{"id":"https://openalex.org/W2105460586","doi":null,"title":"Molecular Mechanism of HIV-1 Infection: Role of Viral and Host Determinants","display_name":"Molecular Mechanism of HIV-1 Infection: Role of Viral and Host Determinants","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2105460586","mag":"2105460586"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/194906","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/194906","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087480223","display_name":"Vasudha Sundaravaradan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vasudha Sundaravaradan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087480223"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.7979999780654907},{"id":"https://openalex.org/keywords/vertical-transmission","display_name":"vertical transmission","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mother-to-child-transmission","display_name":"mother-to-child transmission","score":0.925000011920929},{"id":"https://openalex.org/keywords/neonatal-hiv-infection","display_name":"neonatal HIV infection","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hiv-1-replication","display_name":"HIV-1 replication","score":0.6470000147819519},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hiv-1-subtype-c","display_name":"HIV-1 subtype C","score":0.6990000009536743},{"id":"https://openalex.org/keywords/hiv-1-subtype-b","display_name":"HIV-1 subtype B","score":0.7789999842643738},{"id":"https://openalex.org/keywords/gp120","display_name":"gp120","score":0.718999981880188},{"id":"https://openalex.org/keywords/reverse-transcriptase","display_name":"reverse transcriptase","score":0.7739999890327454},{"id":"https://openalex.org/keywords/viral-heterogeneity","display_name":"viral heterogeneity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/ctl-epitopes","display_name":"CTL epitopes","score":0.8399999737739563},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.5440000295639038},{"id":"https://openalex.org/keywords/cellular-gene-expression","display_name":"cellular gene expression","score":0.5860000252723694},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9950000047683716},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mononuclear-cells","display_name":"mononuclear cells","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.76406329870224},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.669963538646698},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6533843874931335},{"id":"https://openalex.org/C140933497","wikidata":"https://www.wikidata.org/wiki/Q7933606","display_name":"Viral pathogenesis","level":4,"score":0.6222243905067444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5723894834518433},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5322138071060181},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4941757023334503},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4761110246181488},{"id":"https://openalex.org/C25897203","wikidata":"https://www.wikidata.org/wiki/Q3241872","display_name":"Viral life cycle","level":4,"score":0.4615156352519989},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.4342689514160156},{"id":"https://openalex.org/C3020564189","wikidata":"https://www.wikidata.org/wiki/Q16963978","display_name":"Host factors","level":3,"score":0.4211902618408203},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.28215527534484863},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/194906","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/194906","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:2105460586","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/194906","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":259,"referenced_works":["https://openalex.org/W20900764","https://openalex.org/W23276160","https://openalex.org/W82820957","https://openalex.org/W791550880","https://openalex.org/W1481103413","https://openalex.org/W1481783157","https://openalex.org/W1483105582","https://openalex.org/W1488614393","https://openalex.org/W1490341201","https://openalex.org/W1495572786","https://openalex.org/W1517394695","https://openalex.org/W1529449434","https://openalex.org/W1532718280","https://openalex.org/W1556472699","https://openalex.org/W1576999979","https://openalex.org/W1581940036","https://openalex.org/W1592797533","https://openalex.org/W1601671592","https://openalex.org/W1605427724","https://openalex.org/W1606434265","https://openalex.org/W1623426438","https://openalex.org/W1660391569","https://openalex.org/W1726325960","https://openalex.org/W1739595091","https://openalex.org/W1791659070","https://openalex.org/W1831506252","https://openalex.org/W1860192217","https://openalex.org/W1876598876","https://openalex.org/W1907128970","https://openalex.org/W1907806866","https://openalex.org/W1923186253","https://openalex.org/W1923989984","https://openalex.org/W1959525771","https://openalex.org/W1965019797","https://openalex.org/W1966743306","https://openalex.org/W1968365367","https://openalex.org/W1971592398","https://openalex.org/W1973711348","https://openalex.org/W1974839791","https://openalex.org/W1974877011","https://openalex.org/W1976086277","https://openalex.org/W1976439804","https://openalex.org/W1977279184","https://openalex.org/W1977282539","https://openalex.org/W1977599839","https://openalex.org/W1977602241","https://openalex.org/W1978847332","https://openalex.org/W1980169905","https://openalex.org/W1980214158","https://openalex.org/W1980494192","https://openalex.org/W1981422768","https://openalex.org/W1981548028","https://openalex.org/W1981788436","https://openalex.org/W1985821700","https://openalex.org/W1987254473","https://openalex.org/W1988433373","https://openalex.org/W1988590957","https://openalex.org/W1988859032","https://openalex.org/W1988885237","https://openalex.org/W1989791734","https://openalex.org/W1989929122","https://openalex.org/W1991488126","https://openalex.org/W1991670386","https://openalex.org/W1992019167","https://openalex.org/W1992092615","https://openalex.org/W1992584725","https://openalex.org/W1993591984","https://openalex.org/W1994646934","https://openalex.org/W1995188936","https://openalex.org/W1996095928","https://openalex.org/W1996115858","https://openalex.org/W1996183144","https://openalex.org/W1997643168","https://openalex.org/W1997739078","https://openalex.org/W1998660799","https://openalex.org/W2000722915","https://openalex.org/W2000884295","https://openalex.org/W2003917700","https://openalex.org/W2004200027","https://openalex.org/W2005177157","https://openalex.org/W2005732333","https://openalex.org/W2005914731","https://openalex.org/W2006164139","https://openalex.org/W2006347626","https://openalex.org/W2007444855","https://openalex.org/W2008954911","https://openalex.org/W2009581957","https://openalex.org/W2010561000","https://openalex.org/W2011153626","https://openalex.org/W2011350578","https://openalex.org/W2012456268","https://openalex.org/W2015158795","https://openalex.org/W2016264635","https://openalex.org/W2016738212","https://openalex.org/W2017370553","https://openalex.org/W2021507100","https://openalex.org/W2021556459","https://openalex.org/W2021644405","https://openalex.org/W2021932640","https://openalex.org/W2023146202","https://openalex.org/W2023450115","https://openalex.org/W2025208167","https://openalex.org/W2027234717","https://openalex.org/W2027954843","https://openalex.org/W2030104330","https://openalex.org/W2030661863","https://openalex.org/W2030864229","https://openalex.org/W2031232276","https://openalex.org/W2032157497","https://openalex.org/W2032722583","https://openalex.org/W2032737565","https://openalex.org/W2033848756","https://openalex.org/W2034248746","https://openalex.org/W2039115028","https://openalex.org/W2040258341","https://openalex.org/W2040831006","https://openalex.org/W2041476640","https://openalex.org/W2043192633","https://openalex.org/W2044524906","https://openalex.org/W2044848832","https://openalex.org/W2048574795","https://openalex.org/W2048632978","https://openalex.org/W2049827120","https://openalex.org/W2050682981","https://openalex.org/W2052506627","https://openalex.org/W2052636198","https://openalex.org/W2052921625","https://openalex.org/W2053174277","https://openalex.org/W2053465368","https://openalex.org/W2054012799","https://openalex.org/W2055853328","https://openalex.org/W2056229188","https://openalex.org/W2056313383","https://openalex.org/W2057448926","https://openalex.org/W2060163862","https://openalex.org/W2060699734","https://openalex.org/W2061563001","https://openalex.org/W2063265842","https://openalex.org/W2066797385","https://openalex.org/W2068884761","https://openalex.org/W2069243230","https://openalex.org/W2071516463","https://openalex.org/W2072901265","https://openalex.org/W2075147125","https://openalex.org/W2075174537","https://openalex.org/W2075445500","https://openalex.org/W2075470140","https://openalex.org/W2077127551","https://openalex.org/W2077470072","https://openalex.org/W2077932756","https://openalex.org/W2080117718","https://openalex.org/W2080157134","https://openalex.org/W2081258532","https://openalex.org/W2082928585","https://openalex.org/W2083719082","https://openalex.org/W2084341498","https://openalex.org/W2084997150","https://openalex.org/W2085919513","https://openalex.org/W2086044183","https://openalex.org/W2087814255","https://openalex.org/W2088222944","https://openalex.org/W2088493593","https://openalex.org/W2088965973","https://openalex.org/W2089142368","https://openalex.org/W2090126383","https://openalex.org/W2091051120","https://openalex.org/W2091262391","https://openalex.org/W2091388219","https://openalex.org/W2093901039","https://openalex.org/W2093946365","https://openalex.org/W2095331952","https://openalex.org/W2095724872","https://openalex.org/W2097784779","https://openalex.org/W2100267080","https://openalex.org/W2100270803","https://openalex.org/W2100488258","https://openalex.org/W2101049386","https://openalex.org/W2103216867","https://openalex.org/W2104919701","https://openalex.org/W2105220936","https://openalex.org/W2105893126","https://openalex.org/W2106448315","https://openalex.org/W2107179385","https://openalex.org/W2107303716","https://openalex.org/W2107815011","https://openalex.org/W2108287388","https://openalex.org/W2109586979","https://openalex.org/W2109664852","https://openalex.org/W2110917275","https://openalex.org/W2111667613","https://openalex.org/W2113037681","https://openalex.org/W2113304454","https://openalex.org/W2115471023","https://openalex.org/W2116709453","https://openalex.org/W2117116691","https://openalex.org/W2117385081","https://openalex.org/W2118393797","https://openalex.org/W2119630025","https://openalex.org/W2120118559","https://openalex.org/W2120396538","https://openalex.org/W2120865735","https://openalex.org/W2120943472","https://openalex.org/W2122767209","https://openalex.org/W2123404862","https://openalex.org/W2123488354","https://openalex.org/W2124061807","https://openalex.org/W2126243170","https://openalex.org/W2126515754","https://openalex.org/W2127532387","https://openalex.org/W2130620201","https://openalex.org/W2130635171","https://openalex.org/W2131460813","https://openalex.org/W2131481128","https://openalex.org/W2132603033","https://openalex.org/W2133533219","https://openalex.org/W2133585817","https://openalex.org/W2135729452","https://openalex.org/W2136817755","https://openalex.org/W2137966586","https://openalex.org/W2138210092","https://openalex.org/W2142504336","https://openalex.org/W2142635246","https://openalex.org/W2142683714","https://openalex.org/W2144634347","https://openalex.org/W2145578434","https://openalex.org/W2146603464","https://openalex.org/W2147294251","https://openalex.org/W2147413871","https://openalex.org/W2147915261","https://openalex.org/W2148273885","https://openalex.org/W2149951876","https://openalex.org/W2151200015","https://openalex.org/W2156748342","https://openalex.org/W2160659225","https://openalex.org/W2161588314","https://openalex.org/W2162513914","https://openalex.org/W2162772698","https://openalex.org/W2164241626","https://openalex.org/W2164436869","https://openalex.org/W2166823869","https://openalex.org/W2166883229","https://openalex.org/W2170975463","https://openalex.org/W2172708696","https://openalex.org/W2172979631","https://openalex.org/W2177206906","https://openalex.org/W2180347587","https://openalex.org/W2208634582","https://openalex.org/W2210178863","https://openalex.org/W2253967183","https://openalex.org/W2271745594","https://openalex.org/W2296472299","https://openalex.org/W2316970929","https://openalex.org/W2321059210","https://openalex.org/W2405525952","https://openalex.org/W2416045060","https://openalex.org/W2425917325","https://openalex.org/W2473182354","https://openalex.org/W2493480757","https://openalex.org/W2602284652"],"related_works":["https://openalex.org/W842384335","https://openalex.org/W426510617","https://openalex.org/W2166417553","https://openalex.org/W2036284515","https://openalex.org/W2131517058","https://openalex.org/W2131328336","https://openalex.org/W1585615630","https://openalex.org/W1592797533","https://openalex.org/W1976573236","https://openalex.org/W7100288842"],"abstract_inverted_index":{"Most":[0],"neonates":[1,82,323,348],"and":[2,14,39,67,77,96,99,106,118,140,152,181,212,226,251,260,265,273,293,308,320,324,343,349],"infants":[3,33,117],"acquire":[4],"HIV-1":[5,53,75,114,123,158,174,256,269,282,317,339],"infection":[6,54,238],"as":[7],"a":[8,35,134,141],"result":[9],"of":[10,25,50,60,89,122,137,144,157,178,203,233,255,281,286,291,336,338],"mother-to-infant":[11],"(vertical)":[12],"transmission":[13,132],"are":[15,55],"infected":[16,32,45,164,347],"with":[17,21,112,173,184,208,221,235,240,315],"the":[18,26,48,191,279,334],"minor":[19],"genotype":[20],"macrophage-tropic":[22],"(R5)":[23],"phenotype":[24],"mother.":[27],"Several":[28],"studies":[29],"suggest":[30],"that":[31,64,108,190,267,311],"have":[34],"higher":[36,209],"viral":[37,65,90,138],"load":[38],"develop":[40],"AIDS":[41],"more":[42],"rapidly":[43],"than":[44],"adults,":[46],"but":[47],"mechanisms":[49,254],"this":[51],"differential":[52,68,74,113,268],"not":[56],"known.":[57],"The":[58,120,253],"hypothesis":[59],"my":[61],"dissertation":[62],"is":[63,276],"determinants":[66],"cellular":[69,103,287],"gene":[70,125,283,288,318],"expression":[71,289,319],"profiles":[72],"influence":[73],"replication":[76,115,210,257,270,321],"disease":[78,249,344],"progression":[79,250,345],"seen":[80],"in":[81,116,215,258,271,322,346],"vs.":[83],"adults.":[84,119],"This":[85],"work":[86],"includes":[87],"characterization":[88,121,156],"determinants,":[91,101],"including":[92,102,304],"reverse":[93],"transcriptase":[94],"(RT)":[95],"envelope":[97,161],"gp120,":[98],"host":[100],"transcription":[104,305],"factors":[105],"cytokines":[107,307],"may":[109,243,312],"be":[110,244,313],"associated":[111,314],"RT":[124],"from":[126,163,166,196],"five":[127],"mother-infant":[128],"pairs":[129],"following":[130],"vertical":[131,340],"revealed":[133],"low":[135],"degree":[136],"heterogeneity":[139],"high":[142],"conservation":[143],"intact":[145],"open":[146],"reading":[147],"frames":[148],"comprising":[149],"functional":[150],"domains":[151],"CTL":[153],"epitopes.":[154],"Biological":[155],"subtype":[159,175,186,192,216,222,227,236,241],"C":[160,193,217,237],"gp120":[162,195],"patients":[165,197],"India":[167],"was":[168,263],"performed":[169,297],"by":[170,298],"constructing":[171],"chimeras":[172,219,225],"B.":[176],"Infection":[177],"cell":[179],"lines":[180],"primary":[182,229],"cells":[183,262,275,296],"chimeric":[185],"C/B":[187],"virus":[188,204,213],"showed":[189],"env":[194,218,224],"contributed":[198],"to":[199],"an":[200],"increased":[201,316],"rate":[202],"entry,":[205],"which":[206],"correlated":[207],"efficiencies":[211],"production":[214],"compared":[220,239],"B":[223,228,242],"isolates.":[230],"Higher":[231],"level":[232,280],"viremia":[234],"responsible":[245],"for":[246],"its":[247],"rapid":[248],"spread.":[252],"neonatal":[259,272,292],"adult":[261,274,294],"determined":[264],"found":[266],"influenced":[277],"at":[278],"expression.":[284],"Evaluation":[285],"profile":[290],"mononuclear":[295],"microarray":[299],"analysis":[300],"identified":[301],"several":[302],"factors,":[303,306],"matrix":[309],"metalloproteinases":[310],"infants.":[325,350],"Taken":[326],"together,":[327],"these":[328],"results":[329],"provide":[330],"new":[331],"insights":[332],"into":[333],"understanding":[335],"mecahnsims":[337],"transmission,":[341],"pathogenesis":[342]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}