{"id":"https://openalex.org/W2105613622","doi":null,"title":"The stem cell mobilizer StemEnhance does not promote tumor growth in an orthotopic model of human breast cancer.","display_name":"The stem cell mobilizer StemEnhance does not promote tumor growth in an orthotopic model of human breast cancer.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2105613622","mag":"2105613622","pmid":"https://pubmed.ncbi.nlm.nih.gov/19331184"},"language":"en","primary_location":{"id":"pmid:19331184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19331184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060290237","display_name":"Christian Drapeau","orcid":"https://orcid.org/0000-0001-7909-0106","observed_orcids":["https://orcid.org/0000-0001-7909-0106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Drapeau","raw_affiliation_strings":["STEMTech HealthSciences, Inc., 1011 Calle Amanecer, San Clemente, CA 92673, USA. cdrapeau@stemtechhealth.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"STEMTech HealthSciences, Inc., 1011 Calle Amanecer, San Clemente, CA 92673, USA. cdrapeau@stemtechhealth.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103384463","display_name":"Huaiyu Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huaiyu Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101523104","display_name":"Zhijian Yang","orcid":"https://orcid.org/0000-0002-5143-0890","observed_orcids":["https://orcid.org/0000-0002-5143-0890"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhijian Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029727052","display_name":"Li Tang","orcid":"https://orcid.org/0000-0001-5929-6975","observed_orcids":["https://orcid.org/0000-0001-5929-6975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M Hoffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040463490","display_name":"David J. Schaeffer","orcid":"https://orcid.org/0000-0002-6040-052X","observed_orcids":["https://orcid.org/0000-0002-6040-052X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J Schaeffer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1357,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55713956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"29","issue":"1","first_page":"443","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.4943999946117401,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.4943999946117401,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.29809999465942383,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.08229999989271164,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mda-mb-435","display_name":"MDA-MB-435","score":0.8230000138282776},{"id":"https://openalex.org/keywords/orthotopic-xenograft-model","display_name":"orthotopic xenograft","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.4690000116825104},{"id":"https://openalex.org/keywords/whole-body-fluorescence-imaging","display_name":"whole-body fluorescence imaging","score":0.5989999771118164},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.654926598072052},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.627305269241333},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6107649803161621},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5414635539054871},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4887959659099579},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4675644338130951},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.465910941362381},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.46257853507995605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39834314584732056},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39395594596862793},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36462777853012085},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32988402247428894},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3207519054412842},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.266732394695282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019650","descriptor_name":"Hematopoietic Stem Cell Mobilization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:19331184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19331184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W206590346","https://openalex.org/W1518520618","https://openalex.org/W1969980017","https://openalex.org/W1970957555","https://openalex.org/W2000031724","https://openalex.org/W2007113681","https://openalex.org/W2016867252","https://openalex.org/W2039617433","https://openalex.org/W2046675963","https://openalex.org/W2047887335","https://openalex.org/W2051948954","https://openalex.org/W2069036256","https://openalex.org/W2073994827","https://openalex.org/W2090241102","https://openalex.org/W2098799011","https://openalex.org/W2102558459","https://openalex.org/W2141815918","https://openalex.org/W2142957631","https://openalex.org/W2159468650","https://openalex.org/W2182163931"],"related_works":["https://openalex.org/W2030480905","https://openalex.org/W2951591859","https://openalex.org/W1983273365","https://openalex.org/W1979976356","https://openalex.org/W3164440545","https://openalex.org/W2089897360","https://openalex.org/W2107402669","https://openalex.org/W2313194784","https://openalex.org/W2288957552","https://openalex.org/W2001680837"],"abstract_inverted_index":{"Bone":[0],"marrow-derived":[1],"stem":[2],"cells":[3],"(BMDSC)":[4],"have":[5],"been":[6],"implicated":[7],"in":[8,113,134,147],"tumor":[9,20,38,97,129,142,165],"formation,":[10],"though":[11],"it":[12],"is":[13],"not":[14,163],"clear":[15],"whether":[16,33],"they":[17],"contribute":[18],"to":[19,31,122],"growth.":[21,39],"A":[22],"novel":[23],"mobilizer":[24],"of":[25,55,68,82,93,160,172],"BMDSC":[26],"(StemEnhance;":[27],"SE)":[28],"was":[29,72,111,144],"used":[30],"investigate":[32],"its":[34],"daily":[35],"administration":[36],"promotes":[37],"Forty":[40],"mice":[41,59],"were":[42,60,86,105,131],"surgically":[43],"transplanted":[44],"with":[45,65],"human":[46,173],"MDA-MB-435-GFP":[47],"breast":[48,175],"cancer":[49],"into":[50],"the":[51,80,83,91,94,114,123,135,148,170],"mammary":[52],"fat":[53],"pad":[54],"nude":[56],"mice,":[57],"The":[58],"gavaged":[61],"for":[62,99],"six":[63],"weeks":[64],"300":[66],"mg/kg":[67],"SE.":[69],"Tumor":[70,108],"growth":[71,109,166,171],"monitored":[73],"using":[74],"live":[75],"whole-body":[76],"fluorescence":[77],"imaging.":[78],"At":[79,90],"end":[81],"study,":[84],"tumors":[85],"excised":[87],"and":[88,102,140],"weighed.":[89],"start":[92],"feeding":[95],"trial,":[96],"areas":[98,130],"both":[100],"control":[101,124,136],"experimental":[103],"group":[104,116,150],"statistically":[106],"identical.":[107],"rate":[110],"slower":[112],"SE":[115,161],"(p":[117],"=":[118,157],"0.014)":[119],"when":[120],"compared":[121],"group.":[125],"After":[126],"6":[127],"weeks,":[128],"40%":[132],"larger":[133],"p":[137,156],"<":[138],"0.01)":[139],"mean":[141],"weight":[143],"35%":[145],"smaller":[146],"SE-treated":[149],"(0.44":[151],"g":[152],"vs.":[153],"0.68":[154],"g;":[155],"0.031).":[158],"Feeding":[159],"did":[162],"promote":[164],"but":[167],"rather":[168],"reduced":[169],"MDA-MB-435":[174],"cancer.":[176]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}