{"id":"https://openalex.org/W2105280248","doi":"https://doi.org/10.1016/s0166-2236(00)02118-4","title":"Rho proteins, mental retardation and the cellular basis of cognition","display_name":"Rho proteins, mental retardation and the cellular basis of cognition","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2105280248","doi":"https://doi.org/10.1016/s0166-2236(00)02118-4","mag":"2105280248","pmid":"https://pubmed.ncbi.nlm.nih.gov/11998687"},"language":"en","primary_location":{"id":"doi:10.1016/s0166-2236(00)02118-4","doi":"https://doi.org/10.1016/s0166-2236(00)02118-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0166-2236(00)02118-4","pdf_url":null,"source":{"id":"https://openalex.org/S114966740","display_name":"Trends in Neurosciences","issn_l":"0166-2236","issn":["0166-2236","1878-108X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Neurosciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103731578","display_name":"G.J.A. Ramakers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ger J.A. Ramakers","raw_affiliation_strings":["Neurons and Networks, Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurons and Networks, Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103731578"],"corresponding_institution_ids":[],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":3.2582,"has_fulltext":false,"cited_by_count":382,"citation_normalized_percentile":{"value":0.95334174,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"25","issue":"4","first_page":"191","last_page":"199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.9869999885559082},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":0.8759999871253967},{"id":"https://openalex.org/keywords/oligophrenin-1","display_name":"OPHN1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/pak3","display_name":"PAK3","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dendritic-abnormalities","display_name":"dendritic abnormalities","score":0.824999988079071},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9750000238418579},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9800000190734863},{"id":"https://openalex.org/keywords/synaptic-connectivity","display_name":"synaptic connectivity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.8519999980926514},{"id":"https://openalex.org/keywords/rho-gtpase-signaling","display_name":"Rho GTPase signaling","score":0.6880000233650208},{"id":"https://openalex.org/keywords/neural-connectivity","display_name":"neuronal connectivity","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.7437646389007568},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6871732473373413},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.5840557217597961},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5802133679389954},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.5596529245376587},{"id":"https://openalex.org/C69125201","wikidata":"https://www.wikidata.org/wiki/Q2034716","display_name":"Axon guidance","level":3,"score":0.4575774371623993},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42570456862449646},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.420392781496048},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.41522371768951416},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27281466126441956},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.17723509669303894},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1443481743335724},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.13154876232147217},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009421","descriptor_name":"Nervous System Malformations","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009421","descriptor_name":"Nervous System Malformations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009421","descriptor_name":"Nervous System Malformations","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0166-2236(00)02118-4","doi":"https://doi.org/10.1016/s0166-2236(00)02118-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0166-2236(00)02118-4","pdf_url":null,"source":{"id":"https://openalex.org/S114966740","display_name":"Trends in Neurosciences","issn_l":"0166-2236","issn":["0166-2236","1878-108X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Neurosciences","raw_type":"journal-article"},{"id":"pmid:11998687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11998687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in neurosciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W1479736082","https://openalex.org/W1488423107","https://openalex.org/W1490646520","https://openalex.org/W1496017988","https://openalex.org/W1499109786","https://openalex.org/W1502719441","https://openalex.org/W1502764703","https://openalex.org/W1522845019","https://openalex.org/W1525734429","https://openalex.org/W1548084460","https://openalex.org/W1567217875","https://openalex.org/W1587505135","https://openalex.org/W1595029695","https://openalex.org/W1637051517","https://openalex.org/W1876061808","https://openalex.org/W1881079438","https://openalex.org/W1960862471","https://openalex.org/W1963806203","https://openalex.org/W1968139369","https://openalex.org/W1976075428","https://openalex.org/W1978985265","https://openalex.org/W1981974944","https://openalex.org/W1984967137","https://openalex.org/W1986349419","https://openalex.org/W1992557615","https://openalex.org/W1992763171","https://openalex.org/W1993056927","https://openalex.org/W1995757732","https://openalex.org/W1997087774","https://openalex.org/W1997814123","https://openalex.org/W1999937407","https://openalex.org/W2001065634","https://openalex.org/W2002825628","https://openalex.org/W2003084435","https://openalex.org/W2004379046","https://openalex.org/W2013591946","https://openalex.org/W2014789681","https://openalex.org/W2014896785","https://openalex.org/W2016196969","https://openalex.org/W2021680936","https://openalex.org/W2022959185","https://openalex.org/W2025444657","https://openalex.org/W2029815010","https://openalex.org/W2032295238","https://openalex.org/W2032419047","https://openalex.org/W2032968624","https://openalex.org/W2033087539","https://openalex.org/W2036940384","https://openalex.org/W2039378730","https://openalex.org/W2048108096","https://openalex.org/W2049811270","https://openalex.org/W2054813108","https://openalex.org/W2063314066","https://openalex.org/W2064784276","https://openalex.org/W2070263067","https://openalex.org/W2075227275","https://openalex.org/W2077792958","https://openalex.org/W2080064173","https://openalex.org/W2083439934","https://openalex.org/W2084900570","https://openalex.org/W2090116050","https://openalex.org/W2090118472","https://openalex.org/W2090449445","https://openalex.org/W2093382854","https://openalex.org/W2094825037","https://openalex.org/W2096791952","https://openalex.org/W2099731590","https://openalex.org/W2102342557","https://openalex.org/W2103062633","https://openalex.org/W2104948489","https://openalex.org/W2105746559","https://openalex.org/W2106913811","https://openalex.org/W2111916392","https://openalex.org/W2112668385","https://openalex.org/W2115654943","https://openalex.org/W2115807387","https://openalex.org/W2121259502","https://openalex.org/W2122864805","https://openalex.org/W2130196728","https://openalex.org/W2130631987","https://openalex.org/W2133258871","https://openalex.org/W2138191175","https://openalex.org/W2148386452","https://openalex.org/W2153915883","https://openalex.org/W2155978280","https://openalex.org/W2160207967","https://openalex.org/W2167956058","https://openalex.org/W2170467038","https://openalex.org/W2171251197","https://openalex.org/W2171501632","https://openalex.org/W2176744910","https://openalex.org/W2245994765"],"related_works":["https://openalex.org/W1586501510","https://openalex.org/W2061895982","https://openalex.org/W99458907","https://openalex.org/W2128186951","https://openalex.org/W38135832","https://openalex.org/W1966740221","https://openalex.org/W1968929045","https://openalex.org/W1990862567","https://openalex.org/W1982121383","https://openalex.org/W2127575685"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":25},{"year":2013,"cited_by_count":26},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}