{"id":"https://openalex.org/W2105428693","doi":null,"title":"N-acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis.","display_name":"N-acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis.","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W2105428693","mag":"2105428693","pmid":"https://pubmed.ncbi.nlm.nih.gov/8240532"},"language":"en","primary_location":{"id":"pmid:8240532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8240532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080369708","display_name":"Eiji Miyoshi","orcid":"https://orcid.org/0000-0002-9430-2362","observed_orcids":["https://orcid.org/0000-0002-9430-2362"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E Miyoshi","raw_affiliation_strings":["Department of Biochemistry, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003653534","display_name":"Atsushi Nishikawa","orcid":"https://orcid.org/0000-0003-4325-1160","observed_orcids":["https://orcid.org/0000-0003-4325-1160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Nishikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028565980","display_name":"Yoshito Ihara","orcid":"https://orcid.org/0000-0002-8674-5681","observed_orcids":["https://orcid.org/0000-0002-8674-5681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063368801","display_name":"Jianxin Gu","orcid":"https://orcid.org/0000-0002-7454-6722","observed_orcids":["https://orcid.org/0000-0002-7454-6722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Gu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039161969","display_name":"Toshihiro Sugiyama","orcid":"https://orcid.org/0000-0001-5551-1340","observed_orcids":["https://orcid.org/0000-0001-5551-1340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sugiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014582936","display_name":"Norio Hayashi","orcid":"https://orcid.org/0000-0001-9309-1113","observed_orcids":["https://orcid.org/0000-0001-9309-1113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Hayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110898035","display_name":"H Fusamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Fusamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021161768","display_name":"Tomoari Kamada","orcid":"https://orcid.org/0000-0001-6195-2513","observed_orcids":["https://orcid.org/0000-0001-6195-2513"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kamada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044178319","display_name":"Naoyuki Taniguchi","orcid":"https://orcid.org/0000-0001-5889-5968","observed_orcids":["https://orcid.org/0000-0001-5889-5968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Taniguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9604,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.87389223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"53","issue":"17","first_page":"3899","last_page":"902"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gnt-iii","display_name":"N-acetylglucosaminyltransferase III","score":0.9990000128746033},{"id":"https://openalex.org/keywords/n-acetylglucosaminyltransferase-v","display_name":"N-acetylglucosaminyltransferase V","score":1.0},{"id":"https://openalex.org/keywords/lec-rats","display_name":"LEC rats","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/chronic-hepatitis","display_name":"chronic hepatitis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.34200000762939453},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6470000147819519},{"id":"https://openalex.org/keywords/chronic-liver-injury","display_name":"chronic liver injury","score":0.6470000147819519},{"id":"https://openalex.org/keywords/glycosyltransferase-expression","display_name":"glycosyltransferase expression","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5740228891372681},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5725972056388855},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.5196465253829956},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5057060718536377},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4942817687988281},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4872249662876129},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4731382429599762},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.46408769488334656},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.45412036776542664},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41475996375083923},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4125021994113922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3284728527069092},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30602937936782837},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16083529591560364},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12950772047042847}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006520","descriptor_name":"Hepatitis, Animal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017351","descriptor_name":"N-Acetylglucosaminyltransferases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8240532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8240532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.320.5608","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.5608","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/53/17/3899.full.pdf","raw_type":"text"},{"id":"mag:2105428693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8240532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W618811661","https://openalex.org/W1511386761","https://openalex.org/W1515230561","https://openalex.org/W1542757377","https://openalex.org/W1594515648","https://openalex.org/W1603050454","https://openalex.org/W1605848306","https://openalex.org/W1857907587","https://openalex.org/W1981775461","https://openalex.org/W1982725119","https://openalex.org/W2010020415","https://openalex.org/W2013586920","https://openalex.org/W2013796022","https://openalex.org/W2036133848","https://openalex.org/W2059058658","https://openalex.org/W2061327866","https://openalex.org/W2077717965","https://openalex.org/W2134812217","https://openalex.org/W2320268855"],"related_works":["https://openalex.org/W7098713063","https://openalex.org/W2068981824","https://openalex.org/W7095191585","https://openalex.org/W2318701653","https://openalex.org/W2016866360","https://openalex.org/W2438359407","https://openalex.org/W2072942165","https://openalex.org/W2051785514","https://openalex.org/W1594515648","https://openalex.org/W2134773230"],"abstract_inverted_index":{"The":[0,133],"LEC":[1,58,80,89,111,207,229],"(Long-Evans":[2,46],"with":[3,21,47,142,166],"a":[4,9,44,53],"cinnamon-like":[5],"color)":[6,50],"rat":[7,42,51,59,90],"is":[8],"mutant":[10],"of":[11,27,65,70,96,101,113,116,136,164,204,214],"the":[12,68,77,88,99,108,137,143,179,184,192,201,205,228],"Long-Evans":[13],"strain":[14],"which":[15],"develops":[16],"hereditary":[17],"hepatitis":[18],"and":[19,24,30,33,118,148,158,171,188,216,224],"hepatoma":[20,165],"age.":[22],"Activities":[23],"mRNA":[25,134,173],"levels":[26,135,190],"N-acetylglucosaminyltransferase":[28],"III":[29],"V":[31],"(GnT-III":[32],"GnT-V,":[34],"respectively)":[35],"were":[36,151,196],"determined":[37],"during":[38],"hepatocarcinogenesis":[39],"in":[40,57,79,87,110,128,131,140,154,178,183,191,200,227],"this":[41],"using":[43],"LEA":[45],"an":[48],"agouti":[49],"as":[52],"control.":[54],"GnT-III":[55,147,170,187,215],"activity":[56,86],"liver":[60,91,222],"increased":[61,92,139],"after":[62,93],"30":[63],"weeks":[64,95,115],"age,":[66,97],"at":[67,98],"stage":[69,100],"chronic":[71,221],"hepatitis,":[72,103],"to":[73,104,198],"about":[74,105],"2.5-11.5":[75],"times":[76,107],"level":[78,109],"rats":[81,112],"aged":[82],"1-9":[83,114],"weeks.":[84],"GnT-V":[85,149,172,189,217],"20":[94],"acute":[102],"1.5-2.5":[106],"age":[117],"then":[119],"remained":[120],"elevated.":[121],"Both":[122],"enzymes":[123,138],"showed":[124],"more":[125],"dramatic":[126],"increases":[127],"males":[129],"than":[130,182],"females.":[132],"proportion":[141],"enzyme":[144],"activities.":[145],"Furthermore,":[146],"mRNAs":[150],"highly":[152],"expressed":[153],"both":[155],"cancer":[156,194,202],"lesion":[157,181],"adjacent":[159],"tissues.":[160],"In":[161],"one":[162],"case":[163],"lymph":[167],"node":[168],"metastasis,":[169],"expression":[174,213],"was":[175,218],"much":[176],"higher":[177],"metastatic":[180],"original":[185,193],"cancer.":[186],"lesions":[195,203],"similar":[197],"those":[199],"other":[206],"rats.":[208,230],"These":[209],"results":[210],"indicated":[211],"that":[212],"induced":[219],"by":[220],"damage":[223],"hepatocarcinogenic":[225],"changes":[226]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}