{"id":"https://openalex.org/W2105523906","doi":"https://doi.org/10.1186/1744-8069-5-49","title":"Tumor Necrosis Factor-Alpha (TNF-\u03b1) Enhances Functional Thermal and Chemical Responses of TRP Cation Channels in Human Synoviocytes","display_name":"Tumor Necrosis Factor-Alpha (TNF-\u03b1) Enhances Functional Thermal and Chemical Responses of TRP Cation Channels in Human Synoviocytes","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2105523906","doi":"https://doi.org/10.1186/1744-8069-5-49","mag":"2105523906","pmid":"https://pubmed.ncbi.nlm.nih.gov/19695100","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3152771"},"language":"en","primary_location":{"id":"doi:10.1186/1744-8069-5-49","doi":"https://doi.org/10.1186/1744-8069-5-49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1744-8069-5-49","pdf_url":null,"source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/1744-8069-5-49","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003738161","display_name":"Mikhail Y. Kochukov","orcid":"https://orcid.org/0000-0002-8723-6360","observed_orcids":["https://orcid.org/0000-0002-8723-6360"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mikhail Y Kochukov","raw_affiliation_strings":["Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023321073","display_name":"Terry Ann McNearney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Terry A McNearney","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas USA","Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas USA","Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103492291","display_name":"Huaizhi Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Huaizhi Yin","raw_affiliation_strings":["Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100426748","display_name":"Liping Zhang","orcid":"https://orcid.org/0000-0002-4628-2950","observed_orcids":["https://orcid.org/0000-0002-4628-2950"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2801012209","display_name":"Albert B. Chandler Hospital","ror":"https://ror.org/03r8nx235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2801012209"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Liping Zhang","raw_affiliation_strings":["Department of Physiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2801012209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101694047","display_name":"Fei Ma","orcid":"https://orcid.org/0000-0003-0883-431X","observed_orcids":["https://orcid.org/0000-0003-0883-431X"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2801012209","display_name":"Albert B. Chandler Hospital","ror":"https://ror.org/03r8nx235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2801012209"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fei Ma","raw_affiliation_strings":["Department of Physiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2801012209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073625061","display_name":"Larissa V. Ponomareva","orcid":"https://orcid.org/0000-0003-2182-8774","observed_orcids":["https://orcid.org/0000-0003-2182-8774"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2801012209","display_name":"Albert B. Chandler Hospital","ror":"https://ror.org/03r8nx235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2801012209"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Larissa Ponomareva","raw_affiliation_strings":["Department of Physiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2801012209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025408147","display_name":"Sarah M. Abshire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2801012209","display_name":"Albert B. Chandler Hospital","ror":"https://ror.org/03r8nx235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2801012209"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah Abshire","raw_affiliation_strings":["Department of Physiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2801012209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032920452","display_name":"Karin N. Westlund","orcid":"https://orcid.org/0000-0002-7388-4834","observed_orcids":["https://orcid.org/0000-0002-7388-4834"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2801012209","display_name":"Albert B. Chandler Hospital","ror":"https://ror.org/03r8nx235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2801012209"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karin N Westlund","raw_affiliation_strings":["Department of Physiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2801012209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003738161","https://openalex.org/A5023321073","https://openalex.org/A5025408147","https://openalex.org/A5032920452","https://openalex.org/A5073625061","https://openalex.org/A5100426748","https://openalex.org/A5101694047","https://openalex.org/A5103492291"],"corresponding_institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2801012209","https://openalex.org/I55302922"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":2.7383,"has_fulltext":true,"cited_by_count":93,"citation_normalized_percentile":{"value":0.89451988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"5","issue":null,"first_page":"49","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/transient-receptor-potential-channels","display_name":"TRP channels","score":0.8309999704360962},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/trpv4","display_name":"TRPV4","score":1.0},{"id":"https://openalex.org/keywords/synoviocytes","display_name":"synoviocytes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.5630000233650208},{"id":"https://openalex.org/keywords/cytosolic-calcium-oscillations","display_name":"cytosolic calcium oscillations","score":0.8420000076293945},{"id":"https://openalex.org/keywords/thermal-stimulation","display_name":"thermal stimulation","score":0.45500001311302185},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.8820000290870667},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9430000185966492},{"id":"https://openalex.org/keywords/resiniferatoxin","display_name":"resiniferatoxin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/joint-pain","display_name":"joint pain","score":0.6190000176429749},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.5389999747276306},{"id":"https://openalex.org/keywords/channel-expression","display_name":"channel expression","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C90420996","wikidata":"https://www.wikidata.org/wiki/Q15324120","display_name":"TRPV4","level":4,"score":0.7269930839538574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6976648569107056},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.658431887626648},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6557565927505493},{"id":"https://openalex.org/C2776354303","wikidata":"https://www.wikidata.org/wiki/Q3277888","display_name":"Resiniferatoxin","level":5,"score":0.6141564846038818},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.5990769863128662},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5349665284156799},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49339190125465393},{"id":"https://openalex.org/C2776989580","wikidata":"https://www.wikidata.org/wiki/Q421320","display_name":"Ionomycin","level":3,"score":0.47254085540771484},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.44935277104377747},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.4442101716995239},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4059198796749115},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3445776104927063},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32427868247032166},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.27045631408691406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18184447288513184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18062859773635864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1471472978591919},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12721353769302368}],"mesh":[{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009997","descriptor_name":"Osmotic Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018689","descriptor_name":"Sensory System Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050051","descriptor_name":"Transient Receptor Potential Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050051","descriptor_name":"Transient Receptor Potential Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050051","descriptor_name":"Transient Receptor Potential Channels","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1744-8069-5-49","doi":"https://doi.org/10.1186/1744-8069-5-49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1744-8069-5-49","pdf_url":null,"source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3152771","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3152771/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3152771/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Pain","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2159725","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3152771","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:19695100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19695100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pain","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.289.3958","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.3958","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/4c/66/Mol_Pain_2009_Aug_20_5_49.tar.gz","raw_type":"text"},{"id":"pmh:oai:uknowledge.uky.edu:physiology_facpub-1022","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/physiology_facpub/22","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Physiology Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:2abaab5cbdeb42489046cae36d0f78a1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2abaab5cbdeb42489046cae36d0f78a1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Pain, Vol 5, Iss 1, p 49 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1744-8069-5-49","doi":"https://doi.org/10.1186/1744-8069-5-49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1744-8069-5-49","pdf_url":null,"source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4923352481","display_name":"CENTRAL CONTROL OF ARTHRITIS AND ARTHRITIC PAIN","funder_award_id":"R01NS032778","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6642579855","display_name":"Peripheral and Central Sensitization in Pain","funder_award_id":"P01NS011255","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306305","display_name":"Dana Foundation","ror":"https://ror.org/01wt3vs82"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105523906.pdf","grobid_xml":"https://content.openalex.org/works/W2105523906.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1492591187","https://openalex.org/W1549243184","https://openalex.org/W1562645017","https://openalex.org/W1571969265","https://openalex.org/W1887877287","https://openalex.org/W1966148069","https://openalex.org/W1970629236","https://openalex.org/W1975220342","https://openalex.org/W1980209044","https://openalex.org/W1984632338","https://openalex.org/W1990589949","https://openalex.org/W1995615606","https://openalex.org/W1995705528","https://openalex.org/W1996949023","https://openalex.org/W1998214061","https://openalex.org/W1998364728","https://openalex.org/W2012333949","https://openalex.org/W2015834221","https://openalex.org/W2018567987","https://openalex.org/W2020877995","https://openalex.org/W2023966975","https://openalex.org/W2024420229","https://openalex.org/W2035619095","https://openalex.org/W2045959196","https://openalex.org/W2046847419","https://openalex.org/W2051613742","https://openalex.org/W2053332960","https://openalex.org/W2060830991","https://openalex.org/W2063152085","https://openalex.org/W2065687666","https://openalex.org/W2071297569","https://openalex.org/W2072942836","https://openalex.org/W2075838219","https://openalex.org/W2076168355","https://openalex.org/W2077427556","https://openalex.org/W2082908786","https://openalex.org/W2083721607","https://openalex.org/W2084415764","https://openalex.org/W2097824035","https://openalex.org/W2102129421","https://openalex.org/W2104721296","https://openalex.org/W2107277218","https://openalex.org/W2116655439","https://openalex.org/W2117366861","https://openalex.org/W2119832782","https://openalex.org/W2121557648","https://openalex.org/W2123481305","https://openalex.org/W2128158693","https://openalex.org/W2141260882","https://openalex.org/W2144888928","https://openalex.org/W2146044794","https://openalex.org/W2168733491","https://openalex.org/W2169915413","https://openalex.org/W2588080549","https://openalex.org/W4247730450"],"related_works":["https://openalex.org/W7100110455","https://openalex.org/W2104721296","https://openalex.org/W2953006922","https://openalex.org/W3038778010","https://openalex.org/W2046617002","https://openalex.org/W2107884320","https://openalex.org/W2144298013","https://openalex.org/W3175572287","https://openalex.org/W2804385570","https://openalex.org/W2145611986"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"have":[2],"shown":[3],"functional":[4],"expression":[5,34,224],"of":[6,61,83,98,123,180,239,257],"several":[7],"TRP":[8,33,231],"channels":[9],"on":[10,229],"human":[11,64],"synovial":[12],"cells,":[13],"proposing":[14],"significance":[15],"in":[16,24,259],"known":[17],"calcium":[18,72,249],"dependent":[19,228],"proliferative":[20],"and":[21,35,40,69,80,87,91,113,134,158,164,175,198,205,222,225,233,241],"secretory":[22],"responses":[23,37,186,256],"joint":[25],"inflammation.":[26],"The":[27],"present":[28],"study":[29],"further":[30],"characterizes":[31],"synoviocyte":[32,220],"activation":[36,96,137],"to":[38,187,212],"thermal":[39],"osmotic":[41,93],"stimuli":[42],"after":[43,170,235],"pre-treatment":[44,101,130],"with":[45,138,183,208],"proinflammatory":[46],"mediator":[47],"tumor":[48],"necrosis":[49],"factor":[50],"alpha":[51],"(TNF-alpha,":[52],"EC50":[53],"1.3221":[54],"x":[55],"10(-10)":[56],"g/L).":[57],"RESULTS:":[58],"Fluorescent":[59],"imaging":[60],"Fura-2":[62],"loaded":[63],"SW982":[65],"synoviocytes":[66,181,258],"reveals":[67],"immediate":[68],"delayed":[70],"cytosolic":[71],"oscillations":[73],"elicited":[74],"by":[75],"(1)":[76],"TRPV1":[77,163,194,210,221,240],"agonists":[78],"capsaicin":[79,109],"resiniferatoxin":[81],"(20-40%":[82],"cells),":[84],"(2)":[85],"moderate":[86],"noxious":[88],"temperature":[89,124,153],"change,":[90],"(3)":[92],"stress":[94],"TRPV4":[95,165,185,199,223,242],"(11.5%":[97],"cells).":[99],"TNF-alpha":[100,129,172,192,216],"(1":[102],"ng/ml,":[103],"8-16":[104],"hr)":[105,177],"significantly":[106],"increases":[107,193],"(doubles)":[108],"responsive":[110],"cell":[111,251],"numbers":[112],"[Ca2+]i":[114,126,147,226],"spike":[115],"frequency,":[116],"as":[117,119,243],"well":[118],"enhances":[120],"average":[121],"amplitude":[122],"induced":[125,154],"responses.":[127],"With":[128],"for":[131,254],"8,":[132],"12,":[133],"16":[135,176],"hr,":[136],"36":[139],"or":[140],"45":[141],"degree":[142],"bath":[143],"solution":[144],"induces":[145],"bimodal":[146],"increase":[148],"(temperature":[149],"controlled":[150],"chamber).":[151],"Initial":[152],"rapid":[155],"transient":[156],"spikes":[157],"subsequent":[159],"slower":[160],"rise":[161],"reflect":[162],"channel":[166],"activation,":[167],"respectively.":[168],"Only":[169],"prolonged":[171],"exposure":[173],"(12":[174,200],"is":[178],"recruitment":[179],"observed":[182],"sensitized":[184],"hypoosmolarity":[188],"(3-4":[189],"fold":[190],"increase).":[191],"(8":[195],"hr":[196,201],"peak)":[197,202],"immunostaining,":[203],"mRNA":[204],"protein":[206],"expression,":[207],"a":[209],"shift":[211],"membrane":[213],"fractions.":[214],"CONCLUSION:":[215],"provides":[217],"differentially":[218],"enhanced":[219],"response":[227],"the":[230],"stimulus":[232],"time":[234],"exposure.":[236],"Augmented":[237],"relevance":[238],"inflammatory":[244,260],"conditions":[245],"persist":[246],"would":[247],"provide":[248],"mediated":[250],"signaling":[252],"required":[253],"pathophysiological":[255],"pain":[261],"states.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
