[78,103,115],"concurrent":[79,209],"chemotherapy":[80],"(paclitaxel":[81],"carboplatin)":[83],"cetuximab.":[85],"RESULTS:":[86],"was":[89,124,147,183],"assessable":[90],"76":[92],"available":[95],"tumor":[96],"tissue":[97],"and":[98],"classified":[99],"positive":[101],"(four":[102],"more":[104],"copies":[106],"per":[107],"cell":[108],">/=":[110],"40%":[111],"cells":[114],"amplification)":[117],"59.2%.":[119],"Response":[120],"(complete":[121,141],"response/partial":[122,142],"response)":[123],"numerically":[125],"higher":[126],"FISH-positive":[128,159,188,206],"(45%)":[129],"versus":[130],"FISH-negative":[131,175],"(26%)":[132],"(P":[134,177,200],"=":[135,155,178,201],".14),":[136],"whereas":[137],"disease":[138],"control":[139],"rate":[140],"response":[143],"stable":[145],"disease)":[146],"statistically":[148],"superior":[149],"(81%":[150],"v":[151],"55%,":[152],"respectively;":[153],"P":[154],".02).":[156],"Patients":[157],"tumors":[160],"had":[161],"median":[163],"progression-free":[164],"survival":[165,181,204],"time":[166,182],"6":[168],"months":[169,173,185,193],"compared":[170,190],"3":[172],".0008).":[179],"Median":[180],"15":[184],"group":[189],"7":[192],"who":[196],"negative.":[199],".04).":[202],"Furthermore,":[203],"favored":[205],"therapy.":[210],"CONCLUSION:":[211],"These":[212],"results":[213],"are":[214],"first":[216],"suggest":[218],"that":[219],"is":[222,240],"Prospective":[235],"validation":[236],"these":[238],"findings":[239],"warranted.":[241]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":28}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}