{"id":"https://openalex.org/W2105524728","doi":"https://doi.org/10.1158/1541-7786.mcr-13-0033-t","title":"Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling","display_name":"Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling","publication_year":2013,"publication_date":"2013-09-05","ids":{"openalex":"https://openalex.org/W2105524728","doi":"https://doi.org/10.1158/1541-7786.mcr-13-0033-t","mag":"2105524728","pmid":"https://pubmed.ncbi.nlm.nih.gov/24008674","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3833835"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.mcr-13-0033-t","doi":"https://doi.org/10.1158/1541-7786.mcr-13-0033-t","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-13-0033-t","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3833835","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037970330","display_name":"Holly E. Barker","orcid":"https://orcid.org/0000-0002-9350-5520","observed_orcids":["https://orcid.org/0000-0002-9350-5520"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Holly E. Barker","raw_affiliation_strings":["Authors' Affiliations:\u20081Section of Cancer Biology, The Institute of Cancer Research, London, United Kingdom; and 2Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Section of Cancer Biology, The Institute of Cancer Research, London, United Kingdom; and 2Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Demelza Bird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Demelza Bird","raw_affiliation_strings":["Authors' Affiliations:\u20081Section of Cancer Biology, The Institute of Cancer Research, London, United Kingdom; and 2Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Section of Cancer Biology, The Institute of Cancer Research, London, United Kingdom; and 2Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111818921","display_name":"Georgina Lang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Georgina Lang","raw_affiliation_strings":["Authors' Affiliations:\u20081Section of Cancer Biology, The Institute of Cancer Research, London, United Kingdom; and 2Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Section of Cancer Biology, The Institute of Cancer Research, London, United Kingdom; and 2Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I142947616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039753115","display_name":"Janine Terra Erler","orcid":"https://orcid.org/0000-0001-8675-6527","observed_orcids":["https://orcid.org/0000-0001-8675-6527"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["DK","GB"],"is_corresponding":true,"raw_author_name":"Janine T. Erler","raw_affiliation_strings":["Authors' Affiliations:\u20081Section of Cancer Biology, The Institute of Cancer Research, London, United Kingdom; and 2Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Section of Cancer Biology, The Institute of Cancer Research, London, United Kingdom; and 2Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039753115"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I142947616"],"apc_list":null,"apc_paid":null,"fwci":4.9622,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.96341647,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"11","issue":"11","first_page":"1425","last_page":"1436"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.45089998841285706,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.45089998841285706,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.21299999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.08030000329017639,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loxl2","display_name":"LOXL2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9660000205039978},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.7919999957084656},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.953000009059906},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mammary-tumors","display_name":"mammary tumors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7429999709129333},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/collagen-matrix","display_name":"collagen matrix","score":0.6079999804496765},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6967025995254517},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43258485198020935},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3358529210090637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.316558837890625}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1158/1541-7786.mcr-13-0033-t","doi":"https://doi.org/10.1158/1541-7786.mcr-13-0033-t","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-13-0033-t","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:24008674","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24008674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2983453","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3833835","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3833835","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3833835/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cancer Res","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/9a7a349f-01d0-4e36-be72-8ac7f7c6b1bc","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/9a7a349f-01d0-4e36-be72-8ac7f7c6b1bc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Barker, H E, Bird, D, Lang, G & Erler, J T 2013, 'Tumor-secreted LOXL2 activates fibroblasts through FAK signaling', Molecular Cancer Research, vol. 11, no. 11, pp. 1425-36. https://doi.org/10.1158/1541-7786.MCR-13-0033-T","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2983453","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3833835","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1893614529","display_name":null,"funder_award_id":"A11355","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G4925855064","display_name":null,"funder_award_id":"A10433","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1505584712","https://openalex.org/W1562296432","https://openalex.org/W1590619267","https://openalex.org/W1916799666","https://openalex.org/W1959606306","https://openalex.org/W1971446783","https://openalex.org/W1975069346","https://openalex.org/W1995255507","https://openalex.org/W1995721099","https://openalex.org/W1996994627","https://openalex.org/W2006892275","https://openalex.org/W2012124753","https://openalex.org/W2013026724","https://openalex.org/W2016193552","https://openalex.org/W2016838970","https://openalex.org/W2024134178","https://openalex.org/W2025018535","https://openalex.org/W2029231027","https://openalex.org/W2033363278","https://openalex.org/W2036145275","https://openalex.org/W2044895919","https://openalex.org/W2053374287","https://openalex.org/W2053837765","https://openalex.org/W2062809449","https://openalex.org/W2070460007","https://openalex.org/W2074325678","https://openalex.org/W2078502914","https://openalex.org/W2082081720","https://openalex.org/W2083839175","https://openalex.org/W2086585598","https://openalex.org/W2087766713","https://openalex.org/W2092644867","https://openalex.org/W2093760162","https://openalex.org/W2093909277","https://openalex.org/W2096280264","https://openalex.org/W2100303404","https://openalex.org/W2101037339","https://openalex.org/W2104416279","https://openalex.org/W2104479723","https://openalex.org/W2110088809","https://openalex.org/W2127842409","https://openalex.org/W2133140093","https://openalex.org/W2133651123","https://openalex.org/W2145400675","https://openalex.org/W2156711378","https://openalex.org/W2159744630","https://openalex.org/W2160698607","https://openalex.org/W2161744213","https://openalex.org/W2169281418","https://openalex.org/W2411069941","https://openalex.org/W2476542314","https://openalex.org/W7036447705"],"related_works":["https://openalex.org/W2983035661","https://openalex.org/W2886710158","https://openalex.org/W2157813647","https://openalex.org/W2020575974","https://openalex.org/W2147213735","https://openalex.org/W6902300089","https://openalex.org/W4412872082","https://openalex.org/W4225554504","https://openalex.org/W1991761947","https://openalex.org/W2898184980"],"abstract_inverted_index":{"UNLABELLED:":[0],"Cancer-associated":[1],"fibroblasts":[2,48,89,153,165,177],"enhance":[3],"cancer":[4],"progression":[5,242],"when":[6],"activated":[7,46,176],"by":[8],"tumor":[9,19,28,51,196,209,241],"cells":[10,206],"through":[11,154,178],"mechanisms":[12,219],"not":[13,193],"yet":[14],"fully":[15],"understood.":[16],"Blocking":[17],"mammary":[18,27,63],"cell-derived":[20],"lysyl":[21],"oxidase-like":[22],"2":[23],"(LOXL2)":[24],"significantly":[25],"inhibited":[26],"cell":[29,197],"invasion":[30,151,198],"and":[31,35,132,150,228,243],"metastasis":[32],"in":[33,49,60,103,125,164,191,207],"transgenic":[34],"orthotopic":[36],"mouse":[37],"models.":[38],"Here,":[39],"we":[40],"discovered":[41],"that":[42,82,99,129,174,187],"tumor-derived":[43,130],"LOXL2":[44,59,109,131,135,158,175,190],"directly":[45],"stromal":[47],"the":[50,66,92,100,160,202,208,218,231,238],"microenvironment.":[52,210],"Genetic":[53],"manipulation":[54],"or":[55],"antibody":[56],"inhibition":[57,188],"of":[58,68,84,108,152,162,189,204,220,226,233,240],"orthotopically":[61],"grown":[62,166],"tumors":[64,104,116,192],"reduced":[65,106],"expression":[67,83,161],"\u03b1-smooth":[69],"muscle":[70],"actin":[71],"(\u03b1-SMA).":[72],"Using":[73],"a":[74,133,223],"marker":[75,96],"for":[76,237],"reticular":[77],"fibroblasts,":[78],"it":[79,171],"was":[80,86,110,172],"determined":[81,173],"\u03b1-SMA":[85,163],"localized":[87],"to":[88],"recruited":[90],"from":[91],"host":[93,205],"tissue.":[94],"This":[95],"also":[97,200],"revealed":[98,128],"matrix":[101],"present":[102],"with":[105,114,120],"levels":[107],"more":[111],"scattered":[112],"compared":[113],"control":[115],"which":[117],"exhibited":[118],"matrices":[119],"dense,":[121],"parallel":[122],"alignments.":[123],"Importantly,":[124],"vitro":[126],"assays":[127],"recombinant":[134],"protein":[136],"induced":[137,159],"fibroblast":[138,221],"branching":[139],"on":[140,167],"collagen":[141,148,168],"matrices,":[142],"as":[143,145],"well":[144],"increased":[146],"fibroblast-mediated":[147],"contraction":[149],"extracellular":[155],"matrix.":[156],"Moreover,":[157],"matrices.":[169],"Mechanistically,":[170],"integrin-mediated":[179],"focal":[180],"adhesion":[181],"kinase":[182],"activation.":[183],"These":[184,212],"results":[185],"indicate":[186],"only":[194],"reduces":[195],"but":[199],"attenuates":[201],"activation":[203],"IMPLICATIONS:":[211],"findings":[213],"reveal":[214],"new":[215],"insight":[216],"into":[217],"activation,":[222],"novel":[224],"function":[225],"LOXL2,":[227],"further":[229],"highlight":[230],"importance":[232],"generating":[234],"LOXL2-targeted":[235],"therapies":[236],"prevention":[239],"metastasis.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
