{"id":"https://openalex.org/W2105433670","doi":"https://doi.org/10.1016/s0140-6736(08)60839-9","title":"Use of a patch containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase II, randomised, double-blind, placebo-controlled field trial","display_name":"Use of a patch containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase II, randomised, double-blind, placebo-controlled field trial","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W2105433670","doi":"https://doi.org/10.1016/s0140-6736(08)60839-9","mag":"2105433670","pmid":"https://pubmed.ncbi.nlm.nih.gov/18554712"},"language":"en","primary_location":{"id":"doi:10.1016/s0140-6736(08)60839-9","doi":"https://doi.org/10.1016/s0140-6736(08)60839-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(08)60839-9","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084972288","display_name":"Sarah A. Frech","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A Frech","raw_affiliation_strings":["IOMAI Corporation, Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOMAI Corporation, Gaithersburg, MD, USA","institution_ids":["https://openalex.org/I4210165951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022890061","display_name":"Herbert L. DuPont","orcid":"https://orcid.org/0000-0003-1652-7168","observed_orcids":["https://orcid.org/0000-0003-1652-7168"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert L DuPont","raw_affiliation_strings":["University of Texas, Houston School of Public Health, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Houston School of Public Health, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015827554","display_name":"August Louis Bourgeois","orcid":"https://orcid.org/0000-0001-8952-5302","observed_orcids":["https://orcid.org/0000-0001-8952-5302"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Louis Bourgeois","raw_affiliation_strings":["Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110658519","display_name":"Robin McKenzie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin McKenzie","raw_affiliation_strings":["Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015918274","display_name":"Jaime Belkind\u2010Gerson","orcid":"https://orcid.org/0000-0002-3733-2127","observed_orcids":["https://orcid.org/0000-0002-3733-2127"]},"institutions":[{"id":"https://openalex.org/I4210128723","display_name":"Instituto Nacional de Salud P\u00fablica","ror":"https://ror.org/032y0n460","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jaime Belkind-Gerson","raw_affiliation_strings":["Instituto Nacional de Salud P\u00fablica, Cuernavaca, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Salud P\u00fablica, Cuernavaca, Mexico","institution_ids":["https://openalex.org/I4210128723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019945705","display_name":"Jos\u00e9 F. Figueroa","orcid":"https://orcid.org/0000-0003-3811-257X","observed_orcids":["https://orcid.org/0000-0003-3811-257X"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose F Figueroa","raw_affiliation_strings":["University of Texas Medical School at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical School at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080586874","display_name":"Pablo C. Okhuysen","orcid":"https://orcid.org/0000-0002-1596-3411","observed_orcids":["https://orcid.org/0000-0002-1596-3411"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pablo C Okhuysen","raw_affiliation_strings":["University of Texas Medical School at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical School at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022117445","display_name":"Norma H Guerrero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norma H Guerrero","raw_affiliation_strings":["Hospital Jardines de Guadalupe, Guadalajara, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Jardines de Guadalupe, Guadalajara, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107502729","display_name":"Francisco Martinez\u2010Sandoval","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130040446","display_name":"Universidad Aut\u00f3noma de Guadalajara","ror":"https://ror.org/05ppk0267","country_code":"MX","type":"education","lineage":["https://openalex.org/I130040446"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Francisco G Martinez-Sandoval","raw_affiliation_strings":["Universidad Aut\u00f3noma de Guadalajara, Guadalajara, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Aut\u00f3noma de Guadalajara, Guadalajara, Mexico","institution_ids":["https://openalex.org/I130040446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036584038","display_name":"Juan HM Mel\u00e9ndez-Romero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130040446","display_name":"Universidad Aut\u00f3noma de Guadalajara","ror":"https://ror.org/05ppk0267","country_code":"MX","type":"education","lineage":["https://openalex.org/I130040446"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Juan HM Mel\u00e9ndez-Romero","raw_affiliation_strings":["Universidad Aut\u00f3noma de Guadalajara, Guadalajara, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Aut\u00f3noma de Guadalajara, Guadalajara, Mexico","institution_ids":["https://openalex.org/I130040446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070027463","display_name":"Zhi\u2010Dong Jiang","orcid":"https://orcid.org/0000-0002-3719-5548","observed_orcids":["https://orcid.org/0000-0002-3719-5548"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhi-Dong Jiang","raw_affiliation_strings":["University of Texas, Houston School of Public Health, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Houston School of Public Health, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034976745","display_name":"Edwin J. Asturias","orcid":"https://orcid.org/0000-0002-1275-0787","observed_orcids":["https://orcid.org/0000-0002-1275-0787"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin J Asturias","raw_affiliation_strings":["Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047751345","display_name":"Jane L. Halpern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane Halpern","raw_affiliation_strings":["Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075822207","display_name":"Olga R. Torres","orcid":"https://orcid.org/0000-0002-0069-6904","observed_orcids":["https://orcid.org/0000-0002-0069-6904"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga R Torres","raw_affiliation_strings":["Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065846765","display_name":"Ana S Hoffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana S Hoffman","raw_affiliation_strings":["Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091454762","display_name":"Christina P. Villar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina P Villar","raw_affiliation_strings":["IOMAI Corporation, Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOMAI Corporation, Gaithersburg, MD, USA","institution_ids":["https://openalex.org/I4210165951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080139101","display_name":"Raniya N Kassem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raniya N Kassem","raw_affiliation_strings":["IOMAI Corporation, Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOMAI Corporation, Gaithersburg, MD, USA","institution_ids":["https://openalex.org/I4210165951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091128747","display_name":"David C. Flyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C Flyer","raw_affiliation_strings":["IOMAI Corporation, Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOMAI Corporation, Gaithersburg, MD, USA","institution_ids":["https://openalex.org/I4210165951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008863078","display_name":"Bo H. Andersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo H Andersen","raw_affiliation_strings":["IOMAI Corporation, Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOMAI Corporation, Gaithersburg, MD, USA","institution_ids":["https://openalex.org/I4210165951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024853480","display_name":"Kazem Kazempour","orcid":"https://orcid.org/0000-0002-3465-848X","observed_orcids":["https://orcid.org/0000-0002-3465-848X"]},"institutions":[{"id":"https://openalex.org/I4405267402","display_name":"Amarex Clinical Research, LLC (United States)","ror":"https://ror.org/02kkvwc98","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267402"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazem Kazempour","raw_affiliation_strings":["Amarex Clinical Research, Germantown, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amarex Clinical Research, Germantown, MD, USA","institution_ids":["https://openalex.org/I4405267402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072137505","display_name":"S. Breisch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267402","display_name":"Amarex Clinical Research, LLC (United States)","ror":"https://ror.org/02kkvwc98","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267402"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sally A Breisch","raw_affiliation_strings":["Amarex Clinical Research, Germantown, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amarex Clinical Research, Germantown, MD, USA","institution_ids":["https://openalex.org/I4405267402"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032295889","display_name":"Gregory M. Glenn","orcid":"https://orcid.org/0000-0002-2030-8665","observed_orcids":["https://orcid.org/0000-0002-2030-8665"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210165951","display_name":"Iomai (United States)","ror":"https://ror.org/0144z1077","country_code":"US","type":"company","lineage":["https://openalex.org/I4210165951"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory M Glenn","raw_affiliation_strings":["IOMAI Corporation, Gaithersburg, MD, USA","Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOMAI Corporation, Gaithersburg, MD, USA","institution_ids":["https://openalex.org/I4210165951"]},{"raw_affiliation_string":"Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5032295889"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210165951"],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":23.7374,"has_fulltext":false,"cited_by_count":204,"citation_normalized_percentile":{"value":0.99745258,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"371","issue":"9629","first_page":"2019","last_page":"2025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12402","display_name":"Travel-related health issues","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12402","display_name":"Travel-related health issues","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.050999999046325684,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traveler-s-diarrhea","display_name":"traveler's diarrhea","score":0.9559999704360962},{"id":"https://openalex.org/keywords/enterotoxigenic-escherichia-coli","display_name":"enterotoxigenic Escherichia coli","score":0.9959999918937683},{"id":"https://openalex.org/keywords/heat-labile-toxin","display_name":"heat-labile toxin","score":0.8920000195503235},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.6050000190734863},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/diarrhea-prevention","display_name":"diarrhea prevention","score":0.5640000104904175},{"id":"https://openalex.org/keywords/travel-medicine","display_name":"travel medicine","score":0.47200000286102295},{"id":"https://openalex.org/keywords/mexico","display_name":"Mexico","score":0.6470000147819519},{"id":"https://openalex.org/keywords/guatemala","display_name":"Guatemala","score":1.0},{"id":"https://openalex.org/keywords/stool-output","display_name":"stool output","score":0.35100001096725464},{"id":"https://openalex.org/keywords/duration-of-diarrhea","display_name":"diarrhea duration","score":0.5149999856948853},{"id":"https://openalex.org/keywords/vaccine-adverse-events","display_name":"vaccine adverse events","score":0.3449999988079071},{"id":"https://openalex.org/keywords/vaccine-cost-effectiveness","display_name":"vaccine cost-effectiveness","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C2777871010","wikidata":"https://www.wikidata.org/wiki/Q265214","display_name":"Enterotoxigenic Escherichia coli","level":5,"score":0.8581783771514893},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7478841543197632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7174640893936157},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6915819644927979},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.6883959770202637},{"id":"https://openalex.org/C37701844","wikidata":"https://www.wikidata.org/wiki/Q3955915","display_name":"Attack rate","level":3,"score":0.4905034899711609},{"id":"https://openalex.org/C2778353597","wikidata":"https://www.wikidata.org/wiki/Q5693152","display_name":"Heat-labile enterotoxin","level":5,"score":0.4854198396205902},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4453936219215393},{"id":"https://openalex.org/C66999527","wikidata":"https://www.wikidata.org/wiki/Q421978","display_name":"Enterotoxin","level":4,"score":0.4127839505672455},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26933950185775757},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.2260076403617859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13918954133987427},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.1308692991733551},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006166","descriptor_name":"Guatemala","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008800","descriptor_name":"Mexico","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014195","descriptor_name":"Travel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022361","descriptor_name":"Escherichia coli Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D022361","descriptor_name":"Escherichia coli Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D022361","descriptor_name":"Escherichia coli Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0140-6736(08)60839-9","doi":"https://doi.org/10.1016/s0140-6736(08)60839-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(08)60839-9","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:18554712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18554712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W141684809","https://openalex.org/W1435540103","https://openalex.org/W1891613825","https://openalex.org/W2028025404","https://openalex.org/W2038968137","https://openalex.org/W2040313647","https://openalex.org/W2048889358","https://openalex.org/W2053243345","https://openalex.org/W2070202755","https://openalex.org/W2085889988","https://openalex.org/W2092534266","https://openalex.org/W2093758325","https://openalex.org/W2098838566","https://openalex.org/W2122034180","https://openalex.org/W2124974796","https://openalex.org/W2139265166","https://openalex.org/W2148784430","https://openalex.org/W2150056219","https://openalex.org/W2150779336","https://openalex.org/W2157739202","https://openalex.org/W2162830842","https://openalex.org/W2166449161","https://openalex.org/W2170398658","https://openalex.org/W2171184029","https://openalex.org/W2482409516","https://openalex.org/W4285719527","https://openalex.org/W6722533143"],"related_works":["https://openalex.org/W2159101101","https://openalex.org/W2053243345","https://openalex.org/W4367059418","https://openalex.org/W7095687762","https://openalex.org/W2085889988","https://openalex.org/W1509067395","https://openalex.org/W1898358747","https://openalex.org/W2043397952","https://openalex.org/W7220727415","https://openalex.org/W4237550209"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":23}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}