{"id":"https://openalex.org/W2105576780","doi":null,"title":"Regulation of vascular endothelial t-PA expression in inflammation: Potential target for pharmacological modulation","display_name":"Regulation of vascular endothelial t-PA expression in inflammation: Potential target for pharmacological modulation","publication_year":2011,"publication_date":"2011-11-03","ids":{"openalex":"https://openalex.org/W2105576780","mag":"2105576780"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/26266","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/26266","pdf_url":"http://hdl.handle.net/2077/26266","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/26266","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033946048","display_name":"Pia Larsson","orcid":"https://orcid.org/0000-0001-9115-4213","observed_orcids":["https://orcid.org/0000-0001-9115-4213"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P. Larsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9115-4213","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033946048"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9860000014305115},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7639999985694885},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6959999799728394},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9279999732971191},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.996999979019165},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9470000267028809},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8889999985694885},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/atherothrombosis","display_name":"atherothrombosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/ischemic-vascular-disease","display_name":"ischemic vascular disease","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6362367868423462},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5632203221321106},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5404812097549438},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.5259107351303101},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.48619288206100464},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.43491289019584656},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.4264603853225708},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.42375677824020386},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4084187150001526},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4050012230873108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3936925530433655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3688485026359558},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36277496814727783}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/26266","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/26266","pdf_url":"http://hdl.handle.net/2077/26266","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:2105576780","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/26266/1/gupea_2077_26266_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/26266","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/26266","pdf_url":"http://hdl.handle.net/2077/26266","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320322169","display_name":"Hj\u00e4rt-Lungfonden","ror":"https://ror.org/052261q33"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320322833","display_name":"Stiftelsen Lars Hiertas Minne","ror":"https://ror.org/03cpsrf24"},{"id":"https://openalex.org/F4320323416","display_name":"Sahlgrenska Universitetssjukhuset","ror":"https://ror.org/04vgqjj36"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105576780.pdf","grobid_xml":"https://content.openalex.org/works/W2105576780.grobid-xml"},"referenced_works_count":192,"referenced_works":["https://openalex.org/W31775548","https://openalex.org/W146966810","https://openalex.org/W1517266115","https://openalex.org/W1554085014","https://openalex.org/W1562555601","https://openalex.org/W1572701068","https://openalex.org/W1574907524","https://openalex.org/W1587031596","https://openalex.org/W1595391532","https://openalex.org/W1630061106","https://openalex.org/W1670199153","https://openalex.org/W1770406708","https://openalex.org/W1819166842","https://openalex.org/W1862006453","https://openalex.org/W1891655359","https://openalex.org/W1965914554","https://openalex.org/W1968317137","https://openalex.org/W1968931577","https://openalex.org/W1969641409","https://openalex.org/W1970807871","https://openalex.org/W1970982602","https://openalex.org/W1972171203","https://openalex.org/W1974162725","https://openalex.org/W1976844018","https://openalex.org/W1977970477","https://openalex.org/W1979640628","https://openalex.org/W1979886338","https://openalex.org/W1981851376","https://openalex.org/W1982485744","https://openalex.org/W1982503979","https://openalex.org/W1983111936","https://openalex.org/W1983347726","https://openalex.org/W1984520299","https://openalex.org/W1984870795","https://openalex.org/W1990384980","https://openalex.org/W1990868699","https://openalex.org/W1992711755","https://openalex.org/W1998362943","https://openalex.org/W1998569586","https://openalex.org/W2001526641","https://openalex.org/W2002698073","https://openalex.org/W2004335766","https://openalex.org/W2005372462","https://openalex.org/W2006708761","https://openalex.org/W2015441781","https://openalex.org/W2015447713","https://openalex.org/W2017587402","https://openalex.org/W2017750793","https://openalex.org/W2018794455","https://openalex.org/W2019491047","https://openalex.org/W2019782036","https://openalex.org/W2020259322","https://openalex.org/W2020328864","https://openalex.org/W2020695410","https://openalex.org/W2022705938","https://openalex.org/W2023666553","https://openalex.org/W2023731005","https://openalex.org/W2025112232","https://openalex.org/W2025149458","https://openalex.org/W2026549010","https://openalex.org/W2026697192","https://openalex.org/W2026914853","https://openalex.org/W2028858807","https://openalex.org/W2029490625","https://openalex.org/W2031018845","https://openalex.org/W2031089158","https://openalex.org/W2034894104","https://openalex.org/W2035292279","https://openalex.org/W2036030925","https://openalex.org/W2036537353","https://openalex.org/W2036593455","https://openalex.org/W2037492035","https://openalex.org/W2037882607","https://openalex.org/W2040557787","https://openalex.org/W2042087846","https://openalex.org/W2042775328","https://openalex.org/W2044410409","https://openalex.org/W2044677434","https://openalex.org/W2044955671","https://openalex.org/W2045135216","https://openalex.org/W2045391439","https://openalex.org/W2046971728","https://openalex.org/W2047797817","https://openalex.org/W2048177509","https://openalex.org/W2048512830","https://openalex.org/W2048741905","https://openalex.org/W2050774972","https://openalex.org/W2050931169","https://openalex.org/W2051235001","https://openalex.org/W2052066772","https://openalex.org/W2052248368","https://openalex.org/W2054273226","https://openalex.org/W2060742356","https://openalex.org/W2061465794","https://openalex.org/W2063177137","https://openalex.org/W2065126426","https://openalex.org/W2066763565","https://openalex.org/W2066963386","https://openalex.org/W2067067340","https://openalex.org/W2069264394","https://openalex.org/W2069328568","https://openalex.org/W2069818772","https://openalex.org/W2071934663","https://openalex.org/W2073273161","https://openalex.org/W2074201999","https://openalex.org/W2074284980","https://openalex.org/W2076223147","https://openalex.org/W2077468629","https://openalex.org/W2077861410","https://openalex.org/W2078320770","https://openalex.org/W2082564973","https://openalex.org/W2086334687","https://openalex.org/W2088383697","https://openalex.org/W2090381051","https://openalex.org/W2091990097","https://openalex.org/W2093126306","https://openalex.org/W2094017049","https://openalex.org/W2094941678","https://openalex.org/W2096165693","https://openalex.org/W2096552213","https://openalex.org/W2096809109","https://openalex.org/W2096961188","https://openalex.org/W2097006357","https://openalex.org/W2098125278","https://openalex.org/W2098249941","https://openalex.org/W2101581238","https://openalex.org/W2102458112","https://openalex.org/W2102657713","https://openalex.org/W2110576380","https://openalex.org/W2111045845","https://openalex.org/W2111907637","https://openalex.org/W2113907907","https://openalex.org/W2117334568","https://openalex.org/W2117691193","https://openalex.org/W2117950541","https://openalex.org/W2119725323","https://openalex.org/W2120549911","https://openalex.org/W2122764406","https://openalex.org/W2123811384","https://openalex.org/W2123914057","https://openalex.org/W2124010496","https://openalex.org/W2124551895","https://openalex.org/W2124877193","https://openalex.org/W2124936150","https://openalex.org/W2129092071","https://openalex.org/W2130087704","https://openalex.org/W2131615503","https://openalex.org/W2132740540","https://openalex.org/W2133321371","https://openalex.org/W2133452708","https://openalex.org/W2134682046","https://openalex.org/W2135568455","https://openalex.org/W2136208700","https://openalex.org/W2137798131","https://openalex.org/W2138783976","https://openalex.org/W2140066110","https://openalex.org/W2140853784","https://openalex.org/W2143329356","https://openalex.org/W2143658931","https://openalex.org/W2144634347","https://openalex.org/W2144883280","https://openalex.org/W2144929276","https://openalex.org/W2145845370","https://openalex.org/W2146270610","https://openalex.org/W2149810777","https://openalex.org/W2150445125","https://openalex.org/W2152088076","https://openalex.org/W2153245357","https://openalex.org/W2157040134","https://openalex.org/W2157603347","https://openalex.org/W2158747282","https://openalex.org/W2160427887","https://openalex.org/W2160613916","https://openalex.org/W2162050622","https://openalex.org/W2163277908","https://openalex.org/W2163500448","https://openalex.org/W2163963420","https://openalex.org/W2165463540","https://openalex.org/W2165779517","https://openalex.org/W2167415368","https://openalex.org/W2167591919","https://openalex.org/W2168528781","https://openalex.org/W2171582135","https://openalex.org/W2284171941","https://openalex.org/W2316376271","https://openalex.org/W2400762994","https://openalex.org/W2405312923","https://openalex.org/W2410490242","https://openalex.org/W2799244551","https://openalex.org/W2991009371","https://openalex.org/W3021659692","https://openalex.org/W4324262972"],"related_works":["https://openalex.org/W2040400789","https://openalex.org/W2042877805","https://openalex.org/W4231215894","https://openalex.org/W4242083419","https://openalex.org/W1547887043","https://openalex.org/W1595391532","https://openalex.org/W2314723910","https://openalex.org/W2316023620","https://openalex.org/W2047797817","https://openalex.org/W2410490242"],"abstract_inverted_index":{"The":[0,14,48],"endogenous":[1,544],"fibrinolytic":[2,19,291,545],"system":[3,20,292,546],"is":[4,25,36,107,376,445],"important":[5],"for":[6,75,254,539,552],"preventing":[7],"occluding":[8],"thrombosis":[9],"and":[10,44,62,84,95,140,165,175,268,293,407,455,501],"subsequent":[11],"tissue":[12],"infarction.":[13,81],"main":[15],"activator":[16,28],"of":[17,52,112,117,130,146,162,172,193,202,211,221,260,277,287,307,317,344,364,431,462,481,509,542],"the":[18,22,42,88,110,115,128,131,144,207,226,243,261,266,272,284,290,294,315,393,396,411,451,460,485,489,543],"in":[21,41,114,148,178,205,265,271,289,302,358,417,440,459,476,484,498,518,521],"vascular":[23,77,151,442,554],"compartment":[24],"tissue-type":[26],"plasminogen":[27],"(t-PA).":[29],"In":[30,237],"a":[31,169,199,251,257,274,310,342,503,548],"clotting":[32],"situation,":[33],"this":[34,63,318,472],"enzyme":[35,319],"released":[37],"from":[38],"storage":[39],"pools":[40],"endothelium":[43],"initiates":[45],"fibrin":[46],"breakdown.":[47],"endothelial":[49,152,179,244,370,401,443],"release":[50],"capacity":[51],"t-PA":[53,93,118,147,173,235,280,288,327,356,371,386,412,438,469,505,517],"can":[54,299,466],"be":[55,69,102,220,300,321,330,480,508,537],"impaired":[56,301],"by":[57,333,392,447],"genetic":[58],"or":[59],"functional":[60],"means":[61,312],"impairment":[64],"has":[65,120],"been":[66,122],"found":[67,218],"to":[68,219,313,351,380,424,450],"associated":[70,90,103],"with":[71,91,104,304],"an":[72,232],"increased":[73,305],"risk":[74,306],"ischemic":[76,553],"disease,":[78],"including":[79],"myocardial":[80],"Hypertension,":[82],"smoking,":[83],"atherosclerosis":[85],"are":[86,161,324,496],"among":[87],"conditions":[89,303],"reduced":[92,105],"production":[94,119,145,177,281,298,316,328,357,372,439,506],"release.":[96],"\\nAnother":[97],"condition":[98],"that":[99,242,296,326,374,384,395,437],"could":[100,320,329,479,507,535],"potentially":[101],"fibrinolysis":[106],"inflammation,":[108],"but":[109],"role":[111,201,276,286],"inflammation":[113],"regulation":[116],"not":[121,230,249],"clearly":[123],"established.":[124],"Thus,":[125],"we":[126,421],"investigated":[127,341],"effect":[129,182,233,354],"pro-inflammatory":[132,208],"cytokines":[133,453,495],"tumor":[134],"necrosis":[135],"factor-\u03b1":[136],"(TNF-\u03b1),":[137],"interleukin-1\u03b2":[138],"(IL-1\u03b2)":[139],"interleukin-6":[141],"(IL-6)":[142],"on":[143,225,234,279,355,528],"cultured":[149,441],"human":[150],"cells.":[153,180],"We":[154,339],"also":[155,217,408,467,475],"studied":[156],"which":[157,426],"intracellular":[158,195],"signaling":[159,196,204,215],"mechanisms":[160],"importance.":[163,223,511],"TNF-\u03b1":[164,454],"IL-1\u03b2":[166],"both":[167,405],"caused":[168],"significant":[170],"reduction":[171,210],"mRNA":[174],"protein":[176],"This":[181,388],"was":[183,216,282,389],"most":[184],"evident":[185],"at":[186],"time":[187],"points":[188],"\u226524":[189],"h.":[190],"Pharmacological":[191],"blocking":[192],"selected":[194],"pathways":[197],"revealed":[198],"central":[200,285],"NF\u03baB":[203],"mediating":[206],"cytokine":[209],"t-PA.":[212],"p38":[213],"MAPK":[214],"some":[222],"IL-6,":[224,458],"other":[227],"hand,":[228],"did":[229],"cause":[231],"production.":[236,470],"fact,":[238],"further":[239,390],"experiments":[240,420],"showed":[241],"cell":[245],"model":[246],"used":[247,346,513],"does":[248],"express":[250],"complete":[252],"receptor":[253,263],"IL-6.":[255],"However":[256],"soluble":[258,464],"form":[259],"IL-6":[262,278],"exists":[264],"circulation":[267],"when":[269],"present":[270,497],"cultures,":[273],"suppressive":[275],"detected.\\nGiven":[283],"fact":[295,394],"its":[297,463],"atherothrombotic":[308],"events,":[309],"pharmacological":[311,540],"increase":[314],"desirable.":[322],"There":[323],"indications":[325],"partly":[331],"regulated":[332],"epigenetic":[334],"mechanisms,":[335],"mainly":[336],"histone":[337,347,382,402],"acetylation.":[338],"thus":[340],"panel":[343],"clinically":[345],"deacetylase":[348],"inhibitors":[349],"(HDACis)":[350],"determine":[352],"their":[353,378,526],"vitro.":[359],"All":[360],"HDACis":[361,514],"tested,":[362],"irrespective":[363],"chemical":[365],"structural":[366],"class,":[367],"potently":[368,515],"stimulated":[369],"indicating":[373],"it":[375,478],"indeed":[377],"ability":[379],"modulate":[381],"acetylation":[383,403],"affects":[385],"synthesis.":[387],"supported":[391],"HDACi":[397],"valproic":[398],"acid":[399],"affected":[400],"status,":[404],"globally":[406],"specifically":[409],"around":[410],"transcription":[413],"start":[414],"site,":[415],"although":[416],"initial":[418],"siRNA":[419],"were":[422,430],"unable":[423],"identify":[425],"specific":[427],"HDAC":[428,529],"enzyme(s)":[429],"importance.\\nIn":[432],"conclusion,":[433],"these":[434,494,533],"data":[435],"suggest":[436],"cells":[444],"suppressed":[446],"prolonged":[448],"exposure":[449],"inflammatory":[452,490],"IL-1\u03b2.":[456],"Moreover,":[457],"presence":[461],"receptor,":[465],"attenuate":[468],"If":[471],"holds":[473],"true":[474],"vivo,":[477],"importance":[482],"e.g.":[483],"local":[486],"environment":[487],"surrounding":[488],"atherosclerotic":[491],"plaque":[492],"where":[493,502],"high":[499],"concentrations":[500],"sufficient":[504],"uttermost":[510],"Clinically":[512],"stimulate":[516],"our":[519],"experimental":[520],"vitro":[522],"model,":[523],"apparently":[524],"via":[525],"effects":[527],"enzymes.":[530],"As":[531],"such,":[532],"substances":[534],"perhaps":[536],"considered":[538],"stimulation":[541],"as":[547],"novel":[549],"prevention":[550],"strategy":[551],"disease.":[555]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
