{"id":"https://openalex.org/W2105823536","doi":"https://doi.org/10.1161/01.res.0000133680.87668.fa","title":"Activated Protein C Induces Endothelial Cell Proliferation by Mitogen-Activated Protein Kinase Activation In Vitro and Angiogenesis In Vivo","display_name":"Activated Protein C Induces Endothelial Cell Proliferation by Mitogen-Activated Protein Kinase Activation In Vitro and Angiogenesis In Vivo","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2105823536","doi":"https://doi.org/10.1161/01.res.0000133680.87668.fa","mag":"2105823536","pmid":"https://pubmed.ncbi.nlm.nih.gov/15166095"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.0000133680.87668.fa","doi":"https://doi.org/10.1161/01.res.0000133680.87668.fa","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.0000133680.87668.fa","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081500257","display_name":"Mitsuhiro Uchiba","orcid":"https://orcid.org/0000-0003-3377-4216","observed_orcids":["https://orcid.org/0000-0003-3377-4216"]},"institutions":[{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210092011","display_name":"Saga Medical School Hospital","ror":"https://ror.org/00g51j712","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092011"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuhiro Uchiba","raw_affiliation_strings":["From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan","the Department of Immunology (K.F.), Saga Medical School, Saga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4210092011","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I177136067","https://openalex.org/I4210092011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070002300","display_name":"Kenji Okajima","orcid":"https://orcid.org/0000-0001-8311-0077","observed_orcids":["https://orcid.org/0000-0001-8311-0077"]},"institutions":[{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210092011","display_name":"Saga Medical School Hospital","ror":"https://ror.org/00g51j712","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092011"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Okajima","raw_affiliation_strings":["From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan","the Department of Immunology (K.F.), Saga Medical School, Saga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4210092011","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I177136067","https://openalex.org/I4210092011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024769815","display_name":"Yuichi Oike","orcid":"https://orcid.org/0000-0003-3245-5395","observed_orcids":["https://orcid.org/0000-0003-3245-5395"]},"institutions":[{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210092011","display_name":"Saga Medical School Hospital","ror":"https://ror.org/00g51j712","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092011"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Oike","raw_affiliation_strings":["From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","Yuichi Oike From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan","the Department of Immunology (K.F.), Saga Medical School, Saga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4210092011","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Yuichi Oike From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]},{"raw_affiliation_string":"the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I177136067","https://openalex.org/I4210092011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081143725","display_name":"Yasuhiro Ito","orcid":"https://orcid.org/0000-0002-7854-0360","observed_orcids":["https://orcid.org/0000-0002-7854-0360"]},"institutions":[{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210092011","display_name":"Saga Medical School Hospital","ror":"https://ror.org/00g51j712","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092011"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Ito","raw_affiliation_strings":["From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","Yasuhiro Ito From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan","the Department of Immunology (K.F.), Saga Medical School, Saga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4210092011","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Yasuhiro Ito From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]},{"raw_affiliation_string":"the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I177136067","https://openalex.org/I4210092011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026332836","display_name":"Kenji Fukudome","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210092011","display_name":"Saga Medical School Hospital","ror":"https://ror.org/00g51j712","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092011"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Fukudome","raw_affiliation_strings":["From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan","the Department of Immunology (K.F.), Saga Medical School, Saga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4210092011","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I177136067","https://openalex.org/I4210092011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113726674","display_name":"Hirotaka Isobe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210092011","display_name":"Saga Medical School Hospital","ror":"https://ror.org/00g51j712","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092011"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Isobe","raw_affiliation_strings":["From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan","the Department of Immunology (K.F.), Saga Medical School, Saga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4210092011","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I177136067","https://openalex.org/I4210092011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054636847","display_name":"Toshio Suda","orcid":"https://orcid.org/0000-0001-7540-1771","observed_orcids":["https://orcid.org/0000-0001-7540-1771"]},"institutions":[{"id":"https://openalex.org/I177136067","display_name":"Saga University","ror":"https://ror.org/04f4wg107","country_code":"JP","type":"education","lineage":["https://openalex.org/I177136067"]},{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210092011","display_name":"Saga Medical School Hospital","ror":"https://ror.org/00g51j712","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092011"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Suda","raw_affiliation_strings":["From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan","the Department of Immunology (K.F.), Saga Medical School, Saga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Diagnostic Medicine (M.U., K.O., H.I.), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan; and the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4210092011","https://openalex.org/I96036126"]},{"raw_affiliation_string":"Department of Cell Differentiation (Y.O., Y.I., T.S.), The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"the Department of Immunology (K.F.), Saga Medical School, Saga, Japan","institution_ids":["https://openalex.org/I177136067","https://openalex.org/I4210092011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.1712,"has_fulltext":true,"cited_by_count":167,"citation_normalized_percentile":{"value":0.98390075,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"95","issue":"1","first_page":"34","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.20509999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/activated-protein-c","display_name":"activated protein C","score":1.0},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9319999814033508},{"id":"https://openalex.org/keywords/endothelial-protein-c-receptor","display_name":"endothelial protein C receptor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/protease-activated-receptor-1","display_name":"protease-activated receptor 1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/protein-kinase-g","display_name":"protein kinase G","score":0.9850000143051147},{"id":"https://openalex.org/keywords/serine-protease-activity","display_name":"serine protease activity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/corneal-neovascularization","display_name":"corneal neovascularization","score":0.7850000262260437},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/antithrombotic-activity","display_name":"antithrombotic activity","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6635940074920654},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6349331140518188},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5706143379211426},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5432135462760925},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5275050401687622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48431530594825745},{"id":"https://openalex.org/C140800825","wikidata":"https://www.wikidata.org/wiki/Q17915625","display_name":"S1PR1","level":5,"score":0.4188937544822693},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.39602917432785034},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37101513147354126},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3391738831996918},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.33486872911453247},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3318617641925812},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.26719802618026733},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.22632208466529846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1541348695755005},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14872664213180542},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001779","descriptor_name":"Blood Coagulation Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D044463","descriptor_name":"Receptor, PAR-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.res.0000133680.87668.fa","doi":"https://doi.org/10.1161/01.res.0000133680.87668.fa","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.0000133680.87668.fa","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:15166095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15166095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01033:0004822185","doi":null,"is_oa":false,"landing_page_url":"https://saga-u.repo.nii.ac.jp/records/12957","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CIRCULATION RESEARCH","raw_type":"journal article"},{"id":"mag:2887200036","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/01.res.0000133680.87668.fa?related-urls=yesl95%2F1%2F34c95%2F1%2F34","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W105186426","https://openalex.org/W126813756","https://openalex.org/W1506421429","https://openalex.org/W1979708961","https://openalex.org/W1995340369","https://openalex.org/W1995588887","https://openalex.org/W1999311869","https://openalex.org/W1999902547","https://openalex.org/W2000985786","https://openalex.org/W2012915372","https://openalex.org/W2021483318","https://openalex.org/W2034455595","https://openalex.org/W2044689705","https://openalex.org/W2054493150","https://openalex.org/W2063908549","https://openalex.org/W2064129448","https://openalex.org/W2073887151","https://openalex.org/W2073933974","https://openalex.org/W2077571136","https://openalex.org/W2082523050","https://openalex.org/W2091193879","https://openalex.org/W2093621392","https://openalex.org/W2103083564","https://openalex.org/W2111796479","https://openalex.org/W2118408607","https://openalex.org/W2133575487","https://openalex.org/W2143062128","https://openalex.org/W2147266392","https://openalex.org/W2158316748","https://openalex.org/W2167609020","https://openalex.org/W2382154612"],"related_works":["https://openalex.org/W2041780590","https://openalex.org/W959773913","https://openalex.org/W2041148365","https://openalex.org/W7100565561","https://openalex.org/W2333872027","https://openalex.org/W2051765823","https://openalex.org/W2055851568","https://openalex.org/W2136287743","https://openalex.org/W2070061207","https://openalex.org/W2910885161"],"abstract_inverted_index":{"Activated":[0],"protein":[1,15,82,137],"C":[2,83],"(APC),":[3],"a":[4,153],"natural":[5],"anticoagulant,":[6],"has":[7],"recently":[8],"been":[9],"demonstrated":[10],"to":[11,144,156,177,218,224],"activate":[12,147],"the":[13,25,51,56,80,92,110,148,178,206],"mitogen-activated":[14],"kinase":[16,138],"(MAPK)":[17],"pathway":[18,27,94,112,151],"in":[19,22,30,50,65,185,190,195,209,222],"endothelial":[20,31,40,70,81,114,124,149,168],"cells":[21,71],"vitro.":[23],"Because":[24],"MAPK":[26,57,93,111,150],"is":[28,35],"implicated":[29],"cell":[32,41,115],"proliferation,":[33,42],"it":[34],"possible":[36],"that":[37,141,157],"APC":[38,54,122,142,160,181,200,215],"induces":[39],"thereby":[43],"causing":[44],"angiogenesis.":[45],"We":[46],"examined":[47],"this":[48,120],"possibility":[49],"present":[52],"study.":[53],"activated":[55,123],"pathway,":[58],"increased":[59],"DNA":[60],"synthesis,":[61],"and":[62,106],"induced":[63,161,183,198],"proliferation":[64,116],"cultured":[66],"human":[67],"umbilical":[68],"vein":[69],"dependent":[72],"on":[73],"its":[74,225],"serine":[75],"protease":[76],"activity.":[77,227],"Antibody":[78],"against":[79,100],"receptor":[84],"(EPCR)":[85],"inhibited":[86,96,118],"these":[87],"events.":[88],"Early":[89],"activation":[90,108,135],"of":[91,109,136,158,167,214],"was":[95],"by":[97,119,134,152,199],"an":[98],"antibody":[99],"protease-activated":[101],"receptor-1,":[102],"whereas":[103,170],"neither":[104],"late":[105],"complete":[107],"nor":[113],"were":[117],"antibody.":[121],"nitric":[125],"oxide":[126],"synthase":[127],"(eNOS)":[128],"via":[129],"phosphatidylinositol":[130],"3-kinase-dependent":[131],"phosphorylation,":[132],"followed":[133],"G,":[139],"suggesting":[140],"bound":[143],"EPCR":[145],"might":[146,201,216],"mechanism":[154],"similar":[155],"VEGF.":[159],"morphogenetic":[162],"changes":[163],"resembling":[164],"tube-like":[165],"structures":[166],"cells,":[169],"DIP-APC":[171],"did":[172],"not.":[173],"When":[174],"applied":[175],"topically":[176],"mouse":[179],"cornea,":[180],"clearly":[182],"angiogenesis":[184],"wild-type":[186],"mice,":[187],"but":[188],"not":[189],"eNOS":[191],"knockout":[192],"mice.":[193],"These":[194],"vitro":[196],"events":[197],"at":[202],"least":[203],"partly":[204],"explain":[205],"angiogenic":[207,212],"activity":[208,213],"vivo.":[210],"This":[211],"contribute":[217],"maintain":[219],"proper":[220],"microcirculation":[221],"addition":[223],"antithrombotic":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
