{"id":"https://openalex.org/W2105426237","doi":null,"title":"THE IMPACT OF THE INTRODUCTION OF AN ENANTIOMER OF AN ALREADY MARKETED RACEMIC PHARMACEUTICAL PRODUCT ON DRUG UTILIZATION AND MARKET SHARE IN THE SOUTH AFRICAN PHARMACEUTICAL MARKET.","display_name":"THE IMPACT OF THE INTRODUCTION OF AN ENANTIOMER OF AN ALREADY MARKETED RACEMIC PHARMACEUTICAL PRODUCT ON DRUG UTILIZATION AND MARKET SHARE IN THE SOUTH AFRICAN PHARMACEUTICAL MARKET.","publication_year":2014,"publication_date":"2014-08-25","ids":{"openalex":"https://openalex.org/W2105426237","mag":"2105426237"},"language":"en","primary_location":{"id":"pmh:oai:wiredspace.wits.ac.za:10539/15241","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10539/15241","pdf_url":"http://hdl.handle.net/10539/15241","source":{"id":"https://openalex.org/S4306400603","display_name":"University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192619145","host_organization_name":"University of the Witwatersrand","host_organization_lineage":["https://openalex.org/I192619145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10539/15241","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059984922","display_name":"Saiyuri Nair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Saiyuri Nair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059984922"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11649","display_name":"Pharmaceutical industry and healthcare","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chiral-switching","display_name":"chiral switching","score":0.9959999918937683},{"id":"https://openalex.org/keywords/enantiomers","display_name":"enantiomers","score":0.824999988079071},{"id":"https://openalex.org/keywords/racemic-drugs","display_name":"racemic drugs","score":0.8169999718666077},{"id":"https://openalex.org/keywords/medication-use","display_name":"medication use","score":0.9120000004768372},{"id":"https://openalex.org/keywords/market-share","display_name":"market share","score":0.8669999837875366},{"id":"https://openalex.org/keywords/pharmaceutical-market","display_name":"pharmaceutical market","score":0.6769999861717224},{"id":"https://openalex.org/keywords/generic-drugs","display_name":"generic drugs","score":0.6259999871253967},{"id":"https://openalex.org/keywords/sales-trends","display_name":"sales trends","score":0.6000000238418579},{"id":"https://openalex.org/keywords/prescribing-patterns","display_name":"prescribing patterns","score":0.48399999737739563},{"id":"https://openalex.org/keywords/patent-challenges","display_name":"patent challenges","score":0.7570000290870667},{"id":"https://openalex.org/keywords/pharmaceutical-marketing","display_name":"pharmaceutical marketing","score":0.453000009059906},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"stereochemistry","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.5537049174308777},{"id":"https://openalex.org/C2779535233","wikidata":"https://www.wikidata.org/wiki/Q12140","display_name":"Pharmaceutical drug","level":3,"score":0.49979233741760254},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.49408963322639465},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.484684020280838},{"id":"https://openalex.org/C16051113","wikidata":"https://www.wikidata.org/wiki/Q828814","display_name":"Market share","level":2,"score":0.4648505747318268},{"id":"https://openalex.org/C2779652045","wikidata":"https://www.wikidata.org/wiki/Q507443","display_name":"Pharmaceutical industry","level":2,"score":0.45818865299224854},{"id":"https://openalex.org/C2778938233","wikidata":"https://www.wikidata.org/wiki/Q7180757","display_name":"Pharmaceutical manufacturing","level":2,"score":0.42047247290611267},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3814045190811157},{"id":"https://openalex.org/C54750564","wikidata":"https://www.wikidata.org/wiki/Q26643","display_name":"Commerce","level":1,"score":0.349664568901062},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.2408003807067871},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22852635383605957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22242391109466553},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19209760427474976},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.1480272114276886},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10826140642166138},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:wiredspace.wits.ac.za:10539/15241","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10539/15241","pdf_url":"http://hdl.handle.net/10539/15241","source":{"id":"https://openalex.org/S4306400603","display_name":"University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192619145","host_organization_name":"University of the Witwatersrand","host_organization_lineage":["https://openalex.org/I192619145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2105426237","doi":null,"is_oa":false,"landing_page_url":"https://wiredspace.wits.ac.za/bitstream/handle/10539/15241/S%20Nair%200402007H%20Final%20Submission%20Report%20Feb%202014.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:wiredspace.wits.ac.za:10539/15241","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10539/15241","pdf_url":"http://hdl.handle.net/10539/15241","source":{"id":"https://openalex.org/S4306400603","display_name":"University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192619145","host_organization_name":"University of the Witwatersrand","host_organization_lineage":["https://openalex.org/I192619145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105426237.pdf","grobid_xml":"https://content.openalex.org/works/W2105426237.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W181940357","https://openalex.org/W582140702","https://openalex.org/W1514933372","https://openalex.org/W1558220791","https://openalex.org/W1576462351","https://openalex.org/W1667663201","https://openalex.org/W1976826745","https://openalex.org/W1977876576","https://openalex.org/W1991998089","https://openalex.org/W2014785034","https://openalex.org/W2036105878","https://openalex.org/W2046654869","https://openalex.org/W2059252785","https://openalex.org/W2060985800","https://openalex.org/W2067033834","https://openalex.org/W2082363592","https://openalex.org/W2082560103","https://openalex.org/W2088294577","https://openalex.org/W2111325415","https://openalex.org/W2112833180","https://openalex.org/W2120504104","https://openalex.org/W2135499572","https://openalex.org/W2137388846","https://openalex.org/W2142938567","https://openalex.org/W2163437684","https://openalex.org/W2170590779","https://openalex.org/W4233411289"],"related_works":["https://openalex.org/W2372095914","https://openalex.org/W2187006251","https://openalex.org/W2050366421","https://openalex.org/W1463581258","https://openalex.org/W3159066361","https://openalex.org/W178411252","https://openalex.org/W7065006200","https://openalex.org/W4212777366","https://openalex.org/W1991998089","https://openalex.org/W2067033834"],"abstract_inverted_index":{"BACKGROUND:":[0],"\\nStereochemistry":[1],"is":[2,58,294,324],"often":[3],"used":[4],"in":[5,93,193],"the":[6,21,38,85,94,108,114,132,135,143,146,150,163,171,177,182,188,213,220,223,228,245,252,264,268,310,333,371],"development":[7],"of":[8,11,20,28,31,40,73,90,107,117,134,145,162,169,203,212,244,251,267,309,328],"drugs.":[9],"Enantiomers":[10],"a":[12,24,44,55,64,129,295,325,367],"chiral":[13,78],"drug":[14,119,265],"are":[15],"two":[16,233],"non-superimposable":[17],"mirror":[18],"images":[19],"molecule":[22,45],"and":[23,48,61,69,87,103,113,125,166,176,200,209,215,237,354],"racemic":[25],"mixture":[26],"consists":[27],"equal":[29],"quantities":[30],"both":[32,170,197],"enantiomers.":[33],"This":[34],"study":[35,183],"looks":[36],"at":[37,254],"phenomenon":[39],"\u201cchiral":[41,292],"switching\u201d":[42],"where":[43],"previously":[46],"developed":[47,60],"marketed":[49],"by":[50,299],"an":[51,315],"innovator":[52,300],"company":[53],"as":[54,63,205,207,343],"racemate":[56,109,172,214,253],"medicine":[57],"later":[59],"launched":[62],"single":[65,115,136,147,178,224,269,311],"enantiomer.":[66],"Drug":[67,307],"utilization":[68,266,308],"market":[70,194,305,360],"share":[71,195],"data":[72,106],"three":[74,118,139,238,277],"molecules":[75],"that":[76,291,322,361],"underwent":[77],"switching":[79],"were":[80,127,285],"investigated":[81],"retrospectively":[82],"to":[83,138,142,261,280,302,350,358,365],"determine":[84,262],"clinical":[86,330],"economic":[88],"impact":[89],"these":[91],"occurrences":[92],"private":[95,151],"South":[96],"African":[97],"pharmaceutical":[98],"market.":[99,152],"\\nMETHOD:":[100],"\\nUnit":[101],"sales":[102,105,168,199],"rand":[104,167,201],"(and":[110,173],"its":[111,174,216,231,281,319],"generics)":[112,175],"enantiomer":[116,137,148,179,225,246,270,312],"substance":[120],"pairs,":[121],"namely":[122],"omeprazole-esomeprazole,":[123],"citalopram-escitalopram":[124],"cetirizine-levocetirizine":[126],"gathered":[128],"year":[130,189,191,221,229],"preceding":[131],"launch":[133,144,236,320],"years":[140,234,239,278],"subsequent":[141,279],"onto":[149],"\\nDATA":[153],"ANALYSIS:":[154],"\\nDescriptive":[155],"statistical":[156],"analysis":[157],"included":[158],"plotting":[159],"trend":[160,317],"lines":[161],"annual":[164],"unit":[165,198],"products":[180],"during":[181],"period,":[184],"pie":[185],"charts":[186],"illustrating":[187],"on":[190],"differences":[192],"(in":[196],"value":[202],"sales)":[204],"well":[206],"box":[208],"whisker":[210],"plots":[211],"generics":[217],"plotted":[218],"for":[219,332],"before":[222],"was":[226,258],"launched,":[227],"after":[230,235,240],"launch,":[232],"launch.":[241,282],"\\nThe":[242],"probability":[243],"being":[247],"prescribed/":[248],"sold":[249],"instead":[250],"different":[255],"time":[256],"points":[257],"also":[259],"calculated":[260],"whether":[263],"increased":[271],"or":[272],"decreased":[273],"from":[274,370],"introduction":[275],"until":[276],"\\nCONCLUSION:":[283],"\\nResults":[284],"consistent":[286],"with":[287],"global":[288],"literature":[289],"indicating":[290,321],"switching\u2019":[293],"successful":[296],"strategy":[297],"employed":[298],"companies":[301],"extend":[303],"their":[304],"share.":[306],"generally":[313],"showed":[314],"upward":[316],"following":[318],"there":[323],"perceived":[326],"belief":[327],"enhanced":[329],"outcomes":[331],"patient.":[334],"There":[335],"are,":[336],"however,":[337],"many":[338],"other":[339],"influencing":[340],"factors":[341],"such":[342],"pricing":[344],"strategies,":[345],"prescription":[346],"status,":[347],"marketing":[348],"efforts":[349],"physicians":[351],"and/or":[352],"consumers":[353],"patent":[355],"challenges":[356],"specific":[357],"each":[359],"make":[362],"it":[363],"difficult":[364],"draw":[366],"general":[368],"conclusion":[369],"case":[372],"studies.":[373]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
