{"id":"https://openalex.org/W2105487708","doi":null,"title":"Wnt signaling, a novel pathway for coronary artery disease and metabolic syndrome","display_name":"Wnt signaling, a novel pathway for coronary artery disease and metabolic syndrome","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2105487708","mag":"2105487708"},"language":"en","primary_location":{"id":"mag:2105487708","doi":null,"is_oa":false,"landing_page_url":"http://ircrj.com/13234.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764521147","display_name":"International Cardivascular Research Journal","issn_l":"2251-9130","issn":["2251-9130","2251-9149"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319077","host_organization_name":"Shiraz University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319077"],"host_organization_lineage_names":["Shiraz University of Medical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Cardivascular Research Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041279122","display_name":"Arya Mani","orcid":"https://orcid.org/0000-0001-6699-259X","observed_orcids":["https://orcid.org/0000-0001-6699-259X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arya Mani","raw_affiliation_strings":["Yale University  ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University  ;","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041279122"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"2","first_page":"59","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.09759999811649323,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.09149999916553497,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":1.0},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5389999747276306},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.49900001287460327},{"id":"https://openalex.org/keywords/abca1","display_name":"ABCA1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/abcg5-8","display_name":"ABCG5/8","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cholesterol-efflux","display_name":"cholesterol efflux","score":0.746999979019165},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8989999890327454},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.675000011920929},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6899999976158142},{"id":"https://openalex.org/keywords/glucose-detection","display_name":"glucose detection","score":0.6019999980926514},{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tangier-disease","display_name":"Tangier disease","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6106004118919373},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.5063830614089966},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4959295690059662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4888586401939392},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47335290908813477},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.45111703872680664},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.43388354778289795},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.433859646320343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4241983890533447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4212988317012787},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4169888496398926},{"id":"https://openalex.org/C2777704780","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ABCA1","level":4,"score":0.4157179594039917},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3536478877067566},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27871209383010864},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.06934988498687744}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2105487708","doi":null,"is_oa":false,"landing_page_url":"http://ircrj.com/13234.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764521147","display_name":"International Cardivascular Research Journal","issn_l":"2251-9130","issn":["2251-9130","2251-9149"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319077","host_organization_name":"Shiraz University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319077"],"host_organization_lineage_names":["Shiraz University of Medical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Cardivascular Research Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1743302011","https://openalex.org/W1965141016","https://openalex.org/W1986515287","https://openalex.org/W1988605096","https://openalex.org/W1994922837","https://openalex.org/W1999603875","https://openalex.org/W2002404925","https://openalex.org/W2013082477","https://openalex.org/W2013460988","https://openalex.org/W2017518223","https://openalex.org/W2021513620","https://openalex.org/W2026348270","https://openalex.org/W2037132744","https://openalex.org/W2037832608","https://openalex.org/W2046982257","https://openalex.org/W2049875806","https://openalex.org/W2051907575","https://openalex.org/W2053265248","https://openalex.org/W2054427773","https://openalex.org/W2063693981","https://openalex.org/W2066606668","https://openalex.org/W2072731310","https://openalex.org/W2075460910","https://openalex.org/W2078126254","https://openalex.org/W2082604269","https://openalex.org/W2086694435","https://openalex.org/W2092494241","https://openalex.org/W2101324476","https://openalex.org/W2105054202","https://openalex.org/W2105350606","https://openalex.org/W2105407346","https://openalex.org/W2111113377","https://openalex.org/W2114511731","https://openalex.org/W2119413986","https://openalex.org/W2122155371","https://openalex.org/W2124663880","https://openalex.org/W2125904354","https://openalex.org/W2127409471","https://openalex.org/W2136140188","https://openalex.org/W2156959752","https://openalex.org/W2163341100","https://openalex.org/W2463447536"],"related_works":["https://openalex.org/W2010943934","https://openalex.org/W2051907575","https://openalex.org/W7096484044","https://openalex.org/W2809934653","https://openalex.org/W2169051917","https://openalex.org/W2788544216","https://openalex.org/W2587950337","https://openalex.org/W2353425152","https://openalex.org/W2015343787","https://openalex.org/W2094885129"],"abstract_inverted_index":{"Genetic":[0,35],"influences":[1],"on":[2,48],"coronary":[3,23,254],"artery":[4,24,255],"disease":[5,25,92,110,256],"Much":[6],"of":[7,13,21,37,65,131,141,147,178,196,226,237,243,251],"the":[8,11,19,66,70,81,101,168,180,224,235,249],"reduction":[9],"in":[10,78,95,115,206,212,228,240],"incidence":[12],"myocardial":[14],"infarction":[15],"is":[16,171],"attributable":[17],"to":[18,75,87,108,166,173,258],"identification":[20,195],"reversible":[22],"risk":[26,50,149],"factors":[27,51,150],"that":[28,43,62,106,117,183],"have":[29,52,187],"been":[30,188],"identified":[31,53],"by":[32,124,159],"epidemiological":[33],"studies.":[34],"studies":[36],"rare":[38],"families":[39],"segregating":[40],"single":[41],"genes":[42,55,116],"impart":[44],"very":[45],"large":[46],"effects":[47],"CAD":[49,143,201],"many":[54,146],"and":[56,90,93,103,202,245,248,253],"physiologic":[57],"pathways1-3.":[58],"For":[59],"example,":[60],"mutations":[61,77,94,114,135],"impair":[63,80,97,118],"function":[64],"LDL":[67,71],"receptor":[68],"or":[69,121],"endocytosis":[72],"machinery":[73],"lead":[74],"hypercholesterolemia,":[76],"ABCA1":[79],"systemic":[82],"cholesterol":[83,98],"efflux":[84,99],"pathway":[85,217,239],"leads":[86,107],"low":[88],"HDL":[89],"Tangier":[91],"ABCG5/8":[96],"from":[100],"enterocyte":[102],"biliary":[104],"system":[105],"a":[109,175,197,216],"called":[111],"sitostrolemia.":[112],"Finally,":[113],"glucose":[119,244],"sensing":[120],"insulin":[122],"secretion":[123],"pancreatic":[125],"beta":[126],"cells":[127],"constitute":[128],"Mendelian":[129],"forms":[130],"diabetes":[132,252],"mellitus1-3.":[133],"These":[134],"account":[136],"for":[137,200],"only":[138],"small":[139],"proportion":[140],"all":[142],"cases.":[144],"Surprisingly,":[145],"these":[148],"cluster":[151],"with":[152],"one":[153],"another":[154],"more":[155],"often":[156],"than":[157],"expected":[158],"chance4,5":[160],";":[161],"while":[162],"this":[163,213,238],"clustering,":[164],"referred":[165],"as":[167,219],"metabolic":[169,203],"syndrome,":[170],"recognized":[172],"be":[174],"common":[176],"cause":[177],"CAD,":[179],"molecular":[181],"mechanisms":[182],"unify":[184],"their":[185],"association":[186],"obscure.":[189],"Following":[190],"we":[191],"will":[192],"describe":[193],"our":[194,232],"gene":[198,214],"responsible":[199],"syndrome":[204],"discovered":[205],"an":[207],"Iranian":[208],"kindred.":[209],"The":[210],"mutation":[211],"impairs":[215],"known":[218],"Wnt":[220,229],"signaling":[221,230],"pathway.":[222],"With":[223],"expansion":[225],"research":[227],"pathways,":[231],"knowledge":[233],"about":[234],"role":[236],"physiological":[241],"processes":[242],"lipid":[246],"metabolism":[247],"pathogenesis":[250],"continues":[257],"increase.":[259]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}