{"id":"https://openalex.org/W2105384751","doi":"https://doi.org/10.1128/jvi.79.16.10258-10267.2005","title":"Mutations of a Residue within the Polyproline-Rich Region of Env Alter the Replication Rate and Level of Cytopathic Effects in Chimeric Avian Retroviral Vectors","display_name":"Mutations of a Residue within the Polyproline-Rich Region of Env Alter the Replication Rate and Level of Cytopathic Effects in Chimeric Avian Retroviral Vectors","publication_year":2005,"publication_date":"2005-07-28","ids":{"openalex":"https://openalex.org/W2105384751","doi":"https://doi.org/10.1128/jvi.79.16.10258-10267.2005","mag":"2105384751","pmid":"https://pubmed.ncbi.nlm.nih.gov/16051819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1182669"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.79.16.10258-10267.2005","doi":"https://doi.org/10.1128/jvi.79.16.10258-10267.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.79.16.10258-10267.2005","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1182669","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000975940","display_name":"Kevin W. Chang","orcid":"https://orcid.org/0000-0002-1529-1547","observed_orcids":["https://orcid.org/0000-0002-1529-1547"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin W. Chang","raw_affiliation_strings":["HIV Drug Resistance Program","HIV Drug Resistance Program, NCI-Frederick, P.O. Box B, Bldg. 539, Rm. 130A, Frederick, MD 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Drug Resistance Program","institution_ids":[]},{"raw_affiliation_string":"HIV Drug Resistance Program, NCI-Frederick, P.O. Box B, Bldg. 539, Rm. 130A, Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031493412","display_name":"Eugene V. Barsov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene V. Barsov","raw_affiliation_strings":["AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIDS Vaccine Program, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065002408","display_name":"Andrea L. Ferris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea L. Ferris","raw_affiliation_strings":["HIV Drug Resistance Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Drug Resistance Program","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063432648","display_name":"Stephen H. Hughes","orcid":"https://orcid.org/0000-0002-9176-4377","observed_orcids":["https://orcid.org/0000-0002-9176-4377"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stephen H. Hughes","raw_affiliation_strings":["HIV Drug Resistance Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Drug Resistance Program","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063432648"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1797,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.5696404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"16","first_page":"10258","last_page":"10267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cytopathic-effect","display_name":"cytopathic effect","score":0.8970000147819519},{"id":"https://openalex.org/keywords/viral-replication-rate","display_name":"viral replication rate","score":0.9430000185966492},{"id":"https://openalex.org/keywords/superinfection","display_name":"superinfection","score":0.7929999828338623},{"id":"https://openalex.org/keywords/dantrolene","display_name":"dantrolene","score":0.8019999861717224},{"id":"https://openalex.org/keywords/er-calcium-release","display_name":"endoplasmic reticulum calcium release","score":0.9639999866485596},{"id":"https://openalex.org/keywords/df-1-cells","display_name":"DF-1 cells","score":0.7820000052452087},{"id":"https://openalex.org/keywords/retroviral-integration","display_name":"retroviral integration","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8888771533966064},{"id":"https://openalex.org/C2779562191","wikidata":"https://www.wikidata.org/wiki/Q673848","display_name":"Murine leukemia virus","level":3,"score":0.6949124336242676},{"id":"https://openalex.org/C2775996393","wikidata":"https://www.wikidata.org/wiki/Q1149147","display_name":"Cytopathic effect","level":3,"score":0.6694055199623108},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6182640194892883},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5804101228713989},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5644227862358093},{"id":"https://openalex.org/C109300003","wikidata":"https://www.wikidata.org/wiki/Q4384651","display_name":"Polyproline helix","level":3,"score":0.47552111744880676},{"id":"https://openalex.org/C2779057330","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis virus","level":3,"score":0.4565872251987457},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4288700819015503},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3537822365760803},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1801929771900177},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.09060096740722656}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003588","descriptor_name":"Cytopathogenic Effect, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003620","descriptor_name":"Dantrolene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015686","descriptor_name":"Gene Products, env","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015686","descriptor_name":"Gene Products, env","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D030101","descriptor_name":"Orthoreovirus, Avian","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D030101","descriptor_name":"Orthoreovirus, Avian","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.79.16.10258-10267.2005","doi":"https://doi.org/10.1128/jvi.79.16.10258-10267.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.79.16.10258-10267.2005","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:135699","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1182669","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1182669","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1182669","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:16051819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16051819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:135699","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1182669","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4399999976158142}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1486089719","https://openalex.org/W1523547189","https://openalex.org/W1550800843","https://openalex.org/W1580152765","https://openalex.org/W1607531254","https://openalex.org/W1750754733","https://openalex.org/W1811276736","https://openalex.org/W1867855488","https://openalex.org/W1878416326","https://openalex.org/W1933088939","https://openalex.org/W1955620128","https://openalex.org/W1965372133","https://openalex.org/W1967446284","https://openalex.org/W1969563526","https://openalex.org/W1988463127","https://openalex.org/W1988892878","https://openalex.org/W1993679430","https://openalex.org/W2002208801","https://openalex.org/W2002918763","https://openalex.org/W2012211657","https://openalex.org/W2015426350","https://openalex.org/W2017396673","https://openalex.org/W2035317074","https://openalex.org/W2035706870","https://openalex.org/W2071636231","https://openalex.org/W2090239621","https://openalex.org/W2090507582","https://openalex.org/W2096121392","https://openalex.org/W2097471575","https://openalex.org/W2100212039","https://openalex.org/W2102299427","https://openalex.org/W2103157722","https://openalex.org/W2119715608","https://openalex.org/W2120444788","https://openalex.org/W2140911321","https://openalex.org/W4299903393"],"related_works":["https://openalex.org/W2120444788","https://openalex.org/W2125040892","https://openalex.org/W2145261002","https://openalex.org/W2096953993","https://openalex.org/W1878416326","https://openalex.org/W2053260806","https://openalex.org/W1985787314","https://openalex.org/W1640074291","https://openalex.org/W412718993","https://openalex.org/W2017444199"],"abstract_inverted_index":{"Previous":[0],"attempts":[1],"to":[2,42,213],"extend":[3],"the":[4,8,29,46,82,86,91,101,116,131,137,145,158,173,186,191,196,204,222,228],"host":[5],"range":[6],"of":[7,70,81,90,136,147,160,177,188,198],"avian":[9,47],"sarcoma/leukosis":[10],"virus":[11,33,215],"(ASLV)-based":[12],"RCASBP":[13,19,23,52,64,95,112,178],"vectors":[14],"produced":[15],"two":[16,73],"viral":[17],"vectors,":[18],"M2C":[20,24,53,65,96,113,179],"(4070A)":[21,54],"and":[22,133,157],"(797-8),":[25],"which":[26,184],"replicate":[27,43],"using":[28],"amphotropic":[30],"murine":[31],"leukemia":[32],"4070A":[34],"Env":[35,92],"protein":[36],"(2).":[37],"Both":[38],"viruses":[39,74],"were":[40],"adapted":[41],"efficiently":[44],"in":[45,60,85,111,153,172,227],"cell":[48],"line":[49],"DF-1,":[50],"but":[51],"caused":[55,230],"extensive":[56],"cytopathic":[57],"effects":[58],"(CPE)":[59],"DF-1":[61,155],"cells":[62,156,181],"whereas":[63,105],"(797-8)":[66],"induced":[67],"low":[68],"levels":[69],"CPE.":[71,161,174],"The":[72,175],"differed":[75],"only":[76],"at":[77,126],"amino":[78,123],"acid":[79,124],"242":[80,128],"polyproline-rich":[83],"region":[84],"surface":[87],"(SU)":[88],"subunit":[89],"protein.":[93],"In":[94,115],"(4070A),":[97],"an":[98],"isoleucine":[99],"replaced":[100],"wild-type":[102],"proline":[103],"residue,":[104],"a":[106,142,168,225],"threonine":[107],"residue":[108],"was":[109,141],"found":[110],"(797-8).":[114],"present":[117,152],"study,":[118],"we":[119],"show":[120],"that":[121,164,218],"other":[122],"substitutions":[125],"position":[127],"strongly":[129],"influence":[130],"CPE":[132,199,229],"replication":[134],"rate":[135],"chimeric":[138],"viruses.":[139,233],"There":[140],"correlation":[143],"between":[144],"amount":[146,197],"unintegrated":[148],"linear":[149],"retroviral":[150],"DNA":[151],"infected":[154],"level":[159],"This":[162],"suggests":[163],"there":[165],"may":[166],"be":[167],"role":[169,226],"for":[170],"superinfection":[171],"treatment":[176,209],"(4070A)-infected":[180],"with":[182,203],"dantrolene,":[183],"inhibits":[185],"release":[187,220],"calcium":[189],"from":[190,221],"endoplasmic":[192],"reticulum":[193],"(ER),":[194],"reduced":[195],"seen":[200],"during":[201],"infection":[202],"highly":[205],"cytotoxic":[206],"virus.":[207],"Dantrolene":[208],"did":[210],"not":[211],"appear":[212],"affect":[214],"production,":[216],"suggesting":[217],"Ca2+":[219],"ER":[223],"had":[224],"by":[231],"these":[232]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
