{"id":"https://openalex.org/W2105523705","doi":"https://doi.org/10.1586/14787210.2.3.345","title":"Micafungin: a therapeutic review","display_name":"Micafungin: a therapeutic review","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2105523705","doi":"https://doi.org/10.1586/14787210.2.3.345","mag":"2105523705","pmid":"https://pubmed.ncbi.nlm.nih.gov/15482200"},"language":"en","primary_location":{"id":"doi:10.1586/14787210.2.3.345","doi":"https://doi.org/10.1586/14787210.2.3.345","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14787210.2.3.345","pdf_url":null,"source":{"id":"https://openalex.org/S185628608","display_name":"Expert Review of Anti-infective Therapy","issn_l":"1478-7210","issn":["1478-7210","1744-8336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anti-infective Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077493786","display_name":"Yasuhito Higashiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhito Higashiyama","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan. higashi-ngs@umin.ac.jp","Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. higashi-ngs@umin.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan. higashi-ngs@umin.ac.jp","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. higashi-ngs@umin.ac.jp","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110503250","display_name":"Shigeru Kohno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Kohno","raw_affiliation_strings":["Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. s-kohno@net.nagasaki-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. s-kohno@net.nagasaki-u.ac.jp","institution_ids":["https://openalex.org/I43777268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I43777268"],"apc_list":null,"apc_paid":null,"fwci":4.2117,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.93963081,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"2","issue":"3","first_page":"345","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micafungin","display_name":"micafungin","score":1.0},{"id":"https://openalex.org/keywords/echinocandins","display_name":"echinocandins","score":0.953000009059906},{"id":"https://openalex.org/keywords/aspergillosis","display_name":"aspergillosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/candidiasis","display_name":"candidiasis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/systemic-fungal-infection","display_name":"systemic fungal infection","score":0.9419999718666077},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8949999809265137},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.796999990940094},{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.9039999842643738},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/aspergillus","display_name":"Aspergillus","score":0.7940000295639038},{"id":"https://openalex.org/keywords/candida","display_name":"Candida","score":1.0}],"concepts":[{"id":"https://openalex.org/C2779020398","wikidata":"https://www.wikidata.org/wiki/Q6827850","display_name":"Micafungin","level":4,"score":0.8601771593093872},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42571690678596497},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3569451868534088},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3213741183280945},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.11968013644218445},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.07480129599571228},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077551","descriptor_name":"Micafungin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002180","descriptor_name":"Candidiasis, Oral","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002180","descriptor_name":"Candidiasis, Oral","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D054714","descriptor_name":"Echinocandins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1586/14787210.2.3.345","doi":"https://doi.org/10.1586/14787210.2.3.345","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14787210.2.3.345","pdf_url":null,"source":{"id":"https://openalex.org/S185628608","display_name":"Expert Review of Anti-infective Therapy","issn_l":"1478-7210","issn":["1478-7210","1744-8336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anti-infective Therapy","raw_type":"journal-article"},{"id":"pmid:15482200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15482200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of anti-infective therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W423196039","https://openalex.org/W1545447618","https://openalex.org/W1982658432","https://openalex.org/W2018482202","https://openalex.org/W2043216325","https://openalex.org/W2076335775","https://openalex.org/W2082389923","https://openalex.org/W2087349592","https://openalex.org/W2099140379","https://openalex.org/W2119259239","https://openalex.org/W2120354182"],"related_works":["https://openalex.org/W2043216325","https://openalex.org/W7096397784","https://openalex.org/W1998630054","https://openalex.org/W2080353009","https://openalex.org/W2128243354","https://openalex.org/W7096532947","https://openalex.org/W2377942036","https://openalex.org/W2030235418","https://openalex.org/W3143481397","https://openalex.org/W2088872317"],"abstract_inverted_index":{"In":[0,95],"recent":[1],"decades,":[2],"the":[3,43,50,90,121],"incidence":[4],"of":[5,35,49,79,92,124],"aspergillosis,":[6],"candidiasis":[7,114,132],"and":[8,21,60,74,113],"clinically":[9],"important":[10],"deep":[11,93],"mycoses":[12],"has":[13,28],"been":[14,29],"increasing,":[15],"with":[16,128,137],"advances":[17],"in":[18,42,63,89,98,126,135],"transplantation":[19],"medicine":[20],"anticancer":[22],"chemotherapy.":[23],"Micafungin":[24,85,116],"(FK463,":[25],"Fujisawa":[26],"Healthcare)":[27],"developed":[30],"as":[31],"a":[32,70,75],"novel":[33],"type":[34],"antifungal":[36,55],"agent,":[37],"which":[38],"inhibits":[39],"1,3-beta-D-glucan":[40],"synthase":[41],"fungal":[44],"cell":[45],"wall.":[46],"Micafungin,":[47],"one":[48],"echinocandins,":[51],"exhibits":[52],"extremely":[53],"high":[54],"activity":[56],"against":[57,107],"Aspergillus":[58],"spp.":[59,62],"Candida":[61],"vitro.":[64],"It":[65],"is":[66,86,117],"also":[67],"characterized":[68],"by":[69],"linear":[71],"pharmacokinetic":[72],"profile":[73],"much":[76],"lower":[77],"prevalence":[78],"adverse":[80],"reactions":[81],"than":[82],"amphotericin":[83,138],"B.":[84],"quite":[87],"useful":[88],"treatment":[91,125],"mycoses.":[94],"clinical":[96],"studies":[97],"Japan,":[99],"micafungin":[100],"was":[101],"found":[102],"to":[103,119],"be":[104],"highly":[105],"effective":[106],"aspergillosis":[108,130],"(57.1%":[109],"overall":[110],"efficacy":[111,122],"rate)":[112],"(78.6%).":[115],"expected":[118],"increase":[120],"rate":[123],"patients":[127],"severe":[129],"or":[131,140],"when":[133],"used":[134],"combination":[136],"B":[139],"mold":[141],"azoles.":[142]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}